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Naji N. Abumrad, M.D.

John L. Sawyers Professor of Surgery
Medical Director, Surgery Patient Care Center
Co-Director, Digestive Disease Research Center
Surgical Oncologist

Contact Information:

Vanderbilt University Medical Center
1161 21st Ave. S., D-4314 MCN
Nashville, TN 37232-2730
615-343-2735
Fax: 615-343-5365

Profile

Dr. Naji Abumrad's clinical interests cover all aspects of general surgery and, particularly, endocrine surgery. His extensive research activities include studies of the mechanism of insulin resistance in the morbidly obese, and in particular, he is conducting studies related to the understanding of the mechanisms involved in the reversal of type 2 diabetes in morbidly obese patients who undergo bariatric surgical procedures. Additional studies carried out in his laboratory, address the metabolic effects of opioid peptides and opiate alkaloids; and in particular cocaine on energy metabolism and fuel mobilization. Dr. Abumrad's work has been funded by NIH grants during most of his academic career.

Dr. Abumrad’s professional interests have earned him appointments to serve on many NIH study sections, such as the Surgery, Anesthesia, and Trauma (1991-94) and Metabolism (1996-1998) Study Sections. In addition, he has just finished a stent as a member (2000-2004) and Chairman of the GMA2 Study Section. He also has served as a member of Secretary Donna Shalala’s Task Force on Breast Cancer in 1994.

He became a member of Alpha Omega Alpha in 1983, and of Sigma Xi, the Scientific Research Society, in 1986. In 1977, Dr. Abumrad received the Best Teacher Award at SUNY, Syracuse, and the Grant W. Liddle Award for Excellence in Teaching at Vanderbilt Medical Center in 1984.

Dr. Abumrad is certified with the American Board of Surgery since 1978 and was recertified in 1996.

Education
  • M.D. - American University of Beirut, 1971
  • Residency - American University of Beirut Medical Center, 1972
  • Residency - State University of New York at Syracuse, 1976
Publications
  • Youssef Y, Richards WO, Sekhar N, Kaiser J, Spagnoli A, Abumrad N, Torquati A. Risk of secondary hyperparathyroidism after laparoscopic gastric bypass surgery in obese women. Surg Endosc [print-electronic]. 2007 Aug; 21(8): 1393-6. PMID: 17318692, DOI: 10.1007/s00464-007-9228-6, ISSN: 1432-2218.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17318692.
  • Cotton BA, Guy JS, Morris JA, Abumrad NN. The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock. 2006 Aug; 26(2): 115-21. PMID: 16878017, PII: 00024382-200608000-00002, DOI: 10.1097/01.shk.0000209564.84822.f2, ISSN: 1073-2322.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16878017.
  • Hansen E, Hajri T, Abumrad NN. Is all fat the same? The role of fat in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus. Surgery. 2006 Jun; 139(6): 711-6. PMID: 16782424, PMCID: PMC3182097, PII: S0039-6060(05)00735-X, DOI: 10.1016/j.surg.2005.10.018, ISSN: 0039-6060.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16782424.
  • Hansen EN, Torquati A, Abumrad NN. Results of bariatric surgery. Annu. Rev. Nutr. 2006; 26: 481-511. PMID: 16704354, DOI: 10.1146/annurev.nutr.26.061505.111242, ISSN: 0199-9885.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16704354.
  • Torquati A, Lutfi R, Abumrad N, Richards WO. Is Roux-en-Y gastric bypass surgery the most effective treatment for type 2 diabetes mellitus in morbidly obese patients?. J. Gastrointest. Surg. 2005 Nov; 9(8): 1112-6; discussion 1117. PMID: 16269382, PII: S1091-255X(05)00584-6, DOI: 10.1016/j.gassur.2005.07.016, ISSN: 1091-255X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16269382.
  • Poulose BK, Ray WA, Arbogast PG, Needleman J, Buerhaus PI, Griffin MR, Abumrad NN, Beauchamp RD, Holzman MD. Resident work hour limits and patient safety. Ann. Surg. 2005 Jun; 241(6): 847-56; discussion 856. PMID: 15912034, PMCID: PMC1357165, PII: 00000658-200506000-00002, ISSN: 0003-4932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15912034.
