The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
Sekhar Raja Konjeti, Ph.D.
See also:
Research Professor
Researcher
Contact Information:
Vanderbilt Department of Radiation Oncology
Medical Center North, E1200
Nashville, TN 37232-5671
615-322-3603
Fax: 615-343-3061
Profile
AWARDS/SCHOLARSHIPS
Senior Research Scholarship from University Grants Commission (awarded based on the rank obtained in the National Level Examination in India)
Junior and Senior Reserach Scholarships from Department of Science and Technology, India
State Merit Scholarship awarded by the State of Andhra Pradesh, India
Education
- Ph.D.-Gulbarga University, Gulbarga, India
- M.Sc. - Mangalore Univeristy, Mangalore, India
- B.Sc. - Andhra University, Waltair, India
Publications
- Venkateswaran, A, Friedman, DB, Walsh, AJ, Skala, MC, Sasi, S, Rachakonda, G, Crooks, PA, Freeman, ML, Sekhar, KR The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Invest New Drugs, 2012.
- Francis, SH, Sekhar, KR, Ke, H, Corbin, JD Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds. Handb Exp Pharmacol, (200), 93-133, 2011.
- Mukhopadhyay, S, Sekhar, KR, Hale, AB, Channon, KM, Farrugia, G, Freeman, ML, Gangula, PR Loss of NRF2 impairs gastric nitrergic stimulation and function. Free Radic Biol Med, 51(3), 619-25, 2011.
- Travis, EL, Rachakonda, G, Zhou, X, Korhonen, K, Sekhar, KR, Biswas, S, Freeman, ML NRF2 deficiency reduces life span of mice administered thoracic irradiation. Free Radic Biol Med, 51(6), 1175-83, 2011.
- Sekhar, KR, Reddy, T, Reddy, N, Crooks, PA, Venkateswaran, A, McDonald, WH, Geng, L, Sasi, S, Van Der Waal, RP, Roti Roti, JL, Salleng, KJ, Rachakonda, G, Freeman, ML The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to the sites of DNA damage, suppressing repair of DNA double strand breaks, and enhancing radiosensitization. Clin Cancer Res, 2011.
- Venkateswaran, A, Reddy, YT, Sonar, VN, Muthusamy, V, Crooks, PA, Freeman, ML, Sekhar, KR Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives. Bioorg Med Chem Lett, 20(24), 7323-6, 2010.
- Sekhar, KR, Rachakonda, G, Freeman, ML Cysteine-based regulation of the CUL3 adaptor protein Keap1. Toxicol Appl Pharmacol, 244(1), 21-26, 2010.
- Rachakonda, G, Sekhar, KR, Jowhar, D, Samson, PC, Wikswo, JP, Beauchamp, RD, Datta, PK, Freeman, ML Increased cell migration and plasticity in Nrf2-deficient cancer cell lines. Oncogene, 2010.
- Reddy, YT, Sekhar, KR, Sasi, N, Reddy, PN, Freeman, ML, Crooks, PA Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents. Bioorg Med Chem Lett, 20(2), 600-2, 2010.
- Pruitt, R, Sasi, N, Freeman, ML, Sekhar, KR Radiosensitization of cancer cells by hydroxychalcones. Bioorg Med Chem Lett, 2010.
- Geng, L, Rachakonda, G, Morré, DJ, Morré, DM, Crooks, PA, Sonar, VN, Roti, JL, Rogers, BE, Greco, S, Ye, F, Salleng, KJ, Sasi, S, Freeman, ML, Sekhar, KR Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature. FASEB J, 23(9), 2986-95, 2009.
- Brown, SL, Sekhar, KR, Rachakonda, G, Sasi, S, Freeman, ML Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway. Cancer Res, 68(2), 364-8, 2008.
- Rachakonda, G, Xiong, Y, Sekhar, KR, Stamer, SL, Liebler, DC, Freeman, ML Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3. Chem Res Toxicol, 21(3), 705-710, 2008.
- Geng, L, Cuneo, KC, Cooper, MK, Wang, H, Sekhar, K, Fu, A, Hallahan, DE Hedgehog signaling in the murine melanoma microenvironment. Angiogenesis, 10(4), 259-67, 2007.
- Sekhar, KR, Sonar, VN, Muthusamy, V, Sasi, S, Laszlo, A, Sawani, J, Horikoshi, N, Higashikubo, R, Bristow, RG, Borrelli, MJ, Crooks, PA, Lepock, JR, Roti Roti, JL, Freeman, ML Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway. Cancer Res, 67(2), 695-701, 2007.
