Vanderbilt-Ingram Cancer Center

Publications

• Yin, H, Vergeade, A, Shi, Q, Zackert, WE, Gruenberg, KC, Bokiej, M, Amin, T, Ying, W, Masterson, TS, Zinkel, SS, Oates, JA, Boutaud, O, Roberts, LJ Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation. Biochem Biophys Res Commun, 423(2), 224-8, 2012.
• Smith, JP, Haddad, EV, Taylor, MB, Oram, D, Blakemore, D, Chen, Q, Boutaud, O, Oates, JA Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome. Hypertension, 59(3), 719-25, 2012.
• Zagol-Ikapitte, I, Amarnath, V, Jadhav, S, Oates, JA, Boutaud, O Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: Application to in vivo pharmacokinetics studies. J Chromatogr B Analyt Technol Biomed Life Sci, 879(15-16), 1098-104, 2011.
• Reed, KA, Tucker, DE, Aloulou, A, Adler, D, Ghomashchi, F, Gelb, MH, Leslie, CC, Oates, JA, Boutaud, O Functional characterization of mutations in inherited human cPLAâ‚‚ deficiency. Biochemistry, 50(10), 1731-8, 2011.
• Chacon, A, Zagol-Ikapitte, I, Amarnath, V, Reyzer, ML, Oates, JA, Caprioli, RM, Boutaud, O On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry. J Mass Spectrom, 46(8), 840-6, 2011.
• Holinstat, M, Boutaud, O, Apopa, PL, Vesci, J, Bala, M, Oates, JA, Hamm, HE Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Arterioscler Thromb Vasc Biol, 31(2), 435-42, 2011.
• Boutaud, O, Moore, KP, Reeder, BJ, Harry, D, Howie, AJ, Wang, S, Carney, CK, Masterson, TS, Amin, T, Wright, DW, Wilson, MT, Oates, JA, Roberts, LJ Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proc Natl Acad Sci U S A, 107(6), 2699-704, 2010.
• Zagol-Ikapitte, I, Amarnath, V, Bala, M, Roberts, LJ, Oates, JA, Boutaud, O Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis. Chem Res Toxicol, 23(1), 240-50, 2010.
• Zagol-Ikapitte, IA, Matafonova, E, Amarnath, V, Bodine, CL, Boutaud, O, Tirona, RG, Oates, JA, Roberts, LJ, Davies, SS Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent ¿¿-Ketoaldehyde Scavenger, by LC/MS/MS. Pharmaceutics, 2(1), 18-29, 2010.
• Boutaud, O, Roberts, LJ Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. Free Radic Biol Med, 2010.
• Smith, JP, Haddad, EV, Downey, JD, Breyer, RM, Boutaud, O PGE2 decreases reactivity of human platelets by activating EP2 and EP4. Thromb Res, 126(1), e23-9, 2010.
• Plunkett, J, Doniger, S, Morgan, T, Haataja, R, Hallman, M, Puttonen, H, Menon, R, Kuczynski, E, Norwitz, E, Snegovskikh, V, Palotie, A, Peltonen, L, Fellman, V, DeFranco, EA, Chaudhari, BP, Oates, J, Boutaud, O, McGregor, TL, McElroy, JJ, Teramo, K, Borecki, I, Fay, JC, Muglia, LJ Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth. BMC Med Genomics, 362, 2010.
• Boutaud, O, Oates, JA Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes. Methods Mol Biol, 64467-90, 2010.
• Mosoni, L, Balage, M, Vazeille, E, Combaret, L, Morand, C, Zagol-Ikapitte, I, Boutaud, O, Marzani, B, Papet, I, Dardevet, D Antioxidant supplementation had positive effects in old rat muscle, but through better oxidative status in other organs. Nutrition, 26(11-12), 1157-62, 2009.
• Carrier, EJ, Amarnath, V, Oates, JA, Boutaud, O Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin. Biochemistry, 48(45), 10775-81, 2009.