  • Shipman J, Guy J, Abumrad NN. Repair of metabolic processes. Crit. Care Med. 2003 Aug; 31(8 Suppl): S512-7. PMID: 12907880, DOI: 10.1097/01.CCM.0000081547.31084.23, ISSN: 0090-3493.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12907880.
  • Goldstein RE, O'Neill JA, Holcomb GW, Morgan WM, Neblett WW, Oates JA, Brown N, Nadeau J, Smith B, Page DL, Abumrad NN, Scott HW. Clinical experience over 48 years with pheochromocytoma. Ann. Surg. 1999 Jun; 229(6): 755-64; discussion 764. PMID: 10363888, PMCID: PMC1420821, ISSN: 0003-4932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10363888.
  • Goldstein RE, Abumrad NN, Lacy DB, Wasserman DH, Cherrington AD. Effects of an acute increase in epinephrine and cortisol on carbohydrate metabolism during insulin deficiency. Diabetes. 1995 Jun; 44(6): 672-81. PMID: 7789632, ISSN: 0012-1797.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7789632.
  • Ghishan FK, Dykes W, Acra S, Pietsch J, Abumrad N. Effect of burn injury on intestinal Na+/H+ exchangers. J. Surg. Res. 1995 Feb; 58(2): 137-42. PMID: 7861764, PII: S0022-4804(85)71022-0, DOI: 10.1006/jsre.1995.1022, ISSN: 0022-4804.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7861764.
  • Flakoll PJ, Borel MJ, Wentzel LS, Williams PE, Lacy DB, Abumrad NN. The role of glucagon in the control of protein and amino acid metabolism in vivo. Metab. Clin. Exp. 1994 Dec; 43(12): 1509-16. PMID: 7990704, ISSN: 0026-0495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7990704.
  • Molina PE, Jabbour K, Williams P, Abumrad NN. Effect of acute ethanol intoxication on glucoregulation during prolonged insulin-induced hypoglycemia. Am. J. Physiol. 1994 Nov; 267(5 Pt 2): R1280-7. PMID: 7977855, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7977855.
  • Wasserman DH, Ruzumna PA, Bracy DP, Lacy DB, Boothe HW, Williams PE, Abumrad NN. Impact of suprapharmacological androgenic steroid administration on basal and insulin-stimulated glucose and amino acid metabolism. Metab. Clin. Exp. 1994 Oct; 43(10): 1266-74. PMID: 7934979, PII: 0026-0495(94)90221-6, ISSN: 0026-0495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7934979.
  • Goldstein RE, Cherrington AD, Reed GW, Lacy DB, Wasserman DH, Abumrad NN. Effects of chronic hypercortisolemia on carbohydrate metabolism during insulin deficiency. Am. J. Physiol. 1994 Apr; 266(4 Pt 1): E618-27. PMID: 8178983, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8178983.
  • Rice DE, Flakoll PJ, May MM, Hill JO, Abumrad NN. The opposing effects of insulin and hyperglycemia in modulating amino acid metabolism during a glucose tolerance test in lean and obese subjects. Metab. Clin. Exp. 1994 Feb; 43(2): 211-6. PMID: 8121304, PII: 0026-0495(94)90247-X, ISSN: 0026-0495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8121304.
  • Goldstein RE, Wasserman DH, Reed GW, Lacy DB, Abumrad NN, Cherrington AD. The effects of acute hypercortisolemia on beta-hydroxybutyrate and glycerol metabolism during insulin deficiency. Horm. Metab. Res. 1994 Jan; 26(1): 9-13. PMID: 7908656, DOI: 10.1055/s-2007-1000764, ISSN: 0018-5043.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7908656.
  • Whitesell RR, Aboumrad MK, Powers AC, Regen DM, Le C, Beechem JM, May JM, Abumrad NA. Coupling of glucose transport and phosphorylation in Xenopus oocytes and cultured cells: determination of the rate-limiting step. J. Cell. Physiol. 1993 Dec; 157(3): 509-18. PMID: 8253862, DOI: 10.1002/jcp.1041570310, ISSN: 0021-9541.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8253862.
