The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers

Matthew D. Breyer, M.D.

Professor
Researcher

Contact Information:

Vanderbilt University Medical Center
S-3223 Medical Center North
Nashville, TN 37232-2372
615-343-9867

Research Specialty

Diabetic nephropathy regulation of cardiovascular renal function by prostaglandins and other lipid mediators

Research Description

We¿re studying the gnenetic mechanisms underlying diabetic kidney disease (diabetic nephropathy or DN), the major cause of kidney failure in the U.S. Of people with diabetes mellitus, only a minority (~30%) get diabetic nephropathy. This is the result of an underlying genetic predispostion. Identification of the relevant genes in people has been slow because the mixed genetic background and diverse environmental factors. We are therefore characterizing the modifier genes causing DN in inbred mouse strains.

Roles for lipid mediators in the genesis of DN, especially cyclooxygenase derived prostaglandins, are another special area of interest.. All type II Diabetic patients are recommended to be on low dose aspirin to prevent cardiovascular problems. The importance of prostaglandins to systemic injury, is underscored by the fact that potent therapeutic drugs Motrin, Aspirin, and other Non-steroidal anti-inflammatory drugs (NSAIDs), all act by blocking the synthesis of prostaglandins via cyclooxygenases (COX1 or COX2). We are testing the hypothesis that changes in prostaglandin synthesis are integral to the development of DN, renal injury and regeneration of the injured kidney.

Finally, once synthesized prostaglandins activate several different families of receptors including nuclear receptors (PPARgamma) and G-protein coupled receptors. The roles of these different receptors are being studied in knockout mice with and without diabetes. Roles for prostaglandins in promoting renal regeneration, cell survival and stem cell differentiation are also being examined in the context of dehydration and diabetes mellitus. .

