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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

Qi  Dai

Qi Dai, M.D., Ph.D.

Professor of Medicine
Cancer Epidemiologist

Contact Information:

Vanderbilt University Medical Center
2525 West End Ave, 8th floor
Nashville, TN 37203-1738

Research Specialty

1) Personalized prevention of cancer and other chronic diseases 2) Molecular epidemiologic studies of nutritional factors and other biomarkers, such as magnesium, calcium, polyphenols (e.g. tea polyphenols, isoflavones, lignans) and oxidative stress in the etiology or pathogenesis of chronic diseases, particularly cancer and dementia.

Research Description

Dr. Qi Dai has over 20 years of experience in etiologic research of cancer and other chronic diseases, including dementia. Dr. Dai’s research programs focuses on evaluating gene-environment interactions in the etiology of chronic diseases and develop strategies for the personalized prevention of these diseases. Dr. Dai obtained his first R01 grant as PI in 2004 to investigate the effect of oxidative stress, antioxidants, polymorphisms of genes in detoxifying reactive oxygen species, and their interactions in the development of breast cancer. Over the years, Dr. Dai has expanded the research theme into the research area of Alzheimer’s disease.

Over the past four years Dr. Dai has been investigating a novel hypothesis regarding the interaction of magnesium and calcium and polymorphisms in magnesium and calcium re(absorption) genes in the risk of colorectal adenomas and other chronic diseases. Based on the promising finding, Dr. Dai and his team are working on three two R01 grants, a grant from the American Institute for Cancer Research (AICR), and two CTSA grants to further investigate the effect of magnesium and calcium in relation to colorectal adenoma and prostate cancer over the past two years.

The following are the ongoing research projects and those completed over the past three years.

Research Support Ongoing

1) R01 CA149633-01 (PI, Qi Dai, Chang Yu) 04/01/10 - 03/31/15

NIH/NCI: Personalized Prevention of Colorectal Cancer

Role: PI

2) R01 AT004660-02 (PI, Qi Dai) 06/01/08 - 05/31/12

NIH : Dietary Calcium and Magnesium, Genetics, and Colorectal Adenoma

Role: PI

3) AICR #08A074-REV 01/01/09 - 12/31/10

Research project: Magnesium, Calcium and Colorectal Adenoma Risk

Role: PI

4) Project supported by UL1 RR024975 (NCRR/NIH) 7/1/10 - 06/30/15

NIH (The Vanderbilt CTSA grant): Personalized Prevention of Colorectal Cancer Trial

The major goal of this project is to provide supports of clinical space and nurses for the ongoing R01 project (CA149633-01).

Role: Project Leader

5) Project supported by UL1 RR024975 (NCRR/NIH) 09/01/10 - 08/31/11

NIH (The Vanderbilt CTSA grant): Oxidative stress, Inflammation and Pathogenesis of Alzheimer's disease

Role: Project Leader

6) Project supported by UL1 RR024975 (NCRR/NIH) 07/17/08 - 07/17/11

NIH (The Vanderbilt CTSA grant): Magnesium, calcium and risk of PIN and prostate cancer

Role: Project Leader

7) R01 CA082729-07A1 (PI, Xiao-Ou Shu) 09/28/07 - 05/31/12

NCI: Cohort Study of Cancer-Inhibitory Dietary Factors in Men

The objectives of this study are to study the dietary cancer-inhibitory factors in a cohort of 67,500 men and to establish biospecimen repository for future genetic and molecular epidemiological study of cancers

Role: Co-I

8) R01 CA141307 (PI, Hua Xu) 09/03/09 - 07/31/13

NCI: An In-Silico Method for Epidemiological Studies Using Electronic Medical Records

Role: Co-I

Completed Research Projects for the Past Three Years

1) R01 CA106591-01 (PI, Qi Dai) 04/01/04 - 03/31/10

NIH: Oxidative Stress, Antioxidants, and Breast Cancer Risk

Role: PI

2) R21AG028182-01 (PI, Amy R Borenstein) 05/15/07- 02/28/10

NIA: Risk factors for brain atrophy, mild cognitive impairment and dementia in Shanghai

Role: PI of the subcontract

3) R01 CA70867 (PI, Wei Zheng) 07/16/09 - 03/31/10

NCI: Cancer Risk Reduction and Diet: A Cohort Study of Women

The major goal of this population-based prospective cohort study is to identify protective dietary factors for cancer and other chronic diseases in a cohort of 75,000 adult women.

Role: Co-I

4) R01 CA 92585 (PI, Xiao-Ou Shu) 09/1/01 - 8/31/07

NIH: Soyfood, gene polymorphisms and risk of endometrial cancer

Role: Co-I