  • Flakoll PJ, Hill JO, Abumrad NN. Acute hyperglycemia enhances proteolysis in normal man. Am. J. Physiol. 1993 Nov; 265(5 Pt 1): E715-21. PMID: 8238497, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8238497.
  • Melki SA, Abumrad NA. Expression of the adipocyte fatty acid-binding protein in streptozotocin-diabetes: effects of insulin deficiency and supplementation. J. Lipid Res. 1993 Sep; 34(9): 1527-34. PMID: 7693843, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7693843.
  • Molina PE, Eltayeb K, Hourani H, Okamura K, Nanney LB, Williams P, Abumrad NN. Hormonal and metabolic effects of neuroglucopenia. Brain Res. 1993 Jun 6/18/1993; 614(1-2): 99-108. PMID: 8348333, PII: 0006-8993(93)91022-K, ISSN: 0006-8993.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8348333.
  • Harmon CM, Abumrad NA. Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids. J. Membr. Biol. 1993 Apr; 133(1): 43-9. PMID: 8320718, ISSN: 0022-2631.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8320718.
  • Goldstein RE, Wasserman DH, McGuinness OP, Lacy DB, Cherrington AD, Abumrad NN. Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism. Am. J. Physiol. 1993 Jan; 264(1 Pt 1): E119-27. PMID: 8430780, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8430780.
  • Goldstein RE, Reed GW, Wasserman DH, Williams PE, Lacy DB, Buckspan R, Abumrad NN, Cherrington AD. The effects of acute elevations in plasma cortisol levels on alanine metabolism in the conscious dog. Metab. Clin. Exp. 1992 Dec; 41(12): 1295-303. PMID: 1461135, ISSN: 0026-0495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1461135.
  • Grimaldi PA, Knobel SM, Whitesell RR, Abumrad NA. Induction of aP2 gene expression by nonmetabolized long-chain fatty acids. Proc. Natl. Acad. Sci. U.S.A. 1992 Nov 11/15/1992; 89(22): 10930-4. PMID: 1438299, PMCID: PMC50456, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1438299.
  • Harmon CM, Luce P, Abumrad NA. Labelling of an 88 kDa adipocyte membrane protein by sulpho-N-succinimidyl long-chain fatty acids: inhibition of fatty acid transport. Biochem. Soc. Trans. 1992 Nov; 20(4): 811-3. PMID: 1487069, ISSN: 0300-5127.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1487069.
  • Ghishan FK, Shewayhat W, Dykes W, Abumrad N. Ontogeny of glutamine transport by rat liver plasma membrane vesicles. J. Dev. Physiol. 1992 Jul; 18(1): 1-7. PMID: 1287073, ISSN: 0141-9846.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1287073.
  • Sharp TA, Reed GW, Sun M, Abumrad NN, Hill JO. Relationship between aerobic fitness level and daily energy expenditure in weight-stable humans. Am. J. Physiol. 1992 Jul; 263(1 Pt 1): E121-8. PMID: 1636689, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1636689.
  • Bennett C, Reed GW, Peters JC, Abumrad NN, Sun M, Hill JO. Short-term effects of dietary-fat ingestion on energy expenditure and nutrient balance. Am. J. Clin. Nutr. 1992 Jun; 55(6): 1071-7. PMID: 1595577, ISSN: 0002-9165.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1595577.
  • Frexes-Steed M, Lacy DB, Collins J, Abumrad NN. Role of leucine and other amino acids in regulating protein metabolism in vivo. Am. J. Physiol. 1992 Jun; 262(6 Pt 1): E925-35. PMID: 1616025, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1616025.
  • Melki SA, Abumrad NA. Glycerolipid synthesis in isolated adipocytes: substrate dependence and influence of norepinephrine. J. Lipid Res. 1992 May; 33(5): 669-78. PMID: 1619361, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1619361.
  • Thomas CD, Peters JC, Reed GW, Abumrad NN, Sun M, Hill JO. Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans. Am. J. Clin. Nutr. 1992 May; 55(5): 934-42. PMID: 1570800, ISSN: 0002-9165.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1570800.
