The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
Raymond F. Burk, M.D.
See also:
Professor of Medicine
VICC Member
Researcher
Contact Information:
Vanderbilt University Medical Center
C2104 Medical Center North
Nashville, TN 37232-2279
615-322-8979
Education
- M.D. - Vanderbilt University, 1968
- Fellowship - University of Texas Southwestern Medical Center, 1974
- Residency - Vanderbilt University Medical Center, 1971
- Internship - Vanderbilt University Medical Center, 1969
Research Specialty
Selenium metabolism and function in animals and human beings.
Publications
- Nakayama, A, Hill, KE, Austin, LM, Motley, AK, Burk, RF All regions of mouse brain are dependent on selenoprotein P for maintenance of selenium. J Nutr, 137(3), 690-3, 2007.
- Burk, RF, Christensen, JM, Maguire, MJ, Austin, LM, Whetsell, WO, May, JM, Hill, KE, Ebner, FF A combined deficiency of vitamins E and C causes severe central nervous system damage in guinea pigs. J Nutr, 136(6), 1576-81, 2006.
- Peters, MM, Hill, KE, Burk, RF, Weeber, EJ Altered hippocampus synaptic function in selenoprotein P deficient mice. Mol Neurodegener, 112, 2006.
- Burk, RF, Hill, KE, Motley, AK, Austin, LM, Norsworthy, BK Deletion of selenoprotein P upregulates urinary selenium excretion and depresses whole-body selenium content. Biochim Biophys Acta, 1760(12), 1789-93, 2006.
- Burk, RF, Norsworthy, BK, Hill, KE, Motley, AK, Byrne, DW Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev, 15(4), 804-10, 2006.
- Valentine, WM, Hill, KE, Austin, LM, Valentine, HL, Goldowitz, D, Burk, RF Brainstem axonal degeneration in mice with deletion of selenoprotein p. Toxicol Pathol, 33(5), 570-6, 2005.
- Ma, S, Hill, KE, Burk, RF, Caprioli, RM Mass spectrometric determination of selenenylsulfide linkages in rat selenoprotein P. J Mass Spectrom, 40(3), 400-4, 2005.
- Olson, GE, Winfrey, VP, Nagdas, SK, Hill, KE, Burk, RF Selenoprotein P is required for mouse sperm development. Biol Reprod, 73(1), 201-11, 2005.
- Burk, RF, Hill, KE Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu Rev Nutr, 25215-35, 2005.
- Hill, KE, Zhou, J, McMahan, WJ, Motley, AK, Burk, RF Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene. J Nutr, 134(1), 157-61, 2004.
- Burk, RF, Hill, KE Selenoprotein P: An Extracellular Protein with Unique Physical Characteristics and a Role in Selenium Homeostasis. Annu Rev Nutr, 2004.
- Olson, GE, Winfrey, VP, Hill, KE, Burk, RF Sequential development of flagellar defects in spermatids and epididymal spermatozoa of selenium-deficient rats. Reproduction, 127(3), 335-42, 2004.
- Hill, KE, Montine, TJ, Motley, AK, Li, X, May, JM, Burk, RF Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs. Am J Clin Nutr, 77(6), 1484-8, 2003.
- Hill, Kristina E, Zhou, Jiadong, McMahan, Wendy J, Motley, Amy K, Atkins, John F, Gesteland, Raymond F, Burk, Raymond F Deletion of selenoprotein P alters distribution of selenium in the mouse. J Biol Chem, 278(16), 13640-6, 2003.
- Mostert, Volker, Hill, Kristina E, Burk, Raymond F Loss of activity of the selenoenzyme thioredoxin reductase causes induction of hepatic heme oxygenase-1. FEBS Lett, 541(1-3), 85-8, 2003.
- Ma, Shuguang, Caprioli, Richard M, Hill, Kristina E, Burk, Raymond F Loss of selenium from selenoproteins: conversion of selenocysteine to dehydroalanine in vitro. J Am Soc Mass Spectrom, 14(6), 593-600, 2003.
- Ma, S, Hill, KE, Burk, RF, Caprioli, RM Mass spectrometric identification of N- and O-glycosylation sites of full-length rat selenoprotein P and determination of selenide-sulfide and disulfide linkages in the shortest isoform. Biochemistry, 42(32), 9703-11, 2003.
- Mostert, Volker, Hill, Kristina E, Ferris, Christopher D, Burk, Raymond F Selective induction of liver parenchymal cell heme oxygenase-1 in selenium-deficient rats. Biol Chem, 384(4), 681-7, 2003.
