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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

Peter E. Clark, M.D.

Professor of Urologic Surgery
Program Director, Department of Urologic Surgery
Urologic Oncologist

  • Appointments
    615-322-2880
    Physicians: 1-877-936-8422
  • Clinical Trials Information
  • Other Telephone Numbers
    Nashville Veterans Affairs Medical Center
    (615) 327-4751 or (800) 228-4973

    Office
    615-322-2101
  • Faxes
    Nashville Veterans Affairs Medical Center Fax
    (615) 873-7901
    Office Fax
    615-322-8990
    Clinic Fax
    615-343-9815
  • Addresses
    Clinic
    Vanderbilt University Medical Center
    Urologic Surgery<br />3823 The Vanderbilt Clinic
    Nashville, TN 37232-5770

    Nashville Veterans Affairs Medical Center
    1310 24th Ave. South
    Nashville , TN 37212-2637
    Website

    Office
    Vanderbilt University Medical Center, Department of Urologic Surgery
    A-1302 Medical Center North
    Nashville, TN 37232-2765
Profile

My primary clinical interest is the surgical managementof genitourinary malignancies including cancer of kidney,bladder, prostate, testicle, and penis. My research interests arein the mechanisms of apoptosis in cancers of genitourinary tractand in particular the kidney and bladder.

