The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
Robert J. Matusik, Ph.D.
See also:
Professor of Urological Surgery, Cell & Developmental Biology and Cancer Biology
Director of Urologic Surgery Research
VICC Member
Researcher
Contact Information:
Vanderbilt University Medical Center
A-1302 Medical Center North
Nashville, TN 37232-2765
615-343-1902
Profile
Robert Matusik is professor of Urologic Surgery, Cancer Biology and Cell & Developmental Biology at Vanderbilt University School of Medicine and director of Urologic Research in the department of Urologic Surgery. He earned his PhD in biochemistry at the University of Rochester in New York in 1976 and completed a post-doctoral fellowship in cell biology at the Baylor College of Medicine in 1979.
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Robert Matusik is professor of Urologic Surgery, Cancer Biology and Cell & Developmental Biology at Vanderbilt University School of Medicine and director of Urologic Research in the department of Urologic Surgery. He earned his PhD in biochemistry at the University of Rochester in New York in 1976 and completed a post-doctoral fellowship in cell biology at the Baylor College of Medicine in 1979. Matusik joined the faculty of the University of Manitoba (Canada) Department of Physiology in 1979 and grew through the ranks to the position of full professor by the time he left in 1996 to join Vanderbilt?s faculty. He also served as a visit scientist for the British Columbia Cancer Agency, based in Vancouver, from 1992-1993.
Matusik holds numerous research grants from the National Institutes of Health and U.S. Department of Defense to support his research into the genetic, molecular and hormonal factors that contribute to the development and progression of prostate cancer. He also serves as a co-investigator in a Department of Defense grant to support development of a prostate cancer program at Meharry Medical College, a historically black institution in Nashville and a collaborator with Vanderbilt through the Meharry-Vanderbilt Alliance.
A former Damon Runyon-Walter Winchell fellow, Matusik has served on numerous study sections, site visit teams and review committees for the National Institutes of Health, the Department of Defense and the Department of Veterans Affairs. He also served on the editorial board of the journal Molecular Endocrinology.
Research Specialty
Androgen Regulation of Gene Expression, Transgenic Mouse Models for Prostate Cancer, and Gene Therapy
Research Description
In North America, one in ten men is diagnosed with prostate cancer. Prostate cancer starts as an androgen dependent disease that progresses to an androgen independent cancer. The androgen independent tumors fail therapy. One of the major impediments to prostate cancer research is that no appropriate animal model system adequately displays the recognized stages of human prostatic disease. Further, no new therapeutic approaches have been developed after current therapy fails. Our laboratory has developed the probasin (PB) gene as a model system for androgen action, to establish new transgenic animal models for prostate cancer, and to test new therapeutic approaches for treatment.
The androgen receptor (AR) can function through similar cis-acting DNA elements similar to the palindromic glucocorticoid response element; however, recent data has shown that distinct AR elements (ARE) exist and function via cooperative interactions of multiple elements in the PB promoter. Further, since the PB promoter directs prostate specific expression in transgenic mice, it has become a model to dissect the key cis-acting DNA elements that control prostate-specific gene expression. Our laboratory has designed new PB promoters that target high levels of transgene expression to the prostate. These new promoters now serve to create new animal models for prostate cancer and to develop gene therapy vectors that will target a therapeutic gene(s) in the treatment of prostate cancer.
The PB promoter has been linked to oncogenes and growth factors to create new transgenic mouse models for prostate cancer. Transgenic mice carrying PB-oncogenes develop various stages of disease including prostatic precursor lesions that advance to an adenocarcinoma and then to high grade metastatic cancer. Gene expression profiles are being analyzed in these animal models to identify the key genes involved in tumor progression. By identifying the genes that are responsible for tumor progression, we can develop new targets for therapeutic intervention. .
Publications
- Yu, X, Wang, Y, DeGraff, DJ, Wills, ML, Matusik, RJ Wnt/β-catenin activation promotes prostate tumor progression in a mouse model. Oncogene, 30(16), 1868-79, 2011.
- Zhang, J, Gao, N, DeGraff, DJ, Yu, X, Sun, Q, Case, TC, Kasper, S, Matusik, RJ Characterization of cis elements of the probasin promoter necessary for prostate-specific gene expression. Prostate, 70(9), 934-51, 2010.
- Jiang, M, Fernandez, S, Jerome, WG, He, Y, Yu, X, Cai, H, Boone, B, Yi, Y, Magnuson, MA, Roy-Burman, P, Matusik, RJ, Shappell, SB, Hayward, SW Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ, 17(3), 469-81, 2010.
