Vanderbilt-Ingram Cancer Center

Publications

• Kanetsuna, Y, Takahashi, K, Nagata, M, Gannon, MA, Breyer, MD, Harris, RC, Takahashi, T Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Am J Pathol, 170(5), 1473-84, 2007.
• Breyer, MD, Tchekneva, E, Qi, Z, Takahashi, T, Fogo, AB, Zhao, HJ, Harris, RC Genetics of diabetic nephropathy: lessons from mice. Semin Nephrol, 27(2), 237-47, 2007.
• Chen, X, Abair, TD, Ibanez, MR, Su, Y, Frey, MR, Dise, RS, Polk, DB, Singh, AB, Harris, RC, Zent, R, Pozzi, A Integrin {alpha}1{beta}1 Controls Reactive Oxygen Species Synthesis by Negatively Regulating Epidermal Growth Factor Receptor-Mediated Rac Activation. Mol Cell Biol, 27(9), 3313-26, 2007.
• Chen, J, Chen, JK, Falck, JR, Anjaiah, S, Capdevila, JH, Harris, RC Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. Mol Cell Biol, 27(8), 3023-34, 2007.
• Cheng, H, Wang, S, Jo, YI, Hao, CM, Zhang, M, Fan, X, Kennedy, C, Breyer, MD, Moeckel, GW, Harris, RC Overexpression of cyclooxygenase-2 predisposes to podocyte injury. J Am Soc Nephrol, 18(2), 551-9, 2007.
• Harris, RC COX-2 and the kidney. J Cardiovasc Pharmacol, 47 Suppl 1S37-42, 2006.
• Kanetsuna, Y, Hirano, K, Nagata, M, Gannon, MA, Takahashi, K, Harris, RC, Breyer, MD, Takahashi, T Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes. Am J Physiol Renal Physiol, 291(6), F1315-22, 2006.
• Zhao, HJ, Wang, S, Cheng, H, Zhang, MZ, Takahashi, T, Fogo, AB, Breyer, MD, Harris, RC Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J Am Soc Nephrol, 17(10), 2664-9, 2006.
• Cheng, H, Harris, RC Potential side effects of renin inhibitors--mechanisms based on comparison with other renin-angiotensin blockers. Expert Opin Drug Saf, 5(5), 631-41, 2006.
• Zhang, MZ, Yao, B, Cheng, HF, Wang, SW, Inagami, T, Harris, RC Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Proc Natl Acad Sci U S A, 103(43), 16045-50, 2006.
• Chen, J, Chen, JK, Neilson, EG, Harris, RC Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophy. J Am Soc Nephrol, 17(6), 1615-23, 2006.
• Yao, B, Xu, J, Qi, Z, Harris, RC, Zhang, MZ Role of renal cortical cyclooxygenase-2 expression in hyperfiltration in rats with high-protein intake. Am J Physiol Renal Physiol, 291(2), F368-74, 2006.
• Harris, RC, Neilson, EG Toward a unified theory of renal progression. Annu Rev Med, 57365-80, 2006.
• Singh, AB, Harris, RC Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell Signal, 17(10), 1183-93, 2005.
• Zhang, MZ, Yao, B, McKanna, JA, Harris, RC Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems. Am J Physiol Renal Physiol, 288(4), F840-5, 2005.
• Breyer, MD, Böttinger, E, Brosius, FC, Coffman, TM, Fogo, A, Harris, RC, Heilig, CW, Sharma, K Diabetic nephropathy: of mice and men. Adv Chronic Kidney Dis, 12(2), 128-45, 2005.
• Cheng, H, Zhang, M, Moeckel, GW, Zhao, Y, Wang, S, Qi, Z, Breyer, MD, Harris, RC Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition. Nephron Exp Nephrol, 101(3), e75-85, 2005.
• Yao, B, Harris, RC, Zhang, MZ Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney. Am J Physiol Regul Integr Comp Physiol, 288(6), R1767-73, 2005.
• Rao, R, Zhang, MZ, Zhao, M, Cai, H, Harris, RC, Breyer, MD, Hao, CM Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am J Physiol Renal Physiol, 288(4), F642-9, 2005.
