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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 
Pampee  Young

Pampee Young, M.D., Ph.D.

Medical Director, Transfusion Medicine
Associate Professor of Pathology and Medicine
Director, Stem Cell Laboratory
Researcher

  • Appointments
    615-936-1098
    Physicians: 1-877-936-8422
  • Clinical Trials Information
  • Other Telephone Numbers
    Monroe Carell Jr. Children's Hospital at Vanderbilt
    615-936-1000

    Vanderbilt University Medical Center
    615-322-5000

    Office
    615-936-1098
  • Faxes
    Office Fax
    615-343-7023
    Clinic Fax
    615-343-7023
  • Addresses
    Clinic
    Vanderbilt University Medical Center
    1161 21st Ave S
    C-3321-A MCN
    Nashville, TN 37232-2561

    Monroe Carell Jr. Children's Hospital at Vanderbilt
    2200 Children's Way
    Nashville, TN 37232
    Website

    Vanderbilt University Medical Center
    1211 Medical Center Drive
    Nashville, TN 37232
    Website

    Office
    Vanderbilt University Medical Center
    1161 21st Ave S
    C-3321-A MCN
    Nashville, TN 37232-2561
Education
 
  • M.D. - University of Texas Southwestern
  • Ph.D. - University of Texas at Dallas
  • Fellowship - University of Washington Medical Center
  • Residency - University of Washington Medical Center
 
Research Specialty

We are interested in studying tissue repair and regeneration with a particular focus on stem cells and the cardiovascular system

Research Description

My laboratory studies the cellular drivers and signaling mechanisms that regulate tissue repair and regeneration. We use mouse models of myocardial and complex cutaneous tissue injuries to study endogenous regulators of repair as well as exogenous factors, including the role of stem cell-mediated cellular therapies, that regulate repair. My research interests dovetails well with my clinical role as Medical Director of Transfusion Medicine and of the Stem Cell Laboratory. In addition, I am dedicated to training future biomedical scientists and medical residents. Our long term goal is to identify signaling pathways which can be targeted to improve tissue repair.

Project 1

Role of Wnt signaling in repair vs. regeneration. Using both genetic models and novel small molecule Wnt pathway modulators, we have identified a pro-regenerative role in both cardiac and complex cutaneous wounds for the canonical Wnt pathway. Our current efforts are to dissect the cellular drivers of regeneration and to identify Wnt targets which mediate the pro-reparative phenotype.

Project 2

How do stem cells mediate repair and can we develop new bioengineered platforms to improve stem cell-based therapeutics? We have partnered with Vanderbilt Bioengeers to develop stem cell-based treatments for ischemic vascular diseases which seek to understand and optimize both stem cell and scaffold properties which result in improved blood flow restoration.

Project 3

We have developed a mouse model which demonstrates that deletion of a vascular smooth muscle cell protein, SPRR3, results in progression of atherosclerosis and ultimately to its most serious consequence, plaque rupture. Current projects are focused on identifying the molecular partners of SPRR3 and testing it as a novel therapeutic using a novel transgenic mouse as well as state-of-art peptide replacement approaches.

Project 4

As a Transfusion Medicine physician, I am involved in multiple clinical/translational projects involving blood and blood products in clinical medicine.

Clinical Interest

Blood banking, transfusion practices, serology

Clinical Research Description

The Vanderbilt University Blood Bank is undergoing automation as well as a major software installment. We continually strive to implement the best Transfusion Practices.

Publications