- Nandana, S, Ellwood-Yen, K, Sawyers, C, Wills, M, Weidow, B, Case, T, Vasioukhin, V, Matusik, R Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model. Prostate, 70(6), 591-600, 2010.
- Yu, X, Wang, Y, Jiang, M, Bierie, B, Roy-Burman, P, Shen, MM, Taketo, MM, Wills, M, Matusik, RJ Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration. Prostate, 69(3), 249-62, 2009.
- Anumanthan, G, Tanaka, ST, Adams, CM, Thomas, JC, Wills, ML, Adams, MC, Hayward, SW, Matusik, RJ, Bhowmick, NA, Brock, JW, Pope, JC Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction. J Urol, 182(4 Suppl), 1775-80, 2009.
- Sun, Q, Yu, X, Degraff, DJ, Matusik, RJ Upstream stimulatory factor 2, a novel FoxA1-interacting protein, is involved in prostate-specific gene expression. Mol Endocrinol, 23(12), 2038-47, 2009.
- Li, X, Wang, Y, Sharif-Afshar, AR, Uwamariya, C, Yi, A, Ishii, K, Hayward, SW, Matusik, RJ, Bhowmick, NA Urothelial transdifferentiation to prostate epithelia is mediated by paracrine TGF-beta signaling. Differentiation, 77(1), 95-102, 2009.
- Anumanthan, G, Makari, JH, Honea, L, Thomas, JC, Wills, ML, Bhowmick, NA, Adams, MC, Hayward, SW, Matusik, RJ, Brock, JW, Pope, JC Directed differentiation of bone marrow derived mesenchymal stem cells into bladder urothelium. J Urol, 180(4 Suppl), 1778-83, 2008.
- Jin, RJ, Lho, Y, Wang, Y, Ao, M, Revelo, MP, Hayward, SW, Wills, ML, Logan, SK, Zhang, P, Matusik, RJ Down-regulation of p57Kip2 induces prostate cancer in the mouse. Cancer Res, 68(10), 3601-8, 2008.
- Gupta, A, Wang, Y, Browne, C, Kim, S, Case, T, Paul, M, Wills, ML, Matusik, RJ Neuroendocrine differentiation in the 12T-10 transgenic prostate mouse model mimics endocrine differentiation of pancreatic beta cells. Prostate, 68(1), 50-60, 2008.
- Matusik, RJ, Jin, RJ, Sun, Q, Wang, Y, Yu, X, Gupta, A, Nandana, S, Case, TC, Paul, M, Mirosevich, J, Oottamasathien, S, Thomas, J Prostate epithelial cell fate. Differentiation, 2008.
- Martinez-Ferrer, M, Iturregui, JM, Uwamariya, C, Starkman, J, Sharif-Afshar, AR, Suzuki, K, Visedsindh, W, Matusik, RJ, Dmochowski, RR, Bhowmick, NA Role of nicotinic and estrogen signaling during experimental acute and chronic bladder inflammation. Am J Pathol, 172(1), 59-67, 2008.
- Placencio, VR, Sharif-Afshar, AR, Li, X, Huang, H, Uwamariya, C, Neilson, EG, Shen, MM, Matusik, RJ, Hayward, SW, Bhowmick, NA Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity. Cancer Res, 68(12), 4709-18, 2008.
- Thomas, JC, Oottamasathien, S, Makari, JH, Honea, L, Sharif-Afshar, AR, Wang, Y, Adams, C, Wills, ML, Bhowmick, NA, Adams, MC, Brock, JW, Hayward, SW, Matusik, RJ, Pope, JC Temporal-spatial protein expression in bladder tissue derived from embryonic stem cells. J Urol, 180(4 Suppl), 1784-9, 2008.
- Jin, RJ, Lho, Y, Connelly, L, Wang, Y, Yu, X, Saint Jean, L, Case, TC, Ellwood-Yen, K, Sawyers, CL, Bhowmick, NA, Blackwell, TS, Yull, FE, Matusik, RJ The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Cancer Res, 68(16), 6762-9, 2008.
- Oottamasathien, S, Wang, Y, Williams, K, Franco, OE, Wills, ML, Thomas, JC, Saba, K, Sharif-Afshar, AR, Makari, JH, Bhowmick, NA, Demarco, RT, Hipkens, S, Magnuson, M, Brock, JW, Hayward, SW, Pope, JC, Matusik, RJ Directed differentiation of embryonic stem cells into bladder tissue. Dev Biol, 304(2), 556-566, 2007.