• Breyer, MD, Böttinger, E, Brosius, FC, Coffman, TM, Harris, RC, Heilig, CW, Sharma, K, , Mouse models of diabetic nephropathy. J Am Soc Nephrol, 16(1), 27-45, 2005.
• Cheng, HF, Zhang, MZ, Harris, RC NITRIC OXIDE STIMULATES CYCLOOXYGENASE-2 IN CULTURED CTAL CELLS THROUGH A P38-DEPENDENT PATHWAY. Am J Physiol Renal Physiol, 2005.
• Cheng, HF, Harris, RC Renal effects of non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors. Curr Pharm Des, 11(14), 1795-804, 2005.
• Chen, JK, Chen, J, Neilson, EG, Harris, RC Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy. J Am Soc Nephrol, 16(5), 1384-91, 2005.
• Fisher, ME, Rossini, M, Simmons, E, Harris, RC, Moeckel, G, Zent, R A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy. Am J Kidney Dis, 44(3), 567-73, 2004.
• Harris, RC, Zhang, MZ, Cheng, HF Cyclooxygenase-2 and the renal renin-angiotensin system. Acta Physiol Scand, 181(4), 543-7, 2004.
• Cheng, HF, Harris, RC Cyclooxygenases, the kidney, and hypertension. Hypertension, 43(3), 525-30, 2004.
• Chen, D, Roberts, R, Pohl, M, Nigam, S, Kreidberg, J, Wang, Z, Heino, J, Ivaska, J, Coffa, S, Harris, RC, Pozzi, A, Zent, R Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol, 287(4), F602-11, 2004.
• Shivakumar, BR, Wang, Z, Hammond, TG, Harris, RC EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor. Cell Biochem Funct, 23(3), 195-204, 2004.
• Singh, AB, Harris, RC Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. J Biol Chem, 279(5), 3543-52, 2004.
• Chen, X, Moeckel, G, Morrow, JD, Cosgrove, D, Harris, RC, Fogo, AB, Zent, R, Pozzi, A Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol, 165(2), 617-30, 2004.
• Singh, AB, Tsukada, T, Zent, R, Harris, RC Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. J Cell Sci, 117(Pt 8), 1365-79, 2004.
• Zhang, MZ, Mai, W, Li, C, Cho, SY, Hao, C, Moeckel, G, Zhao, R, Kim, I, Wang, J, Xiong, H, Wang, H, Sato, Y, Wu, Y, Nakanuma, Y, Lilova, M, Pei, Y, Harris, RC, Li, S, Coffey, RJ, Sun, L, Wu, D, Chen, XZ, Breyer, MD, Zhao, ZJ, McKanna, JA, Wu, G PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A, 101(8), 2311-6, 2004.
• Zhang, MZ, Sanchez Lopez, P, McKanna, JA, Harris, RC Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Endocrinology, 145(3), 1402-9, 2004.
• Qi, Z, Whitt, I, Mehta, A, Jin, J, Zhao, M, Harris, RC, Fogo, AB, Breyer, MD Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Am J Physiol Renal Physiol, 286(3), F590-6, 2004.
• Cheng, HF, Harris, RC Does cyclooxygenase-2 affect blood pressure. Curr Hypertens Rep, 5(1), 87-92, 2003.
• Harris, RC, Chung, E, Coffey, RJ EGF receptor ligands. Exp Cell Res, 284(1), 2-13, 2003.
• Wang, Z, Chen, JK, Wang, SW, Moeckel, G, Harris, RC Importance of functional EGF receptors in recovery from acute nephrotoxic injury. J Am Soc Nephrol, 14(12), 3147-54, 2003.
• Harris, RC Interactions between COX-2 and the renin-angiotensin system in the kidney. Acta Physiol Scand, 177(4), 423-7, 2003.
• Means, AL, Ray, KC, Singh, AB, Washington, MK, Whitehead, RH, Harris, RC, Wright, CV, Coffey, RJ, Leach, SD Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology, 124(4), 1020-36, 2003.