Publications

  • Qi, Z, Fujita, H, Jin, J, Davis, LS, Wang, Y, Fogo, AB, Breyer, MD Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. Diabetes, 54(9), 2628-37, 2005.
  • Cheng, H, Zhang, M, Moeckel, GW, Zhao, Y, Wang, S, Qi, Z, Breyer, MD, Harris, RC Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition. Nephron Exp Nephrol, 101(3), e75-85, 2005.
  • Rao, R, Zhang, MZ, Zhao, M, Cai, H, Harris, RC, Breyer, MD, Hao, CM Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am J Physiol Renal Physiol, 288(4), F642-9, 2005.
  • Breyer, MD, Böttinger, E, Brosius, FC, Coffman, TM, Harris, RC, Heilig, CW, Sharma, K, , Mouse models of diabetic nephropathy. J Am Soc Nephrol, 16(1), 27-45, 2005.
  • Guan, Y, Hao, C, Cha, DR, Rao, R, Lu, W, Kohan, DE, Magnuson, MA, Redha, R, Zhang, Y, Breyer, MD Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med, 11(8), 861-6, 2005.
  • Schneider, A, Guan, Y, Zhang, Y, Magnuson, MA, Pettepher, C, Loftin, CD, Langenbach, R, Breyer, RM, Breyer, MD Generation of a conditional allele of the mouse prostaglandin EP4 receptor. Genesis, 40(1), 7-14, 2004.
  • Rao, R, Hao, CM, Breyer, MD Hypertonic stress activates glycogen synthase kinase 3beta-mediated apoptosis of renal medullary interstitial cells, suppressing an NFkappaB-driven cyclooxygenase-2-dependent survival pathway. J Biol Chem, 279(6), 3949-55, 2004.
  • Schneider, A, Zhang, Y, Zhang, M, Lu, WJ, Rao, R, Fan, X, Redha, R, Davis, L, Breyer, RM, Harris, R, Guan, Y, Breyer, MD Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney. Kidney Int, 65(4), 1205-13, 2004.
  • Qi, Z, Whitt, I, Mehta, A, Jin, J, Zhao, M, Harris, RC, Fogo, AB, Breyer, MD Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Am J Physiol Renal Physiol, 286(3), F590-6, 2004.
  • Moeckel, GW, Zhang, L, Fogo, AB, Hao, CM, Pozzi, A, Breyer, MD COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. J Biol Chem, 278(21), 19352-7, 2003.
  • Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD "COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress." J Biol Chem. , 278(21), 19352-7, 2003.
  • Schneider A, Zhang Y, Guan Y, Davis LS, Breyer MD "Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice." Am J Physiol Renal Physiol., 284(2), F411-7., 2003.
  • Saito, O, Guan, Y, Qi, Z, Davis, LS, Kömhoff, M, Sugimoto, Y, Narumiya, S, Breyer, RM, Breyer, MD Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract. Am J Physiol Renal Physiol, 284(6), F1164-70, 2003.
  • Saito O, Guan Y, Qi Z, Davis LS, Komhoff M, Sugimoto Y, Narumiya S, Breyer RM, Breyer MD "Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract." Am J Physiol Renal Physiol, 284(6), F1164-70, 2003.
  • Davidson, JM, Breyer, MD Inflammatory modulation and wound repair. J Invest Dermatol, 120(5), xi-xii, 2003.
  • Peti-Peterdi J, Komlosi P, Fuson AL, Guan Y, Schneider A, Qi Z, Redha R, Rosivall L, Breyer MD, Bell PD "Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cells." J. Clin. Invest., 112(1), 76-82, 2003.
  • Guan, Y, LS Davis, Brett Stillman, YW, Zhang, HR Jacobson, RM Breyer, MD Breyer "Cloning and expression of the rabbit Prostaglandin EP2 receptor." BMC Pharmacol, 2(1), 14-22, 2002.
  • Guan, Y, Stillman, BA, Zhang, Y, Schneider, A, Saito, O, Davis, LS, Redha, R, Breyer, RM, Breyer, MD Cloning and expression of the rabbit prostaglandin EP2 receptor. BMC Pharmacol, 214, 2002.
  • Qi, Zhonghua; Chuanming Hao; RL Langenbach, RM Breyer, Reyadh Redha, Jason Morrow, MD Breyer "Opposite effects of Cyclooxygensases-1 and -2 activity on the pressor response to angiotensin II." J. Clin. Invest., 11061-69, 2002.
  • Qi, Z, Hao, CM, Langenbach, RI, Breyer, RM, Redha, R, Morrow, JD, Breyer, MD Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J Clin Invest, 110(1), 61-9, 2002.
  • Hao, CM, R Redha J Morrow, MD Breyer "Peroxisome Proliferator activated receptor delta activation promotes cell survival following hypertonic stress." Journal of Biological Chemistry, 277(14), 21341-21345, 2002.