- Suzuki, K, Yu, X, Chaurand, P, Araki, Y, Lareyre, JJ, Caprioli, RM, Orgebin-Crist, MC, Matusik, RJ Epididymis-specific lipocalin promoters. Asian J Androl, 9(4), 515-21, 2007.
- Wang, Y, Kasper, S, Yuan, J, Jin, RJ, Zhang, J, Ishii, K, Wills, ML, Hayward, SW, Matusik, RJ Androgen-dependent prostate epithelial cell selection by targeting ARR(2)PBneo to the LPB-Tag model of prostate cancer. Lab Invest, 86(10), 1074-88, 2006.
- Shao, TC, Li, HL, Kasper, S, Matusik, R, Ittmann, M, Cunningham, GR Comparison of the growth-promoting effects of testosterone and 7-alpha-methyl-19-nor-testosterone (MENT) on the prostate and levator ani muscle of LPB-tag transgenic mice. Prostate, 66(4), 369-76, 2006.
- Lees, JR, Charbonneau, B, Swanson, AK, Jensen, R, Zhang, J, Matusik, R, Ratliff, TL Deletion is neither sufficient nor necessary for the induction of peripheral tolerance in mature CD8+ T cells. Immunology, 117(2), 248-61, 2006.
- Suzuki, K, Yu, X, Chaurand, P, Araki, Y, Lareyre, JJ, Caprioli, RM, Matusik, RJ, Orgebin-Crist, MC Epididymis-specific promoter-driven gene targeting: A transcription factor which regulates epididymis-specific gene expression. Mol Cell Endocrinol, 250184-189, 2006.
- Mirosevich, J, Gao, N, Gupta, A, Shappell, SB, Jove, R, Matusik, RJ Expression and role of Foxa proteins in prostate cancer. Prostate, 66(10), 1013-1028, 2006.
- Uchida, K, Masumori, N, Takahashi, A, Itoh, N, Kato, K, Matusik, RJ, Tsukamoto, T Murine androgen-independent neuroendocrine carcinoma promotes metastasis of human prostate cancer cell line LNCaP. Prostate, 66(5), 536-45, 2006.
- Lees, JR, Charbonneau, B, Hayball, JD, Diener, K, Brown, M, Matusik, R, Cohen, MB, Ratliff, TL T-cell recognition of a prostate specific antigen is not sufficient to induce prostate tissue destruction. Prostate, 66(6), 578-90, 2006.
- Yu, X, Suzuki, K, Wang, Y, Gupta, A, Jin, R, Orgebin-Crist, MC, Matusik, R The Role of Forkhead Box A2 (Foxa2) to Restrict Androgen Regulated Gene Expression of Lipocalin 5 in the Mouse Epididymis. Mol Endocrinol, 102418-2431, 2006.
- Yi, Y, Mirosevich, J, Shyr, Y, Matusik, R, George, AL Coupled analysis of gene expression and chromosomal location. Genomics, 85(3), 401-12, 2005.
- Mirosevich, J, Gao, N, Matusik, RJ Expression of Foxa transcription factors in the developing and adult murine prostate. Prostate, 62(4), 339-52, 2005.
- Gao, N, Ishii, K, Mirosevich, J, Kuwajima, S, Oppenheimer, SR, Roberts, RL, Jiang, M, Yu, X, Shappell, SB, Caprioli, RM, Stoffel, M, Hayward, SW, Matusik, RJ Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development, 132(15), 3431-43, 2005.
- Yu, X, Gupta, A, Wang, Y, Suzuki, K, Mirosevich, J, Orgebin-Crist, MC, Matusik, RJ Foxa1 and foxa2 interact with the androgen receptor to regulate prostate and epididymal genes differentially. Ann N Y Acad Sci, 106177-93, 2005.
- Best, CJ, Gillespie, JW, Yi, Y, Chandramouli, GV, Perlmutter, MA, Gathright, Y, Erickson, HS, Georgevich, L, Tangrea, MA, Duray, PH, González, S, Velasco, A, Linehan, WM, Matusik, RJ, Price, DK, Figg, WD, Emmert-Buck, MR, Chuaqui, RF Molecular alterations in primary prostate cancer after androgen ablation therapy. Clin Cancer Res, 11(19 Pt 1), 6823-34, 2005.
