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Ned A. Porter, Ph.D.

Stevenson Professor of Chemistry
Professor of Biochemistry
Researcher

Contact Information:

7330 Stevenson Center
Vanderbilt University
Nashville, TN 37232
615-343-4371
Fax: 615-343-7262

Research Description

.Most of our research has centered on the study of free radical reactions. Areas of interest include: Mechanism of the free radical reactions of natural products such as lipids and phospholipids with molecular oxygen; mechanism and utility of free radical reactions in the construction of new substructures; and the control of stereochemistry in free radical additions, including polymerization, reactions in aggregates, such as micelles and membrane bilayers, and enzyme photoactivation.

Publications
  • Furse KE, Pratt DA, Porter NA, Lybrand TP. Molecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behavior. Biochemistry. 2006 Mar 3/14/2006; 45(10): 3189-205. PMID: 16519514, PMCID: PMC2504530, DOI: 10.1021/bi052337p, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16519514.
  • Furse KE, Pratt DA, Schneider C, Brash AR, Porter NA, Lybrand TP. Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity. Biochemistry. 2006 Mar 3/14/2006; 45(10): 3206-18. PMID: 16519515, PMCID: PMC2504531, DOI: 10.1021/bi052338h, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16519515.
  • Yin H, Porter NA, Morrow JD. Separation and identification of F2-isoprostane regioisomers and diastereomers by novel liquid chromatographic/mass spectrometric methods. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005 Nov 11/15/2005; 827(1): 157-64. PMID: 15890564, PII: S1570-0232(05)00242-4, DOI: 10.1016/j.jchromb.2005.03.038, ISSN: 1570-0232.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15890564.
  • Kim HY, Pratt DA, Seal JR, Wijtmans M, Porter NA. Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein. J. Med. Chem. 2005 Nov 11/3/2005; 48(22): 6787-9. PMID: 16250637, DOI: 10.1021/jm0507173, ISSN: 0022-2623.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16250637.
  • Schneider C, Boeglin WE, Yin H, Ste DF, Hachey DL, Porter NA, Brash AR. Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal. Lipids. 2005 Nov; 40(11): 1155-62. PMID: 16459928, ISSN: 0024-4201.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16459928.
  • Norris JL, Hangauer MJ, Porter NA, Caprioli RM. Nonacid cleavable detergents applied to MALDI mass spectrometry profiling of whole cells. J Mass Spectrom. 2005 Oct; 40(10): 1319-26. PMID: 16220468, DOI: 10.1002/jms.914, ISSN: 1076-5174.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16220468.
  • Norris JL, Porter NA, Caprioli RM. Combination detergent/MALDI matrix: functional cleavable detergents for mass spectrometry. Anal. Chem. 2005 Aug 8/1/2005; 77(15): 5036-40. PMID: 16053319, DOI: 10.1021/ac050460g, ISSN: 0003-2700.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16053319.
  • Yin H, Musiek ES, Gao L, Porter NA, Morrow JD. Regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo. J. Biol. Chem [print-electronic]. 2005 Jul 7/15/2005; 280(28): 26600-11. PMID: 15894799, PII: M503088200, DOI: 10.1074/jbc.M503088200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15894799.
  • Milne GL, Seal JR, Havrilla CM, Wijtmans M, Porter NA. Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. J. Lipid Res [print-electronic]. 2005 Feb; 46(2): 307-19. PMID: 15547297, PII: M400311-JLR200, DOI: 10.1194/jlr.M400311-JLR200, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15547297.
  • Yin H, Porter NA. New insights regarding the autoxidation of polyunsaturated fatty acids. Antioxid. Redox Signal. 2005 Jan; 7(1-2): 170-84. PMID: 15650406, DOI: 10.1089/ars.2005.7.170, ISSN: 1523-0864.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15650406.
