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Mary Ann Thompson Arildsen, M.D., Ph.D.

Associate Professor of Pathology, Microbiology and Immunology
Researcher

Contact Information:

Vanderbilt University Medical Center
4605 TVC (4310)
Nashville, TN 37232
615-322-3320

Education
  • M.D. - University of Pennsylvania, 1983
  • Ph.D. - University of Pennsylvania, 1983
  • Fellowship - New York University Medical Center
  • Internship - NationalCancer Institute of the National Institute of Health
  • Post Graduate Training - Institute for Cancer Research
  • Post Graduate Training - National Cancer Institute of the National Institute of Health
  • Post Graduate Training - Vanderbilt University Medical Center
  • Residency - National Institutes of Health
Research Description

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Publications
  • Thompson MA, Edmonds MD, Liang S, McClintock-Treep S, Wang X, Li S, Eischen CM. MiR-31 and miR-17-5p levels change during transformation of follicular lymphoma. Hum. Pathol [print-electronic]. 2016 Apr; 50: 118-26. PMID: 26997445, PMCID: PMC4804154, PII: S0046-8177(15)00481-5, DOI: 10.1016/j.humpath.2015.11.011, ISSN: 1532-8392.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26997445.
  • Wang XJ, Medeiros LJ, Lin P, Yin CC, Hu S, Thompson MA, Li S. MYC cytogenetic status correlates with expression and has prognostic significance in patients with MYC/BCL2 protein double-positive diffuse large B-cell lymphoma. Am. J. Surg. Pathol. 2015 Sep; 39(9): 1250-8. PMID: 25828389, DOI: 10.1097/PAS.0000000000000433, ISSN: 1532-0979.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25828389.
  • Cleveland SM, Goodings C, Tripathi RM, Elliott N, Thompson MA, Guo Y, Shyr Y, Davé UP. LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Exp. Hematol [print-electronic]. 2014 Jul; 42(7): 581-93.e5. PMID: 24792354, PMCID: PMC4241760, PII: S0301-472X(14)00155-6, DOI: 10.1016/j.exphem.2014.04.010, ISSN: 1873-2399.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24792354.
  • Seegmiller Adam, Thompson Mary Ann. Hematology and Immunology: Quality in Laboratory Diagnosis. New York City (United States): Demos Medical; 2014.95 p.
  • Smith MC, Cohen DN, Greig B, Yenamandra A, Vnencak-Jones C, Thompson MA, Kim AS. The ambiguous boundary between EBV-related hemophagocytic lymphohistiocytosis and systemic EBV-driven T cell lymphoproliferative disorder. Int J Clin Exp Pathol. 2014; 7(9): 5738-49. PMID: 25337215, PMCID: PMC4203186, ISSN: 1936-2625.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25337215.
  • Smith S, Tripathi R, Goodings C, Cleveland S, Mathias E, Hardaway JA, Elliott N, Yi Y, Chen X, Downing J, Mullighan C, Swing DA, Tessarollo L, Li L, Love P, Jenkins NA, Copeland NG, Thompson MA, Du Y, Davé UP. LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways. PLoS ONE. 2014; 9(1): e85883. PMID: 24465765, PMCID: PMC3897537, PII: PONE-D-13-40599, DOI: 10.1371/journal.pone.0085883, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24465765.
  • Stevens PL, Johnson DB, Thompson MA, Keedy VL, Frangoul HA, Snyder KM. Adult neuroblastoma complicated by increased intracranial pressure: a case report and review of the literature. Case Rep Oncol Med [print-electronic]. 2014; 2014: 341980. PMID: 25328733, PMCID: PMC4190830, DOI: 10.1155/2014/341980, ISSN: 2090-6706.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25328733.
  • Thompson, M.A.. Wintrobe's Clinical Hematology. 13th Edition. Philadelphia (United States): Lippincott Williams & Wilkins; 2014.Chapter on Molecular Genetics of Acute Leukemia.
  • Seegmiller AC, Kim AS, Mosse CA, Levy MA, Thompson MA, Kressin MK, Jagasia MH, Strickland SA, Reddy NM, Marx ER, Sinkfield KJ, Pollard HN, Plummer WD, Dupont WD, Shultz EK, Dittus RS, Stead WW, Santoro SA, Zutter MM. Optimizing personalized bone marrow testing using an evidence-based, interdisciplinary team approach. Am. J. Clin. Pathol. 2013 Nov; 140(5): 643-50. PMID: 24124142, PMCID: PMC4159763, PII: 140/5/643, DOI: 10.1309/AJCP8CKE9NEINQFL, ISSN: 1943-7722.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24124142.
  • Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, Hunt A, Bhaskara S, Luzwick JW, Sampathi S, Chen X, Thompson MA, Cortez D, Hiebert SW. HDAC3 is essential for DNA replication in hematopoietic progenitor cells. J. Clin. Invest [print-electronic]. 2013 Jul; 123(7): 3112-23. PMID: 23921131, PMCID: PMC3696547, PII: 60806, DOI: 10.1172/JCI60806, ISSN: 1558-8238.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23921131.