- Ishii, K, Shappell, SB, Matusik, RJ, Hayward, SW Use of tissue recombination to predict phenotypes of transgenic mouse models of prostate carcinoma. Lab Invest, 851086-1103, 2005.
- Masumori, Naoya, Tsuchiya, Karen, Tu, William H, Lee, Charles, Kasper, Susan, Tsukamoto, Taiji, Shappell, Scott B, Matusik, Robert J An allograft model of androgen independent prostatic neuroendocrine carcinoma derived from a large probasin promoter-T antigen transgenic mouse line. J Urol, 171(1), 439-42, 2004.
- Zhang, JianFeng, Gao, Nan, Kasper, Susan, Reid, Kimberly, Nelson, Colleen, Matusik, Robert J An androgen-dependent upstream enhancer is essential for high levels of probasin gene expression. Endocrinology, 145(1), 134-48, 2004.
- Suzuki, Kichiya, Drevet, Joel, Hinton, Barry T, Huhtaniemi, Ilpo, Lareyre, Jean-Jacques, Matusik, Robert J, Pons, Eric, Poutanen, Matti, Sipilä, Petra, Orgebin-Crist, Marie-Claire Epididymis-specific promoter-driven gene targeting: a new approach to control epididymal function. Mol Cell Endocrinol, 216(1-2), 15-22, 2004.
- Klezovitch, O, Chevillet, J, Mirosevich, J, Roberts, RL, Matusik, RJ, Vasioukhin, V Hepsin promotes prostate cancer progression and metastasis. Cancer Cell, 6(2), 185-95, 2004.
- Kirchhoff, Christiane, Araki, Yoshihiko, Huhtaniemi, Ilpo, Matusik, Robert J, Osterhoff, Caroline, Poutanen, Matti, Samalecos, Annemarie, Sipilä, Petra, Suzuki, Kichiya, Orgebin-Crist, Marie-Claire Immortalization by large T-antigen of the adult epididymal duct epithelium. Mol Cell Endocrinol, 216(1-2), 83-94, 2004.
- Suzuki, K, Lareyre, JJ, Sánchez, D, Gutierrez, G, Araki, Y, Matusik, RJ, Orgebin-Crist, MC Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2. Gene, 33949-59, 2004.
- Jin, RJ, Wang, Y, Masumori, N, Ishii, K, Tsukamoto, T, Shappell, SB, Hayward, SW, Kasper, S, Matusik, RJ NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice. Cancer Res, 64(15), 5489-95, 2004.
- Shappell, Scott B, Olson, Sandra J, Hannah, S Erin, Manning, Suzanne, Roberts, Richard L, Masumori, Naoya, Jisaka, Mitsuo, Boeglin, William E, Vader, Virginia, Dave, Dhiren S, Shook, M Frances, Thomas, Tania Z, Funk, Colin D, Brash, Alan R, Matusik, Robert J Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma. Cancer Res, 632256-67, 2003.
- Fouchécourt, Sophie, Lareyre, Jean-Jacques, Chaurand, Pierre, DaGue, Beverly B, Suzuki, Kichiya, Ong, David E, Olson, Gary E, Matusik, Robert J, Caprioli, Richard M, Orgebin-Crist, Marie-Claire Identification, immunolocalization, regulation, and postnatal development of the lipocalin EP17 (epididymal protein of 17 kilodaltons) in the mouse and rat epididymis. Endocrinology, 144887-900, 2003.
- Ellwood-Yen, K, Graeber, TG, Wongvipat, J, Iruela-Arispe, ML, Zhang, J, Matusik, R, Thomas, GV, Sawyers, CL Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell, 4(3), 223-38, 2003.
- Wen, Yong, Giri, Dipak, Yan, Duen-Hwa, Spohn, Bill, Zinner, Ralph G, Xia, Weiya, Thompson, Timothy C, Matusik, Robert J, Hung, Mien-Chie Prostate-specific antitumor activity by probasin promoter-directed p202 expression. Mol Carcinog, 37(3), 130-7, 2003.
- Suzuki, Kichiya, Araki, Yoshihiko, Zhu, Mei-Ying, Lareyre, Jean-Jacques, Matusik, Robert J, Orgebin-Crist, Marie-Claire The 5'-flanking region of the murine epididymal protein of 17 kilodaltons gene targets transgene expression in the epididymis. Endocrinology, 144877-86, 2003.