  • Wijtmans M, Pratt DA, Brinkhorst J, Serwa R, Valgimigli L, Pedulli GF, Porter NA. Synthesis and reactivity of some 6-substituted-2,4-dimethyl-3-pyridinols, a novel class of chain-breaking antioxidants. J. Org. Chem. 2004 Dec 12/24/2004; 69(26): 9215-23. PMID: 15609958, DOI: 10.1021/jo048842u, ISSN: 0022-3263.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15609958.
  • Seal JR, Porter NA. Liquid chromatography coordination ion-spray mass spectrometry (LC-CIS-MS) of docosahexaenoate ester hydroperoxides. Anal Bioanal Chem [print-electronic]. 2004 Sep; 380(2): 356. PMID: 15338093, DOI: 10.1007/s00216-004-2758-z, ISSN: 1618-2642.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15338093.
  • Tallman KA, Roschek B, Porter NA. Factors influencing the autoxidation of fatty acids: effect of olefin geometry of the nonconjugated diene. J. Am. Chem. Soc. 2004 Aug 8/4/2004; 126(30): 9240-7. PMID: 15281813, DOI: 10.1021/ja049104q, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15281813.
  • Schneider C, Porter NA, Brash AR. Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal. Chem. Res. Toxicol. 2004 Jul; 17(7): 937-41. PMID: 15257619, DOI: 10.1021/tx049913n, ISSN: 0893-228X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15257619.
  • Masterson DS, Porter NA. Mechanism of beta-silyl diacyl peroxide decomposition: a mild and stereoselective synthesis of beta-silyl esters. J. Org. Chem. 2004 May 5/28/2004; 69(11): 3693-9. PMID: 15152998, DOI: 10.1021/jo049852y, ISSN: 0022-3263.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15152998.
  • Seal JR, Porter NA. Liquid chromatography coordination ion-spray mass spectrometry (LC-CIS-MS) of docosahexaenoate ester hydroperoxides. Anal Bioanal Chem [print-electronic]. 2004 Feb; 378(4): 1007-13. PMID: 14634702, DOI: 10.1007/s00216-003-2274-6, ISSN: 1618-2642.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14634702.
  • Yin H, Morrow JD, Porter NA. Identification of a novel class of endoperoxides from arachidonate autoxidation. J. Biol. Chem [print-electronic]. 2004 Jan 1/30/2004; 279(5): 3766-76. PMID: 14594817, PII: M307137200, DOI: 10.1074/jbc.M307137200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14594817.
  • Masterson DS, Yin H, Chacon A, Hachey DL, Norris JL, Porter NA. Lysine peroxycarbamates: free radical-promoted peptide cleavage. J. Am. Chem. Soc. 2004 Jan 1/28/2004; 126(3): 720-1. PMID: 14733538, DOI: 10.1021/ja038615u, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14733538.
  • Musiek ES, Cha JK, Yin H, Zackert WE, Terry ES, Porter NA, Montine TJ, Morrow JD. Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2004 Jan 1/5/2004; 799(1): 95-102. PMID: 14659440, PII: S1570023203008675, ISSN: 1570-0232.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14659440.
  • Norris JL, Porter NA, Caprioli RM. Mass spectrometry of intracellular and membrane proteins using cleavable detergents. Anal. Chem. 2003 Dec 12/1/2003; 75(23): 6642-7. PMID: 14640740, DOI: 10.1021/ac034802z, ISSN: 0003-2700.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14640740.
  • Truong TT, Marriott PJ, Porter NA, Leeming R. Application of comprehensive two-dimensional gas chromatography to the quantification of overlapping faecal sterols. J Chromatogr A. 2003 Nov 11/26/2003; 1019(1-2): 197-210. PMID: 14650615, ISSN: 0021-9673.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14650615.
