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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

Michael L.  Freeman

Michael L. Freeman, Ph.D.

Professor of Radiation Oncology
Professor of Radiology and Radiological Sciences
Professor of Cancer Biology

Contact Information:

Vanderbilt Department of Radiation Oncology
Medical Center North, E-1200
Nashville, TN 37232

Research Description

Radiation Oncology leverages cutting edge advancements in physics and engineering for the treatment of cancer. Co-registration of diagnostic data sets into a coherent 3D-treatment plan allows individualized precision tumor targeting. Radiation oncology has the potential to provide outstanding personalized cancer treatment. However, cancer cell radioresistance and normal tissue injury represent two important limitations that can limit the ability of ionizing radiation to provide local/regional control of tumor growth. To addresses these limitations our laboratory initiated a cancer drug discovery program that seeks to develop efficacious radiation sensitizers. Two-indol-3-yl-methylenequinuclidin-3-ols and 5-((N-benzyl-1H-indol-3-yl)-methylene)pyrimidine-2,4,6(1H,3H,5H) trione have been synthesized and are currently being evaluated using defined DNA substrates, cell-based and murine mouse models. Elucidating the underlying mechanisms that drive the pathophysiology of normal tissue injury produced by ionizing radiation is also a focus of this laboratory. A holistic approach is used that encompasses well defined biochemical assays, cell-based assays such as ChIP Exo and transcriptome profiling, as well as GEMMs.