- Gao, L, Wang, J, Sekhar, KR, Yin, H, Yared, NF, Schneider, SN, Sasi, S, Dalton, TP, Anderson, ME, Chan, JY, Morrow, JD, Freeman, ML Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3. J Biol Chem, 282(4), 2529-37, 2007.
- Sonar, VN, Thirupathi Reddy, Y, Sekhar, KR, Sasi, S, Freeman, ML, Crooks, PA Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents. Bioorg Med Chem Lett, 17(24), 6821-6824, 2007.
- Stacy, DR, Ely, K, Massion, PP, Yarbrough, WG, Hallahan, DE, Sekhar, KR, Freeman, ML Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas. Head Neck, 28(9), 813-8, 2006.
- Cao, C, Subhawong, T, Albert, JM, Kim, KW, Geng, L, Sekhar, KR, Gi, YJ, Lu, B Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Cancer Res, 66(20), 10040-7, 2006.
- Kim, KW, Mutter, RW, Cao, C, Albert, JM, Shinohara, ET, Sekhar, KR, Lu, B Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation. Mol Cancer Ther, 5(11), 2659-65, 2006.
- Cao, C, Shinohara, ET, Li, H, Niermann, KJ, Kim, KW, Sekhar, KR, Gleave, M, Freeman, M, Lu, B Clusterin as a therapeutic target for radiation sensitization in a lung cancer model. Int J Radiat Oncol Biol Phys, 63(4), 1228-36, 2005.
- Weeks, JL, Blount, MA, Beasley, A, Zoraghi, R, Thomas, MK, Sekhar, KR, Corbin, JD, Francis, SH Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11. Methods Mol Biol, 307239-62, 2005.
- Bakin, AV, Stourman, NV, Sekhar, KR, Rinehart, C, Yan, X, Meredith, MJ, Arteaga, CL, Freeman, ML Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins. Free Radic Biol Med, 38(3), 375-87, 2005.
- Hong, F, Sekhar, KR, Freeman, ML, Liebler, DC Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation. J Biol Chem, 280(36), 31768-75, 2005.
- Blount, MA, Beasley, A, Zoraghi, R, Sekhar, KR, Bessay, EP, Francis, SH, Corbin, JD Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation. Mol Pharmacol, 66(1), 144-52, 2004.
- Weeks, JL, Zoraghi, R, Beasley, A, Sekhar, KR, Francis, SH, Corbin, JD High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients. Int J Impot Res, 17(1), 5-9, 2004.
- Geng, L, Osusky, K, Konjeti, S, Fu, A, Hallahan, D Radiation-guided drug delivery to tumor blood vessels results in improved tumor growth delay. J Control Release, 99(3), 369-81, 2004.
- Sekhar, KR, Crooks, PA, Sonar, VN, Friedman, DB, Chan, JY, Meredith, MJ, Starnes, JH, Kelton, KR, Summar, SR, Sasi, S, Freeman, ML NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols. Cancer Res, 63(17), 5636-45, 2003.
- Sekhar KR, and Freeman ML "Regulation of Glutamate Cysteine Ligase." Recent Res. Devel. Biophys. Biochem, 329-43, 2003.
- Francis, SH, Sekhar, KR, Rouse, AB, Grimes, KA, Corbin, JD Single step isolation of sildenafil from commercially available Viagra tablets. Int J Impot Res, 15(5), 369-72, 2003.
- Saha, D, Sekhar, KR, Cao, C, Morrow, JD, Choy, H, Freeman, ML The antiangiogenic agent SU5416 down-regulates phorbol ester-mediated induction of cyclooxygenase 2 expression by inhibiting nicotinamide adenine dinucleotide phosphate oxidase activity. Cancer Res, 63(20), 6920-7, 2003.
- Sekhar, KR, Yan, XX, Freeman, ML Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2. Oncogene, 21(44), 6829-34, 2002.
- Sekhar, KR, Spitz, DR, Harris, S, Nguyen, TT, Meredith, MJ, Holt, JT, Gius, D, Marnett, LJ, Summar, ML, Freeman, ML, Guis, D Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase. Free Radic Biol Med, 32(7), 650-62, 2002.
- Sekhar, KR, Soltaninassab, SR, Borrelli, MJ, Xu, ZQ, Meredith, MJ, Domann, FE, Freeman, ML Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase. Biochem Biophys Res Commun, 270(1), 311-7, 2000.
- Soltaninassab, SR, Sekhar, KR, Meredith, MJ, Freeman, ML Multi-faceted regulation of gamma-glutamylcysteine synthetase. J Cell Physiol, 182(2), 163-70, 2000.
- Sekhar, KR, Freeman, ML Autophosphorylation inhibits the activity of gamma-glutamylcysteine synthetase. J Enzyme Inhib, 14(4), 323-30, 1999.
