Vanderbilt-Ingram Cancer Center

Publications

• Wang, N, Li, Z, Ding, R, Frank, GD, Senbonmatsu, T, Landon, EJ, Inagami, T, Zhao, ZJ Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling. J Biol Chem, 281(31), 21878-83, 2006.
• Zhang, MZ, Yao, B, Cheng, HF, Wang, SW, Inagami, T, Harris, RC Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Proc Natl Acad Sci U S A, 103(43), 16045-50, 2006.
• Utsunomiya, H, Nakamura, M, Kakudo, K, Inagami, T, Tamura, M Angiotensin II AT2 receptor localization in cardiovascular tissues by its antibody developed in AT2 gene-deleted mice. Regul Pept, 126(3), 155-61, 2005.
• Kagawa, N, Senbonmatsu, TA, Satoh, K, Ichihara, K, Yamagata, N, Hatano, O, Saito, T, Nguyen, VQ, Waterman, MR, Price, E, Atkinson, JB, Inagami, T Tetracycline protects myocardium against ischemic injury. Front Biosci, 10608-19, 2005.
• Senbonmatsu, Takaaki, Saito, Takako, Landon, Erwin J, Watanabe, Otsu, Price, Edward, Roberts, Richard L, Imboden, Hans, Fitzgerald, Trinita G, Gaffney, F Andrew, Inagami, Tadashi A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. EMBO J, 22(24), 6471-82, 2003.
• Frank, Gerald D, Mifune, Mizuo, Inagami, Tadashi, Ohba, Motoi, Sasaki, Terukatsu, Higashiyama, Shigeki, Dempsey, Peter J, Eguchi, Satoru Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta. Mol Cell Biol, 23(5), 1581-9, 2003.
• Eguchi, S, Frank, G D, Mifune, M, Inagami, T Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodelling. Biochem Soc Trans, 31(Pt 6), 1198-202, 2003.
• Saito, Shuichi, Frank, Gerald D, Motley, Evangeline D, Utsunomiya, Hirotoshi, Inagami, Tadashi, Eguchi, Satoru Cyclosporin A inhibits angiotensin II-induced c-Jun NH(2)-terminal kinase activation but not protein synthesis in vascular smooth muscle cells. Eur J Pharmacol, 443(1-3), 47-50, 2002.
• Takagi, Tetsuo, Nakano, Yuichiro, Takekoshi, Susumu, Inagami, Tadashi, Tamura, Masaaki Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis. Carcinogenesis, 23(7), 1235-41, 2002.
• Saito, Shuichi, Frank, Gerald D, Mifune, Mizuo, Ohba, Motoi, Utsunomiya, Hirotoshi, Motley, Evangeline D, Inagami, Tadashi, Eguchi, Satoru Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. J Biol Chem, 277(47), 44695-700, 2002.
• Saito, Shuichi, Frank, Gerald D, Motley, Evangeline D, Dempsey, Peter J, Utsunomiya, Hirotoshi, Inagami, Tadashi, Eguchi, Satoru Metalloprotease inhibitor blocks angiotensin II-induced migration through inhibition of epidermal growth factor receptor transactivation. Biochem Biophys Res Commun, 294(5), 1023-9, 2002.
• Xin, Hong-Bo, Senbonmatsu, Takaaki, Cheng, Dong-Sheng, Wang, Yong-Xiao, Copello, Julio A, Ji, Guang-Ju, Collier, Mei Lin, Deng, Ke-Yu, Jeyakumar, Loice H, Magnuson, Mark A, Inagami, Tadashi, Kotlikoff, Michael I, Fleischer, Sidney Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Nature, 416(6878), 334-8, 2002.
• Frank, Gerald D, Saito, Shuichi, Motley, Evangeline D, Sasaki, Terukatsu, Ohba, Motoi, Kuroki, Toshio, Inagami, Tadashi, Eguchi, Satoru Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2. Mol Endocrinol, 16(2), 367-77, 2002.