  • Wijtmans M, Pratt DA, Valgimigli L, DiLabio GA, Pedulli GF, Porter NA. 6-Amino-3-pyridinols: towards diffusion-controlled chain-breaking antioxidants. Angew. Chem. Int. Ed. Engl. 2003 Sep 9/22/2003; 42(36): 4370-3. PMID: 14502714, DOI: 10.1002/anie.200351881, ISSN: 1433-7851.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14502714.
  • Gao L, Zackert WE, Hasford JJ, Danekis ME, Milne GL, Remmert C, Reese J, Yin H, Tai HH, Dey SK, Porter NA, Morrow JD. Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. J. Biol. Chem [print-electronic]. 2003 Aug 8/1/2003; 278(31): 28479-89. PMID: 12746435, PII: M303984200, DOI: 10.1074/jbc.M303984200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12746435.
  • Seal JR, Havrilla CM, Porter NA, Hachey DL. Analysis of unsaturated compounds by Ag+ coordination ionspray mass spectrometry: studies of the formation of the Ag+/lipid complex. J. Am. Soc. Mass Spectrom. 2003 Aug; 14(8): 872-80. PMID: 12892911, PII: S1044030503003398, DOI: 10.1016/S1044-0305(03)00339-8, ISSN: 1044-0305.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12892911.
  • Pratt DA, Mills JH, Porter NA. Theoretical calculations of carbon-oxygen bond dissociation enthalpies of peroxyl radicals formed in the autoxidation of lipids. J. Am. Chem. Soc. 2003 May 5/14/2003; 125(19): 5801-10. PMID: 12733921, DOI: 10.1021/ja034182j, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12733921.
  • Yin H, Havrilla CM, Gao L, Morrow JD, Porter NA. Mechanisms for the formation of isoprostane endoperoxides from arachidonic acid. "Dioxetane" intermediate versus beta-fragmentation of peroxyl radicals. J. Biol. Chem [print-electronic]. 2003 May 5/9/2003; 278(19): 16720-5. PMID: 12609993, PII: M300604200, DOI: 10.1074/jbc.M300604200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12609993.
  • Pratt DA, Porter NA. Role of hyperconjugation in determining carbon-oxygen bond dissociation enthalpies in alkylperoxyl radicals. Org. Lett. 2003 Feb 2/20/2003; 5(4): 387-90. PMID: 12583725, DOI: 10.1021/ol027094x, ISSN: 1523-7060.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12583725.
  • Montine TJ, Montine KS, Reich EE, Terry ES, Porter NA, Morrow JD. Antioxidants significantly affect the formation of different classes of isoprostanes and neuroprostanes in rat cerebral synaptosomes. Biochem. Pharmacol. 2003 Feb 2/15/2003; 65(4): 611-7. PMID: 12566089, PII: S0006295202016076, ISSN: 0006-2952.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12566089.
  • Yin H, Porter NA. Specificity of the ferrous oxidation of xylenol orange assay: analysis of autoxidation products of cholesteryl arachidonate. Anal. Biochem. 2003 Feb 2/15/2003; 313(2): 319-26. PMID: 12605870, PII: S0003269702006218, ISSN: 0003-2697.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12605870.
  • Fessel JP, Porter NA, Moore KP, Sheller JR, Roberts LJ. Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2002 Dec 12/24/2002; 99(26): 16713-8. PMID: 12482927, PMCID: PMC139209, PII: 252649099, DOI: 10.1073/pnas.252649099, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12482927.
  • Masterson DS, Porter NA. Diastereoselective free radical halogenation, azidation, and rearrangement of beta-silyl Barton esters. Org. Lett. 2002 Nov 11/28/2002; 4(24): 4253-6. PMID: 12443071, PII: ol0268182, DOI: 10.1021/ol0268182, ISSN: 1523-7060.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12443071.
  • Fam SS, Murphey LJ, Terry ES, Zackert WE, Chen Y, Gao L, Pandalai S, Milne GL, Roberts LJ, Porter NA, Montine TJ, Morrow JD. Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. J. Biol. Chem [print-electronic]. 2002 Sep 9/27/2002; 277(39): 36076-84. PMID: 12133837, PII: M205638200, DOI: 10.1074/jbc.M205638200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12133837.