• Zhang, MZ, Wang, SW, Cheng, H, Zhang, Y, McKanna, JA, Harris, RC Regulation of renal cortical cyclooxygenase-2 in young rats. Am J Physiol Renal Physiol, 285(5), F881-8, 2003.
• Harris, RC Cyclooxygenase-2 and the kidney: functional and pathophysiological implications. J Hypertens Suppl, 20(6), S3-9, 2002.
• Cheng, HF, Harris, RC Cyclooxygenase-2 expression in cultured cortical thick ascending limb of Henle increases in response to decreased extracellular ionic content by both transcriptional and post-transcriptional mechanisms. Role of p38-mediated pathways. J Biol Chem, 277(47), 45638-43, 2002.
• Harris, RC Cyclooxygenase-2 inhibition and renal physiology. Am J Cardiol, 89(6A), 10D-17D, 2002.
• Cheng, HF, Wang, CJ, Moeckel, GW, Zhang, MZ, McKanna, JA, Harris, RC Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Kidney Int, 62(3), 929-39, 2002.
• Burleigh, ME, Babaev, VR, Oates, JA, Harris, RC, Gautam, S, Riendeau, D, Marnett, LJ, Morrow, JD, Fazio, S, Linton, MF Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation, 105(15), 1816-23, 2002.
• Chen, JK, Capdevila, J, Harris, RC Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells. Proc Natl Acad Sci U S A, 99(9), 6029-34, 2002.
• Capdevila, JH, Harris, RC, Falck, JR Microsomal cytochrome P450 and eicosanoid metabolism. Cell Mol Life Sci, 59(5), 780-9, 2002.
• Zhang, MZ, Hao, CM, Breyer, MD, Harris, RC, McKanna, JA Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla. Am J Physiol Renal Physiol, 283(3), F509-16, 2002.
• Cheng, HF, Wang, SW, Zhang, MZ, McKanna, JA, Breyer, R, Harris, RC Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. Am J Physiol Regul Integr Comp Physiol, 283(3), R638-46, 2002.
• Takemura, T., Hino, S., Kuwajima, H., Yanagida, H, Okada, M., Nagata, M, Sasaki, S., Barasch, J., Harris, R.C. and Yoshioka, K "Induction of collecting duct morphogenesis in vitro by heparin-binding EGF-like growth factor." J.A.S.N., 12964-972, 2001.
• Chen, J-K, Capdevila, J.C. and Harris, R.C "A novel role for cP450 expoxygenase to inhibit apoptosis in renal epithelial cells." Mol. Cell Biol., 216322-6331, 2001.
• Chen, J-K, Zimpelmann, J., Harris, R.C. and Burns, K.D "Angiotensin IV induces tyrosine phosphorylation of focal adhesion kinase and paxillin in proximal tubule cells." Am. J. Physiol. , 280F980-988, 2001.
• Breyer, MD, Harris, RC Cyclooxygenase 2 and the kidney. Curr Opin Nephrol Hypertens, 10(1), 89-98, 2001.
• Chen, JK, Capdevila, J, Harris, RC Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Mol Cell Biol, 21(18), 6322-31, 2001.
• Cheng, HF, Wang, JL, Zhang, MZ, Wang, SW, McKanna, JA, Harris, RC Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition. Am J Physiol Renal Physiol, 280(3), F449-56, 2001.
• Cheng, H-F., Wang, J-L., Zhang, M-Z, Wang, S-W, McKanna, J.A. and Harris, R. C "Genetic deletion of cyclooxygenase-2 prevents increased renin expression in response to ACE inhibition." Am. J. Physiol., 280F449-F456, 2001.
• Sakai, M. Tsukada, T. and Harris, R.C "Induction of HB-EGF expression by reactive oxygen species: role of AP-1-mediated transcriptional activation." Experimental Nephrology , 928-30, 2001.
• Harris, RC, Breyer, MD Physiological regulation of cyclooxygenase-2 in the kidney. Am J Physiol Renal Physiol, 281(1), F1-11, 2001.
