Vanderbilt-Ingram Cancer Center

Publications

• Siesser, PM, Meenderink, LM, Ryzhova, L, Michael, KE, Dumbauld, DW, García, AJ, Kaverina, I, Hanks, SK A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly. Cell Motil Cytoskeleton, 65(1), 25-39, 2008.
• Luo, W, Slebos, RJ, Hill, S, Li, M, Brábek, J, Amanchy, R, Chaerkady, R, Pandey, A, Ham, AJ, Hanks, SK Global Impact of Oncogenic Src on a Phosphotyrosine Proteome. J Proteome Res, 2008.
• Constancio-Lund, SS, Brabek, J, Hanks, SK Src transformation of colonic epithelial cells: Enhanced anchorage-independent growth in an Apc(+/min) background. Mol Carcinog, 2008.
• Kim, W, Seok Kang, Y, Soo Kim, J, Shin, NY, Hanks, SK, Song, WK The Integrin-coupled Signaling Adaptor p130Cas Suppresses Smad3 Function in Transforming Growth Factor-{beta} Signaling. Mol Biol Cell, 19(5), 2135-46, 2008.
• Liu, G, Li, W, Gao, X, Li, X, Jürgensen, C, Park, HT, Shin, NY, Yu, J, He, ML, Hanks, SK, Wu, JY, Guan, KL, Rao, Y p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci, 27(4), 957-68, 2007.
• Frey, MT, Tsai, IY, Russell, TP, Hanks, SK, Wang, YL Cellular responses to substrate topography: role of myosin II and focal adhesion kinase. Biophys J, 90(10), 3774-82, 2006.
• Rivera, GM, Antoku, S, Gelkop, S, Shin, NY, Hanks, SK, Pawson, T, Mayer, BJ Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Proc Natl Acad Sci U S A, 103(25), 9536-41, 2006.
• Siesser, PM, Hanks, SK The signaling and biological implications of FAK overexpression in cancer. Clin Cancer Res, 12(11 Pt 1), 3233-7, 2006.
• Cai, S, Bulus, N, Fonseca-Siesser, PM, Chen, D, Hanks, SK, Pozzi, A, Zent, R CD98 modulates integrin beta1 function in polarized epithelial cells. J Cell Sci, 118(Pt 5), 889-99, 2005.
• Brábek, J, Constancio, SS, Siesser, PF, Shin, NY, Pozzi, A, Hanks, SK Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Mol Cancer Res, 3(6), 307-15, 2005.
• Bianchi, M, De Lucchini, S, Marin, O, Turner, DL, Hanks, SK, Villa-Moruzzi, E Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochem J, 391(Pt 2), 359-70, 2005.
• Brábek, Jan, Hanks, Steven K Assaying protein kinase activity. Methods Mol Biol, 28479-90, 2004.
• Wang, YL, Burridge, K, Dembo, M, Gabbiani, G, Hanks, SK, Hosoya, H, Janmey, P, Karlsson, R, Lindberg, U, Mabuchi, I, Otey, C, Rottner, K, Small, JV, Wang, CL, Zigmond, S Biomedical research publication system. Science, 303(5666), 1974-6, 2004.
• Brábek, Jan, Constancio, Sábata S, Shin, Nah-Young, Pozzi, Ambra, Weaver, Alissa M, Hanks, Steven K CAS promotes invasiveness of Src-transformed cells. Oncogene, 23(44), 7406-15, 2004.
• Kurenova, Elena, Xu, Li-Hui, Yang, Xihui, Baldwin, Albert S, Craven, Rolf J, Hanks, Steven K, Liu, Zheng-Gang, Cance, William G Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol Cell Biol, 24(10), 4361-71, 2004.
• Hecker, Timothy P, Ding, Qiang, Rege, Tanya A, Hanks, Steven K, Gladson, Candece L Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells. Oncogene, 23(22), 3962-71, 2004.
• Fonseca, Priscila M, Shin, Nah-Young, Brábek, Jan, Ryzhova, Larisa, Wu, Jiong, Hanks, Steven K Regulation and localization of CAS substrate domain tyrosine phosphorylation. Cell Signal, 16(5), 621-9, 2004.
• Yano, H, Mazaki, Y, Kurokawa, K, Hanks, SK, Matsuda, M, Sabe, H Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J Cell Biol, 166(2), 283-95, 2004.
• Shin, Nah-Young, Dise, Rebecca S, Schneider-Mergener, Jens, Ritchie, Marylyn D, Kilkenny, Dawn M, Hanks, Steven K Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration. J Biol Chem, 279(37), 38331-7, 2004.