  • Feng H, Kavrakova IK, Pratt DA, Tellinghuisen J, Porter NA. Lewis acid-promoted Kharasch-Curran additions: a competition kinetics study of bromine atom transfer addition of N-alpha-bromoacetyl-oxazolidinone to 1-hexene. J. Org. Chem. 2002 Aug 8/23/2002; 67(17): 6050-4. PMID: 12182641, PII: jo0201676, ISSN: 0022-3263.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12182641.
  • Yin H, Havrilla CM, Morrow JD, Porter NA. Formation of isoprostane bicyclic endoperoxides from the autoxidation of cholesteryl arachidonate. J. Am. Chem. Soc. 2002 Jul 7/3/2002; 124(26): 7745-54. PMID: 12083928, PII: ja0201092, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12083928.
  • Culbertson SM, Antunes F, Havrilla CM, Milne GL, Porter NA. Determination of the alpha-tocopherol inhibition rate constant for peroxidation in low-density lipoprotein. Chem. Res. Toxicol. 2002 Jun; 15(6): 870-6. PMID: 12067255, PII: tx020012t, ISSN: 0893-228X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12067255.
  • Thuring JW, Li H, Porter NA. Comparative study of the active site caging of serine proteases: thrombin and factor Xa. Biochemistry. 2002 Feb 2/12/2002; 41(6): 2002-13. PMID: 11827547, PII: bi0106078, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11827547.
  • Huiyong Yin, Christine M. Havrilla, Jason D. Morrow and Ned A. Porter. Formation of Isoprostane Bicylic Endoperoxides from the Autoxidation of Cholesteryl Arachidonate. J. Amer. Chem. Soc. 2002; 124: 7745-54.
  • Tallman KA, Pratt DA, Porter NA. Kinetic products of linoleate peroxidation: rapid beta-fragmentation of nonconjugated peroxyls. J. Am. Chem. Soc. 2001 Nov 11/28/2001; 123(47): 11827-8. PMID: 11716752, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11716752.
  • Milne GL, Porter NA. Separation and identification of phospholipid peroxidation products. Lipids. 2001 Nov; 36(11): 1265-75. PMID: 11795860, ISSN: 0024-4201.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11795860.
  • Culbertson SM, Vinqvist MR, Barclay LR, Porter NA. Minimizing tocopherol-mediated radical phase transfer in low-density lipoprotein oxidation with an amphiphilic unsymmetrical azo initiator. J. Am. Chem. Soc. 2001 Sep 9/19/2001; 123(37): 8951-60. PMID: 11552801, PII: ja010060k, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11552801.
  • Schneider C, Tallman KA, Porter NA, Brash AR. Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. J. Biol. Chem [print-electronic]. 2001 Jun 6/15/2001; 276(24): 20831-8. PMID: 11259420, PII: M101821200, DOI: 10.1074/jbc.M101821200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11259420.
  • Yin H, Hachey DL, Porter NA. Analysis of diacyl peroxides by Ag+ coordination ionspray tandem mass spectrometry: free radical pathways of complex decomposition. J. Am. Soc. Mass Spectrom. 2001 Apr; 12(4): 449-55. PMID: 11322191, PII: S1044-0305(01)00205-7, DOI: 10.1016/S1044-0305(01)00205-7, ISSN: 1044-0305.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11322191.
  • Truong TT, Marriott PJ, Porter NA. Analytical study of comprehensive and targeted multidimensional gas chromatography incorporating modulated cryogenic trapping. J AOAC Int. 2001 Mar; 84(2): 323-35. PMID: 11324594, ISSN: 1060-3271.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11324594.