- Burk, Raymond F, Hill, Kristina E, Motley, Amy K Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P. J Nutr, 133(5 Suppl 1), 1517S-20S, 2003.
- Ma, Shuguang, Hill, Kristina E, Caprioli, Richard M, Burk, Raymond F Mass spectrometric characterization of full-length rat selenoprotein P and three isoforms shortened at the C terminus. Evidence that three UGA codons in the mRNA open reading frame have alternative functions of specifying selenocysteine insertion or translation termination. J Biol Chem, 277(15), 12749-54, 2002.
- Burk, Raymond F Selenium, an antioxidant nutrient. Nutr Clin Care, 5(2), 75-9, 2002.
- May, James M, Morrow, Jason D, Burk, Raymond F Thioredoxin reductase reduces lipid hydroperoxides and spares alpha-tocopherol. Biochem Biophys Res Commun, 292(1), 45-9, 2002.
- Atkinson, J B, Hill, K E, Burk, R F Centrilobular endothelial cell injury by diquat in the selenium-deficient rat liver. Lab Invest, 81(3), 193-200, 2001.
- Atkinson, J B, Hill, K E, Burk, R F Centrilobular endothelial cell injury by diquat in the selenium-deficient rat liver. Lab Invest, 81(2), 193-200, 2001.
- Hill, K E, Motley, A K, Li, X, May, J M, Burk, R F Combined selenium and vitamin E deficiency causes fatal myopathy in guinea pigs. J Nutr, 131(6), 1798-802, 2001.
- Hondal, R J, Ma, S, Caprioli, R M, Hill, K E, Burk, R F Heparin-binding histidine and lysine residues of rat selenoprotein P. J Biol Chem, 276(19), 15823-31, 2001.
- Li, X, Cobb, C E, Hill, K E, Burk, R F, May, J M Mitochondrial uptake and recycling of ascorbic acid. Arch Biochem Biophys, 387(1), 143-53, 2001.
- Burk, R F, Hill, K E, Motley, A K Plasma selenium in specific and non-specific forms. Biofactors, 14(1-4), 107-14, 2001.
- Li, X, Hill, K E, Burk, R F, May, J M Selenium spares ascorbate and alpha-tocopherol in cultured liver cell lines under oxidant stress. FEBS Lett, 508(3), 489-92, 2001.
- Burk, Raymond Selenium: recent clinical advances. Curr Opin Gastroenterol, 17(2), 162-166, 2001.
- Yang, X., K.E. Hill, M.J. Maguire, and R.F. Burk "Synthesis and secretion of selenoprotein P by cultured rat astrocytes." Biochim Biophys Acta, 1474390-396, 2000.
- Yang, X, Hill, K E, Maguire, M J, Burk, R F Synthesis and secretion of selenoprotein P by cultured rat astrocytes. Biochim Biophys Acta, 1474(3), 390-6, 2000.
- Hondal, R.J., A.K. Motley, K.E. Hill, and R.F. Burk "Failure of selenomethionine residues in albumin to protect against peroxynitrite oxidation of dihydrorhodamine 123." Arch Biochem Biophys , 3729-34, 1999.
- Hondal, R J, Motley, A K, Hill, K E, Burk, R F Failure of selenomethionine residues in albumin and immunoglobulin G to protect against peroxynitrite. Arch Biochem Biophys, 371(1), 29-34, 1999.
- Burk, R F, Hill, K E Orphan selenoproteins. Bioessays, 21(3), 231-7, 1999.
- Morrow, J D, Roberts, L J, Daniel, V C, Awad, J A, Mirochnitchenko, O, Swift, L L, Burk, R F Comparison of formation of D2/E2-isoprostanes and F2-isoprostanes in vitro and in vivo--effects of oxygen tension and glutathione. Arch Biochem Biophys, 353(1), 160-71, 1998.
- Burk, R F, Early, D S, Hill, K E, Palmer, I S, Boeglin, M E Plasma selenium in patients with cirrhosis. Hepatology, 27(3), 794-8, 1998.
- May, J.M., C.E. Cobb, S. Mendiratta, K.E. Hill, and R.F. Burk "Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase." J Biol Chem, 27323039-23045, 1998.
- May, J M, Cobb, C E, Mendiratta, S, Hill, K E, Burk, R F Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase. J Biol Chem, 273(36), 23039-45, 1998.
- Hill, K E, McCollum, G W, Burk, R F Determination of thioredoxin reductase activity in rat liver supernatant. Anal Biochem, 253(1), 123-5, 1997.