• Potet, F, Petersen, CI, Boutaud, O, Shuai, W, Stepanovic, SZ, Balser, JR, Kupershmidt, S Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator. J Mol Cell Cardiol, 46(2), 257-67, 2009.
• Nam, TG, Nara, SJ, Zagol-Ikapitte, I, Cooper, T, Valgimigli, L, Oates, JA, Porter, NA, Boutaud, O, Pratt, DA Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis. Org Biomol Chem, 7(24), 5103-12, 2009.
• Adler, DH, Phillips, JA, Cogan, JD, Iverson, TM, Schnetz-Boutaud, N, Stein, JA, Brenner, DA, Milne, GL, Morrow, JD, Boutaud, O, Oates, JA The enteropathy of prostaglandin deficiency. J Gastroenterol, 44 Suppl 191-7, 2009.
• Bala, M, Chin, CN, Logan, AT, Amin, T, Marnett, LJ, Boutaud, O, Oates, JA Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase. Biochem Pharmacol, 75(7), 1472-81, 2008.
• Adler, DH, Cogan, JD, Phillips, JA, Schnetz-Boutaud, N, Milne, GL, Iverson, T, Stein, JA, Brenner, DA, Morrow, JD, Boutaud, O, Oates, JA Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest, 118(6), 2121-31, 2008.
• Davies, SS, Amarnath, V, Brame, CJ, Boutaud, O, Roberts, LJ Measurement of chronic oxidative and inflammatory stress by quantification of isoketal/levuglandin gamma-ketoaldehyde protein adducts using liquid chromatography tandem mass spectrometry. Nat Protoc, 2(9), 2079-91, 2007.
• Aronoff, DM, Oates, JA, Boutaud, O New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases. Clin Pharmacol Ther, 79(1), 9-19, 2006.
• Boutaud, O, Montine, TJ, Chang, L, Klein, WL, Oates, JA PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42. J Neurochem, 96(4), 917-23, 2006.
• Davies, SS, Brantley, EJ, Voziyan, PA, Amarnath, V, Zagol-Ikapitte, I, Boutaud, O, Hudson, BG, Oates, JA, Roberts, LJ Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry, 45(51), 15756-67, 2006.
• Boutaud, O, Andreasson, KI, Zagol-Ikapitte, I, Oates, JA Cyclooxygenase-dependent lipid-modification of brain proteins. Brain Pathol, 15(2), 139-42, 2005.
• Zagol-Ikapitte, I, Masterson, TS, Amarnath, V, Montine, TJ, Andreasson, KI, Boutaud, O, Oates, JA Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer''s disease severity. J Neurochem, 94(4), 1140-5, 2005.
• Zagol-Ikapitte, I, Bernoud-Hubac, N, Amarnath, V, Roberts, LJ, Boutaud, O, Oates, JA Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine. Biochemistry, 43(18), 5503-10, 2004.
• Brame, CJ, Boutaud, O, Davies, SS, Yang, T, Oates, JA, Roden, D, Roberts, LJ Modification of proteins by isoketal-containing oxidized phospholipids. J Biol Chem, 279(14), 13447-51, 2004.
• Kozak, W, Aronoff, DM, Boutaud, O, Kozak, A 11,12-epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide. Exp Biol Med (Maywood), 228(7), 786-94, 2003.
• Aronoff, DM, Boutaud, O, Marnett, LJ, Oates, JA Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. J Pharmacol Exp Ther, 304(2), 589-95, 2003.
• Aronoff, DM, Boutaud, O, Marnett, LJ, Oates, JA Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. Adv Exp Med Biol, 525125-8, 2003.
• Boutaud, O, Li, J, Zagol, I, Shipp, EA, Davies, SS, Roberts, LJ, Oates, JA Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation. J Biol Chem, 278(19), 16926-8, 2003.
• Sawaoka, H, Dixon, DA, Oates, JA, Boutaud, O Tristetraprolin binds to the 3''-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. J Biol Chem, 278(16), 13928-35, 2003.