Education
  • B.A. Cornell University, Ithaca NY, 1989
  • M.D. Harvard Medical School, Boston MA, 1994
  • Urologic Residency: The Cleveland Clinic Foundation, Cleveland OH, 2000
  • Urologic Oncology Fellowship: The University of Southern California, Los Angeles CA, 2002
Publications
  • Borden LS, Clark PE, Lovato J, Hall MC, Stindt D, Harmon M, M Mohler R, Torti FM. Vinorelbine, doxorubicin, and prednisone in androgen-independent prostate cancer. Cancer. 2006 Sep 9/1/2006; 107(5): 1093-100. PMID: 16888761, DOI: 10.1002/cncr.22078, ISSN: 0008-543X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16888761.
  • Clark PE, Hall MC, Borden LS, Miller AA, Hu JJ, Lee WR, Stindt D, D'Agostino R, Lovato J, Harmon M, Torti FM. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy. Urology. 2006 Jun; 67(6): 1257-61. PMID: 16765186, PII: S0090-4295(05)01789-9, DOI: 10.1016/j.urology.2005.12.035, ISSN: 1527-9995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16765186.
  • Lockett KL, Hall MC, Clark PE, Chuang SC, Robinson B, Lin HY, Su LJ, Hu JJ. DNA damage levels in prostate cancer cases and controls. Carcinogenesis [print-electronic]. 2006 Jun; 27(6): 1187-93. PMID: 16364923, PII: bgi288, DOI: 10.1093/carcin/bgi288, ISSN: 0143-3334.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16364923.
  • Gwynn ES, Clark PE. Bladder cancer. Curr Opin Oncol. 2006 May; 18(3): 277-83. PMID: 16552241, PII: 00001622-200605000-00011, DOI: 10.1097/01.cco.0000219258.75961.1a, ISSN: 1531-703X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16552241.
  • Rackley JD, Clark PE, Hall MC. Complementary and alternative medicine for advanced prostate cancer. Urol. Clin. North Am. 2006 May; 33(2): 237-46, viii. PMID: 16631462, PII: S0094-0143(05)00125-4, DOI: 10.1016/j.ucl.2005.12.007, ISSN: 0094-0143.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16631462.
  • Rossi PJ, Clark PE, Papagikos MA, McCullough DL, Lee WR. Percentage of positive biopsies associated with freedom from biochemical recurrence after low-dose-rate prostate brachytherapy alone for clinically localized prostate cancer. Urology. 2006 Feb; 67(2): 349-53. PMID: 16461084, PII: S0090-4295(05)01206-9, DOI: 10.1016/j.urology.2005.08.047, ISSN: 1527-9995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16461084.
  • Gwynn ES, Clark PE, Hall MC. Recent advances in the treatment of bladder cancer. Expert Rev Anticancer Ther. 2005 Dec; 5(6): 1023-30. PMID: 16336093, DOI: 10.1586/14737140.5.6.1023, ISSN: 1744-8328.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16336093.
  • Gwynn ES, Clark PE. Inflammatory myofibroblastic tumor associated with renal cell carcinoma. Urology. 2005 Oct; 66(4): 880. PMID: 16230166, PII: S0090-4295(05)00413-9, DOI: 10.1016/j.urology.2005.03.065, ISSN: 1527-9995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16230166.
  • Clark PE, Veys JA, Eskridge MR, Woodruff RD, Hall MC. Prognostic significance of clinicopathologic and deoxyribonucleic acid flow cytometric variables in non-metastatic renal cell carcinoma in the modern era. Urol. Oncol. 2005 Sep; 23(5): 328-32. PMID: 16144666, PII: S1078-1439(05)00019-0, DOI: 10.1016/j.urolonc.2005.01.017, ISSN: 1078-1439.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16144666.
  • Clark PE, Stein JP, Groshen SG, Cai J, Miranda G, Lieskovsky G, Skinner DG. Radical cystectomy in the elderly: comparison of clincal outcomes between younger and older patients. Cancer. 2005 Jul 7/1/2005; 104(1): 36-43. PMID: 15912515, DOI: 10.1002/cncr.21126, ISSN: 0008-543X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15912515.
  • Borden LS, Clark PE, Hall MC. Bladder cancer. Curr Opin Oncol. 2005 May; 17(3): 275-80. PMID: 15818174, PII: 00001622-200505000-00014, ISSN: 1040-8746.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15818174.
  • Clark PE, Hall MC. Contemporary management of the urethra in patients after radical cystectomy for bladder cancer. Urol. Clin. North Am. 2005 May; 32(2): 199-206. PMID: 15862617, PII: S0094-0143(05)00023-6, DOI: 10.1016/j.ucl.2005.01.004, ISSN: 0094-0143.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15862617.