- Corbin, JD, Beasley, A, Turko, IV, Haik, TL, Mangum, KA, Wells, JN, Francis, SH, Sekhar, KR A photoaffinity probe covalently modifies the catalytic site of the cGMP-binding cGMP-specific phosphodiesterase (PDE-5). Cell Biochem Biophys, 29(1-2), 145-57, 1998.
- Meredith, MJ, Cusick, CL, Soltaninassab, S, Sekhar, KS, Lu, S, Freeman, ML Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux. Biochem Biophys Res Commun, 248(3), 458-63, 1998.
- Sekhar, KR, Freeman, ML PEST sequences in proteins involved in cyclic nucleotide signalling pathways. J Recept Signal Transduct Res, 18(2-3), 113-32, 1998.
- Sekhar, KR, Long, M, Long, J, Xu, ZQ, Summar, ML, Freeman, ML Alteration of transcriptional and post-transcriptional expression of gamma-glutamylcysteine synthetase by diethyl maleate. Radiat Res, 147(5), 592-7, 1997.
- Senisterra, GA, Huntley, SA, Escaravage, M, Sekhar, KR, Freeman, ML, Borrelli, M, Lepock, JR Destabilization of the Ca2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37 degrees C. Biochemistry, 36(36), 11002-11, 1997.
- Sekhar, KR, Meredith, MJ, Kerr, LD, Soltaninassab, SR, Spitz, DR, Xu, ZQ, Freeman, ML Expression of glutathione and gamma-glutamylcysteine synthetase mRNA is Jun dependent. Biochem Biophys Res Commun, 234(3), 588-93, 1997.
- McDuffee, AT, Senisterra, G, Huntley, S, Lepock, JR, Sekhar, KR, Meredith, MJ, Borrelli, MJ, Morrow, JD, Freeman, ML Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response. J Cell Physiol, 171(2), 143-51, 1997.
- Sekhar KR, Grondin P, Francis SH and Corbin JD "Design and Synthesis of Xanthine and Cyclic GMP Analogs as Potent Inhibitors of PDE V and PDE I." Phosphodiesterase Inhibitors, 135-145, 1996.
- Corbin, JD, Woodall, CC, Colbran, JL, McAllister, LM, Sekhar, KR, Francis, SH Identifying protein kinases in crude extracts that phosphorylate cyclic GMP-binding cyclic-GMP specific phosphodiesterase. Agents Actions Suppl, 4327-33, 1993.
- Sekhar, KR, Hatchett, RJ, Shabb, JB, Wolfe, L, Francis, SH, Wells, JN, Jastorff, B, Butt, E, Chakinala, MM, Corbin, JD Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type I alpha, compared with type I beta, cGMP-dependent protein kinase. Mol Pharmacol, 42(1), 103-8, 1992.
- Hiremath SP, Sonar VN, Sekhar KR and Purohit MG "Synthesis of Substituted 5,6-Dihydroindolo[2,1-b][1,3]Diazepines, 1,2,3,4,5,6- Hexahydroindolo[3,2-b][1,4] Diazepin-5-Ones and 5,6,7,12- Tetrahydroindolo[3,2-b][1,5]Benzodiazepin-6-Ones." Proc. Natl. Acad. Sci., India, 60A367-376, 1990..
- Hiremath SP, Shivaramaiah K, Sekhar KR and Purohit MG "Synthesis of Substituted 2,5 bis(1,3,4-oxadiazolyl/Thiadiazolyl/1,2,4-Triazolyl)Indoles and Study of Their Biological Activities." Indian J. Chem, 29B1118-1124, 1990..
- Hiremath SP, Sekhar KR, Sonar VN and Purohit MG "Synthesis of 1,2,4-Triazolo[3,4-f] 1,2,4-Triazino[3,4-a]Indoles." Indian J. Chem., 29B372-375, 1990..
- Hiremath SP, Sonar VN, Sekhar KR and Purohit MG "Synthesis of Oxadiazolyl , Thiadiazolyl and Triazolylindoles and Indolylthiazolidinones." Indian J. Chem, 28B626-630, 1989.
- Hiremath SP, Sekhar KR, and Purohit MG "Synthesis of Indolylpyrimidinediones and Indolylthiazolidinones." Indian J. Chem., 27B678-680, 1988.
- Hiremath SP, Ashok U, Sekhar KR, and Purohit MG "Synthesis of Various Pyrazole-1-Carbonylindoles." Indian J. Chem, 27B758-762, 1988.
You do not have JavaScript enabled. This site works better with JavaScript turned on.
