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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

J. Oliver McIntyre, Ph.D.

Research Professor of Cancer Biology
Researcher

Contact Information:

Vanderbilt University Medical Center
771 Preston Building, 23rd & Pierce Avenues
Nashville, TN 37232-6840
615-936-2913
Fax: 615-936-2911

Publications
  • Harrell PC, McCawley LJ, Fingleton B, McIntyre JO, Matrisian LM. Proliferative effects of apical, but not basal, matrix metalloproteinase-7 activity in polarized MDCK cells. Exp. Cell Res [print-electronic]. 2005 Feb 2/15/2005; 303(2): 308-20. PMID: 15652345, PII: S0014-4827(04)00574-9, DOI: 10.1016/j.yexcr.2004.09.020, ISSN: 0014-4827.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15652345.
  • Fingleton B, Menon R, Carter KJ, Overstreet PD, Hachey DL, Matrisian LM, McIntyre JO. Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy. Clin. Cancer Res. 2004 Dec 12/1/2004; 10(23): 7865-74. PMID: 15585619, PII: 10/23/7865, DOI: 10.1158/1078-0432.CCR-04-1252, ISSN: 1078-0432.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15585619.
  • McIntyre JO, Fingleton B, Wells KS, Piston DW, Lynch CC, Gautam S, Matrisian LM. Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem. J. 2004 Feb 2/1/2004; 377(Pt 3): 617-28. PMID: 14556651, PMCID: PMC1223892, PII: BJ20030582, DOI: 10.1042/BJ20030582, ISSN: 1470-8728.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14556651.
  • McIntyre JO, Matrisian LM. Molecular imaging of proteolytic activity in cancer. J. Cell. Biochem. 2003 Dec 12/15/2003; 90(6): 1087-97. PMID: 14635184, DOI: 10.1002/jcb.10713, ISSN: 0730-2312.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14635184.
  • Jeyakumar LH, Ballester L, Cheng DS, McIntyre JO, Chang P, Olivey HE, Rollins-Smith L, Barnett JV, Murray K, Xin HB, Fleischer S. FKBP binding characteristics of cardiac microsomes from diverse vertebrates. Biochem. Biophys. Res. Commun. 2001 Mar 3/9/2001; 281(4): 979-86. PMID: 11237759, PII: S0006-291X(01)94444-4, DOI: 10.1006/bbrc.2001.4444, ISSN: 0006-291X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11237759.
  • Loeb-Hennard C, McIntyre JO. (R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain. Biochemistry. 2000 Oct 10/3/2000; 39(39): 11928-38. PMID: 11009606, PII: bi000425y, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11009606.
  • Picklo MJ, Amarnath V, McIntyre JO, Graham DG, Montine TJ. 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. J. Neurochem. 1999 Apr; 72(4): 1617-24. PMID: 10098869, ISSN: 0022-3042.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10098869.
  • Green, D., Marks, A.R., Fleischer, S., and McIntyre, J.O. Wild Type and Mutant Human Heart (R)-3- Hydroxybutyrate Dehydrogenase Expressed in Insect Cells. Biochemistry. 1996; 35: 8158-65.
  • Klein, K., Rudy, B., McIntyre, J.O., Fleischer, S., and Trommer, W.E. Specific Interaction of (R)-3-Hydroxybutyrate Dehydrogenase with Membrane Phosphatidylcholine as Studied by ESR Specroscopy in Oriented Phospholipid Multibilayers: Coenzyme Binding Enhances the Interaction with Phosphatidylcholine. Biochemistry. 1996; 35: 3044-9.
  • Dalton LA, McIntyre JO, Fleischer S. Effect of selective thiol-group derivatization on enzyme kinetics of (R)-3-hydroxybutyrate dehydrogenase. Biochem. J. 1993 Dec 12/15/1993; 296 ( Pt 3): 563-9. PMID: 8280053, PMCID: PMC1137735, ISSN: 0264-6021.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8280053.
  • Adami P, Duncan TM, McIntyre JO, Carter CE, Fu C, Melin M, Latruffe N, Fleischer S. Monoclonal antibodies for structure-function studies of (R)-3-hydroxybutyrate dehydrogenase, a lipid-dependent membrane-bound enzyme. Biochem. J. 1993 Jun 6/15/1993; 292 ( Pt 3): 863-72. PMID: 7686368, PMCID: PMC1134194, ISSN: 0264-6021.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7686368.
  • Fleischer B, McIntyre JO, Kempner ES. Target sizes of galactosyltransferase, sialyltransferase, and uridine diphosphatase in Golgi apparatus of rat liver. Biochemistry. 1993 Mar 3/2/1993; 32(8): 2076-81. PMID: 8383532, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8383532.
  • Cortese JD, McIntyre JO, Duncan TM, Fleischer S. Cooperativity in lipid activation of 3-hydroxybutyrate dehydrogenase: role of lecithin as an essential allosteric activator. Biochemistry. 1989 Apr 4/4/1989; 28(7): 3000-8. PMID: 2742824, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2742824.
  • McIntyre JO, Latruffe N, Brenner SC, Fleischer S. Comparison of 3-hydroxybutyrate dehydrogenase from bovine heart and rat liver mitochondria. Arch. Biochem. Biophys. 1988 Apr; 262(1): 85-98. PMID: 3355176, PII: 0003-9861(88)90171-3, ISSN: 0003-9861.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3355176.