  • Clark PE, Stein JP, Groshen SG, Cai J, Miranda G, Lieskovsky G, Skinner DG. Radical cystectomy in the elderly: Comparison of survival between younger and older patients. Cancer. 2005 Feb 2/1/2005; 103(3): 546-52. PMID: 15630702, DOI: 10.1002/cncr.20805, ISSN: 0008-543X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15630702.
  • Clark PE, Farver CF, Ulchaker JC, Angermeier K. A rare case of an extra-adrenal myelolipoma arising in the renal sinus: a case report and review of the literature. ScientificWorldJournal. 2005 Jan 1/28/2005; 5: 109-17. PMID: 15702223, PII: 10.1100/tsw.2005.18, DOI: 10.1100/tsw.2005.18, ISSN: 1537-744X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15702223.
  • Papagikos MA, Deguzman AF, Rossi PJ, McCullough DL, Clark PE, Lee WR. Dosimetric quantifiers for low-dose-rate prostate brachytherapy: is V(100) superior to D(90)?. Brachytherapy. 2005; 4(4): 252-8. PMID: 16344254, PII: S1538-4721(05)00150-9, DOI: 10.1016/j.brachy.2005.09.001, ISSN: 1538-4721.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16344254.
  • Clark PE, Stein JP, Groshen SG, Miranda G, Cai J, Lieskovsky G, Skinner DG. The management of urethral transitional cell carcinoma after radical cystectomy for invasive bladder cancer. J. Urol. 2004 Oct; 172(4 Pt 1): 1342-7. PMID: 15371837, PII: 00005392-200410000-00028, ISSN: 0022-5347.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15371837.
  • Lockett KL, Hall MC, Xu J, Zheng SL, Berwick M, Chuang SC, Clark PE, Cramer SD, Lohman K, Hu JJ. The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function. Cancer Res. 2004 Sep 9/1/2004; 64(17): 6344-8. PMID: 15342424, PII: 64/17/6344, DOI: 10.1158/0008-5472.CAN-04-0338, ISSN: 0008-5472.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15342424.
  • Kubinski DJ, Clark PE, Assimos DG, Hall MC. Utility of frozen section analysis of resection margins during partial nephrectomy. Urology. 2004 Jul; 64(1): 31-4. PMID: 15245928, PII: S0090429504003280, DOI: 10.1016/j.urology.2004.03.011, ISSN: 1527-9995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15245928.
  • Zagoria RJ, Hawkins AD, Clark PE, Hall MC, Matlaga BR, Dyer RB, Chen MY. Percutaneous CT-guided radiofrequency ablation of renal neoplasms: factors influencing success. AJR Am J Roentgenol. 2004 Jul; 183(1): 201-7. PMID: 15208139, DOI: 10.2214/ajr.183.1.1830201, ISSN: 0361-803X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15208139.
  • Clark PE, Streem SB. Endourologic management of upper tract transitional cell carcinoma. ScientificWorldJournal. 2004 Jun 6/7/2004; 4 Suppl 1: 62-75. PMID: 15349530, DOI: 10.1100/tsw.2004.49, ISSN: 1537-744X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15349530.
  • Clark PE, Hall MC, Miller A, Ridenhour KP, Stindt D, Lovato JF, Patton SE, Brinkley W, Das S, Torti FM. Phase II trial of combination interferon-alpha and thalidomide as first-line therapy in metastatic renal cell carcinoma. Urology. 2004 Jun; 63(6): 1061-5. PMID: 15183950, PII: S009042950400144X, DOI: 10.1016/j.urology.2004.01.035, ISSN: 1527-9995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15183950.
  • Borden LS, Clark PE, Hall MC. Bladder cancer. Curr Opin Oncol. 2004 May; 16(3): 257-62. PMID: 15069323, PII: 00001622-200405000-00012, ISSN: 1040-8746.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15069323.
  • Matlaga BR, Zagoria RJ, Clark PE, Hall MC. Radiofrequency ablation of renal tumors. Curr Urol Rep. 2004 Feb; 5(1): 39-44. PMID: 14733836, ISSN: 1527-2737.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14733836.
  • Quek ML, Stein JP, Clark PE, Daneshmand S, Miranda G, Cai J, Groshen S, Cote RJ, Lieskovsky G, Quinn DI, Skinner DG. Microscopic and gross extravesical extension in pathological staging of bladder cancer. J. Urol. 2004 Feb; 171(2 Pt 1): 640-5. PMID: 14713777, DOI: 10.1097/01.ju.0000108664.39035.51, ISSN: 0022-5347.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14713777.
  • Clark PE, Torti FM. Prostate cancer and bone metastases: medical treatment. Clin. Orthop. Relat. Res. 2003 Oct; (415 Suppl): S148-57. PMID: 14600605, DOI: 10.1097/01.blo.0000093840.72468.e1, ISSN: 0009-921X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14600605.