• Miller, Michael A, Ruest, Paul J, Kosinski, Mary, Hanks, Steven K, Greenstein, David An Eph receptor sperm-sensing control mechanism for oocyte meiotic maturation in Caenorhabditis elegans. Genes Dev, 17(2), 187-200, 2003.
• Torsoni, Adriana S, Constancio, Sabata S, Nadruz, Wilson, Hanks, Steven K, Franchini, Kleber G Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes. Circ Res, 93(2), 140-7, 2003.
• Hanks, Steven K, Ryzhova, Larisa, Shin, Nah-Young, Brábek, Jan Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front Biosci, 8d982-96, 2003.
• Hanks, Steven K Genomic analysis of the eukaryotic protein kinase superfamily: a perspective. Genome Biol, 4(5), 111, 2003.
• Li, Guochun, Gustafson-Brown, Cindy, Hanks, Steven K, Nason, Katie, Arbeit, Jeffrey M, Pogliano, Kit, Wisdom, Ronald M, Johnson, Randall S c-Jun is essential for organization of the epidermal leading edge. Dev Cell, 4(6), 865-77, 2003.
• Roy, Shyamali, Ruest, Paul J, Hanks, Steven K FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation. J Cell Biochem, 84(2), 377-88, 2002.
• Donaldson, John C, Dise, Rebecca S, Ritchie, Marylyn D, Hanks, Steven K Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity. J Biol Chem, 277(32), 29028-35, 2002.
• Wang, H B, Dembo, M, Hanks, S K, Wang, Y Focal adhesion kinase is involved in mechanosensing during fibroblast migration. Proc Natl Acad Sci U S A, 98(20), 11295-300, 2001.
• Ruest, P J, Shin, N Y, Polte, T R, Zhang, X, Hanks, S K Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src. Mol Cell Biol, 21(22), 7641-52, 2001.
• Maru, Y, Hanks, S K, Shibuya, M The tubulogenic activity associated with an activated form of Flt-1 kinase is dependent on focal adhesion kinase. Biochim Biophys Acta, 1540(2), 147-53, 2001.
• Sonoda, Y, Matsumoto, Y, Funakoshi, M, Yamamoto, D, Hanks, S K, Kasahara, T Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J Biol Chem, 275(21), 16309-15, 2000.
• Donaldson, J C, Dempsey, P J, Reddy, S, Bouton, A H, Coffey, R J, Hanks, S K Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. Exp Cell Res, 256(1), 168-78, 2000.
• Ruest, P J, Roy, S, Shi, E, Mernaugh, R L, Hanks, S K Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site. Cell Growth Differ, 11(1), 41-8, 2000.
• Yamakita, Y, Totsukawa, G, Yamashiro, S, Fry, D, Zhang, X, Hanks, S K, Matsumura, F Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK. J Cell Biol, 144(2), 315-24, 1999.
• Zhang, X, Chattopadhyay, A, Ji, Q S, Owen, J D, Ruest, P J, Carpenter, G, Hanks, S K Focal adhesion kinase promotes phospholipase C-gamma1 activity. Proc Natl Acad Sci U S A, 96(16), 9021-6, 1999.
• Owen, J D, Ruest, P J, Fry, D W, Hanks, S K Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Mol Cell Biol, 19(7), 4806-18, 1999.
• Cary, L A, Han, D C, Polte, T R, Hanks, S K, Guan, J L Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol, 140(1), 211-21, 1998.
• Polte, T R, Hanks, S K Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs. J Biol Chem, 272(9), 5501-9, 1997.
• Hanks, S K, Polte, T R Signaling through focal adhesion kinase. Bioessays, 19(2), 137-45, 1997.
• Withers, B E, Hanks, S K, Fry, D W Correlations between the expression, phosphotyrosine content and enzymatic activity of focal adhesion kinase, pp125FAK, in tumor and nontransformed cells. Cancer Biochem Biophys, 15(3), 127-39, 1996.
• Calalb, M B, Zhang, X, Polte, T R, Hanks, S K Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. Biochem Biophys Res Commun, 228(3), 662-8, 1996.
• Zhang, X, Wright, C V, Hanks, S K Cloning of a Xenopus laevis cDNA encoding focal adhesion kinase (FAK) and expression during early development. Gene, 160(2), 219-22, 1995.
• Polte, T R, Hanks, S K Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc Natl Acad Sci U S A, 92(23), 10678-82, 1995.
• Kitagawa, M, Higashi, H, Suzuki-Takahashi, I, Segawa, K, Hanks, S K, Taya, Y, Nishimura, S, Okuyama, A Phosphorylation of E2F-1 by cyclin A-cdk2. Oncogene, 10(2), 229-36, 1995.
• Hanks, S K, Hunter, T Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J, 9(8), 576-96, 1995.