  • Flakoll PJ, Wentzel LS, Rice DE, Hill JO, Abumrad NN. Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: role of amino acid availability. Diabetologia. 1992 Apr; 35(4): 357-66. PMID: 1516764, ISSN: 0012-186X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1516764.
  • Whitesell RR, Powers AC, Regen DM, Abumrad NA. Transport and metabolism of glucose in an insulin-secreting cell line, beta TC-1. Biochemistry. 1991 Dec 12/10/1991; 30(49): 11560-6. PMID: 1747375, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1747375.
  • Donahue EP, Brown LL, Flakoll PJ, Abumrad NN. Rapid measurement of leucine-specific activity in biological fluids by ion-exchange chromatography and post-column ninhydrin detection. J. Chromatogr. 1991 Nov 11/15/1991; 571(1-2): 29-36. PMID: 1810959.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1810959.
  • Moore JM, Earnest MA, DiSimone AG, Abumrad NN, Fletcher JR. A PAF receptor antagonist, BN 52021, attenuates thromboxane release and improves survival in lethal canine endotoxemia. Circ. Shock. 1991 Sep; 35(1): 53-9. PMID: 1660355, ISSN: 0092-6213.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1660355.
  • Nammour TM, Williams PE, Badr KF, Abumrad NN, Jacobson HR. The amino acid-induced alteration in renal hemodynamics is glucagon independent. J. Am. Soc. Nephrol. 1991 Aug; 2(2): 164-71. PMID: 1954329, ISSN: 1046-6673.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1954329.
  • Abumrad NA, Forest CC, Regen DM, Sanders S. Increase in membrane uptake of long-chain fatty acids early during preadipocyte differentiation. Proc. Natl. Acad. Sci. U.S.A. 1991 Jul 7/15/1991; 88(14): 6008-12. PMID: 2068077, PMCID: PMC52011, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2068077.
  • Abumrad NA, Forest C, Regen DM, Barnella US, Melki SA. Metabolism of oleic acid in differentiating BFC-1 preadipose cells. Am. J. Physiol. 1991 Jul; 261(1 Pt 1): E76-86. PMID: 1858876, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1858876.
  • Flakoll PJ, Brown LL, Frexes-Steed M, Abumrad NN. Use of amino acid clamps to investigate the role of insulin in regulating protein breakdown in vivo. JPEN J Parenter Enteral Nutr. 1991 May; 15(3): 81S-85S. PMID: 1865564, ISSN: 0148-6071.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1865564.
  • Harmon CM, Luce P, Beth AH, Abumrad NA. Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: inhibition of fatty acid transport. J. Membr. Biol. 1991 May; 121(3): 261-8. PMID: 1865490, ISSN: 0022-2631.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1865490.
  • Flakoll PJ, Kulaylat M, Frexes-Steed M, Hill JO, Abumrad NN. Amino acids enhance insulin resistance to exogenous glucose infusion in overnight-fasted humans. JPEN J Parenter Enteral Nutr. 1991 Mar; 15(2): 123-7. PMID: 2051553, ISSN: 0148-6071.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2051553.
  • Wasserman DH, Geer RJ, Williams PE, Becker T, Lacy DB, Abumrad NN. Interaction of gut and liver in nitrogen metabolism during exercise. Metab. Clin. Exp. 1991 Mar; 40(3): 307-14. PMID: 1672034, PII: 0026-0495(91)90115-D, ISSN: 0026-0495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1672034.
  • Wasserman DH, Geer RJ, Rice DE, Bracy D, Flakoll PJ, Brown LL, Hill JO, Abumrad NN. Interaction of exercise and insulin action in humans. Am. J. Physiol. 1991 Jan; 260(1 Pt 1): E37-45. PMID: 1987792, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1987792.
  • Abumrad NA, Melki SA, Harmon CM. Transport of fatty acid in the isolated rat adipocyte and in differentiating preadipose cells. Biochem. Soc. Trans. 1990 Dec; 18(6): 1130-2. PMID: 2088822, ISSN: 0300-5127.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2088822.