• Wang, JL, Cheng, HF, Shappell, S, Harris, RC A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats. Kidney Int, 57(6), 2334-42, 2000.
• Harris, RC Cyclooxygenase-2 in the kidney. J Am Soc Nephrol, 11(12), 2387-94, 2000.
• Kömhoff, M, Wang, JL, Cheng, HF, Langenbach, R, McKanna, JA, Harris, RC, Breyer, MD Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development. Kidney Int, 57(2), 414-22, 2000.
• Capdevila, JH, Falck, JR, Harris, RC Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res, 41(2), 163-81, 2000.
• Haralson, MA, DiMari, SJ, Hoover, RL, Harris, RC Effects of epidermal growth factor on collagen expression by rat kidney mesangial cells in culture. Matrix Biol, 19(1), 47-59, 2000.
• Harris, RC, Cheng, H, Wang, J, Zhang, M, McKanna, JA Interactions of the renin-angiotensin system and neuronal nitric oxide synthase in regulation of cyclooxygenase-2 in the macula densa. Acta Physiol Scand, 168(1), 47-51, 2000.
• Cheng, HF, Wang, JL, Zhang, MZ, McKanna, JA, Harris, RC Nitric oxide regulates renal cortical cyclooxygenase-2 expression. Am J Physiol Renal Physiol, 279(1), F122-9, 2000.
• Chen, J-K, Capdevila, J.C. and Harris, R.C "Overexpression of C-Terminal Src Kinase (CSK) Blocks 14,15-Epoxyeicosatrienoic Acid-Induced Tyrosine Phosphorylation and Mitogenesis." J. Biol. Chem., 27513789-13792, 2000.
• Chen, JK, Capdevila, J, Harris, RC Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. J Biol Chem, 275(18), 13789-92, 2000.
• Cheng, H-F., Wang, J-L., Zhang, M-Z, McKanna, J.A. and Harris, R.C "Regulation of macula densa cyclooxygenase-2 expression by neuronal nitric oxide synthase." Am. J. Physiol, 279F122-9, 2000.
• Cheng, HF, Wang, JL, Zhang, MZ, McKanna, JA, Harris, RC Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride. J Clin Invest, 106(5), 681-8, 2000.
• Wang, J-L., Cheng, H-F., Sheppel, S. and Harris, R.C "The cyclooxygenase-2 inhibitor, SC58326, decreasesproteinuria and retards progression of glomerulosclerosis in the rat remnant kidney." Kidney Int, 572334-42, 2000.
• Cheng, H-F, Wang, J-F, Zhang, M-Z, McKanna, J.A. and Harris, R.C "Angiotensin II attenuates renal cortical cyclooxygenase-2 expression." J. Clin. Invest., 103953-961, 1999.
• Cheng, HF, Wang, JL, Zhang, MZ, Miyazaki, Y, Ichikawa, I, McKanna, JA, Harris, RC Angiotensin II attenuates renal cortical cyclooxygenase-2 expression. J Clin Invest, 103(7), 953-61, 1999.
• Gibbs, SR, Goins, RA, Belvin, EL, Dimari, SJ, Merriam, AP, Bowling-Brown, S, Harris, RC, Haralson, MA Characterization of the collagen phenotype of rabbit proximal tubule cells in culture. Connect Tissue Res, 40(3), 173-88, 1999.
• Takemura, T, Hino, S, Murata, Y, Yanagida, H, Okada, M, Yoshioka, K, Harris, RC Coexpression of CD9 augments the ability of membrane-bound heparin-binding epidermal growth factor-like growth factor (proHB-EGF) to preserve renal epithelial cell viability. Kidney Int, 55(1), 71-81, 1999.
• Wang, JL, Cheng, HF, Harris, RC Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. Hypertension, 34(1), 96-101, 1999.
• Wang, J-L., Cheng, H-F. and Harris, R.C "Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension." Hypertension, 3496-191, 1999.
• Zhang, M-Z, Harris, R.C and McKanna, J.A "Modulation of expression of cyclooxygenase-2 in rat kidney by endogenous glucocorticoids and mineralocorticoids." Proc. Natl. Acad. Sci. USA , 9615280-15285, 1999.