• Calalb, M B, Polte, T R, Hanks, S K Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol, 15(2), 954-63, 1995.
• Polte, T R, Naftilan, A J, Hanks, S K Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II. J Cell Biochem, 55(1), 106-19, 1994.
• Schlaepfer, D D, Hanks, S K, Hunter, T, van der Geer, P Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature, 372(6508), 786-91, 1994.
• Gates, R E, King, L E, Hanks, S K, Nanney, L B Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds and in culture. Cell Growth Differ, 5(8), 891-9, 1994.
• Devor, B B, Zhang, X, Patel, S K, Polte, T R, Hanks, S K Chicken and mouse focal adhesion kinases are similar in structure at their amino termini. Biochem Biophys Res Commun, 190(3), 1084-9, 1993.
• Gates, R E, Hanks, S K, King, L E Focal-adhesion components are enriched in ventral membranes isolated from transformed keratinocytes in culture. Biochem J, 289 ( Pt 1)221-6, 1993.
• Hanks, S K, Calalb, M B, Harper, M C, Patel, S K Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci U S A, 89(18), 8487-91, 1992.
• Matsushime, H, Ewen, M E, Strom, D K, Kato, J Y, Hanks, S K, Roussel, M F, Sherr, C J Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell, 71(2), 323-34, 1992.
• Calalb, M B, Fox, D T, Hanks, S K Molecular cloning and enzymatic analysis of the rat homolog of 'PhK-gamma T,' an isoform of phosphorylase kinase catalytic subunit. J Biol Chem, 267(3), 1455-63, 1992.
• Hanks, S.K "Eukaryotic protein kinases." Curr. Op. Struct. Biol., 1369-383, 1991.
• Hanks, S K, Quinn, A M Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol, 20038-62, 1991.
• Hanks, S K, Lindberg, R A Use of degenerate oligonucleotide probes to identify clones that encode protein kinases. Methods Enzymol, 200525-32, 1991.
• Hanks, S K Messenger ribonucleic acid encoding an apparent isoform of phosphorylase kinase catalytic subunit is abundant in the adult testis. Mol Endocrinol, 3(1), 110-6, 1989.
• Lawton, M A, Yamamoto, R T, Hanks, S K, Lamb, C J Molecular cloning of plant transcripts encoding protein kinase homologs. Proc Natl Acad Sci U S A, 86(9), 3140-4, 1989.
• Maldonado, F, Hanks, S K A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha. Nucleic Acids Res, 16(16), 8189-90, 1988.
• Hanks, S K, Armour, R, Baldwin, J H, Maldonado, F, Spiess, J, Holley, R W Amino acid sequence of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of the cDNA. Proc Natl Acad Sci U S A, 85(1), 79-82, 1988.
• Hanks, S K, Quinn, A M, Hunter, T The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science, 241(4861), 42-52, 1988.
• Hanks, S K Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family. Proc Natl Acad Sci U S A, 84(2), 388-92, 1987.
• Mitchell, R L, Hanks, S K, Verma, I M Proto-oncogene fos: an inducible multifaceted gene. Symp Fundam Cancer Res, 3999-113, 1986.
• Hanks, S K, Riggs, M G Selective insolubility of active hsp70 gene chromatin. Biochim Biophys Acta, 867(3), 124-34, 1986.
• Brown, D B, Hanks, S K, Murphy, E C, Rao, P N Early initiation of DNA synthesis in G1 phase HeLa cells following fusion with red cell ghosts loaded with S-phase cell extracts. Exp Cell Res, 156(1), 251-9, 1985.
• Gollin, S M, Wray, W, Hanks, S K, Hittelman, W N, Rao, P N The ultrastructural organization of prematurely condensed chromosomes. J Cell Sci Suppl, 1203-21, 1984.
• Hanks, S K, Gollin, S M, Rao, P N, Wray, W, Hittelman, W N Cell cycle-specific changes in the ultrastructural organization of prematurely condensed chromosomes. Chromosoma, 88(5), 333-42, 1983.
• Hanks, S K, Rodriguez, L V, Rao, P N Relationship between histone phosphorylation and premature chromosome condensation. Exp Cell Res, 148(2), 293-302, 1983.
• Hanks, S K, Brown, D B, Rao, P N Induction of premature chromosome condensation at high frequency following polyethylene glycol-mediated fusion of lectin-bound cells. Exp Cell Res, 138(1), 215-9, 1982.
• Rao, P N, Hanks, S K Chromatin structure during the prereplicative phases in the life cycle of mammalian cells. Cell Biophys, 2(4), 327-37, 1980.
• Hanks, S K, Rao, P N Initiation of DNA synthesis in the prematurely condensed chromosomes of G1 cells. J Cell Biol, 87(1), 285-91, 1980.