  • Claus Schneider, Keri A. Tallman, Ned A. Porter, and Alan R. Brash. Two distinct pathways of formation of 4-hydroxy-nonenal . Mechanisms of non-enzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxy-alkenals. J. Biol. Chem. 2001; 276: 20831-8.
  • Culbertson SM, Porter NA. Design of unsymmetrical azo initiators to increase radical generation efficiency in low-density lipoproteins. Free Radic. Res. 2000 Dec; 33(6): 705-18. PMID: 11237093, ISSN: 1071-5762.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11237093.
  • Pollastri MP, Porter NA, McIntosh TJ, Simon SA. Synthesis, structure, and thermal properties of 1,2-dipalmitoylgalloylglycerol (DPGG), a novel self-adhering lipid. Chem. Phys. Lipids. 2000 Jan; 104(1): 67-74. PMID: 10660213, PII: S0009-3084(99)00110-3, ISSN: 0009-3084.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10660213.
  • Christine M. Havrilla, David L. Hachey, and Ned A. Porter. Coordination (Ag+) Ion Spray-Mass Spectrometry of Peroxidation Products of Cholesterol Linoleate and Cholesterol Arachidonate: High-Performance Liquid Chromatography-Mass Spectrometry Analysis of Peroxide Products from Polyunsaturated Lipid Autoxidation. J. Amer. Chem. Soc. 2000; 122: 8042-55.
  • S. M. Culbertson and N. A. Porter. The Initiation of Radical Reactions in Molecular Aggregates and Lipoproteins. Free Radical Research. 2000; 33(6): 705-18.
  • Yin H, Hachey DL, Porter NA. Structural analysis of diacyl peroxides by electrospray tandem mass spectrometry with ammonium acetate: bond homolysis of peroxide-ammonium and peroxide-proton adducts. Rapid Commun. Mass Spectrom. 2000; 14(14): 1248-54. PMID: 10918375, PII: 10.1002/1097-0231(20000730)14:14<1248::AID-RCM18>3.0.CO;2-B, DOI: 10.1002/1097-0231(20000730)14:14<1248::AID-RCM18>3.0.CO;2-B, ISSN: 0951-4198.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10918375.
  • McIntosh TJ, Pollastri MP, Porter NA, Simon SA. Polyphenols increase adhesion between lipid bilayers by forming interbilayer bridges. Basic Life Sci. 1999; 66: 451-70. PMID: 10800456, ISSN: 0090-5542.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10800456.
  • Arroyo JG, Jones PB, Porter NA, Hatchell DL. In vivo photoactivation of caged-thrombin. Thromb. Haemost. 1997 Aug; 78(2): 791-3. PMID: 9268172, ISSN: 0340-6245.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9268172.
  • Porter NA, Bush KA, Kinter KS. Photo-reversible binding of thrombin to avidin by means of a photolabile inhibitor. J. Photochem. Photobiol. B, Biol. 1997 Mar; 38(1): 61-9. PMID: 9134755, PII: S1011-1344(96)07427-1, ISSN: 1011-1344.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9134755.
  • Huh NW, Porter NA, McIntosh TJ, Simon SA. The interaction of polyphenols with bilayers: conditions for increasing bilayer adhesion. Biophys. J. 1996 Dec; 71(6): 3261-77. PMID: 8968596, PMCID: PMC1233814, PII: S0006-3495(96)79519-X, DOI: 10.1016/S0006-3495(96)79519-X, ISSN: 0006-3495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8968596.
  • Kenar JA, Havrilla CM, Porter NA, Guyton JR, Brown SA, Klemp KF, Selinger E. Identification and quantification of regioisomeric cholesteryl linoleate hydroperoxides in oxidized human low density lipoprotein and high density lipoprotein. Chem. Res. Toxicol. 1996 Jun; 9(4): 737-44. PMID: 8831818, PII: tx9600098, DOI: 10.1021/tx9600098, ISSN: 0893-228X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8831818.