- Gao, Nan, Zhang, Jianfeng, Rao, Mira A., Case, Thomas C., Mirosevich, Janni, Wang, Yongqing, Jin, Renjie, Gupta, Aparna, Rennie, Paul S., Matusik, Robert J The Role of Hepatocyte Nuclear Factor-3{alpha} (Foxa1) and Androgen Receptor in Transcriptional Regulation of Prostatic Genes. Mol Endocrinol, (17), 1484-1507, 2003.
- Tu, William H, Thomas, Tania Z, Masumori, Naoya, Bhowmick, Neil A, Gorska, Agnieszka E, Shyr, Yu, Kasper, Susan, Case, Tom, Roberts, Richard L, Shappell, Scott B, Moses, Harold L, Matusik, Robert J The loss of TGF-beta signaling promotes prostate cancer metastasis. Neoplasia, 5(3), 267-77, 2003.
- Shappell SB., Masumori M, Thomas TZ, Case T, Paul M, Kasper S, Matusik RJ. "Transgenic mouse models of prostate carcinoma: Anatomic, Histopathologic, and molecular considerations.." In: Prostate Cancer: Scientific and Clinical Aspects of Bridging the Gap, ed. by PD Abel and E-N Lalani. Imperial College Press (London), , 245-319(Chapter 3), 2003.
- Fouchécourt, Sophie, Chaurand, Pierre, DaGue, Beverly B, Lareyre, Jean-Jacques, Matusik, Robert J, Caprioli, Richard M, Orgebin-Crist, Marie-Claire Epididymal lipocalin-type prostaglandin D2 synthase: identification using mass spectrometry, messenger RNA localization, and immunodetection in mouse, rat, hamster, and monkey. Biol Reprod, 66(2), 524-33, 2002.
- Song, Zhigang, Wu, Xiantuo, Powell, William C, Cardiff, Robert D, Cohen, Michael B, Tin, Robert T, Matusik, Robert J, Miller, Gary J, Roy-Burman, Pradip Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasia. Cancer Res, 62(17), 5096-105, 2002.
- Araki, Yoshihiko, Suzuki, Kichiya, Matusik, Robert J, Obinata, Masuo, Orgebin-Crist, Marie-Claire Immortalized epididymal cell lines from transgenic mice overexpressing temperature-sensitive simian virus 40 large T-antigen gene. J Androl, 23(6), 854-69, 2002.
- Logg, Christopher R, Logg, Aki, Matusik, Robert J, Bochner, Bernard H, Kasahara, Noriyuki Tissue-specific transcriptional targeting of a replication-competent retroviral vector. J Virol, 7612783-91, 2002.
- Shappell, S B, Gupta, R A, Manning, S, Whitehead, R, Boeglin, W E, Schneider, C, Case, T, Price, J, Jack, G S, Wheeler, T M, Matusik, R J, Brash, A R, Dubois, R N 15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells. Cancer Res, 61(2), 497-503, 2001.
- Masumori, N, Thomas, T Z, Chaurand, P, Case, T, Paul, M, Kasper, S, Caprioli, R M, Tsukamoto, T, Shappell, S B, Matusik, R J A probasin-large T antigen transgenic mouse line develops prostate adenocarcinoma and neuroendocrine carcinoma with metastatic potential. Cancer Res, 61(5), 2239-49, 2001.
- Xie, X, Zhao, X, Liu, Y, Zhang, J, Matusik, R J, Slawin, K M, Spencer, D M Adenovirus-mediated tissue-targeted expression of a caspase-9-based artificial death switch for the treatment of prostate cancer. Cancer Res, 61(18), 6795-804, 2001.
- Lareyre, J J, Winfrey, V P, Kasper, S, Ong, D E, Matusik, R J, Olson, G E, Orgebin-Crist, M C Gene duplication gives rise to a new 17-kilodalton lipocalin that shows epididymal region-specific expression and testicular factor(s) regulation. Endocrinology, 142(3), 1296-308, 2001.
- Wu, X, Wu, J, Huang, J, Powell, W C, Zhang, J, Matusik, R J, Sangiorgi, F O, Maxson, R E, Sucov, H M, Roy-Burman, P Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation. Mech Dev, 101(1-2), 61-9, 2001.
- Buchanan, G, Yang, M, Harris, J M, Nahm, H S, Han, G, Moore, N, Bentel, J M, Matusik, R J, Horsfall, D J, Marshall, V R, Greenberg, N M, Tilley, W D Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function. Mol Endocrinol, 15(1), 46-56, 2001.