  • Geer RJ, Richards WO, O'Dorisio TM, Woltering EO, Williams S, Rice D, Abumrad NN. Efficacy of octreotide acetate in treatment of severe postgastrectomy dumping syndrome. Ann. Surg. 1990 Dec; 212(6): 678-87. PMID: 2256759, PMCID: PMC1358252, ISSN: 0003-4932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2256759.
  • Whitesell RR, Regen DM, Pelletier D, Abumrad NA. Evidence that downregulation of hexose transport limits intracellular glucose in 3T3-L1 fibroblasts. Diabetes. 1990 Oct; 39(10): 1228-34. PMID: 2210075, ISSN: 0012-1797.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2210075.
  • Abumrad NN, Frexes-Steed M. What getting sick means. JPEN J Parenter Enteral Nutr. 1990 Sep; 14(5 Suppl): 157S-163S. PMID: 2232099, ISSN: 0148-6071.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2232099.
  • Hourani H, Lacy DB, Nammour TM, Abumrad NN, Morris JA. Differential effects of alpha and beta adrenergic blockade on glucose and lactate metabolism during acute stress. J Trauma. 1990 Sep; 30(9): 1116-23; discussion 1123. PMID: 2170667, ISSN: 0022-5282.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2170667.
  • Hourani H, Williams P, Morris JA, May ME, Abumrad NN. Effect of insulin-induced hypoglycemia on protein metabolism in vivo. Am. J. Physiol. 1990 Sep; 259(3 Pt 1): E342-50. PMID: 2119145, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2119145.
  • Abumrad NN, Yazigi N, Cersosimo E, Hourani H, Gedde S, Bulus N, Williams P. Glutamine metabolism during starvation. JPEN J Parenter Enteral Nutr. 1990 Jul; 14(4 Suppl): 71S-76S. PMID: 2402056, ISSN: 0148-6071.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2402056.
  • al-Mahroos FT, Abumrad N, Ghishan FK. Developmental changes in glutamine transport by rat jejunal basolateral membrane vesicles. Proc. Soc. Exp. Biol. Med. 1990 Jul; 194(3): 186-92. PMID: 2356187, ISSN: 0037-9727.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2356187.
  • Frexes-Steed M, Warner ML, Bulus N, Flakoll P, Abumrad NN. Role of insulin and branched-chain amino acids in regulating protein metabolism during fasting. Am. J. Physiol. 1990 Jun; 258(6 Pt 1): E907-17. PMID: 2193532, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2193532.
  • al-Mahroos FT, Bulus N, Abumrad N, Said H, Ghishan FK. Maturational changes in glutamine transport by rat jejunal brush border membrane vesicles. Pediatr. Res. 1990 May; 27(5): 519-24. PMID: 2345680, DOI: 10.1203/00006450-199005000-00021, ISSN: 0031-3998.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2345680.
  • Ghishan FK, Arab N, Bulus N, Said H, Pietsch J, Abumrad N. Glutamine transport by human intestinal basolateral membrane vesicle. Am. J. Clin. Nutr. 1990 Apr; 51(4): 612-6. PMID: 2321568, ISSN: 0002-9165.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2321568.
  • Van Voorhis K, Said HM, Abumrad N, Ghishan FK. Effect of chemically induced diabetes mellitus on glutamine transport in rat intestine. Gastroenterology. 1990 Apr; 98(4): 862-6. PMID: 2155843, PII: S0016508590001147, ISSN: 0016-5085.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2155843.
  • Hill JO, Peters JC, Swift LL, Yang D, Sharp T, Abumrad N, Greene HL. Changes in blood lipids during six days of overfeeding with medium or long chain triglycerides. J. Lipid Res. 1990 Mar; 31(3): 407-16. PMID: 2187945, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2187945.
  • Flakoll PJ, Kulaylat M, Frexes-Steed M, Hourani H, Brown LL, Hill JO, Abumrad NN. Amino acids augment insulin's suppression of whole body proteolysis. Am. J. Physiol. 1989 Dec; 257(6 Pt 1): E839-47. PMID: 2692456, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2692456.