- May, J M, Mendiratta, S, Hill, K E, Burk, R F Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase. J Biol Chem, 272(36), 22607-10, 1997.
- Burk, R F, Hill, K E, Boeglin, M E, Ebner, F F, Chittum, H S Selenoprotein P associates with endothelial cells in rat tissues. Histochem Cell Biol, 108(1), 11-5, 1997.
- Hill, K E, Burk, R F Selenoprotein P: recent studies in rats and in humans. Biomed Environ Sci, 10(2-3), 198-208, 1997.
- Hill, K E, McCollum, G W, Boeglin, M E, Burk, R F Thioredoxin reductase activity is decreased by selenium deficiency. Biochem Biophys Res Commun, 234(2), 293-5, 1997.
- Hill, K E, Chittum, H S, Lyons, P R, Boeglin, M E, Burk, R F Effect of selenium on selenoprotein P expression in cultured liver cells. Biochim Biophys Acta, 1313(1), 29-34, 1996.
- Hill, K E, Dasouki, M, Phillips, J A, Burk, R F Human selenoprotein P gene maps to 5q31. Genomics, 36(3), 550-1, 1996.
- Himeno, S, Chittum, H S, Burk, R F Isoforms of selenoprotein P in rat plasma. Evidence for a full-length form and another form that terminates at the second UGA in the open reading frame. J Biol Chem, 271(26), 15769-75, 1996.
- Awad, J A, Roberts, L J, Burk, R F, Morrow, J D Isoprostanes--prostaglandin-like compounds formed in vivo independently of cyclooxygenase: use as clinical indicators of oxidant damage. Gastroenterol Clin North Am, 25(2), 409-27, 1996.
- Chittum, H S, Himeno, S, Hill, K E, Burk, R F Multiple forms of selenoprotein P in rat plasma. Arch Biochem Biophys, 325(1), 124-8, 1996.
- Payne, J L, McCarty, K R, Drougas, J G, Chapman, W C, Wright, J K, Pinson, N Y, Beliles, K E, Newsom, V L, Hunter, E B, Raiford, D S, Awad, J A, Burk, R F, Donovan, K L, Van Buren, D H, Pinson, C W Outcomes analysis for 50 liver transplant recipients: the Vanderbilt experience. Am Surg, 62(4), 320-5, 1996.
- Hill, K E, Xia, Y, Akesson, B, Boeglin, M E, Burk, R F Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects. J Nutr, 126(1), 138-45, 1996.
- Burk, R F, Hill, K E, Awad, J A, Morrow, J D, Lyons, P R Liver and kidney necrosis in selenium-deficient rats depleted of glutathione. Lab Invest, 72(6), 723-30, 1995.
- Burk, R F, Hill, K E, Awad, J A, Morrow, J D, Kato, T, Cockell, K A, Lyons, P R Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P. Hepatology, 21(2), 561-9, 1995.
- Burk, R F, Hill, K E Reduced glutathione release into rat plasma by extrahepatic tissues. Am J Physiol, 269(3 Pt 1), G396-9, 1995.
- Awad, J A, Morrow, J D, Hill, K E, Roberts, L J, Burk, R F Detection and localization of lipid peroxidation in selenium- and vitamin E-deficient rats using F2-isoprostanes. J Nutr, 124(6), 810-6, 1994.
- Longmire, A W, Swift, L L, Roberts, L J, Awad, J A, Burk, R F, Morrow, J D Effect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes. Biochem Pharmacol, 47(7), 1173-7, 1994.
- Awad, J A, Burk, R F, Roberts, L J Effect of selenium deficiency and glutathione-modulating agents on diquat toxicity and lipid peroxidation in rats. J Pharmacol Exp Ther, 270(3), 858-64, 1994.
- Drougas, J G, Hunter, E B, Raiford, D S, Burk, R F, Awad, J A, Wright, J K, Lopez, R R, Donovan, K L, Franks, J J, Thomas, A T Liver transplantation: results with Vanderbilt's first 25 liver recipients. J Tenn Med Assoc, 87(1), 7-10, 1994.
- Akesson, B, Bellew, T, Burk, R F Purification of selenoprotein P from human plasma. Biochim Biophys Acta, 1204(2), 243-9, 1994.
- Burk, R F, Hill, K E Selenoprotein P. A selenium-rich extracellular glycoprotein. J Nutr, 124(10), 1891-7, 1994.
- Burk, R F Clinical effects of selenium deficiency. Prog Clin Biol Res, 380181-90, 1993.
- Hill, K E, Lloyd, R S, Burk, R F Conserved features of selenoprotein P cDNA. Biochem Soc Trans, 21(4), 832-5, 1993.