• Harris, RC Potential mechanisms and physiologic actions of intracellular angiotensin II. Am J Med Sci, 318(6), 374-9, 1999.
• Zhang, MZ, Harris, RC, McKanna, JA Regulation of cyclooxygenase-2 (COX-2) in rat renal cortex by adrenal glucocorticoids and mineralocorticoids. Proc Natl Acad Sci U S A, 96(26), 15280-5, 1999.
• Chen, J-K, Falck, Wang, D-W J.R., Capdevila, J.C. and Harris, R.C "Transfection of an active cP450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as a second messenger in response to epidermal growth factor." J. Biol. Chem, 2744764-4769, 1999.
• Chen, JK, Wang, DW, Falck, JR, Capdevila, J, Harris, RC Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. J Biol Chem, 274(8), 4764-9, 1999.
• Becker, BN, Kondo, S, Chen, JK, Harris, RC Tyrosine kinase inhibition affects type 1 angiotensin II receptor internalization. J Recept Signal Transduct Res, 19(6), 975-93, 1999.
• Miyazaki, Y, Tsuchida, S, Nishimura, H, Pope, JC, Harris, RC, McKanna, JM, Inagami, T, Hogan, BL, Fogo, A, Ichikawa, I Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest, 102(8), 1489-97, 1998.
• Miyazaki, Y., Tsuchida, S., Nishimura, H., Pope, J.C., Harris, R.C., McKanna, J. M., Inagami, T., Hogan,B.L.M., Fogo, A. and Ichikawa, I "Angiotensin induces the urinary peristaltic machinery during the perinatal period." J. Clin. Invest, 1021489-1497, 1998.
• McKanna, JA, Zhang, MZ, Wang, JL, Cheng, H, Harris, RC Constitutive expression of cyclooxygenase-2 in rat vas deferens. Am J Physiol, 275(1 Pt 2), R227-33, 1998.
• Chen, J-K, Falck, J.R. Reddy, K.M., Capdevila, J.C. and Harris, R.C "Epoxyeicosatrienoic Acids and their sulfonamide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells." , J. Biol. Chem.29254-29261, 1998.
• Chen, JK, Falck, JR, Reddy, KM, Capdevila, J, Harris, RC Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. J Biol Chem, 273(44), 29254-61, 1998.
• Wang, J-L, Cheng, H-F, Zhou, M-Z, McKanna, J.A. and Harris, R.C "Increased cyclooxygenase-2 expression after subtotal renal ablation." Am. J. Physiol, 275F613- F622, 1998.
• "Mechanical stretch/relaxation stimulates a novel cellular renin-angiotensin system in cultured rat mesangial cell." Experimental Nephrology, 657-66, 1998.
• Becker, BN, Yasuda, T, Kondo, S, Vaikunth, S, Homma, T, Harris, RC Mechanical stretch/relaxation stimulates a cellular renin-angiotensin system in cultured rat mesangial cells. Exp Nephrol, 6(1), 57-66, 1998.
• Harris, RC, Wang, JL, Cheng, HF, Zhang, MZ, McKanna, JA Prostaglandins in macula densa function. Kidney Int Suppl, 67S49-52, 1998.
• Wang, JL, Cheng, HF, Zhang, MZ, McKanna, JA, Harris, RC Selective increase of cyclooxygenase-2 expression in a model of renal ablation. Am J Physiol, 275(4 Pt 2), F613-22, 1998.
• Cheng, HF, Wang, JL, Vinson, GP, Harris, RC Young SHR express increased type 1 angiotensin II receptors in renal proximal tubule. Am J Physiol, 274(1 Pt 2), F10-7, 1998.
• Cheng, H-F, Wang, J-L, Vinson, G.P. and Harris, R.C "Young spontaneous hypertensive rats (SHR) express increased type 1 angiotensin II receptors (AT1R) in renal proximal tubule." Am. J. Physiol (Renal Physiol.), 274F10-F17, 1998.
