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Oliver G. Mcdonald, M.D., Ph.D.

Assistant Professor of Pathology, Microbiology and Immunology
Pathologist

Profile

Clinical Practice: Diagnostic pathology of gastrointestinal, pancreatic, and hepatobiliary disease

Research Interests: Molecular mechanisms controlling pancreatic cancer progression. 

Education
 
  • University of Virginia MD, PhD (MSTP) 2001-2007
  • Johns Hopkins, Pathology residency 2007-2011
  • Johns Hopkins, GI Pathology Fellowship 2011-2013
 
Research Description

Epigenetic reprogramming of chromatin structure during neoplastic transformation and malignant progression

Publications
  • Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem. Biol [print-electronic]. 2014 Jun 6/20/2014; 9(6): 1284-93. PMID: 24707965, PMCID: PMC4076021, DOI: 10.1021/cb500018s, ISSN: 1554-8937.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24707965.
  • McDonald OG, Maitra A, Hruban RH. Human correlates of provocative questions in pancreatic pathology. Adv Anat Pathol. 2012 Nov; 19(6): 351-62. PMID: 23060061, PMCID: PMC3487591, PII: 00125480-201211000-00001, DOI: 10.1097/PAP.0b013e318273f998, ISSN: 1533-4031.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23060061.
  • Hansen KD, Timp W, Bravo HC, Sabunciyan S, Langmead B, McDonald OG, Wen B, Wu H, Liu Y, Diep D, Briem E, Zhang K, Irizarry RA, Feinberg AP. Increased methylation variation in epigenetic domains across cancer types. Nat. Genet. 2011 Aug; 43(8): 768-75. PMID: 21706001, PMCID: PMC3145050, PII: ng.865, DOI: 10.1038/ng.865, ISSN: 1546-1718.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21706001.
  • McDonald OG, Wu H, Timp W, Doi A, Feinberg AP. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat. Struct. Mol. Biol. 2011 Aug; 18(8): 867-74. PMID: 21725293, PMCID: PMC3150339, PII: nsmb.2084, DOI: 10.1038/nsmb.2084, ISSN: 1545-9985.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21725293.
  • Hastings NE, Simmers MB, McDonald OG, Wamhoff BR, Blackman BR. Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming. Am. J. Physiol., Cell Physiol [print-electronic]. 2007 Dec; 293(6): C1824-33. PMID: 17913848, PII: 00385.2007, DOI: 10.1152/ajpcell.00385.2007, ISSN: 0363-6143.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17913848.
  • McDonald OG, Owens GK. Programming smooth muscle plasticity with chromatin dynamics. Circ. Res. 2007 May 5/25/2007; 100(10): 1428-41. PMID: 17525382, PII: 100/10/1428, DOI: 10.1161/01.RES.0000266448.30370.a0, ISSN: 1524-4571.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17525382.
  • Gan Q, Yoshida T, McDonald OG, Owens GK. Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells. Stem Cells [print-electronic]. 2007 Jan; 25(1): 2-9. PMID: 17023513, PII: 2006-0383, DOI: 10.1634/stemcells.2006-0383, ISSN: 1066-5099.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17023513.
  • Davis CA, Haberland M, Arnold MA, Sutherland LB, McDonald OG, Richardson JA, Childs G, Harris S, Owens GK, Olson EN. PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol. Cell. Biol. 2006 Apr; 26(7): 2626-36. PMID: 16537907, PMCID: PMC1430312, PII: 26/7/2626, DOI: 10.1128/MCB.26.7.2626-2636.2006, ISSN: 0270-7306.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16537907.
  • McDonald OG, Wamhoff BR, Hoofnagle MH, Owens GK. Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo. J. Clin. Invest. 2006 Jan; 116(1): 36-48. PMID: 16395403, PMCID: PMC1323266, DOI: 10.1172/JCI26505, ISSN: 0021-9738.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16395403.
  • Liu Y, Sinha S, McDonald OG, Shang Y, Hoofnagle MH, Owens GK. Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression. J. Biol. Chem [print-electronic]. 2005 Mar 3/11/2005; 280(10): 9719-27. PMID: 15623517, PII: M412862200, DOI: 10.1074/jbc.M412862200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15623517.
  • Hendrix JA, Wamhoff BR, McDonald OG, Sinha S, Yoshida T, Owens GK. 5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo. J. Clin. Invest. 2005 Feb; 115(2): 418-27. PMID: 15690088, PMCID: PMC546420, DOI: 10.1172/JCI22648, ISSN: 0021-9738.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15690088.
  • Wamhoff BR, Hoofnagle MH, Burns A, Sinha S, McDonald OG, Owens GK. A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis. Circ. Res [print-electronic]. 2004 Nov 11/12/2004; 95(10): 981-8. PMID: 15486317, PII: 01.RES.0000147961.09840.fb, DOI: 10.1161/01.RES.0000147961.09840.fb, ISSN: 1524-4571.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15486317.
  • Wamhoff BR, Bowles DK, McDonald OG, Sinha S, Somlyo AP, Somlyo AV, Owens GK. L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Circ. Res [print-electronic]. 2004 Aug 8/20/2004; 95(4): 406-14. PMID: 15256479, PII: 01.RES.0000138582.36921.9e, DOI: 10.1161/01.RES.0000138582.36921.9e, ISSN: 1524-4571.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15256479.
  • McDonald OG, Krynetski EY, Evans WE. Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation. Pharmacogenetics. 2002 Mar; 12(2): 93-9. PMID: 11875363, ISSN: 0960-314X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11875363.