  • Breyer, RM, Kennedy, CR, Zhang, Y, Guan, Y, Breyer, MD Targeted gene disruption of the prostaglandin E2 EP2 receptor. Adv Exp Med Biol, 507321-6, 2002.
  • Zheng F, Fornoni A, Elliot SJ, Guan Y, Breyer MD, Striker LJ, Striker GE Upregulation of type I collagen by TGF-beta in mesangial cells is blocked by PPARgamma activation. Am J Physiol Renal Physiol., 282(4), F639-48, 2002.
  • Holla, V., F. Adas, J. Imig. X. Zhao, E. Price, N. Olsen, WS Kovacs, MA Magnuson, DS Keeney, MD Breyer, JR Falck, MR Waterman, JH Capdevila "Alterations in the regulation of androgen sensitive CYP4a Monooxygenases cause hypertension." Proc. Natl. Acad. Sci. USA , 98(9), 5211-5216, 2001.
  • Qu, W. JA Bradbury, CC Tsao, R Maronpot, JG Harry, LS Davis, MD Breyer, JR Falck, J Chen, RL Rosenberg, and DC Zeldin "Cloning, characterization and Functional Significance of CYP2J9, a New Mouse Cytochrome P440 Arachidonic Acid omega-1 Hydroxylase Abundant in Brain." J. Biol. Chem., 276(27), 25467-25479, 2001.
  • Breyer, MD, Harris, RC Cyclooxygenase 2 and the kidney. Curr Opin Nephrol Hypertens, 10(1), 89-98, 2001.
  • Breyer, M.D., and Harris, R.C "Cyclooxygenase-2 selective NSAIDs and the kidney." Current Opinions in Nephrology and Hypertension , 1089-98, 2001.
  • Breyer, MD, Hao, C, Qi, Z Cyclooxygenase-2 selective inhibitors and the kidney. Curr Opin Crit Care, 7(6), 393-400, 2001.
  • Guan, YF., A Schneider, YH Zhang, RM Breyer, MD Breyer "Expression and function of peroxisome proliferator activated receptor gamma in rabbit glomerulus and medullary microvasculature." Am. J. Physiol, 281F1036-1046, 2001.
  • Breyer, MD, Breyer, RM G protein-coupled prostanoid receptors and the kidney. Annu Rev Physiol, 63579-605, 2001.
  • Breyer, M.D., and Breyer, R.M "G-protein coupled prostanoid receptors and the kidney." Annu. Rev. Physiol., 579-605, 2001.
  • Guan, YF and Breyer, MD "Peroxisome Proliferator activated receptors (PPARs): Novel Therapeutic targets in renal disease." Kidney Int , 60(1), 14-30, 2001.
  • Guan, Y, Zhang, Y, Schneider, A, Davis, L, Breyer, RM, Breyer, MD Peroxisome proliferator-activated receptor-gamma activity is associated with renal microvasculature. Am J Physiol Renal Physiol, 281(6), F1036-46, 2001.
  • Harris, R.C., and Breyer, M.D "Physiologic regulation of cyclooxygenase-2 in the kidney." Am. J. Physiol.: Renal Physiol., 281(1), F1-F11, 2001.
  • Breyer, R.M., Bagdassarian, C.K., Myers, S.A., and Breyer, M.D "Prostanoid receptors: subtypes and signaling." Ann. Rev. Pharmacol. Toxicol, 41661-690, 2001.
  • Guan, YF, YH Zhang, A Schneider, D. Riendeau, JA Mancini, L Davis, M K?mhoff, RM Breyer, and MD Breyer "Urogenital Distribution of a mouse membrane associated prostaglandin E2 synthase (mPGES)." Am. J. Physiol., 281F1173-1177, 2001.
  • Guan, Y, Zhang, Y, Schneider, A, Riendeau, D, Mancini, JA, Davis, L, Kömhoff, M, Breyer, RM, Breyer, MD Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase. Am J Physiol Renal Physiol, 281(6), F1173-7, 2001.
  • K?mhoff, M., Nusing, R., Seyberth, H., and Breyer, M.D "COX2 expression in macula densa of Bartter syndrome kidneys." Kidney Int, 582420-2424, 2000.
  • YH Zhang, YF Guan, A Schneider, S Brandon, RM Breyer, and MD Breyer "Characterization of Murine Vasopressor and Vasodepressor Prostaglandin E2 Receptors." Hypertension , 351129-34, 2000.
  • Zhang, Y, Guan, Y, Schneider, A, Brandon, S, Breyer, RM, Breyer, MD Characterization of murine vasopressor and vasodepressor prostaglandin E(2) receptors. Hypertension, 35(5), 1129-34, 2000.
  • Komhoff, M, Wang, S, McKanna, JM, Langenbach, RC, Harris, RC, MD Breyer "Cyclooxygenase 2 inhibition impairs glomerulogenesis and renal cortical development." Kidney Int , 57414-422, 2000.
  • Kömhoff, M, Jeck, ND, Seyberth, HW, Gröne, HJ, Nüsing, RM, Breyer, MD Cyclooxygenase-2 expression is associated with the renal macula densa of patients with Bartter-like syndrome. Kidney Int, 58(6), 2420-4, 2000.
  • Kömhoff, M, Wang, JL, Cheng, HF, Langenbach, R, McKanna, JA, Harris, RC, Breyer, MD Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development. Kidney Int, 57(2), 414-22, 2000.