• Boutaud, O, Dixon, DA, Oates, JA, Sawaoka, H Tristetraprolin binds to the COX-2 mRNA 3'' untranslated region in cancer cells. Adv Exp Med Biol, 525157-60, 2003.
• Smith, LH, Boutaud, O, Breyer, M, Morrow, JD, Oates, JA, Vaughan, DE Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro. Arterioscler Thromb Vasc Biol, 22(6), 983-8, 2002.
• Boutaud, O, Aronoff, DM, Richardson, JH, Marnett, LJ, Oates, JA Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc Natl Acad Sci U S A, 99(10), 7130-5, 2002.
• Davies, SS, Amarnath, V, Montine, KS, Bernoud-Hubac, N, Boutaud, O, Montine, TJ, Roberts, LJ Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. FASEB J, 16(7), 715-7, 2002.
• Cox, B, Murphey, LJ, Zackert, WE, Chinery, R, Graves-Deal, R, Boutaud, O, Oates, JA, Coffey, RJ, Morrow, JD Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione. Biochim Biophys Acta, 1584(1), 37-45, 2002.
• Boutaud, O, Ou, JJ, Chaurand, P, Caprioli, RM, Montine, TJ, Oates, JA Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers. J Neurochem, 82(4), 1003-6, 2002.
• Abraham, BD, Sono, M, Boutaud, O, Shriner, A, Dawson, JH, Brash, AR, Gaffney, BJ Characterization of the coral allene oxide synthase active site with UV-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopy: evidence for tyrosinate ligation to the ferric enzyme heme iron. Biochemistry, 40(7), 2251-9, 2001.
• Boutaud, O, Brame, CJ, Chaurand, P, Li, J, Rowlinson, SW, Crews, BC, Ji, C, Marnett, LJ, Caprioli, RM, Roberts, LJ, Oates, JA Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. Biochemistry, 40(23), 6948-55, 2001.
• Bernoud-Hubac, N, Davies, SS, Boutaud, O, Montine, TJ, Roberts, LJ Formation of highly reactive gamma-ketoaldehydes (neuroketals) as products of the neuroprostane pathway. J Biol Chem, 276(33), 30964-70, 2001.
• Boutaud, O, Li, J, Chaurand, P, Brame, CJ, Marnett, LJ, Roberts, LJ, Oates, JA Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins. Adv Exp Med Biol, 500133-7, 2001.
• Benayoud, F., Abouabdellah, A., Richard, C., Bonnet-Delpon, D., B?gu?, J.-P, Levasseur, D., Boutaud, O. and Schuber, F "Trifluoromethyl ketones derived from squalene: inhibition of the cholesterol biosynthesis in HepG2 cells." Tetrahedron Lett., 416367-6370, 2000.
• Boutaud, O, Brame, CJ, Salomon, RG, Roberts, LJ, Oates, JA Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway. Biochemistry, 38(29), 9389-96, 1999.
• Boutaud, O, Brash, AR Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomalla. J Biol Chem, 274(47), 33764-70, 1999.
• Koljak, R, Boutaud, O, Shieh, BH, Samel, N, Brash, AR Identification of a naturally occurring peroxidase-lipoxygenase fusion protein. Science, 277(5334), 1994-6, 1997.
• Viola, F, Brusa, P, Balliano, G, Ceruti, M, Boutaud, O, Schuber, F, Cattel, L Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives. Biochem Pharmacol, 50(6), 787-96, 1995.
• Boutaud, O, Ceruti, M, Cattel, L, Schuber, F Retention of the label during the conversion of [3-3H] squalene into (3S)-2,3-oxidosqualene catalyzed by mammalian squalene oxidase. Biochem Biophys Res Commun, 208(1), 42-7, 1995.
• Boutaud, O, Dolis, D, Schuber, F Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase. Biochem Biophys Res Commun, 188(2), 898-904, 1992.