  • Quek ML, Stein JP, Clark PE, Daneshmand S, Miranda G, Cai J, Groshen S, Lieskovsky G, Quinn DI, Raghavan D, Skinner DG. Natural history of surgically treated bladder carcinoma with extravesical tumor extension. Cancer. 2003 Sep 9/1/2003; 98(5): 955-61. PMID: 12942562, DOI: 10.1002/cncr.11569, ISSN: 0008-543X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12942562.
  • Borden LS, Clark PE, Hall MC. Bladder cancer. Curr Opin Oncol. 2003 May; 15(3): 227-33. PMID: 12778017, ISSN: 1040-8746.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12778017.
  • Jia L, Kim J, Shen H, Clark PE, Tilley WD, Coetzee GA. Androgen receptor activity at the prostate specific antigen locus: steroidal and non-steroidal mechanisms. Mol. Cancer Res. 2003 Mar; 1(5): 385-92. PMID: 12651911, ISSN: 1541-7786.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12651911.
  • Clark PE, Irvine RA, Coetzee GA. The androgen receptor CAG repeat and prostate cancer risk. Methods Mol. Med. 2003; 81: 255-66. PMID: 12725125, DOI: 10.1385/1-59259-372-0:255, ISSN: 1543-1894.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12725125.
  • Clark PE. Urinary diversion after radical cystectomy. Curr Treat Options Oncol. 2002 Oct; 3(5): 389-402. PMID: 12194804, ISSN: 1527-2729.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12194804.
  • Wilson SS, Clark PE, Stein JP. Angiomyolipoma with vena caval extension. Urology. 2002 Oct; 60(4): 695-6. PMID: 12385937, PII: S0090429502018976, ISSN: 1527-9995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12385937.
  • Clark PE, Novick AC. Exophytic noninvasive growth pattern of renal angiomyolipomas: implications for nephron sparing surgery. J. Urol. 2001 Feb; 165(2): 513-4. PMID: 11176411, PII: S0022-5347(05)66737-7, DOI: 10.1097/00005392-200102000-00040, ISSN: 0022-5347.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11176411.
  • Clark PE, Peereboom DM, Dreicer R, Levin HS, Clark SB, Klein EA. Phase II trial of neoadjuvant estramustine and etoposide plus radical prostatectomy for locally advanced prostate cancer. Urology. 2001 Feb; 57(2): 281-5. PMID: 11182337, PII: S0090-4295(00)00914-6, ISSN: 1527-9995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11182337.
  • Clark PE, Schover LR, Uzzo RG, Hafez KS, Rybicki LA, Novick AC. Quality of life and psychological adaptation after surgical treatment for localized renal cell carcinoma: impact of the amount of remaining renal tissue. Urology. 2001 Feb; 57(2): 252-6. PMID: 11182331, PII: S0090-4295(00)00927-4, ISSN: 1527-9995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11182331.
  • Clark PE, Klein EA. Surgery for invasive bladder tumors: technique and outcome. Curr Opin Urol. 1999 Sep; 9(5): 413-8. PMID: 10579079, ISSN: 0963-0643.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10579079.
  • Uzzo RG, Rayman P, Kolenko V, Clark PE, Cathcart MK, Bloom T, Novick AC, Bukowski RM, Hamilton T, Finke JH. Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells. J. Clin. Invest. 1999 Sep; 104(6): 769-76. PMID: 10491412, PMCID: PMC408430, DOI: 10.1172/JCI6775, ISSN: 0021-9738.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10491412.
  • Uzzo RG, Rayman P, Kolenko V, Clark PE, Bloom T, Ward AM, Molto L, Tannenbaum C, Worford LJ, Bukowski R, Tubbs R, Hsi ED, Bander NH, Novick AC, Finke JH. Mechanisms of apoptosis in T cells from patients with renal cell carcinoma. Clin. Cancer Res. 1999 May; 5(5): 1219-29. PMID: 10353760, ISSN: 1078-0432.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10353760.
  • Uzzo RG, Clark PE, Rayman P, Bloom T, Rybicki L, Novick AC, Bukowski RM, Finke JH. Alterations in NFkappaB activation in T lymphocytes of patients with renal cell carcinoma. J. Natl. Cancer Inst. 1999 Apr 4/21/1999; 91(8): 718-21. PMID: 10218511, ISSN: 0027-8874.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10218511.
  • Clark PE, Streem SB, Geisinger MA. 13-year experience with percutaneous management of upper tract transitional cell carcinoma. J. Urol. 1999 Mar; 161(3): 772-5; discussion 775. PMID: 10022682, PII: S0022-5347(01)61765-8, ISSN: 0022-5347.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10022682.
  • Capelouto CC, Clark PE, Ransil BJ, Loughlin KR. A review of scrotal violation in testicular cancer: is adjuvant local therapy necessary?. J. Urol. 1995 Mar; 153(3 Pt 2): 981-5. PMID: 7853587, ISSN: 0022-5347.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7853587.