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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

Ryoma  Ohi

Ryoma Ohi, Ph.D.

Associate Professor of Cell and Developmental Biology
Cell Biology Researcher

Contact Information:

Vanderbilt University Medical Center, Department of Cell and Developmental Biology
465 21st Avenue South, 3120B MRB III
Nashville, TN 37232-8240
Fax: 615-343-4539

  • B.S., Vanderbilt University
  • Ph.D., Vanderbilt University
  • Postdoctoral Fellowship, Harvard Medical School
Research Specialty

Microtubule organization and dynamics during cell division

Research Description

Our group studies animal cell division. During this process, the microtubule cytoskeleton is organized into a transient structure called the mitotic spindle. This apparatus attaches replicated chromosomes via kinetochores and generates forces that power the division of chromosomes among two daughter cells. We apply a multidisciplinary approach to examine the process of mitotic spindle assembly and the interface between kinetochores and microtubules. We use quantitative light microscopy to investigate protein behavior in the mitotic spindle, biochemistry to understand the function of key mitotic regulators, and small molecules to perturb spindle function. Our long term goal is to use our findings to develop new anti-mitotic oncological therapies. Currently, our lab is studying how several families of kinesin-like proteins impact spindle assembly and function in animal cells. We are particularly interested in the roles of the kinesin-8s at spindle microtubule plus-ends, the mechanisms by which the kinesin-5 and kinesin-12 motors enforce spindle bipolarity, and the roles of kinesin-13s during cytokinesis.