• Ichihara, Sahoko, Senbonmatsu, Takaaki, Price, Edward, Ichiki, Toshihiro, Gaffney, F Andrew, Inagami, Tadashi Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction. Circulation, 106(17), 2244-9, 2002.
• Satoh, K, Ichihara, K, Landon, E J, Inagami, T, Tang, H 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors block calcium-dependent tyrosine kinase Pyk2 activation by angiotensin II in vascular endothelial cells. involvement of geranylgeranylation of small G protein Rap1. J Biol Chem, 276(19), 15761-7, 2001.
• S. Eguchi, P.J. Dempsey, G. D. Frank, E.D. Motley, T. Inagami "Activation of MAPKs by Angiotensin II in vascular smooth muscle cells: Metalloprotease-dependent EG receptor activation is required for activation of ERK and p58 MAPK but not for JNK." J. Biol. Chem, 2767957-7962, 2001.
• Eguchi, S, Dempsey, P J, Frank, G D, Motley, E D, Inagami, T Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloprotease-dependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK. J Biol Chem, 276(11), 7957-62, 2001.
• S. Ichihara, T. Senbonmatsu, E. Price, Jr., T. Ichiki, F. A. Gaffney, T. Inagami "Angiotensin II Type 2 Receptor is essential for left ventricular hypertrophy and cardiac fibrosis." Circulation, 104346-351, 2001.
• Ichihara, S, Senbonmatsu, T, Price, E, Ichiki, T, Gaffney, F A, Inagami, T Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation, 104(3), 346-51, 2001.
• Inagami, T, Senbonmatsu, T Dual effects of angiotensin II type 2 receptor on cardiovascular hypertrophy. Trends Cardiovasc Med, 11(8), 324-8, 2001.
• T. Inagami and T. Senbonmatsu "Dual effects of angiotensin II type 2 receptor on cardiovascular hypertrophy. Trends in Cardiovascular Medicine." , 11324-328, 2001.
• K. Satoh, K. Ichihara, E.J. Landon, T. Inagami, H. Tang "HMG-CoA Reductase Inhibitors Block Calcium-dependent Tyrosine Kinase Pyk2 Activation by Angiotensin II in Vascular Endothelial Cells. Involvement of Geranylgerany-lation of small G protein Rap 1." J. Biol. Chem., 27615761-67, 2001.
• Miyata, I, Shiota, C, Chaki, S, Okuyama, S, Inagami, T Localization and characterization of a short isoform of the corticotropin-releasing factor receptor type 2alpha (CRF(2)alpha-tr) in the rat brain. Biochem Biophys Res Commun, 280(2), 553-7, 2001.
• Guo DF, Sun YL, Hamet P, Inagami T "The angiotensin II type 1 receptor and receptor-associated proteins." Cell Res, 11(3), 165-80, 2001.
• Frank, G D, Eguchi, S, Motley, E D, Sasaki, T, Inagami, T Unique regulation of c-Jun N-terminal kinase by PYK2/CAK-beta in angiotensin II-stimulated vascular smooth muscle cells. Biochem Biophys Res Commun, 286(4), 692-6, 2001.
• T Yamakawa, S Tanaka, K Numaguchi, Y Yamakawa, ED Motley, S Ichihara, T Inagami "Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat VAS cells." Hypertension, 35313-318, 2000.
• Inagami, T, Eguchi, S Angiotensin II-mediated vascular smooth muscle cell growth signaling. Braz J Med Biol Res, 33(6), 619-24, 2000.
• Senbonmatsu, T, Ichihara, S, Price, E, Gaffney, FA, Inagami, T Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overloa. J Clin Invest, 106(2), R1-5, 2000.
• Senbonmatsu, , Ichihara, , Price, , Gaffney, , Inagami, Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overloa. J Clin Invest, 106(2), R1-5, 2000.
• Senbonmatsu, T, Ichihara, S, Price, E, Gaffney, F A, Inagami, T Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest, 106(3), R25-9, 2000.
• T. Senbonmatsu, S. Ichihara, E. Price, Jr., F. A. Gaffney, T. Inagami "Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload." J. Clin. Invest., 105R9-14, 2000.