  • Hao, CM, F. Yull, M K?mhoff, T. Blackwell, LS Davis MD Breyer "Dehydration activates a NF-kappaB driven COX2 dependent survival mechanism in renal medullary interstitial cells." J. Clin. Invest., 106973-982, 2000.
  • Hao, CM, Yull, F, Blackwell, T, Kömhoff, M, Davis, LS, Breyer, MD Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells. J Clin Invest, 106(8), 973-82, 2000.
  • K?mhoff, M., Guan, YF, HW Shappell, LS Davis, G Jack, Y. Shyr, M. Koch, S.B. Shappell, and MD Breyer "Enhanced Expression of Cyclooxygenase-2 in High Grade Human Transitional Cell Bladder Carcinomas." American Jour. Pathology, 15729-35, 2000.
  • Kömhoff, M, Guan, Y, Shappell, HW, Davis, L, Jack, G, Shyr, Y, Koch, MO, Shappell, SB, Breyer, MD Enhanced expression of cyclooxygenase-2 in high grade human transitional cell bladder carcinomas. Am J Pathol, 157(1), 29-35, 2000.
  • Qi, Z, C-M Hao, K Salter, RF Redha, and MD Breyer "Cyclic AMP dependent protein kinase type II regulates electrogenic ion transport in rabbit collecting duct." Am. J. Physiol., 276F622-628, 1999.
  • Audoly, L., LJ Ma, I Feoktistov, MD Breyer, RM Breyer "EP3 receptor activation of cAMP response element mediated gene transcription." J. Pharmacol. Exp. Ther., 289140-148, 1999.
  • Guan, Y-F, YW Zhang, RM Breyer, LS Davis, MD Breyer "Expression of Peroxisome Proliferator-Activated Receptor-g (PPARg) in human bladder cancer and its role inducing cell death." Neoplasia, 1(4), 330-339, 1999.
  • Guan, YF, Zhang, YH, Breyer, RM, Davis, L, Breyer, MD Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death. Neoplasia, 1(4), 330-9, 1999.
  • Kennedy, CRJ, Y. Zhang, S Brandon, YF Guan, K. Coffee, CD Funk, MA Magnuson, JA Oates, MD Breyer, RM Breyer "Hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor." Nature Medicine , 5(2), 217-220, 1999.
  • Stillman, BA, Breyer, MD, Breyer, RM Importance of the extracellular domain for prostaglandin EP(2) receptor function. Mol Pharmacol, 56(3), 545-51, 1999.
  • Stillman, BA, MD Breyer, RM Breyer "Importance of the extracellular domain for prostaglandin EP2 receptor function." Mol. Pharmacol, 56545-551, 1999.
  • Ma, J., W. Qu, PE Scarborough, KB Tomer, CR Moomaw, R. Maronpot, LS Davis MD Breyer, and DC Zeldin "Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney." J. Biol. Chem., 27417777-17788, 1999.
  • Kennedy, CR, Zhang, Y, Brandon, S, Guan, Y, Coffee, K, Funk, CD, Magnuson, MA, Oates, JA, Breyer, MD, Breyer, RM Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat Med, 5(2), 217-20, 1999.
  • Hao, CM, M. Komhoff, YF Guan, RF Redha, MD Breyer "Selective targeting of cyclooxygenase 2 reveals its role in renal medullary interstitial cell survival." Am. J. Physiol, 277F352-359, 1999.
  • Hao, CM, Kömhoff, M, Guan, Y, Redha, R, Breyer, MD Selective targeting of cyclooxygenase-2 reveals its role in renal medullary interstitial cell survival. Am J Physiol, 277(3 Pt 2), F352-9, 1999.
  • Guan,YF, YH Zhang, RM. Breyer, B Fowler, LS Davis, RL H้bert, MD Breyer "PGE2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor." J. Clin. Invest , 102194-201, 1998.
  • Guan, Y, Zhang, Y, Breyer, RM, Fowler, B, Davis, L, Hébert, RL, Breyer, MD Prostaglandin E2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor. J Clin Invest, 102(1), 194-201, 1998.
  • Guan, Y, M. Chang, W-Y Cho, YW, Zhang, R Redha, LS Davis, S Chang, RN DuBois, CM Hao, MD Breyer "Cloning expression and regulation of rabbit Cyclooxygenase-2 in renal medullary interstitial cells." Am. J. Physiol., 273F18-26, 1997.
  • Guan, Y, YW Zhang, LS Davis, MD Breyer "Expression of peroxisome proliferator activated receptors in urinary tract of rabbit and man." Am. J. Physiol., 273F1013-1022, 1997.
  • Chang, MS, JC Tsai, R. Yang. RN DuBois, MD Breyer, DM O'Day "Induction of cyclooxygenase-2 in the anterior uvea after glaucoma filtration surgery in rabbits." Curr Eye Res, 161147-1151, 1997.
