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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center


Natasha G. Deane, Ph.D.

Research Associate Professor of Surgery (Surgical Oncology)

Contact Information:

Vanderbilt University Medical Center
D2300 MCN 1161 21st Ave
Nashville, TN 37232
Fax: 615-322-6174

Research Description

My formal training is in molecular virology with post-doctoral training in molecular imaging. Since starting in a research faculty position in the Department of Surgery in 2004, I have been actively involved in the analysis of the molecular underpinnings of human colon cancer progression with validation in both cellular and mouse models. Through genetic maniulation of components of the TGFbeta signaling pathway, I study the importance of this pathway for various aspects of cancer progression in vivo with particular emphasis on tumor cell epithelial to mesenchymal transition (EMT) and tumor invasiveness. My work is highly inter-disciplinary in nature and I rely on very productive collaborations with investigators in the Departments of Medicine and Preventive Medicine and Biostatistics. Our group consists of both research and clinical faculty overseeing about 12 trainees and technical staff, combined.

Clinical Interest

Human colon cancer

Clinical Research Description

Our group uses clinical samples from colon cancer resections combined with longitudinal outcomes data to analyze molecular patterns associated with human colon cancer progression and responsiveness to therapy.