• Senbonmatsu, , Ichihara, , Price, , Gaffney, , Inagami, Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest, 106(3), R25-R29, 2000.
• Ohnaka, K, Numaguchi, K, Yamakawa, T, Inagami, T Induction of cyclooxygenase-2 by angiotensin II in cultured rat vascular smooth muscle cells. Hypertension, 35(1 Pt 1), 68-75, 2000.
• K Ohnaka, K Numaguchi, T Inagami "Induction of cyclooxygenase-2 by angiotensin II in cultured rat vascular smooth vascular cells." Hypertension, 3568-75, 2000.
• Tang, H, Nishishita, T, Fitzgerald, T, Landon, E J, Inagami, T Inhibition of AT1 receptor internalization by concanavalin A blocks angiotensin II-induced ERK activation in vascular smooth muscle cells. Involvement of epidermal growth factor receptor proteolysis but not AT1 receptor internalization. J Biol Chem, 275(18), 13420-6, 2000.
• V Gross, WH Schunck, H Honeck, AF Milia, E Kargel, T Walther, M Bader, T Inagami, FC Luft "Inhibition of pressure natriuresis in mice lacking the AT2 receptor." Kidney Int, 57191-202, 2000.
• Yamakawa, T, Tanaka, S, Numaguchi, K, Yamakawa, Y, Motley, E D, Ichihara, S, Inagami, T Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension, 35(1 Pt 2), 313-8, 2000.
• Frank, G D, Motley, E D, Inagami, T, Eguchi, S PYK2/CAKbeta represents a redox-sensitive tyrosine kinase in vascular smooth muscle cells. Biochem Biophys Res Commun, 270(3), 761-5, 2000.
• H Tang, ZJ Zhao, EJ Landon, T Inagami "Regulation of calcium-sensitive tyrosine kinase PYK2 by angiotensin II in ER of YES tyrosine kinase and tyrosine phosphatase SHP-2." J Biol Chem, 2758389-8396, 2000.
• Tang, H, Zhao, Z J, Landon, E J, Inagami, T Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells. Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2. J Biol Chem, 275(12), 8389-96, 2000.
• Fujinaka, H, Miyazaki, Y, Matsusaka, T, Yoshida, H, Fogo, A B, Inagami, T, Ichikawa, I Salutary role for angiotensin in partial urinary tract obstruction. Kidney Int, 58(5), 2018-27, 2000.
• Eguchi, S, Inagami, T Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase. Regul Pept, 91(1-3), 13-20, 2000.
• TE Hunley, M Tamura, B Stoneking, H Nishimura, T Ichiki, T Inagami, V Kon "The angiotensin type 2 receptor tonically inhibits the Ang converting enzyme in AT2 null mutant mice." Kid Intl, 57570-577, 2000.
• Hunley, T E, Tamura, M, Stoneking, B J, Nishimura, H, Ichiki, T, Inagami, T, Kon, V The angiotensin type II receptor tonically inhibits angiotensin- converting enzyme in AT2 null mutant mice. Kidney Int, 57(2), 570-7, 2000.
• F Suzuki, T Nakagawa, H Kakidachi, K Murakami, T Inagami, Y Nakamura "The dominant role of the prosegment of proreinin in determining the rate of trypsin: studies with molecular chimeras." Biochem Biophys Res Commun, 267577-580, 2000.
• S. Eguchi, H. Iwasaki, H. Ueno, G.D. Frank, E.D. Motley, K. Eguchi, F. Marumo, Y. Hirata, & T. Inagami "Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser411 in vascular smooth muscle cells." J. Biol. Chem, 27436843-51, 1999.
• K Numaguchi, S Eguchi, T Yamakawa, ED Motley, T Inagami "Mechano-transduction of rat aortic VSMC requires RhoA and intact actin filaments." Circ Res, 85 5-11, 1999.
• Y Kitami, D Li-Zhi, T Fukuoka, K Hiwada and T Inagami "A high level of CCAAT-enhancer binding protein-? expression is a major determinant for markedly elevated differential gene expression of the platelet derived growth factor receptor ? in the vascular smooth muscle cells of genetically hypertensive rats." Circ Res, 64-7384, 1999.