  • Hao, C-M, RM Breyer, LS Davis, and MD Breyer "Intra-renal distribution of Rabbit PKC-zeta." Kidney Int, 1831-1837 51, 1997.
  • Breyer, RM, Y Guan, R Redha, LS Davis, C. Nian, HR Jacobson, and MD Breyer "Cloning and expression of the rabbit prostaglandin EP4 receptor." Am. J. Physiol., 270F485-493, 1996.
  • Breyer MD, LS Davis, HR Jacobson, and RM Breyer "Differential localization of Prostaglandin E receptor subtypes in human kidney." Am. J. Physiol., 270F912-918, 1996.
  • Breyer MD, and D Fredin "Effect of vasopressin on intracellular Na+ concentration in the collecting duct." Kidney Int., 50S57-61, 1996.
  • Sakairi, Y, Jacobson, HR, Noland, TD, Capdevila, JH, Falck, JR, Breyer, MD 5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis. Am J Physiol, 268(5 Pt 2), F931-9, 1995.
  • Sakairi, Y, TD Noland, HR Jacobson, J Capdevila, JR Falck, and MD Breyer "5,6-Epoxyeicosatrienoic acid inhibits collecting duct ion transport via a cyclooxygenase-dependent mechanism coupled to PGE2 production." Am. J. Physiol., 37F931-995, 1995.
  • DeCoy, DL, Snapper, JR, Breyer, MD Anti sense DNA down-regulates proteins kinase C-epsilon and enhances vasopressin-stimulated Na+ absorption in rabbit cortical collecting duct. J Clin Invest, 95(6), 2749-56, 1995.
  • DeCoy, DL, JR Snapper, MD Breyer "Anti-sense DNA down-regulates protein kinase C-e and enhances vasopressin stimulated Na+ absorption in rabbit cortical collecting duct." J. Clin. Invest, 952749-2756, 1995.
  • Ghishan, FK, S. Knobel, JA Barnard, MD Breyer "Expression of a Novel sodium-hydrogen exchanger in the gastrointestinal tract and kidney." J. Membrane Biol., 144267-271, 1995.
  • Sakairi, Y, HR Jacobson, TD Noland, MD Breyer "Luminal Prostaglandin E receptors regulate salt and water transport in the rabbit cortical collecting duct." Am. J. Physiol., 269F257-265, 1995.
  • Sakairi, Y, Jacobson, HR, Noland, TD, Breyer, MD Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct. Am J Physiol, 269(2 Pt 2), F257-65, 1995.
  • Burns, KD, J. Capdevila, S Wei, MD Breyer, T. Homma, R.C. Harris "Role of cytochrome P-450 epoxygenase metabolites in EGF sginaling in renal proximal tubules." Am. J. Physiol. Cell , 269C831-840, 1995.
  • Breyer, RM, RB Emeson, MD Breyer, LS Davis, RM Abromson, SM Ferrenbach "Alternative splicing generates multiple isoforms of the rabbit kidney prostaglandin E2 receptor." J. Biol. Chem., 269(8), 6163-6169, 1994.
  • Harris, RC, McKanna, JA, Akai, Y, Jacobson, HR, Dubois, RN, Breyer, MD Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest, 94(6), 2504-10, 1994.
  • Harris, RC, JA McKanna, Y. Akai, HR Jacobson, RN DuBois, and MD Breyer "Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction." J.Clin. Invest., 942504-2510, 1994.
  • Superdock, K.R., D. Snyders, M.D. Breyer "An ATP-inhibited Cl- Channel in apical membanes of collecting duct." Am.J. Physiol., 34C957-65, 1993.
  • Furuya, H., Jacobson, HR, and Breyer, MD "Evidence for basolateral membrane Ca++/H+ exchange in outer medullary collecting duct." Am. J. Physiol., 264F88-F93, 1993.
  • Hebert, RL, Jacobson, HR, and Breyer MD "Evidence that separate prostaglandin receptors modulate water permeability and sodium transport in rabbit collecting duct." Am. J. Physiol, 265F643-650, 1993.
  • Breyer, MD, Jacobson, HR, Davis, LS, Breyer, RM In situ hybridization and localization of mRNA for the rabbit prostaglandin EP3 receptor. Kidney Int, 44(6), 1372-8, 1993.
  • Breyer, MD, HR Jacobson, LS Davis, and RM Breyer "In situ hybridization and localization of mRNA for the rabbit prostaglandin EP3 receptor." Kidney Int., 431372-1378, 1993.
  • Takeda, M., T. Homma, MD Breyer, N. Horiba, RL Hoover, S Kawamoto, and V Kon "Volume and agonist regulation of phosphorylation of myosin light chain in glomerular mesangial cells." Am. J. Physiol., 264F421-426, 1993.
  • Noland, T, Carter, C, Jacobson, HR, Breyer, MD "PGE2 regulates cAMP generation in cultured rabbit cortical collecting duct cells: evidence for dual inhibitory pathways." Am. J. Physiol., 263C1208-1215, 1992.