• Harris, RC, Becker, BN, Cheng, HF Acute and chronic mechanisms for regulating proximal tubule angiotensin II receptor expression. J Am Soc Nephrol, 8(2), 306-13, 1997.
• Becker, BN, Cheng, HF, Harris, RC Apical ANG II-stimulated PLA2 activity and Na+ flux: a potential role for Ca2+-independent PLA2. Am J Physiol, 273(4 Pt 2), F554-62, 1997.
• Zhang, MZ, Wang, JL, Cheng, HF, Harris, RC, McKanna, JA Cyclooxygenase-2 in rat nephron development. Am J Physiol, 273(6 Pt 2), F994-1002, 1997.
• Becker, BN, Kondo, S, Cheng, HF, Harris, RC Effect of glucose, pyruvate, and insulin on type 1 angiotensin II receptor expression in SV40-immortalized rabbit proximal tubule epithelial cells. Kidney Int, 52(1), 87-92, 1997.
• Harris, RC Growth factors and cytokines in acute renal failure. Adv Ren Replace Ther, 4(2 Suppl 1), 43-53, 1997.
• Sakai, M., Zhang, M. Homma, T., Garrick, B., Abraham, J.A. McKanna, J.A. and Harris, R.C "Production of Heparin Binding Epidermal Growth Factor-like Growth Factor in the Early Phase of Regeneration Following Acute Renal Injury." J. Clin. Invest., 992128-2138, 1997.
• Sakai, M, Zhang, M, Homma, T, Garrick, B, Abraham, JA, McKanna, JA, Harris, RC Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. J Clin Invest, 99(9), 2128-38, 1997.
• Takemura, T., Kondo, S., Homma, T., Sakai, M. and Harris, R.C "The membrane bound form of heparin-binding epidermal growth factor-like growth factor (HB-EGF) promotes survival of cultured renal epithelial cells." J. Biol. Chem., 27231036-31042, 1997.
• Takemura, T, Kondo, S, Homma, T, Sakai, M, Harris, RC The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells. J Biol Chem, 272(49), 31036-42, 1997.
• Becker, BN, Harris, RC A potential mechanism for proximal tubule angiotensin II-mediated sodium flux associated with receptor-mediated endocytosis and arachidonic acid release. Kidney Int Suppl, 57S66-72, 1996.
• Cheng, H-F., Becker, B.N. and Harris, R.C "Dopamine decreases expression of type 1 angiotensin II receptors in renal proximal tubule." J. Clin. Invest, 972745-2752, 1996.
• Cheng, HF, Becker, BN, Harris, RC Dopamine decreases expression of type-1 angiotensin II receptors in renal proximal tubule. J Clin Invest, 97(12), 2745-52, 1996.
• Yasuda, T, Kondo, S, Homma, T, Harris, RC Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. J Clin Invest, 98(9), 1991-2000, 1996.
• Yasuda, T., Hondo, S. Homma, T. and Harris, R.C "Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells." J. Clin.Invest., 981991-2000, 1996.
• Harris, RC, Cheng, HF The intrarenal renin-angiotensin system: a paracrine system for the local control of renal function separate from the systemic axis. Exp Nephrol, 4 Suppl 12-7, 1996.
• Harris, RC The macula densa: recent developments. J Hypertens, 14(7), 815-22, 1996.
• Cheng, H-F., Becker, B. N., Burns, K.D. and Harris, RC "Angiotensin II regulates its receptor sites inrabbit proximal tubule." J. Clin. Invest, 952012-2019, 1995.
• Cheng, HF, Becker, BN, Burns, KD, Harris, RC Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule. J Clin Invest, 95(5), 2012-9, 1995.
• Harris, RC, Martinez-Maldonado, M Angiotensin II-mediated renal injury. Miner Electrolyte Metab, 21(4-5), 328-35, 1995.
• Homma, T., Sakai, M., Yasuda, T. Cheng, H-F., Coffey, Jr., R.J. and Harris, RC "Heparin-binding epidermal growth factor-like growth factor mRNA increases in response to acute renal injury." J. Clin. Invest., 961018-1025, 1995.
