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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

VICC toll-free number 1-877-936-8422

Michael R.  Dohn

Michael R. Dohn, Ph.D.

Research Assistant Professor

Contact Information:

Vanderbilt University Medical Center
771 Preston Research Building
Nashville, TN 37232
615-343-9533

Research Description

Autism, depression, and anxiety disorders are associated with an imbalance in the serotonin system, which often involves changes in the function of the serotonin transporter (SERT). SERT interacts with and is regulated by integrins, transmembrane proteins that link the extracellular matrix to the intracellular cytoskeleton. My research focuses on the physical and functional interactions between SERT and the integrin beta3 subunit in the brain. Using mouse models that alter integrin beta3 function, we 1) analyze the signaling pathways involved in beta3-mediated regulation of SERT activity and 2) evaluate the role of these signaling mechanisms in mouse behaviors linked to SERT function. These studies highlight the complex regulation of serotonin homeostasis and social behaviors by integrin beta3 and reveal an important role for integrins in modulating risk for neuropsychiatric disorders.

Publications
  • Yu, HH, Dohn, MR, Markham, NO, Coffey, RJ, and Reynolds, AB. P120-catenin controls contractility along the vertical axis of epithelial lateral membranes. Journal of Cell Science. 2016 Jan 1/1/2016;
    Available from: http://www.ncbi.nlm.nih.gov/pubmed?term=26585313.
  • Markham NO, Doll CA, Dohn MR, Miller RK, Yu H, Coffey RJ, McCrea PD, Gamse JT, Reynolds AB. DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia. Mol. Biol. Cell [print-electronic]. 2014 Sep 9/1/2014; 25(17): 2592-603. PMID: 25009281, PMCID: PMC4148249, PII: mbc.E13-08-0492, DOI: 10.1091/mbc.E13-08-0492, ISSN: 1939-4586.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25009281.
  • Dohn MR, Mundell NA, Sawyer LM, Dunlap JA, Jessen JR. Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation. Dev. Biol [print-electronic]. 2013 Nov 11/1/2013; 383(1): 39-51. PMID: 24021482, PII: S0012-1606(13)00469-7, DOI: 10.1016/j.ydbio.2013.08.027, ISSN: 1095-564X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24021482.
  • Smith AL, Dohn MR, Brown MV, Reynolds AB. Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin. Mol. Biol. Cell [print-electronic]. 2012 Jan; 23(1): 99-110. PMID: 22031287, PMCID: PMC3248908, PII: mbc.E11-06-0497, DOI: 10.1091/mbc.E11-06-0497, ISSN: 1939-4586.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22031287.
  • Naydenov NG, Brown B, Harris G, Dohn MR, Morales VM, Baranwal S, Reynolds AB, Ivanov AI. A membrane fusion protein aSNAP is a novel regulator of epithelial apical junctions. PLoS ONE [print-electronic]. 2012; 7(4): e34320. PMID: 22485163, PMCID: PMC3317505, PII: PONE-D-11-24140, DOI: 10.1371/journal.pone.0034320, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22485163.
  • Periyasamy-Thandavan S, Takhar S, Singer A, Dohn MR, Jackson WH, Welborn AE, LeRoith D, Marrero M, Thangaraju M, Huang S, Schoenlein PV. Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim. Breast Cancer Res. 2012; 14(2): R52. PMID: 22429491, PMCID: PMC3446386, PII: bcr3153, DOI: 10.1186/bcr3153, ISSN: 1465-542X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22429491.
  • Dohn MR, Brown MV, Reynolds AB. An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth. J. Cell Biol [print-electronic]. 2009 Feb 2/9/2009; 184(3): 437-50. PMID: 19188496, PMCID: PMC2646551, PII: jcb.200807096, DOI: 10.1083/jcb.200807096, ISSN: 1540-8140.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19188496.
  • Wildenberg GA, Dohn MR, Carnahan RH, Davis MA, Lobdell NA, Settleman J, Reynolds AB. P120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell. 2006 Dec 12/1/2006; 127(5): 1027-39. PMID: 17129786, PII: S0092-8674(06)01407-3, DOI: 10.1016/j.cell.2006.09.046, ISSN: 0092-8674.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17129786.
  • Schoenlein PV, Barrett JT, Kulharya A, Dohn MR, Sanchez A, Hou DY, McCoy J. Radiation therapy depletes extrachromosomally amplified drug resistance genes and oncogenes from tumor cells via micronuclear capture of episomes and double minute chromosomes. Int. J. Radiat. Oncol. Biol. Phys. 2003 Mar 3/15/2003; 55(4): 1051-65. PMID: 12605985, PII: S0360301602044735, ISSN: 0360-3016.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12605985.
  • Dohn M, Nozell S, Willis A, Chen X. Tumor suppressor gene-inducible cell lines. Methods Mol. Biol. 2003; 223: 221-35. PMID: 12777734, PII: 1-59259-329-1-221, DOI: 10.1385/1-59259-329-1:221, ISSN: 1064-3745.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12777734.
  • Dohn M, Jiang J, Chen X. Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis. Oncogene. 2001 Oct 10/4/2001; 20(45): 6503-15. PMID: 11641774, DOI: 10.1038/sj.onc.1204816, ISSN: 0950-9232.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11641774.
  • Dohn M, Zhang S, Chen X. P63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene. 2001 May 5/31/2001; 20(25): 3193-205. PMID: 11423969, DOI: 10.1038/sj.onc.1204427, ISSN: 0950-9232.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11423969.
  • Dohn, MR, Kooker, CG, Bastarache, L, Jessen, T, Rinaldi, C, Varney, S, Mazalouskas, MD, Oliver, KH, Pan, H, Sutcliffe, JS, Valez Edwards, DR, Denny, JC, and Carneiro, AMD. Integrin beta3 Pro33 Gain-of-Function Variant Reduces Serotonin Transporter Activity and Alters Social and Emotional Behaviors.