• Inagami, T, Kambayashi, Y, Ichiki, T, Tsuzuki, S, Eguchi, S, Yamakawa, T Angiotensin receptors: molecular biology and signalling. Clin Exp Pharmacol Physiol, 26(7), 544-9, 1999.
• S Okuyama, T Sakagawa, S Chaki, Y Imagawa, T Ichiki, T Inagami "Anxiety-like behavior in mice lacking the ang II type-2 receptor." Brain Resch, 821150-159, 1999.
• Miyata, I, Shiota, C, Ikeda, Y, Oshida, Y, Chaki, S, Okuyama, S, Inagami, T Cloning and characterization of a short variant of the corticotropin-releasing factor receptor subtype from rat amygdala. Biochem Biophys Res Commun, 256(3), 692-6, 1999.
• Matsusaka, T, Katori, H, Inagami, T, Fogo, A, Ichikawa, I Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice. J Clin Invest, 103(10), 1451-8, 1999.
• Inagami, T, Eguchi, S, Numaguchi, K, Motley, E D, Tang, H, Matsumoto, T, Yamakawa, T Cross-talk between angiotensin II receptors and the tyrosine kinases and phosphatases. J Am Soc Nephrol, 10 Suppl 11S57-61, 1999.
• S. Eguchi, H. Iwasaki, Y. Hirata, G.D. Frank, E. D. Motley, T. Yamakawa, K. Numaguchi, T. Inagami "Epidermal growth factor receptor is indispensable for c-Fos expresion and protein synthesis by angiotensin II." E. J. Pharm., 376203-06, 1999.
• Eguchi, S, Iwasaki, H, Hirata, Y, Frank, G D, Motley, E D, Yamakawa, T, Numaguchi, K, Inagami, T Epidermal growth factor receptor is indispensable for c-Fos expression and protein synthesis by angiotensin II. Eur J Pharmacol, 376(1-2), 203-6, 1999.
• H Tang, Z Zhao, X-Y Huang, EJ Landon, T Inagami "Fyn Kinase-directed activation of SH2 domain-containing protein tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells." J Biol Chem, 27412401-12407, 1999.
• Tang, H, Zhao, Z J, Huang, X Y, Landon, E J, Inagami, T Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells. J Biol Chem, 274(18), 12401-7, 1999.
• T Yamakawa, S Eguchi, T Matsumoto, Y Yamakawa, K Numaguchi, I Miyata, C M Reynolds, ED Motley, T Inagami "Intracellular signaling in rat cultured vascular smooth muscle cells: Role of NF-? B and p38 MAP kinase on tumor necrosis factor-alpha production." Endocrinology, 3562-3573140, 1999.
• Yamakawa, T, Eguchi, S, Matsumoto, T, Yamakawa, Y, Numaguchi, K, Miyata, I, Reynolds, C M, Motley, E D, Inagami, T Intracellular signaling in rat cultured vascular smooth muscle cells: roles of nuclear factor-kappaB and p38 mitogen-activated protein kinase on tumor necrosis factor-alpha production. Endocrinology, 140(8), 3562-72, 1999.
• Eguchi, S, Iwasaki, H, Ueno, H, Frank, G D, Motley, E D, Eguchi, K, Marumo, F, Hirata, Y, Inagami, T Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt. J Biol Chem, 274(52), 36843-51, 1999.
• Tamura, M, Wanaka, Y, Landon, E J, Inagami, T Intracellular sodium modulates the expression of angiotensin II subtype 2 receptor in PC12W cells. Hypertension, 33(2), 626-32, 1999.
• Numaguchi, K, Eguchi, S, Yamakawa, T, Motley, E D, Inagami, T Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments. Circ Res, 85(1), 5-11, 1999.
• Inagami, T Molecular biology and signaling of angiotensin receptors: an overview. J Am Soc Nephrol, 10 Suppl 11S2-7, 1999.