• Homma, T, Sakai, M, Cheng, HF, Yasuda, T, Coffey, RJ, Harris, RC Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. J Clin Invest, 96(2), 1018-25, 1995.
• Becker, BN, Cheng, HF, Burns, KD, Harris, RC Polarized rabbit type 1 angiotensin II receptors manifest differential rates of endocytosis and recycling. Am J Physiol, 269(4 Pt 1), C1048-56, 1995.
• Burns, KD, Capdevila, J, Wei, S, Breyer, MD, Homma, T, Harris, RC Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule. Am J Physiol, 269(4 Pt 1), C831-40, 1995.
• Threadgill, D.W., Dlugosz, A.A., Hansen, L., Tennenbaum, T., Lichi, U., Yee, D, LeMantia, C., Mourton, T., Herrup, K., Harris, RC, Barnard, J.A., Yuspa,S.H., Coffey, and Magnuson, T "Targeted disruption of mouse EGF-receptor: Evidence that genetic background affects mutant phenotype." Science, 269230-234, 1995.
• Harris, RC, McKanna, JA, Akai, Y, Jacobson, HR, Dubois, RN, Breyer, MD Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest, 94(6), 2504-10, 1994.
• Harris, R.C., McKanna, J.A., Akai, Y., Jacobson, H.R., Dubois, R.N. and Breyer, M.D "Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction." J. Clin. Invest, 942504-2510, 1994.
• Harris, RC, Ismail, N Extrarenal complications of the nephrotic syndrome. Am J Kidney Dis, 23(4), 477-97, 1994.
• Akai, Y, Homma, T, Burns, KD, Yasuda, T, Badr, KF, Harris, RC Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase. Am J Physiol, 267(2 Pt 1), C482-90, 1994.
• Cheng, HF, Burns, KD, Harris, RC Reduced proximal tubule angiotensin II receptor expression in streptozotocin-induced diabetes mellitus. Kidney Int, 46(6), 1603-10, 1994.
• Harris, RC, Akai, Y, Yasuda, T, Homma, T Role of physical factors in the regulation of mesangial cell growth and the interaction with vasoactive agents. Exp Nephrol, 2(2), 104, 1994.
• Harris, RC, Akai, Y, Yasuda, T, Homma, T The role of physical forces in alterations of mesangial cell function. Kidney Int Suppl, 45S17-21, 1994.
• Burns, K.D., Inagami, T. and Harris, R.C "Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium." Am. J. Physiol, 264F645-F654, 1993.
• Burns, KD, Inagami, T, Harris, RC Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium. Am J Physiol, 264(4 Pt 2), F645-54, 1993.
• Homma, T, Zhang, JY, Shimizu, T, Prakash, C, Blair, IA, Harris, RC Cyclooxygenase-derived metabolites of 8,9-epoxyeicosatrienoic acid are potent mitogens for cultured rat glomerular mesangial cells. Biochem Biophys Res Commun, 191(1), 282-8, 1993.
• Harris, RC, Burns, KD, Alattar, M, Homma, T, Nakamura, T Hepatocyte growth factor stimulates phosphoinositide hydrolysis and mitogenesis in cultured renal epithelial cells. Life Sci, 52(13), 1091-100, 1993.
• Takahashi, K, Harris, RC, Capdevila, JH, Karara, A, Makita, K, Jacobson, HR, Munger, KA, Badr, KF Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: counterregulation of hyperfiltration. J Am Soc Nephrol, 3(8), 1496-500, 1993.
• Burns, KD, Homma, T, Harris, RC The intrarenal renin-angiotensin system. Semin Nephrol, 13(1), 13-30, 1993.
• Homma, T. Akai, Y. Burns, K.D. and Harris, R.C "Activation of S6 kinase activity by repeated cycles of stretching and relaxation in cultured rat glomerular mesangial cells:Evidence for involvement of protein kinase C." 5J. Biol.Chem., 26723129-2313, 1992.
• Homma, T, Akai, Y, Burns, KD, Harris, RC Activation of S6 kinase by repeated cycles of stretching and relaxation in rat glomerular mesangial cells. Evidence for involvement of protein kinase C. J Biol Chem, 267(32), 23129-35, 1992.