- Andriani, F, Nan, B, Yu, J, Li, X, Weigel, N L, McPhaul, M J, Kasper, S, Kagawa, S, Fang, B, Matusik, R J, Denner, L, Marcelli, M Use of the probasin promoter ARR2PB to express Bax in androgen receptor-positive prostate cancer cells. J Natl Cancer Inst, 93(17), 1314-24, 2001.
- Zhang, J, Thomas, T Z, Kasper, S, Matusik, R J A small composite probasin promoter confers high levels of prostate-specific gene expression through regulation by androgens and glucocorticoids in vitro and in vivo. Endocrinology, 141(12), 4698-710, 2000.
- Lareyre, J J, Reid, K, Nelson, C, Kasper, S, Rennie, P S, Orgebin-Crist, M C, Matusik, R J Characterization of an androgen-specific response region within the 5' flanking region of the murine epididymal retinoic acid binding protein gene. Biol Reprod, 63(6), 1881-92, 2000.
- Kasper, S, Matusik, R J Rat probasin: structure and function of an outlier lipocalin. Biochim Biophys Acta, 1482(1-2), 249-58, 2000.
- Lareyre, J J, Thomas, T Z, Zheng, W L, Kasper, S, Ong, D E, Orgebin-Crist, M C, Matusik, R J A 5-kilobase pair promoter fragment of the murine epididymal retinoic acid-binding protein gene drives the tissue-specific, cell-specific, and androgen-regulated expression of a foreign gene in the epididymis of transgenic mice. J Biol Chem, 274(12), 8282-90, 1999.
- Brash, AR, Jisaka, M, Boeglin, WE, Chang, MS, Keeney, DS, Nanney, LB, Kasper, S, Matusik, RJ, Olson, SJ, Shappell, SB Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues. Adv Exp Med Biol, 46983-9, 1999.
- Kasper, S, Rennie, P S, Bruchovsky, N, Lin, L, Cheng, H, Snoek, R, Dahlman-Wright, K, Gustafsson, J A, Shiu, R P, Sheppard, P C, Matusik, R J Selective activation of the probasin androgen-responsive region by steroid hormones. J Mol Endocrinol, 22(3), 313-25, 1999.
- Bai, G, Kasper, S, Matusik, R J, Rennie, P S, Moshier, J A, Krongrad, A Androgen regulation of the human ornithine decarboxylase promoter in prostate cancer cells. J Androl, 19(2), 127-35, 1998.
- Kasper, S, Sheppard, PC, Yan, Y, Pettigrew, N, Borowsky, AD, Prins, GS, Dodd, JG, Duckworth, ML, Matusik, RJ Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer. Lab Invest, 78(6), i-xv, 1998.
- Kasper, S, Sheppard, P C, Yan, Y, Pettigrew, N, Borowsky, A D, Prins, G S, Dodd, J G, Duckworth, M L, Matusik, R J Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer. Lab Invest, 78(3), 319-33, 1998.
- Snoek, R, Bruchovsky, N, Kasper, S, Matusik, R J, Gleave, M, Sato, N, Mawji, N R, Rennie, P S Differential transactivation by the androgen receptor in prostate cancer cells. Prostate, 36(4), 256-63, 1998.
- Lareyre JJ, Mattei M-G, Kasper S, Ong DE, Matusik RJ and Orgebin-Crist M-C "Genomic organization and chromosomal localization of the murine epididymal retinoic acid binding protein (mE-RABP) gene." Mol. Reprod. and Dev, 50387-395, 1998.
- Lareyre, J J, Mattéi, M G, Kasper, S, Ong, D E, Matusik, R J, Orgebin-Crist, M C Genomic organization and chromosomal localization of the murine epididymal retinoic acid-binding protein (mE-RABP) gene. Mol Reprod Dev, 50(4), 387-95, 1998.
- Chan, J, Song, C S, Matusik, R J, Chatterjee, B, Roy, A K Inhibition of androgen action by dehydroepiandrosterone sulfotransferase transfected in PC-3 prostate cancer cells. Chem Biol Interact, 109(1-3), 267-78, 1998.
- Lareyre JJ, Zheng WL, Zhao GQ, Kasper S, Newcomer ME, Matusik RJ, Ong DE and Orgebin-Crist MC "Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein mRNA." Endocrinol, 1392971-2981, 1998.
- Lareyre, J J, Zheng, W L, Zhao, G Q, Kasper, S, Newcomer, M E, Matusik, R J, Ong, D E, Orgebin-Crist, M C Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein messenger ribonucleic acid. Endocrinology, 139(6), 2971-81, 1998.