  • Snyder, HM, Noland, T, and Breyer,MD "Activation of cyclic AMP-dependent protein kinase mediates the hydroosmotic effect of vasopressin in the collecting duct." Am. J. Physiol, 263C147-153 , 1992.
  • Takeda, M., MD Breyer, TD Noland, T Homma, RL Hoover, T Inagami, and V. Kon "Endothelin-1 receptor antagonist: Effects on endothelin and cyclosporine treated mesangial cells." Kidney Int., 421713-1719, 1992.
  • Burns, KD, Homma,T.Breyer, MD, Harris, RC "Cytosolic acidification stimulates a calcium influx mechanism that activates Na+-H+ exchange in LLC-PK1." Am. J. Physiol. , 261F617-625, 1991.
  • Breyer MD "Feedback inhibition of cAMP stimulated Na+ transport in the rabbit cortical collecting duct via Na+ dependent basolateral Ca++ influx." J. Clin. Invest, 881502-1510, 1991.
  • Furuya, H.,MD Breyer, and HR Jacobson "Functional characterization of a and b intercalated cell types in the rabbit cortical collecting duct." Am. J. Physiol., 261F377-385,, 1991.
  • Snyder HM, Fredin, D., and Breyer MD "Muscarinic receptor activation inhibits vasopressin stimulated water permeability in the rabbit cortical collecting duct." Am. J. Physiol., 260F929-F938, 1991.
  • Hébert, RL, Jacobson, HR, Breyer, MD Prostaglandin E2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium. J Clin Invest, 87(6), 1992-8, 1991.
  • Hebert, RL, Jacobson, HR, and Breyer M.D "Prostaglandin E2 inhibits sodium transport in the rabbit cortical collecting duct by increasing intracellular calcium." J.Clin. Invest., 871992-1998, 1991.
  • Breyer, M.D "Regulation of water and salt transport in collecting duct through calcium-dependent signaling mechanisms." Am. J.Physiol., 260F1-F11, 1991.
  • Hebert RL, Jacobson HR, and Breyer MD "PGE2 inhibits AVP induced water flow in cortical collecting ducts by protein kinase C activation." Am J Physiol , 259F318-325, 1990.
  • Hébert, RL, Jacobson, HR, Breyer, MD PGE2 inhibits AVP-induced water flow in cortical collecting ducts by protein kinase C activation. Am J Physiol, 259(2 Pt 2), F318-25, 1990.
  • Breyer, MD, Redha, R, Breyer, JA Segmental distribution of epidermal growth factor binding sites in rabbit nephron. Am J Physiol, 259(4 Pt 2), F553-8, 1990.
  • Breyer MD, Redha R, Breyer JA "Segmental distribution of epidermal growth factor binding sites in the rabbit nephron." Am. J. Physiol., 259F553-558, 1990.
  • Breyer MD and Jacobson HR "Regulation of Medullary Collecting Duct Cell pH by Basolateral Na+/H+ and Cl-/Base Exchange." J Clin Invest , 84996-1004, 1989.
  • Mesangial Cell, Glomerular and Renal Vascular Responses to Endothelin in Rat Kidney "Badr KF, Murray JJ, Breyer MD, Takahashi K, Inagami T, Harris RC." J Clin Invest , 83336-342, 1989.
  • Hirt D, Capdevila JH, Falck JR, Breyer MD and Jacobson HR "Cytochrome P-450 metabolites of arachidonic acid are potent inhibitors of the action of vasopressin in rabbit cortical collecting duct." J Clin Invest., 841805-1812, 1989.
  • Ando Y, Breyer MD, and Jacobson HR "Dose dependent heterogeneous actions of vasopressin in rabbit cortical collecting ducts." Am J Physiol, 256F556-F562, 1989.
  • Ando Y, Jacobson HR, and Breyer MD "Phosphatidic acid inhibits the hydroosmotic effect of vasopressin in the collecting duct by activation of endogenous protein kinase C." Am J Physiol , 257F524-F530, 1989.
  • Breyer MD. Jacobson HR, and Breyer JA "Epidermal growth factor inhibits the hydroosmotic effect of vasopressin in the isolated perfused rabbit cortical collecting tubule." J Clin Invest , 821313-1320, 1988.
  • Ando Y, Jacobson HR, and Breyer MD "Phorbol ester and A23187 have additive but mechanistically separate effects on vasopressin action in rabbit collecting tubule." J Clin Invest , 811578-1584, 1988.
  • Ando Y, Jacobson HR, and Breyer MD "Phorbol myristate acetate dioctanoyl-glycerol phosphatidic acid inhibit the hydroosmotic effect of vasopressin on rabbit cortical collecting tubule." J Clin Invest , 80590-593, 1987.

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