  • Boelte KC, Gordy LE, Joyce S, Thompson MA, Yang L, Lin PC. Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1. PLoS ONE. 2011; 6(4): e18534. PMID: 21494556, PMCID: PMC3073977, DOI: 10.1371/journal.pone.0018534, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21494556.
  • Davé UP, Akagi K, Tripathi R, Cleveland SM, Thompson MA, Yi M, Stephens R, Downing JR, Jenkins NA, Copeland NG. Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy. PLoS Genet [print-electronic]. 2009 May; 5(5): e1000491. PMID: 19461887, PMCID: PMC2679194, DOI: 10.1371/journal.pgen.1000491, ISSN: 1553-7404.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19461887.
  • Chyla BJ, Moreno-Miralles I, Steapleton MA, Thompson MA, Bhaskara S, Engel M, Hiebert SW. Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol. Cell. Biol [print-electronic]. 2008 Oct; 28(20): 6234-47. PMID: 18710942, PMCID: PMC2577421, PII: MCB.00404-08, DOI: 10.1128/MCB.00404-08, ISSN: 1098-5549.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18710942.
  • Yang G, Thompson MA, Brandt SJ, Hiebert SW. Histone deacetylase inhibitors induce the degradation of the t(8;21) fusion oncoprotein. Oncogene [print-electronic]. 2007 Jan 1/4/2007; 26(1): 91-101. PMID: 16799637, PII: 1209760, DOI: 10.1038/sj.onc.1209760, ISSN: 0950-9232.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16799637.
  • Salmon JS, Thompson MA, Arildsen RC, Greer JP. Non-Hodgkin's lymphoma involving the liver: clinical and therapeutic considerations. Clin Lymphoma Myeloma. 2006 Jan; 6(4): 273-80. PMID: 16507204, PII: S1557-9190(11)70402-4, ISSN: 1557-9190.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16507204.
  • Moreno-Miralles I, Pan L, Keates-Baleeiro J, Durst-Goodwin K, Yang C, Kim HG, Thompson MA, Klug CA, Cleveland JL, Hiebert SW. The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia. J. Biol. Chem [print-electronic]. 2005 Dec 12/2/2005; 280(48): 40097-103. PMID: 16199529, PII: M506855200, DOI: 10.1074/jbc.M506855200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16199529.
  • Amann JM, Chyla BJ, Ellis TC, Martinez A, Moore AC, Franklin JL, McGhee L, Meyers S, Ohm JE, Luce KS, Ouelette AJ, Washington MK, Thompson MA, King D, Gautam S, Coffey RJ, Whitehead RH, Hiebert SW. Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol. Cell. Biol. 2005 Nov; 25(21): 9576-85. PMID: 16227606, PMCID: PMC1265807, PII: 25/21/9576, DOI: 10.1128/MCB.25.21.9576-9585.2005, ISSN: 0270-7306.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16227606.
  • Yang G, Khalaf W, van de Locht L, Jansen JH, Gao M, Thompson MA, van der Reijden BA, Gutmann DH, Delwel R, Clapp DW, Hiebert SW. Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein. Mol. Cell. Biol. 2005 Jul; 25(14): 5869-79. PMID: 15988004, PMCID: PMC1168824, PII: 25/14/5869, DOI: 10.1128/MCB.25.14.5869-5879.2005, ISSN: 0270-7306.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15988004.
  • Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S, Brandt SJ, Roberts J, Zhang X, Shyr Y, Kinney MC. Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas. Hum. Pathol. 2005 May; 36(5): 494-504. PMID: 15948116, PII: S0046817705001280, DOI: 10.1016/j.humpath.2005.03.004, ISSN: 0046-8177.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15948116.
  • Uherova P, Olson S, Thompson MA, Juskevicius R, Hamilton KS. Expression of c-FLIP in classic and nodular lymphocyte-predominant Hodgkin lymphoma. Appl. Immunohistochem. Mol. Morphol. 2004 Jun; 12(2): 105-10. PMID: 15354734, ISSN: 1541-2016.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15354734.
  • King D, Yang G, Thompson MA, Hiebert SW. Loss of neurofibromatosis-1 and p19(ARF) cooperate to induce a multiple tumor phenotype. Oncogene. 2002 Jul 7/25/2002; 21(32): 4978-82. PMID: 12118376, DOI: 10.1038/sj.onc.1205632, ISSN: 0950-9232.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12118376.
  • Chang L, Thompson MA. Activity of the distal positive element of the peripherin gene is dependent on proteins binding to an Ets-like recognition site and a novel inverted repeat site. J. Biol. Chem. 1996 Mar 3/15/1996; 271(11): 6467-75. PMID: 8626448, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8626448.
  • Adams AD, Choate DM, Thompson MA. NF1-L is the DNA-binding component of the protein complex at the peripherin negative regulatory element. J. Biol. Chem. 1995 Mar 3/24/1995; 270(12): 6975-83. PMID: 7896848, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7896848.