- Lareyre JJ, Mattei M-G, Kasper S, Newcomer ME, Ong DE, Matusik RJ and Orgebin- Crist M-C "Structure and putative function of a murine epididymal retinoic acid-binding protein (mE-RABP)." J. of Reprod. and Fert. Supplement , 5359-65, 1998.
- Lareyre, J J, Mattéi, M G, Kasper, S, Newcomer, M E, Ong, D E, Matusik, R J, Orgebin-Crist, M C Structure and putative function of a murine epididymal retinoic acid-binding protein (mE-RABP). J Reprod Fertil Suppl, 5359-65, 1998.
- Green, JE, Greenberg, NM, Ashendel, CL, Barrett, JC, Boone, C, Getzenberg, RH, Henkin, J, Matusik, R, Janus, TJ, Scher, HI Workgroup 3: transgenic and reconstitution models of prostate cancer. Prostate, 36(1), 59-63, 1998.
- Yan, Y, Sheppard, P C, Kasper, S, Lin, L, Hoare, S, Kapoor, A, Dodd, J G, Duckworth, M L, Matusik, R J Large fragment of the probasin promoter targets high levels of transgene expression to the prostate of transgenic mice. Prostate, 32(2), 129-39, 1997.
- Leonard MP, Sareen S, Hills K, Sheppard PC and Matusik RJ "Early characterization of a novel metastatic disease model of murine neuroblastoma." J. of Urol, 1565696-700, 1996.
- Snoek, R, Rennie, P S, Kasper, S, Matusik, R J, Bruchovsky, N Induction of cell-free, in vitro transcription by recombinant androgen receptor peptides. J Steroid Biochem Mol Biol, 59(3-4), 243-50, 1996.
- Barrios R, Lebovitz RM, Wiseman AL, Weisoly DL, Matusik RJ, DeMayo F and Lieberman MW "Ras T24 driven by a probasin promoter induces prostatic hyperplasia in transgenic mice." Transgenics, 223-28, 1996.
- Levy I, Matusik RJ, Dodd J, Gallagher R and Meyer F "Joint workshop on laboratory aspects of proposed national prostate cancer screening trial: Part II. The establishment of a biorepository (Laboratory Centre for Disease Control, Health Canada)." Chronic Diseases of Canada, 16129-130, 1995.
- Greenberg, N M, DeMayo, F, Finegold, M J, Medina, D, Tilley, W D, Aspinall, J O, Cunha, G R, Donjacour, A A, Matusik, R J, Rosen, J M Prostate cancer in a transgenic mouse. Proc Natl Acad Sci U S A, 92(8), 3439-43, 1995.
- Dubé, J Y, Chapdelaine, P, Guérin, S, Leclerc, S, Rennie, P S, Matusik, R J, Tremblay, R R Search for androgen response elements in the proximal promoter of the canine prostate arginine esterase gene. J Androl, 16(4), 304-11, 1995.
- Kasper S, Rennie PS, Bruchovsky N, Sheppard PC, Cheng H, Lin L, Shin RPC, Snoek R and Matusik RJ "Cooperative binding of androgen receptors to two DNA sequences is required for androgen induction of the probasin gene." J. of Biol. Chem, 26931763-31769, 1994.
- Dedhar, S, Rennie, P S, Shago, M, Hagesteijn, C Y, Yang, H, Filmus, J, Hawley, R G, Bruchovsky, N, Cheng, H, Matusik, R J Inhibition of nuclear hormone receptor activity by calreticulin. Nature, 367(6462), 480-3, 1994.
- Greenberg NM, DeMayo FJ, Sheppard PC, Barrios R, Lebovitz R, Finegold M, Dodd JG, Duckworth ML, Rosen RJ and Matusik R "The rat probasin gene promoter directs hormonally-and developmentally-regulated expression of a heterologous gene specifically to the prostate in transgenic mice." Molecular Endocrinology, 8230-239, 1994.
- Rennie PS, Bruchovsky N, Leco KJ, Sheppard PC, McQueen SA, Cheng H, Snoek R, Hamel A, Block ME, MacDonald BS Nickel BE, Chang C, Liao, S, Cattini PA and Matusik RJ "Characterization of two cis-acting elements involved in the androgen regulation of the probasin gene." Molecular Endocrinology, 723-36, 1993.
- Kazemi-Esfajani P, Beitel L, Trifiro M, Kaufman M, Rennie PS, Sheppard P, Matusik RJ, and Pinsky L "Substitution of valine 865 by methionine or leucine causes complete or partial androgen insensitivity, respectively with distinct androgen receptor phenotype." Molecular Endocrinology, 737-46, 1993.