• Tsuchida, S, Miyazaki, Y, Matsusaka, T, Hunley, T E, Inagami, T, Fogo, A, Ichikawa, I Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature. Kidney Int, 56(2), 509-16, 1999.
• Nishimura, H, Yerkes, E, Hohenfellner, K, Miyazaki, Y, Ma, J, Hunley, T E, Yoshida, H, Ichiki, T, Threadgill, D, Phillips, J A, Hogan, B M, Fogo, A, Brock, J W, Inagami, T, Ichikawa, I Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell, 3(1), 1-10, 1999.
• H Nishimura, E Yerkes, K Hohenfellner, Y Miyazaki, J Ma, TE Hunley, H Yoshida, T Ichiki, D Threadgill, JA Phillips III, BML Hogan, A Fogo, JW Brock III, T Inagami, and I Ichikawa "Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men." Mol Cell, 31-10, 1999.
• H.M. Siragy, T. Ichiki, T. Inagami, R.M. Carey. "Sustained hypersensitivity to Angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) ang, receptor." Proc. Natl. Acad. Sci. USA, 966506-10, 1999.
• H. Tang, D.M. Kerins, Q. Hao, T. Inagami, D.E. Vaughan "The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells." J. Biol. Chem., 27318268-18272, 1998.
• Inagami, T A memorial to Robert Tiegerstedt: the centennial of renin discovery. Hypertension, 32(6), 953-7, 1998.
• Ma, J, Nishimura, H, Fogo, A, Kon, V, Inagami, T, Ichikawa, I Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int, 53(4), 937-44, 1998.
• Miyazaki, Y, Tsuchida, S, Nishimura, H, Pope, J C, Harris, R C, McKanna, J M, Inagami, T, Hogan, B L, Fogo, A, Ichikawa, I Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest, 102(8), 1489-97, 1998.
• "Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen- activated protein kinase activation in vascular smooth muscle cells." J. Biol. Chem, 2738890-8896, 1998.
• Eguchi, S, Numaguchi, K, Iwasaki, H, Matsumoto, T, Yamakawa, T, Utsunomiya, H, Motley, E D, Kawakatsu, H, Owada, K M, Hirata, Y, Marumo, F, Inagami, T Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J Biol Chem, 273(15), 8890-6, 1998.
• A. Ishihata, S. Uno, D.-F. Guo, Y. Katano, T. Inagami "Inhibition of the expression of the gene for the angiotensin AT1 receptor by angiotensin II in the rat adreanl gland." E. J. of Pharm, 350129-139, 1998.
• Ishihata, A, Uno, S, Guo, D F, Katano, Y, Inagami, T Inhibition of the expression of the gene for the angiotensin AT1 receptor by angiotensin II in the rat adrenal gland. Eur J Pharmacol, 350(1), 129-39, 1998.
• T Yamakawa, S Eguchi, Y Yamakawa, ED Motley, K Numaguchi, H Utsunomiya, T Inagami "Isophosphatidyl-choline stimulates MAP kinase activity in rat vascular smooth muscle cells." Hypertension, 31248-254, 1998.
• Yamakawa, T, Eguchi, S, Yamakawa, Y, Motley, E D, Numaguchi, K, Utsunomiya, H, Inagami, T Lysophosphatidylcholine stimulates MAP kinase activity in rat vascular smooth muscle cells. Hypertension, 31(1 Pt 2), 248-53, 1998.
• S Tsuchida, T Matsusaka, X Chen, S Okubo, F Niimura, H Nishimura, A Fogo, H Utsunomiya, T Inagami and I Ichikawa "Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes." J. Clin. Invest, 101755-760, 1998.
• Tsuchida, S, Matsusaka, T, Chen, X, Okubo, S, Niimura, F, Nishimura, H, Fogo, A, Utsunomiya, H, Inagami, T, Ichikawa, I Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest, 101(4), 755-60, 1998.
• Tamura, M, Landon, E J, Inagami, T Na+,K+-ATPase inhibitors in rat urine: origins and physiological significance. Clin Exp Hypertens, 20(5-6), 543-50, 1998.