  • Cersosimo E, Williams P, Geer R, Lairmore T, Ghishan F, Abumrad NN. Importance of ammonium ions in regulating hepatic glutamine synthesis during fasting. Am. J. Physiol. 1989 Oct; 257(4 Pt 1): E514-9. PMID: 2801934, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2801934.
  • Radosevich PM, Nash JA, Lacy DB, O'Donovan C, Williams PE, Abumrad NN. Effects of low- and high-intensity exercise on plasma and cerebrospinal fluid levels of ir-beta-endorphin, ACTH, cortisol, norepinephrine and glucose in the conscious dog. Brain Res. 1989 Sep 9/25/1989; 498(1): 89-98. PMID: 2551459, ISSN: 0006-8993.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2551459.
  • Nash JA, Radosevich PM, Lacy DB, Rizk N, Hourani H, Williams PE, Abumrad NN. Effects of naloxone on glucose homeostasis during insulin-induced hypoglycemia. Am. J. Physiol. 1989 Sep; 257(3 Pt 1): E367-73. PMID: 2528911, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2528911.
  • Whitesell RR, Regen DM, Abumrad NA. Evidence for functionally distinct glucose transporters in basal and insulin-stimulated adipocytes. Biochemistry. 1989 Aug 8/22/1989; 28(17): 6937-43. PMID: 2684269, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2684269.
  • Abumrad NN, Morse EL, Lochs H, Williams PE, Adibi SA. Possible sources of glutamine for parenteral nutrition: impact on glutamine metabolism. Am. J. Physiol. 1989 Aug; 257(2 Pt 1): E228-34. PMID: 2504051, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2504051.
  • Bulus N, Cersosimo E, Ghishan F, Abumrad NN. Physiologic importance of glutamine. Metab. Clin. Exp. 1989 Aug; 38(8 Suppl 1): 1-5. PMID: 2668700, ISSN: 0026-0495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2668700.
  • Hubbard MM, Husami TW, Abumrad NN. Nonfunctioning adrenal tumors. Dilemmas in management. Am Surg. 1989 Aug; 55(8): 516-22. PMID: 2764401, ISSN: 0003-1348.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2764401.
  • Bulus NM, Abumrad NN, Ghishan FK. Characteristics of glutamine transport in dog jejunal brush-border membrane vesicles. Am. J. Physiol. 1989 Jul; 257(1 Pt 1): G80-5. PMID: 2750912, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2750912.
  • Hill JO, Peters JC, Yang D, Sharp T, Kaler M, Abumrad NN, Greene HL. Thermogenesis in humans during overfeeding with medium-chain triglycerides. Metab. Clin. Exp. 1989 Jul; 38(7): 641-8. PMID: 2739575, ISSN: 0026-0495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2739575.
  • Whitesell RR, Regen DM, Beth AH, Pelletier DK, Abumrad NA. Activation energy of the slowest step in the glucose carrier cycle: break at 23 degrees C and correlation with membrane lipid fluidity. Biochemistry. 1989 Jun 6/27/1989; 28(13): 5618-25. PMID: 2775725, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2775725.
  • Wasserman DH, Abumrad NN. Physiological bases for the treatment of the physically active individual with diabetes. Sports Med. 1989 Jun; 7(6): 376-92. PMID: 2662324, ISSN: 0112-1642.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2662324.
  • Abumrad NN, Williams P, Frexes-Steed M, Geer R, Flakoll P, Cersosimo E, Brown LL, Melki I, Bulus N, Hourani H. Inter-organ metabolism of amino acids in vivo. Diabetes Metab Rev. 1989 May; 5(3): 213-26. PMID: 2656153, ISSN: 0742-4221.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2656153.
  • Pietsch JB, Leonard D, Neblett WW, Abumrad NN, Ghishan FK. Burn injury alters intestinal glutamine transport. J. Surg. Res. 1989 Apr; 46(4): 296-9. PMID: 2704226, PII: 0022-4804(89)90190-X, ISSN: 0022-4804.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2704226.
  • Ghishan FK, Sutter W, Said H, Leonard D, Pietsch J, Abumrad N. Glutamine transport by rat basolateral membrane vesicles. Biochim. Biophys. Acta. 1989 Feb 2/13/1989; 979(1): 77-81. PMID: 2917169, PII: 0005-2736(89)90525-7, ISSN: 0006-3002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2917169.
