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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 
Pampee  Young

Pampee Young, M.D., Ph.D.

Medical Director, Transfusion Medicine
Associate Professor of Pathology and Medicine
Director, Stem Cell Laboratory
Researcher

  • Appointments
    615-936-1098
    Physicians: 1-877-936-8422
  • Clinical Trials Information
  • Other Telephone Numbers
    Monroe Carell Jr. Children's Hospital at Vanderbilt
    615-936-1000

    Vanderbilt University Medical Center
    615-322-5000

    Office
    615-936-1098
  • Faxes
    Office Fax
    615-343-7023
    Clinic Fax
    615-343-7023
  • Addresses
    Clinic
    Vanderbilt University Medical Center
    1161 21st Ave S
    C-3321-A MCN
    Nashville, TN 37232-2561

    Monroe Carell Jr. Children's Hospital at Vanderbilt
    2200 Children's Way
    Nashville, TN 37232
    Website

    Vanderbilt University Medical Center
    1211 Medical Center Drive
    Nashville, TN 37232
    Website

    Office
    Vanderbilt University Medical Center
    1161 21st Ave S
    C-3321-A MCN
    Nashville, TN 37232-2561
Education
 
  • M.D. - University of Texas Southwestern
  • Ph.D. - University of Texas at Dallas
  • Fellowship - University of Washington Medical Center
  • Residency - University of Washington Medical Center
 
Research Specialty

The focus of research is on understanding the biology of adult stem cells within the context of two broad biological processes--malignancy and regeneration.

Research Description

The focus of research is on understanding the biology of adult stem cells within the context of two broad biological processes--malignancy and regeneration. The role of adult stem cells to modulate repair and regeneration is of great interest. Our work focuses on gaining a better understanding of bone marrow derived stem cells using both mouse and human cells. Specifically, we are committed to understanding the characteristics of stem cell progenitors, their differentiation, the mechanism by which stem cells mediate regeneration and also the host/stem cell interactions.

Project 1

Mesenchymal stem cells hold much promise as tools to mediate repair. We have recently identified that Wnt pathway inhibition regulates MSC biology. We use mouse models of myocardial infarction or pressure overload hypertrophy (as a heart failure model) to study the role of wnt modulation in MSC-mediated repair. Our hope is to understand how to modulate endogenous MSCs after injury to control repair and regeneration.

Project 2

Bone marrow derived endothelial progenitor cells (EPCs) are derived from both committed and uncommitted hematopoietic cells. We have characterized myeloid to endothelial plasticity over the last few years and have focused our attention on the mechanism of this plasticity. We have recently identified TNF as a modulator of endothelial differentiation. Moreover, we have also begun to better understand the role of these myelod/endothelial cells in cancer and regeneration.

Project 3

Our vascular system is impacted by both physiologic and pathologic biomechanical stress. We have identified that SPRR3 is a mechanosensitive protein expressed by vascular smooth muscle cells and have begun to study its role in the cardiovascular system using a mouse knockout model.

Clinical Interest

Blood banking, transfusion practices, serology

Clinical Research Description

The Vanderbilt University Blood Bank is undergoing automation as well as a major software installment. We continually strive to implement the best Transfusion Practices.

Publications