• Stoneking, B J, Hunley, T E, Nishimura, H, Ma, J, Fogo, A, Inagami, T, Tamura, M, Adams, M C, Brock, J W, Kon, V Renal angiotensin converting enzyme promotes renal damage during ureteral obstruction. J Urol, 160(3 Pt 2), 1070-4, 1998.
• Tang, H, Guo, D F, Porter, J P, Wanaka, Y, Inagami, T Role of cytoplasmic tail of the type 1A angiotensin II receptor in agonist- and phorbol ester-induced desensitization. Circ Res, 82(5), 523-31, 1998.
• H. Tang, D.-F. Guo, J.P. Porter, Y. Wanaka, and T. Inagami "Role of cytoplasmic tail of the type-1A angiotensin II receptor in agonist-and phorbol ester-induced desensitization." Circulation Res, 81523-531, 1998.
• Tang, H, Kerins, D M, Hao, Q, Inagami, T, Vaughan, D E The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. J Biol Chem, 273(29), 18268-72, 1998.
• Inagami, T, Eguchi, S, Tsuzuki, S, Ichiki, T Angiotensin II receptors AT1 and AT2--new mechanisms of signaling and antagonistic effects of AT1 and AT2. Jpn Circ J, 61(10), 807-13, 1997.
• Xu, Y, Guo, D F, Davidson, M, Inagami, T, Carpenter, G Interaction of the adaptor protein Shc and the adhesion molecule cadherin. J Biol Chem, 272(21), 13463-6, 1997.
• Tsuzuki, S, Matoba, T, Eguchi, S, Inagami, T Angiotensin II type 2 receptor inhibits cell proliferation and activates tyrosine phosphatase. Hypertension, 28(5), 916-8, 1996.
• S Tsuzuki, T Matoba, S Eguchi, T Inagami "Angiotensin II type 2 receptor inhibits cell proliferation and tyrosine phosphatase." Hypertension, 28916-918, 1996.
• Matsusaka, T, Nishimura, H, Utsunomiya, H, Kakuchi, J, Niimura, F, Inagami, T, Fogo, A, Ichikawa, I Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. J Clin Invest, 98(8), 1867-77, 1996.
• Ichiki, T, Kambayashi, Y, Inagami, T Differential inducibility of angiotensin II AT2 receptor between SHR and WKY vascular smooth muscle cells. Kidney Int Suppl, 55S14-7, 1996.
• S Eguchi, T Matsumoto, E Motley,H Utsunomiya, T Inagami "Identification of an Essential Signaling cascade for mitogen-activated protein kinase activation by Ang II." J Biol Chem, 27114169-14175, 1996.
• Eguchi, S, Matsumoto, T, Motley, E D, Utsunomiya, H, Inagami, T Identification of an essential signaling cascade for mitogen-activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. Possible requirement of Gq-mediated p21ras activation coupled to a Ca2+/calmodulin-sensitive tyrosine kinase. J Biol Chem, 271(24), 14169-75, 1996.
• Tsuzuki, S, Eguchi, S, Inagami, T Inhibition of cell proliferation and activation of protein tyrosine phosphatase mediated by angiotensin II type 2 (AT2) receptor in R3T3 cells. Biochem Biophys Res Commun, 228(3), 825-30, 1996.
• Ichiki, T, Kambayashi, Y, Inagami, T Molecular cloning and expression of angiotensin II type 2 receptor gene. Adv Exp Med Biol, 396145-52, 1996.
• Tamura, M, Piston, D W, Tani, M, Naruse, M, Landon, E J, Inagami, T Ouabain increases aldosterone release from bovine adrenal glomerulosa cells: role of renin-angiotensin system. Am J Physiol, 270(1 Pt 1), E27-35, 1996.
• Ichiki, T, Kambayashi, Y, Inagami, T Transcription of the rat angiotensin II type 2 receptor gene. Biochem Biophys Res Commun, 222(2), 566-71, 1996.
• Mosqueda-Garcia, R, Yates, K, O'Leary, J, Inagami, T Cardiovascular and respiratory effects of endothelin in the ventrolateral medulla of the normotensive rat. Hypertension, 26(2), 263-71, 1995.