  • Radosevich PM, Lacy DB, Brown LL, Williams PE, Abumrad NN. Central effects of beta-endorphins on glucose homeostasis in the conscious dog. Am. J. Physiol. 1989 Feb; 256(2 Pt 1): E322-30. PMID: 2521986, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2521986.
  • Van Voorhis K, Said HM, Ghishan FK, Abumrad NN. Transport of glutamine in rat intestinal brush-border membrane vesicles. Biochim. Biophys. Acta. 1989 Jan 1/16/1989; 978(1): 51-5. PMID: 2492432, PII: 0005-2736(89)90497-5, ISSN: 0006-3002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2492432.
  • Abumrad NA, Harmon CM, Barnela US, Whitesell RR. Insulin antagonism of catecholamine stimulation of fatty acid transport in the adipocyte. Studies on its mechanism of action. J. Biol. Chem. 1988 Oct 10/15/1988; 263(29): 14678-83. PMID: 2459120, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2459120.
  • Radosevich PM, Lacy DB, Brown LL, Williams PE, Abumrad NN. Effects of insulin-induced hypoglycemia on plasma and cerebrospinal fluid levels of ir-beta-endorphins, ACTH, cortisol, norepinephrine, insulin and glucose in the conscious dog. Brain Res. 1988 Aug 8/23/1988; 458(2): 325-38. PMID: 2850080, PII: 0006-8993(88)90475-1, ISSN: 0006-8993.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2850080.
  • Kikuchi K, Abumrad NN, Ghishan FK. Na+/H+ exchange by brush border membrane vesicles of human ileal small intestine. Gastroenterology. 1988 Aug; 95(2): 388-93. PMID: 2455671, PII: S0016508588002264, ISSN: 0016-5085.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2455671.
  • Brown LL, Williams PE, Becker TA, Ensley RJ, May ME, Abumrad NN. Rapid high-performance liquid chromatographic method to measure plasma leucine: importance in the study of leucine kinetics in vivo. J. Chromatogr. 1988 Apr 4/29/1988; 426(2): 370-5. PMID: 3292555.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3292555.
  • Kulaylat MN, Frexes-Steed M, Geer R, Williams PE, Abumrad NN. The role of leucine in hepatic ketogenesis. Surgery. 1988 Mar; 103(3): 351-60. PMID: 2894077, PII: 0039-6060(88)90273-5, ISSN: 0039-6060.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2894077.
  • Abumrad NA, Briscoe P, Beth AH, Whitesell RR. Temperature dependence of glucose transport in erythrocytes from normal and alloxan-diabetic rats. Biochim. Biophys. Acta. 1988 Feb 2/18/1988; 938(2): 222-30. PMID: 3342233, PII: 0005-2736(88)90161-7, ISSN: 0006-3002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3342233.
  • Lipman JJ, Colowick SP, Lawrence PL, Abumrad NN. Aluminum induced encephalopathy in the rat. Life Sci. 1988; 42(8): 863-75. PMID: 3343887, ISSN: 0024-3205.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3343887.
  • McGee GS, Kulaylat MM, Abumrad NN. Defective glucose utilization in patients with functioning beta-cell tumors persists after tumor excision. Ann. Surg. 1987 Oct; 206(4): 449-57. PMID: 2821936, PMCID: PMC1493209, ISSN: 0003-4932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2821936.
  • Noland TD, Abumrad NA, Beth AH, Garbers DL. Protein phosphorylation in intact bovine epididymal spermatozoa: identification of the type II regulatory subunit of cyclic adenosine 3',5'-monophosphate-dependent protein kinase as an endogenous phosphoprotein. Biol. Reprod. 1987 Aug; 37(1): 171-80. PMID: 3651544, ISSN: 0006-3363.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3651544.
  • Scott HW, Abumrad NN, Orth DN. Tumors of the adrenal cortex and Cushing's syndrome. Ann. Surg. 1985 May; 201(5): 586-94. PMID: 2986563, PMCID: PMC1250765, ISSN: 0003-4932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2986563.