  • Porter NA, Caldwell SE, Mills KA. Mechanisms of free radical oxidation of unsaturated lipids. Lipids. 1995 Apr; 30(4): 277-90. PMID: 7609594, ISSN: 0024-4201.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7609594.
  • Porter NA, Dussault P, Breyer RA, Kaplan J, Morelli J. The resolution of racemic hydroperoxides: a chromatography-based separation of perketals derived from arachidonic, linoleic, and oleic acid hydroperoxides. Chem. Res. Toxicol. 1990 May; 3(3): 236-43. PMID: 2131835, ISSN: 0893-228X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2131835.
  • Porter NA, Bruhnke JD. Photocoagulation of human plasma: acyl serine proteinase photochemistry. Photochem. Photobiol. 1990 Jan; 51(1): 37-43. PMID: 2304978, ISSN: 0031-8655.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2304978.
  • Pryor WA, Porter NA. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic. Biol. Med. 1990; 8(6): 541-3. PMID: 2193853, ISSN: 0891-5849.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2193853.
  • Wagner CR, Porter NA. A phospholipase C protocol for phospholipid peroxidation analysis. Chem. Res. Toxicol. 1988 Sep; 1(5): 274-80. PMID: 2979743, ISSN: 0893-228X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2979743.
  • Pizzo SV, Turner AD, Porter NA, Gonias SL. Evaluation of p-amidinophenyl esters as potential antithrombotic agents. Thromb. Haemost. 1986 Dec 12/15/1986; 56(3): 387-90. PMID: 2436336, ISSN: 0340-6245.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2436336.
  • Turner AD, Monroe DM, Roberts HR, Porter NA, Pizzo SV. P-Amidino esters as irreversible inhibitors of factors IXa and Xa and thrombin. Biochemistry. 1986 Aug 8/26/1986; 25(17): 4929-35. PMID: 3490273, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3490273.
  • Pizzo SV, Turner AD, Gonias SL, Monroe DM, Roberts HR, Porter NA. Nontoxic irreversible inhibitors of factors IXa, Xa, and thrombin: potential therapeutic agents for the in vivo regulation of thrombin generation and activity. Ann. N. Y. Acad. Sci. 1986; 485: 199-203. PMID: 3494415, ISSN: 0077-8923.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3494415.
  • Stidham MA, Siedow JN, McIntosh TJ, Porter NA, Moreland DE. Effects of phenylamide herbicides on the physical properties of phosphatidylcholine membranes. Biochim. Biophys. Acta. 1985 Feb 2/14/1985; 812(3): 721-30. PMID: 3970904, PII: 0005-2736(85)90266-4, ISSN: 0006-3002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3970904.
  • McIntosh TJ, Simon SA, Ellington JC, Porter NA. New structural model for mixed-chain phosphatidylcholine bilayers. Biochemistry. 1984 Aug 8/28/1984; 23(18): 4038-44. PMID: 6487589, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6487589.
  • Porter NA. Chemistry of lipid peroxidation. Meth. Enzymol. 1984; 105: 273-82. PMID: 6727666, ISSN: 0076-6879.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6727666.
  • Nicholas AW, Khouri LG, Ellington JC, Porter NA. Synthesis of mixed-acid phosphatidylcholines and high pressure liquid chromatographic analysis of isomeric lysophosphatidylcholines. Lipids. 1983 Jun; 18(6): 434-8. PMID: 6877049, ISSN: 0024-4201.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6877049.
  • Fridovich SE, Porter NA. Oxidation of arachidonic acid in micelles by superoxide and hydrogen peroxide. J. Biol. Chem. 1981 Jan 1/10/1981; 256(1): 260-5. PMID: 6256348, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6256348.
  • Porter NA, Weenen H. High-performance liquid chromatographic separations of phospholipids and phospholipid oxidation products. Meth. Enzymol. 1981; 72: 34-40. PMID: 7198177, ISSN: 0076-6879.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7198177.