• Kambayashi, Y, Takahashi, K, Bardhan, S, Inagami, T Cloning and expression of protein tyrosine phosphatase-like protein derived from a rat pheochromocytoma cell line. Biochem J, 306 ( Pt 2)331-5, 1995.
• Inagami, T, Yamano, Y, Bardhan, S, Chaki, S, Guo, D F, Ohyama, K, Kambayashi, Y, Takahashi, K, Ichiki, T, Tsuzuki, S Cloning, expression and regulation of angiotensin II receptors. Adv Exp Med Biol, 377311-7, 1995.
• Kakuchi, J, Ichiki, T, Kiyama, S, Hogan, B L, Fogo, A, Inagami, T, Ichikawa, I Developmental expression of renal angiotensin II receptor genes in the mouse. Kidney Int, 47(1), 140-7, 1995.
• Ichiki, T, Labosky, P A, Shiota, C, Okuyama, S, Imagawa, Y, Fogo, A, Niimura, F, Ichikawa, I, Hogan, B L, Inagami, T Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature, 377(6551), 748-50, 1995.
• Ichiki,T., Labosky, P.A., Shiota, C., Okuyama, S., Imagawa, Y., Fogo, A., Niimura, F., Ichikawa, I., Hogan, B.L.M., Inagami, T "Effects on blood pressure and reduced exploratory behavior in mice lacking angiotensin II type 2 receptor." Nature, 377748-750, 1995.
• Inagami, T, Naruse, M, Hoover, R Endothelium as an endocrine organ. Annu Rev Physiol, 57171-89, 1995.
• T Ichiki, T Inagami "Expression Genomic Organization, and Transcription of the Mouse Angiotensin II Type 2 Receptor Gene." Circ Res, 76693-700, 1995.
• Ichiki, T, Inagami, T Expression, genomic organization, and transcription of the mouse angiotensin II type 2 receptor gene. Circ Res, 76(5), 693-700, 1995.
• Niimura, F, Labosky, P A, Kakuchi, J, Okubo, S, Yoshida, H, Oikawa, T, Ichiki, T, Naftilan, A J, Fogo, A, Inagami, T Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest, 96(6), 2947-54, 1995.
• Guo, D F, Uno, S, Ishihata, A, Nakamura, N, Inagami, T Identification of a cis-acting glucocorticoid responsive element in the rat angiotensin II type 1A promoter. Circ Res, 77(2), 249-57, 1995.
• Tang, H, Shirai, H, Inagami, T Inhibition of protein kinase C prevents rapid desensitization of type 1B angiotensin II receptor. Circ Res, 77(2), 239-48, 1995.
• Shirai, H, Takahashi, K, Katada, T, Inagami, T Mapping of G protein coupling sites of the angiotensin II type 1 receptor. Hypertension, 25(4 Pt 2), 726-30, 1995.
• Kitami, Y, Inui, H, Uno, S, Inagami, T Molecular structure and transcriptional regulation of the gene for the platelet-derived growth factor alpha receptor in cultured vascular smooth muscle cells. J Clin Invest, 96(1), 558-67, 1995.
• T Ichiki, Y Kambayashi, and T Inagami "Multiple growth factors modulate mRNA expression of angiotensin II type-2 receptor in R3T3 cells." Circ Res, 771070-1076, 1995.
• Ichiki, T, Kambayashi, Y, Inagami, T Multiple growth factors modulate mRNA expression of angiotensin II type-2 receptor in R3T3 cells. Circ Res, 77(6), 1070-6, 1995.
• Inagami, T Recent progress in molecular and cell biological studies of angiotensin receptors. Curr Opin Nephrol Hypertens, 4(1), 47-54, 1995.
• Guo, D F, Uno, S, Inagami, T Steroid hormones upregulate rat angiotensin II type 1A receptor gene: role of glucocorticoid responsive elements in rat angiotensin II type 1A promoter. J Steroid Biochem Mol Biol, 53(1-6), 69-73, 1995.