• Harris, RC, Haralson, MA, Badr, KF Continuous stretch-relaxation in culture alters rat mesangial cell morphology, growth characteristics, and metabolic activity. Lab Invest, 66(5), 548-54, 1992.
• McKanna, JA, Chuncharunee, A, Munger, KA, Breyer, JA, Cohen, S, Harris, RC Localization of p35 (annexin I, lipocortin I) in normal adult rat kidney and during recovery from ischemia. J Cell Physiol, 153(3), 467-76, 1992.
• Harris, R.C "S6 kinase activity in proximal tubule cells. Evidence for activation by epidermal growth factor and angiotensin II in vitro and by contralateral nephrectomy in vivo." Am. J. Physiol., 263F127-F134, 1992.
• Harris, RC Potential physiologic roles for epidermal growth factor in the kidney. Am J Kidney Dis, 17(6), 627-30, 1991.
• Awazu, M, Kon, V, Harris, RC, Imada, T, Inagami, T, Ichikawa, I Renal sympathetic nerves modulate glomerular ANP receptors and filtration. Am J Physiol, 261(1 Pt 2), F29-35, 1991.
• Homma, T, Harris, RC Time-dependent biphasic regulation of Na+/K+/Cl- cotransport in rat glomerular mesangial cells. J Biol Chem, 266(21), 13553-9, 1991.
• Homma, T. and Harris, R.C "Time-dependent biphasic regulation of Na+/K+/Cl- cotransport in rat glomerular mesangial cells." J. Biol. Chem., 26613553-13559, 1991.
• Kon, V., Harris, R.C. and Ichikawa, I "A regulatory role for large vessels in organ circulation: Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat." J. Clin. Invest, 851728-1733, 1990.
• Kon, V, Harris, RC, Ichikawa, I A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat. J Clin Invest, 85(6), 1728-33, 1990.
• Homma, T., Burns, K. and Harris R.C "Agonist stimulation of Na/K/Cl cotransport in cultured rat mesangial cells: Evidence for protein kinase C-dependent and calcium/calmodulin-dependent pathways." J. Biol. Chem., 265:17613-17620, 1990.
• Harris, RC, Homma, T, Jacobson, HR, Capdevila, J Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. J Cell Physiol, 144(3), 429-37, 1990.
• Harris, RC, Munger, KA, Badr, KF, Takahashi, K Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites. FASEB J, 4(6), 1654-60, 1990.
• Harris, RC, Badr, KF Recovery of prostaglandin synthesis in rat glomerular mesangial cells after aspirin inhibition: induction of cyclooxygenase activity by serum and epidermal growth factor. Prostaglandins, 39(2), 213-22, 1990.
• Harris, RC, Daniel, TO Epidermal growth factor binding, stimulation of phosphorylation, and inhibition of gluconeogenesis in rat proximal tubule. J Cell Physiol, 139(2), 383-91, 1989.
• Badr, KF, DeBoer, DK, Takahashi, K, Harris, RC, Fogo, A, Jacobson, HR Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2. Am J Physiol, 256(1 Pt 2), F35-43, 1989.
• Badr, KF, Mong, S, Hoover, RL, Schwartzberg, M, Ebert, J, Jacobson, HR, Harris, RC Leukotriene D4 binding and signal transduction in rat glomerular mesangial cells. Am J Physiol, 257(2 Pt 2), F280-7, 1989.
• Badr, KF, Murray, JJ, Breyer, MD, Takahashi, K, Inagami, T, Harris, RC Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways. J Clin Invest, 83(1), 336-42, 1989.
• Badr, K.F., Murray, J.J., Breyer, M.D., Takahashi, K., Inagami, T. and Harris, R.C "Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney: Elucidation of signal transduction pathways." J. Clin.Invest, 83336-342, 1989.
• Harris, R.C., Hoover, R.L., Jacobson, H.R. and Badr, K.F "Evidence for glomerular actions of epidermal growth factor in the rat." J. Clin Invest., 821028-1039, 1988.