- Hill, K E, Lloyd, R S, Burk, R F Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. Proc Natl Acad Sci U S A, 90(2), 537-41, 1993.
- Burk, R F, Hill, K E Regulation of selenoproteins. Annu Rev Nutr, 1365-81, 1993.
- Hill, K E, Lyons, P R, Burk, R F Differential regulation of rat liver selenoprotein mRNAs in selenium deficiency. Biochem Biophys Res Commun, 185(1), 260-3, 1992.
- Kato, T, Read, R, Rozga, J, Burk, R F Evidence for intestinal release of absorbed selenium in a form with high hepatic extraction. Am J Physiol, 262(5 Pt 1), G854-8, 1992.
- Morrow, J D, Awad, J A, Kato, T, Takahashi, K, Badr, K F, Roberts, L J, Burk, R F Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. J Clin Invest, 90(6), 2502-7, 1992.
- Hill, K E, Hunt, R W, Jones, R, Hoover, R L, Burk, R F Metabolism of nitroglycerin by smooth muscle cells. Involvement of glutathione and glutathione S-transferase. Biochem Pharmacol, 43(3), 561-6, 1992.
- Burk, R F, Hill, K E Some properties of selenoprotein P. Biol Trace Elem Res, 33151-3, 1992.
- Morrow, J D, Hill, K E, Burk, R F, Nammour, T M, Badr, K F, Roberts, L J Formation of unique biologically active prostaglandins in vivo by a non-cyclooxygenase free radical catalyzed mechanism. Adv Prostaglandin Thromboxane Leukot Res, 21A125-8, 1991.
- Burk, R F Molecular biology of selenium with implications for its metabolism. FASEB J, 5(9), 2274-9, 1991.
- Burk, R F, Hill, K E, Read, R, Bellew, T Response of rat selenoprotein P to selenium administration and fate of its selenium. Am J Physiol, 261(1 Pt 1), E26-30, 1991.
- Hill, K E, Lloyd, R S, Yang, J G, Read, R, Burk, R F The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame. J Biol Chem, 266(16), 10050-3, 1991.
- Morrow, J D, Hill, K E, Burk, R F, Nammour, T M, Badr, K F, Roberts, L J A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci U S A, 87(23), 9383-7, 1990.
- Williams, A T, Burk, R F Carbon tetrachloride hepatotoxicity: an example of free radical-mediated injury. Semin Liver Dis, 10(4), 279-84, 1990.
- Piao, JH, Hill, KE, Hunt, RW, Burk, RF Effect of selenium deficiency on tissue taurine concentration and urinary taurine excretion in the rat. J Nutr Biochem, 1(8), 427-32, 1990.
- Burk, R F, Hill, K E, Hunt, R W, Martin, A E Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it. Res Commun Chem Pathol Pharmacol, 69(1), 115-8, 1990.
- Burk, R F Protection against free radical injury by selenoenzymes. Pharmacol Ther, 45(3), 383-5, 1990.
- Read, R, Bellew, T, Yang, J G, Hill, K E, Palmer, I S, Burk, R F Selenium and amino acid composition of selenoprotein P, the major selenoprotein in rat serum. J Biol Chem, 265(29), 17899-905, 1990.
- Konz, K H, Haap, M, Hill, K E, Burk, R F, Walsh, R A Diastolic dysfunction of perfused rat hearts induced by hydrogen peroxide. Protective effect of selenium. J Mol Cell Cardiol, 21(8), 789-95, 1989.
- Yang, J G, Hill, K E, Burk, R F Dietary selenium intake controls rat plasma selenoprotein P concentration. J Nutr, 119(7), 1010-2, 1989.
- Burk, R F, Ludden, T M Exhaled alkanes as indices of in vivo lipid peroxidation. Biochem Pharmacol, 38(7), 1029-32, 1989.
- Hill, K E, Ziegler, D M, Konz, K H, Haap, M, Hunt, R W, Burk, R F Nitroglycerin and isosorbide dinitrate stimulation of glutathione disulfide efflux from perfused rat liver. Biochem Pharmacol, 38(21), 3807-10, 1989.
- Burk, R F Recent developments in trace element metabolism and function: newer roles of selenium in nutrition. J Nutr, 119(7), 1051-4, 1989.
- Burk, R F, Hill, K E, Lane, J M Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome P-450. Biochem Biophys Res Commun, 152(3), 1463-7, 1988.
- Burk, R F Selenium deficiency in search of a disease. Hepatology, 8(2), 421-3, 1988.
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