- Berczi, I, Nagy, E, de Toledo, S M, Matusik, R J, Friesen, H G Pituitary hormones regulate c-myc and DNA synthesis in lymphoid tissue. J Immunol, 146(7), 2201-6, 1991.
- Harris, S E, Harris, M A, Johnson, C M, Bean, M F, Dodd, J G, Matusik, R J, Carr, S A, Crabb, J W Structural characterization of the rat seminal vesicle secretion II protein and gene. J Biol Chem, 265(17), 9896-903, 1990.
- Spence, A M, Sheppard, P C, Davie, J R, Matuo, Y, Nishi, N, McKeehan, W L, Dodd, J G, Matusik, R J Regulation of a bifunctional mRNA results in synthesis of secreted and nuclear probasin. Proc Natl Acad Sci U S A, 86(20), 7843-7, 1989.
- Matuo, Y, Adams, P S, Nishi, N, Yasumitsu, H, Crabb, J W, Matusik, R J, McKeehan, W L The androgen-dependent rat prostate protein, probasin, is a heparin-binding protein that co-purifies with heparin-binding growth factor-1. In Vitro Cell Dev Biol, 25(6), 581-4, 1989.
- Sweetland, R, Sheppard, P C, Dodd, J G, Matusik, R J Post-castration rebound of an androgen regulated prostatic gene. Mol Cell Biochem, 84(1), 3-15, 1988.
- Matusik, R J, Fleming, W H, Hamel, A, Westenbrink, T G, Hrabarchuk, B, MacDonald, R, Ramsey, E, Gartner, J G, Pettigrew, N M, Johnston, B Expression of the c-myc proto-oncogene in prostatic tissue. Prog Clin Biol Res, 23991-112, 1987.
- Dodd, J G, Kreis, C, Sheppard, P C, Hamel, A, Matusik, R J Effect of androgens on mRNA for a secretory protein of rat dorsolateral prostate and seminal vesicles. Mol Cell Endocrinol, 47(3), 191-200, 1986.
- Fleming, W H, Hamel, A, MacDonald, R, Ramsey, E, Pettigrew, N M, Johnston, B, Dodd, J G, Matusik, R J Expression of the c-myc protooncogene in human prostatic carcinoma and benign prostatic hyperplasia. Cancer Res, 46(3), 1535-8, 1986.
- Matusik, R J, Kreis, C, McNicol, P, Sweetland, R, Mullin, C, Fleming, W H, Dodd, J G Regulation of prostatic genes: role of androgens and zinc in gene expression. Biochem Cell Biol, 64(6), 601-7, 1986.
- Fleming, W H, Murphy, P R, Murphy, L J, Hatton, T W, Matusik, R J, Friesen, H G Human growth hormone induces and maintains c-myc gene expression in Nb2 lymphoma cells. Endocrinology, 117(6), 2547-9, 1985.
- Dodd, J G, Sheppard, P C, Matusik, R J Characterization and cloning of rat dorsal prostate mRNAs. Androgen regulation of two closely related abundant mRNAs. J Biol Chem, 258(17), 10731-7, 1983.
- Fleming, W H, Pettigrew, N M, Matusik, R J, Friesen, H G Thymic origin of the prolactin-dependent Nb2 lymphoma cell line. Cancer Res, 42(8), 3138-41, 1982.
- Rosen, J M, Matusik, R J, Richards, D A, Gupta, P, Rodgers, J R Multihormonal regulation of casein gene expression at the transcriptional and posttransciptional levels in the mammary gland. Recent Prog Horm Res, 36157-93, 1980.
- Matusik, R J, Rosen, J M Prolactin regulation of casein gene expression: possible mediators. Endocrinology, 106(1), 252-9, 1980.
- Guyette, W A, Matusik, R J, Rosen, J M Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression. Cell, 17(4), 1013-23, 1979.
- Matusik, R J, Rosen, J M Prolactin induction of casein mRNA in organ culture. A model system for studying peptide hormone regulation of gene expression. J Biol Chem, 253(7), 2343-7, 1978.
- Matusik, R J, Hilf, R Relationship of adenosine 3'',5''-cyclic monophosphate and guanosine 3'',5''-cyclic monophosphate to growth of dimethylbenz(a)anthracene-induced mammary tumors in rats. J Natl Cancer Inst, 56(3), 659-61, 1976.
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