  • Porter NA, Wolf RA, Pagels WR, Marnett LJ. A test for the intermediacy of 11-hydroperoxyeicosa-5,8,12,14-tetraenoic acid [11-HPETE] in prostaglandin biosynthesis. Biochem. Biophys. Res. Commun. 1980 Jan 1/29/1980; 92(2): 349-55. PMID: 6766722, PII: 0006-291X(80)90340-X, ISSN: 0006-291X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6766722.
  • Siegel MI, McConnell RT, Porter NA, Selph JL, Truax JF, Vinegar R, Cuatrecasas P. Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenan pleural exudates. Biochem. Biophys. Res. Commun. 1980 Jan 1/29/1980; 92(2): 688-95. PMID: 6766725, PII: 0006-291X(80)90388-5, ISSN: 0006-291X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6766725.
  • Siegel MI, McConnell RT, Porter NA, Cuatrecasas P. Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs. Proc. Natl. Acad. Sci. U.S.A. 1980 Jan; 77(1): 308-12. PMID: 6767237, PMCID: PMC348259, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6767237.
  • Porter NA, Wolf RA, Yarbro EM, Weenen H. The autoxidation of arachidonic acid: formation of the proposed SRS-A intermediate. Biochem. Biophys. Res. Commun. 1979 Aug 8/28/1979; 89(4): 1058-64. PMID: 496937, PII: 0006-291X(79)92115-6, ISSN: 0006-291X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/496937.
  • Siegel MI, McConnell RT, Abrahams SL, Porter NA, Cuatrecasas P. Regulation of arachidonate metabolism via lipoxygenase and cyclo-oxygenase by 12-HPETE, the product of human platelet lipoxygenase. Biochem. Biophys. Res. Commun. 1979 Aug 8/28/1979; 89(4): 1273-80. PMID: 115466, PII: 0006-291X(79)92146-6, ISSN: 0006-291X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/115466.
  • Porter NA, Gilmore DW. 2,3-dioxabicyclo[2.2.1]heptane [letter]. J. Am. Chem. Soc. 1977 May 5/11/1977; 99(10): 3503-4. PMID: 853188, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/853188.
  • Menzel DB, Roycroft JH, Nixon JR, Isaac SR, Porter NA. Monocyclic peroxides as inhibitors of arachidonic acid and prostaglandin endoperoxide analog initiated aggregation of human platelets. Res. Commun. Chem. Pathol. Pharmacol. 1976 Dec; 15(4): 767-85. PMID: 1005919, ISSN: 0034-5164.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1005919.
  • Porter NA, Nixon J, Isaac R. Cyclic peroxides and the thiobarbituric assay. Biochim. Biophys. Acta. 1976 Sep 9/27/1976; 441(3): 506-12. PMID: 974096, ISSN: 0006-3002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/974096.
  • Porter NA, Funk MO, Gilmore D, Isaac R, Nixon J. The formation of cyclic peroxides from unsaturated hydroperoxides: Models for prostaglandin biosynthesis. J. Am. Chem. Soc. 1976 Sep 9/15/1976; 98(19): 6000-5. PMID: 965634, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/965634.
  • Funk MO, Isacc R, Porter NA. Preparation and purification of lipid hydroperoxides from arachidonic and gamma-linolenic acids. Lipids. 1976 Feb; 11(2): 113-7. PMID: 814377, ISSN: 0024-4201.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/814377.
  • Porter NA, Funk MO. Letter: Peroxy radical cyclization as a model for prostaglandin biosynthesis. J. Org. Chem. 1975 Nov 11/28/1975; 40(24): 3614-5. PMID: 1185331, ISSN: 0022-3263.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1185331.
  • Funk MO, Isaac R, Porter NA. Letter: Free radical cyclization of unsaturated hydroperoxides. J. Am. Chem. Soc. 1975 Mar 3/5/1975; 97(5): 1281-2. PMID: 1133388, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1133388.