• Stein, C M, Nelson, R, Deegan, R, He, H, Inagami, T, Frazer, M, Badr, K F, Wood, M, Wood, A J Tachyphylaxis of human forearm vascular responses does not occur rapidly after exposure to isoproterenol. Hypertension, 25(6), 1294-300, 1995.
• Ichiki, T, Inagami, T Transcriptional regulation of the mouse angiotensin II type 2 receptor gene. Hypertension, 25(4 Pt 2), 720-5, 1995.
• Inagami, T, Yamano, Y, Guo, D F, Furuta, H, Ohyama, K, Kambayashi, Y, Bardhan, S, Takahashi, K, Ichiki, T Angiotensin II receptors: cloning and expression. Braz J Med Biol Res, 27(8), 1733-8, 1994.
• Yoshida, H, Kakuchi, J, Yoshikawa, N, Saruta, T, Inagami, T, Phillips, J A, Ichikawa, I Angiotensin II type 1 receptor gene abnormality in a patient with Bartter's syndrome. Kidney Int, 46(6), 1505-9, 1994.
• Yoshida, M, Hamakubo, T, Inagami, T Angiotensin II-mediated pressor effect of rat joining peptide. Am J Physiol, 266(3 Pt 2), R802-8, 1994.
• Inagami, T Atrial natriuretic factor as a volume regulator. J Clin Pharmacol, 34(5), 424-6, 1994.
• Ichiki, T, Herold, C L, Kambayashi, Y, Bardhan, S, Inagami, T Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor. Biochim Biophys Acta, 1189(2), 247-50, 1994.
• Inagami, T, Iwai, N, Sasaki, K, Yamano, Y, Bardhan, S, Chaki, S, Guo, D F, Furuta, H, Ohyama, K, Kambayashi, Y Cloning, expression and regulation of angiotensin II receptors. Eur Heart J, 15 Suppl D104-7, 1994.
• Inui, H, Kitami, Y, Tani, M, Kondo, T, Inagami, T Differences in signal transduction between platelet-derived growth factor (PDGF) alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesis. J Biol Chem, 269(48), 30546-52, 1994.
• Kondo, T, Inui, H, Konishi, F, Inagami, T Enhanced phospholipase D activity in vascular smooth muscle cells derived from spontaneously hypertensive rats. Clin Exp Hypertens, 16(1), 17-28, 1994.
• Guo, D F, Inagami, T Epidermal growth factor-enhanced human angiotensin II type 1 receptor. Hypertension, 23(6 Pt 2), 1032-5, 1994.
• Tamura, M, Harris, T M, Phillips, D, Blair, I A, Wang, Y F, Hellerqvist, C G, Lam, S K, Inagami, T Identification of two cardiac glycosides as Na(+)-pump inhibitors in rat urine and diet. J Biol Chem, 269(16), 11972-9, 1994.
• Inagami, T, Guo, D F, Kitami, Y Molecular biology of angiotensin II receptors: an overview. J Hypertens Suppl, 12(10), S83-94, 1994.
• Tsuzuki, S, Ichiki, T, Nakakubo, H, Kitami, Y, Guo, D F, Shirai, H, Inagami, T Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. Biochem Biophys Res Commun, 200(3), 1449-54, 1994.
• Kambayashi, Y, Takahashi, K, Bardhan, S, Inagami, T Molecular structure and function of angiotensin type 2 receptor. Kidney Int, 46(6), 1502-4, 1994.
• Inui, H, Kondo, T, Konishi, F, Kitami, Y, Inagami, T Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells. Biochem Biophys Res Commun, 205(2), 1338-44, 1994.
• Takahasi, K, Bardhan, S, Kambayashi, Y, Shirai, H, Inagami, T Protein tyrosine phosphatase inhibition by angiotensin II in rat pheochromocytoma cells through type 2 receptor, AT2. Biochem Biophys Res Commun, 198(1), 60-6, 1994.
• Velasco, C E, Turner, M, Inagami, T, Atkinson, J B, Virmani, R, Jackson, E K, Murray, J J, