The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
Robbert Slebos, Ph.D., M.H.S.
See also:
Research Assistant Professor of Cancer Biology and Otolaryngology
VICC Member
Researcher
Contact Information:
Vanderbilt University Medical Center
654 Preston Research Building, 2220 Pierce Avenue
Nashville , TN 37232-6838
615-936-2806
Fax: 615-936-2805
Education
- Ph.D. in Molecular Biology, University of Amsterdam, Netherlands, 1991
- M.H.S. in Clinical Research, Duke University, Durham NC, 2003
Research Specialty
Translational research using shotgun proteomics for the detection of biomarkers of early detection, response prediction and prognosis of colorectal cancer and head and neck cancer.
Publications
- Li, M, Gray, W, Zhang, H, Chung, CH, Billheimer, D, Yarbrough, WG, Liebler, DC, Shyr, Y, Slebos, RJ Comparative shotgun proteomics using spectral count data and quasi-likelihood modeling. J Proteome Res, 9(8), 4295-305, 2010.
- Lin, D, Li, J, Slebos, RJ, Liebler, DC Cysteinyl peptide capture for shotgun proteomics: global assessment of chemoselective fractionation. J Proteome Res, 9(10), 5461-72, 2010.
- Tu, C, Rudnick, PA, Martinez, MY, Cheek, KL, Stein, SE, Slebos, RJ, Liebler, DC Depletion of abundant plasma proteins and limitations of plasma proteomics. J Proteome Res, 9(10), 4982-91, 2010.
- Chung, CH, Aulino, J, Muldowney, NJ, Hatakeyama, H, Baumann, J, Burkey, B, Netterville, J, Sinard, R, Yarbrough, WG, Cmelak, AJ, Slebos, RJ, Shyr, Y, Parker, J, Gilbert, J, Murphy, BA Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol, 21(4), 864-70, 2010.
- Hatakeyama, H, Cheng, H, Wirth, P, Counsell, A, Marcrom, SR, Wood, CB, Pohlmann, PR, Gilbert, J, Murphy, B, Yarbrough, WG, Wheeler, DL, Harari, PM, Guo, Y, Shyr, Y, Slebos, RJ, Chung, CH Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. PLoS One, 5(9), e12702, 2010.
- Dasari, S, Chambers, MC, Slebos, RJ, Zimmerman, LJ, Ham, AJ, Tabb, DL TagRecon: high-throughput mutation identification through sequence tagging. J Proteome Res, 9(4), 1716-26, 2010.
- Fiske, WH, Tanksley, J, Nam, KT, Goldenring, JR, Slebos, RJ, Liebler, DC, Abtahi, AM, La Fleur, B, Ayers, GD, Lind, CD, Washington, MK, Coffey, RJ Efficacy of cetuximab in the treatment of Menetrier''s disease. Sci Transl Med, 1(8), 8ra18, 2009.
- Sprung, RW, Brock, JW, Tanksley, JP, Li, M, Washington, MK, Slebos, RJ, Liebler, DC Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis. Mol Cell Proteomics, 8(8), 1988-98, 2009.
- Baumann, JL, Cohen, S, Evjen, AN, Law, JH, Vadivelu, S, Attia, A, Schindler, JS, Chung, CH, Wirth, PS, Meijer, CJ, Snijders, PJ, Yarbrough, WG, Slebos, RJ Human papillomavirus in early laryngeal carcinoma. Laryngoscope, 119(8), 1531-7, 2009.
- Chung, CH, Mirakhur, B, Chan, E, Le, QT, Berlin, J, Morse, M, Murphy, BA, Satinover, SM, Hosen, J, Mauro, D, Slebos, RJ, Zhou, Q, Gold, D, Hatley, T, Hicklin, DJ, Platts-Mills, TA Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. N Engl J Med, 358(11), 1109-17, 2008.
- Slebos, RJ, Brock, JW, Winters, NF, Stuart, SR, Martinez, MA, Li, M, Chambers, MC, Zimmerman, LJ, Ham, AJ, Tabb, DL, Liebler, DC Evaluation of strong cation exchange versus isoelectric focusing of peptides for multidimensional liquid chromatography-tandem mass spectrometry. J Proteome Res, 7(12), 5286-94, 2008.
- Luo, W, Slebos, RJ, Hill, S, Li, M, Brábek, J, Amanchy, R, Chaerkady, R, Pandey, A, Ham, AJ, Hanks, SK Global impact of oncogenic Src on a phosphotyrosine proteome. J Proteome Res, 7(8), 3447-60, 2008.
- Slebos, RJ, Li, M, Vadivelu, S, Burkey, BB, Netterville, JL, Sinard, R, Gilbert, J, Murphy, B, Chung, CH, Shyr, Y, Yarbrough, WG Microsatellite mutations in buccal cells are associated with aging and head and neck carcinoma. Br J Cancer, 98(3), 619-26, 2008.
- Palka, KT, Slebos, RJ, Chung, CH Update on molecular diagnostic tests in head and neck cancer. Semin Oncol, 35(3), 198-210, 2008.
- Flake, GP, Rivera, MP, Funkhouser, WK, Maygarden, SJ, Meadows, KL, Long, EH, Stockton, PS, Jones, TC, Yim, HW, Slebos, RJ, Taylor, JA Detection of Pre-Invasive Lung Cancer: Technical Aspects of the LIFE Project. Toxicol Pathol, 35(1), 65-74, 2007.
- Yarbrough, WG, Whigham, A, Brown, B, Roach, M, Slebos, R Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys, 69(2 Suppl), S98-101, 2007.
- Yim, HW, Slebos, RJ, Randell, SH, Umbach, DM, Parsons, AM, Rivera, MP, Detterbeck, FC, Taylor, JA Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells. Cancer Lett, 246(1-2), 24-33, 2007.
- Chung, CH, Parker, JS, Ely, K, Carter, J, Yi, Y, Murphy, BA, Ang, KK, El-Naggar, AK, Zanation, AM, Cmelak, AJ, Levy, S, Slebos, RJ, Yarbrough, WG Gene Expression Profiles Identify Epithelial-to-Mesenchymal Transition and Activation of Nuclear Factor-{kappa}B Signaling as Characteristics of a High-risk Head and Neck Squamous Cell Carcinoma. Cancer Res, 66(16), 8210-8218, 2006.
- Slebos, RJ, Yi, Y, Ely, K, Carter, J, Evjen, A, Zhang, X, Shyr, Y, Murphy, BM, Cmelak, AJ, Burkey, BB, Netterville, JL, Levy, S, Yarbrough, WG, Chung, CH Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma. Clin Cancer Res, 12(3 Pt 1), 701-9, 2006.
- Chung, CH, Ely, K, McGavran, L, Varella-Garcia, M, Parker, J, Parker, N, Jarrett, C, Carter, J, Murphy, BA, Netterville, J, Burkey, BB, Sinard, R, Cmelak, A, Levy, S, Yarbrough, WG, Slebos, RJ, Hirsch, FR Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol, 24(25), 4170-6, 2006.
- Slebos, RJ, Li, M, Evjen, AN, Coffa, J, Shyr, Y, Yarbrough, WG Mutagenic effect of cadmium on tetranucleotide repeats in human cells. Mutat Res, 602(1-2), 92-9, 2006.
- Yarbrough, WG, Slebos, RJ, Liebler, D Proteomics: clinical applications for head and neck squamous cell carcinoma. Head Neck, 28(6), 549-58, 2006.
- Slebos, RJ, Livanos, E, Yim, HW, Randell, SH, Parsons, AM, Detterbeck, FC, Rivera, MP, Taylor, JA Chromosomal abnormalities in bronchial epithelium from smokers, nonsmokers, and lung cancer patients. Cancer Genet Cytogenet, 159(2), 137-42, 2005.
- Slebos, Robbert J C, Umbach, David M, Sommer, Courtney A, Horner, Geoffrey A, Choi, Jane Y, Taylor, Jack A Analytical and statistical methods to evaluate microsatellite allelic imbalance in small amounts of DNA. Lab Invest, 2004.
- Slebos, RJ, Little, RE, Umbach, DM, Antipkin, Y, Zadaorozhnaja, TD, Mendel, NA, Sommer, CA, Conway, K, Parrish, E, Gulino, S, Taylor, JA Mini-and microsatellite mutations in children from Chernobyl accident cleanup workers. Mutat Res, 559(1-2), 143-51, 2004.
- Jin, Yong Hwan, Clark, Alan B, Slebos, Robbert J C, Al-Refai, Hanan, Taylor, Jack A, Kunkel, Thomas A, Resnick, Michael A, Gordenin, Dmitry A, Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat Genet, 34326-9, 2003.
- Slebos, Robbert J C, Oh, Daniel S, Umbach, David M, Taylor, Jack A, Mutations in tetranucleotide repeats following DNA damage depend on repeat sequence and carcinogenic agent. Cancer Res, 626052-60, 2002.
- Slebos, R J, Taylor, J A, A novel host cell reactivation assay to assess homologous recombination capacity in human cancer cell lines. Biochem Biophys Res Commun, 281212-9, 2001.
- Slebos, R J, Hoppin, J A, Tolbert, P E, Holly, E A, Brock, J W, Zhang, R H, Bracci, P M, Foley, J, Stockton, P, McGregor, L M, Flake, G P, Taylor, J A, K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study. Cancer Epidemiol Biomarkers Prev, 91223-32, 2000.
- Lax, S F, Kendall, B, Tashiro, H, Slebos, R J, Hedrick, L The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways.. Cancer, 88(4), 814-24, 2000.
- Slebos, R J, Resnick, M A, Taylor, J A Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement.. Cancer Res, 58(23), 5333-6, 1998.
- Wilentz, R E, Chung, C H, Sturm, P D, Musler, A, Sohn, T A, Offerhaus, G J, Yeo, C J, Hruban, R H, Slebos, R J K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma.. Cancer, 82(1), 96-103, 1998.
- Ceha, H M, Clement, M J, Polak, M M, Offerhaus, G J, Slebos, R J Mutational analysis of the P16-binding domain of cyclin-dependent kinase 4 in tumors in the head region of the pancreas.. Pancreas, 17(1), 85-8, 1998.
- Ceha, H M, Nasser, I, Medema, R H, Slebos, R J Several noncontiguous domains of CDK4 are involved in binding to the P16 tumor suppressor protein.. Biochem Biophys Res Commun, 249(2), 550-5, 1998.
- Slebos, R J, Baas, I O, Clement, M J, Offerhaus, G J, Askin, F B, Hruban, R H, Westra, W H p53 alterations in atypical alveolar hyperplasia of the human lung.. Hum Pathol, 29(8), 801-8, 1998.
- Hruban, R H, Sturm, P D, Slebos, R J, Wilentz, R E, Musler, A R, Yeo, C J, Sohn, T A, van Velthuysen, M L, Offerhaus, G J Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients.. Am J Pathol, 151(4), 943-9, 1997.
- Dijkhuizen, S M, Entius, M M, Clement, M J, Polak, M M, Van den Berg, F M, Craanen, M E, Slebos, R J, Offerhaus, G J Multiple hyperplastic polyps in the stomach: evidence for clonality and neoplastic potential.. Gastroenterology, 112(2), 561-6, 1997.
- Rodenhuis, S, Boerrigter, L, Top, B, Slebos, R J, Mooi, W J, van't Veer, L, van Zandwijk, N Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study.. J Clin Oncol, 15(1), 285-91, 1997.
- Entius, M M, Westerman, A M, Giardiello, F M, van Velthuysen, M L, Polak, M M, Slebos, R J, Wilson, J H, Hamilton, S R, Offerhaus, G J Peutz-Jeghers polyps, dysplasia, and K-ras codon 12 mutations.. Gut, 41(3), 320-2, 1997.
- Slebos, R J, Baas, I O, Clement, M, Polak, M, Mulder, J W, van den Berg, F M, Hamilton, S R, Offerhaus, G J Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma.. Br J Cancer, 74(2), 165-71, 1996.
- Chung, C H, Wilentz, R E, Polak, M M, Ramsoekh, T B, Noorduyn, L A, Gouma, D J, Huibregtse, K, Offerhaus, G J, Slebos, R J Clinical significance of K-ras oncogene activation in ampullary neoplasms.. J Clin Pathol, 49(6), 460-4, 1996.
- Westra, W H, Baas, I O, Hruban, R H, Askin, F B, Wilson, K, Offerhaus, G J, Slebos, R J K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.. Cancer Res, 56(9), 2224-8, 1996.
- Baas, I O, van den Berg, F M, Mulder, J W, Clement, M J, Slebos, R J, Hamilton, S R, Offerhaus, G J Potential false-positive results with antigen enhancement for immunohistochemistry of the p53 gene product in colorectal neoplasms.. J Pathol, 178(3), 264-7, 1996.
- Slebos, R J, Kessis, T D, Chen, A W, Han, S M, Hedrick, L, Cho, K R, Functional consequences of directed mutations in human papillomavirus E6 proteins: abrogation of p53-mediated cell cycle arrest correlates with p53 binding and degradation in vitro. Virology, 208111-20, 1995.
- Offerhaus, G J, Slebos, R J [Molecular-genetic detection of colorectal carcinoma in the feces]. Ned Tijdschr Geneeskd, 139(52), 2714-5, 1995.
- Kern, J A, Slebos, R J, Top, B, Rodenhuis, S, Lager, D, Robinson, R A, Weiner, D, Schwartz, D A C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.. J Clin Invest, 93(2), 516-20, 1994.
- Slebos, R J, Lee, M H, Plunkett, B S, Kessis, T D, Williams, B O, Jacks, T, Hedrick, L, Kastan, M B, Cho, K R p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.. Proc Natl Acad Sci U S A, 91(12), 5320-4, 1994.
- Kessis, T D, Slebos, R J, Nelson, W G, Kastan, M B, Plunkett, B S, Han, S M, Lorincz, A T, Hedrick, L, Cho, K R Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.. Proc Natl Acad Sci U S A, 90(9), 3988-92, 1993.
- Westra, W H, Slebos, R J, Offerhaus, G J, Goodman, S N, Evers, S G, Kensler, T W, Askin, F B, Rodenhuis, S, Hruban, R H K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung.. Cancer, 72(2), 432-8, 1993.
- Slichenmyer, W J, Nelson, W G, Slebos, R J, Kastan, M B Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.. Cancer Res, 53(18), 4164-8, 1993.
- Westra, W H, Offerhaus, G J, Goodman, S N, Slebos, R J, Polak, M, Baas, I O, Rodenhuis, S, Hruban, R H Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking.. Am J Surg Pathol, 17(3), 213-20, 1993.
- Kessis, T D, Slebos, R J, Han, S M, Shah, K, Bosch, X F, Muñoz, N, Hedrick, L, Cho, K R p53 gene mutations and MDM2 amplification are uncommon in primary carcinomas of the uterine cervix.. Am J Pathol, 143(5), 1398-405, 1993.
- Slebos, R J, Boerrigter, L, Evers, S G, Wisman, P, Mooi, W J, Rodenhuis, S A rapid and simple procedure for the routine detection of ras point mutations in formalin-fixed, paraffin-embedded tissues.. Diagn Mol Pathol, 1(2), 136-41, 1992.
- Rodenhuis, S, Slebos, R J Clinical significance of ras oncogene activation in human lung cancer.. Cancer Res, 52(9 Suppl), 2665s-2669s, 1992.
- Slebos, R J, Rodenhuis, S The ras gene family in human non-small-cell lung cancer.. J Natl Cancer Inst Monogr, (13), 23-9, 1992.
- Slebos, R J, Habets, G G, Evers, S G, Mooi, W J, Rodenhuis, S Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.. Int J Cancer, 48(1), 51-6, 1991.
- Breuer, M, Wientjens, E, Verbeek, S, Slebos, R, Berns, A Carcinogen-induced lymphomagenesis in pim-1 transgenic mice: dose dependence and involvement of myc and ras. Cancer Res, 51(3), 958-63, 1991.
- Oudejans, J J, Slebos, R J, Zoetmulder, F A, Mooi, W J, Rodenhuis, S Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver.. Int J Cancer, 49(6), 875-9, 1991.
- Rygaard, K, Slebos, R J, Spang-Thomsen, M Radiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-myc, L-myc, c-raf-1 and K-ras proto-oncogenes.. Int J Cancer, 49(2), 279-84, 1991.
- Slebos, R J, Hruban, R H, Dalesio, O, Mooi, W J, Offerhaus, G J, Rodenhuis, S Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung.. J Natl Cancer Inst, 83(14), 1024-7, 1991.
- Slebos, R J, Kibbelaar, R E, Dalesio, O, Kooistra, A, Stam, J, Meijer, C J, Wagenaar, S S, Vanderschueren, R G, van Zandwijk, N, Mooi, W J K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung.. N Engl J Med, 323(9), 561-5, 1990.
- Rodenhuis, S, Slebos, R J The ras oncogenes in human lung cancer.. Am Rev Respir Dis, 142(6 Pt 2), S27-30, 1990.
- Slebos, R J, Evers, S G, Wagenaar, S S, Rodenhuis, S Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.. Br J Cancer, 59(1), 76-80, 1989.
- Slebos, R J, Rodenhuis, S The molecular genetics of human lung cancer.. Eur Respir J, 2(5), 461-9, 1989.
- Breuer, M, Slebos, R, Verbeek, S, van Lohuizen, M, Wientjens, E, Berns, A Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice. Nature, 340(6228), 61-3, 1989.
- Höppener, J W, Mosselman, S, Roholl, P J, Lambrechts, C, Slebos, R J, de Pagter-Holthuizen, P, Lips, C J, Jansz, H S, Sussenbach, J S Expression of insulin-like growth factor-I and -II genes in human smooth muscle tumours.. EMBO J, 7(5), 1379-85, 1988.
- Rodenhuis, S, Slebos, R J, Boot, A J, Evers, S G, Mooi, W J, Wagenaar, S S, van Bodegom, P C, Bos, J L Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.. Cancer Res, 48(20), 5738-41, 1988.
- Slebos, R J, de Graeff, A, Van Zandwijk, N, Mooi, W J, Bos, J L, Rodenhuis, S Recurrent breast cancer and an adenocarcinoma of the lung occurring in one patient: c-myc oncogene amplification and K-ras codon 12 point mutation as tumour markers.. Eur J Cancer Clin Oncol, 24(9), 1529-30, 1988.
- de Graeff, A, Slebos, R J, Rodenhuis, S Resistance to cisplatin and analogues: mechanisms and potential clinical implications.. Cancer Chemother Pharmacol, 22(4), 325-32, 1988.
- Höppener, J W, Steenbergh, P H, Slebos, R J, de Pagter-Holthuizen, P, Roos, B A, Jansen, M, Van den Brande, J L, Sussenbach, J S, Jansz, H S, Lips, C J Expression of insulin-like growth factor-I and -II genes in rat medullary thyroid carcinoma.. FEBS Lett, 215(1), 122-6, 1987.
- Höppener, J W, Steenbergh, P H, Slebos, R J, Visser, A, Lips, C J, Jansz, H S, Bechet, J M, Lenoir, G M, Born, W, Haller-Brem, S Expression of the second calcitonin/calcitonin gene-related peptide gene in Ewing sarcoma cell lines.. J Clin Endocrinol Metab, 64(4), 809-17, 1987.
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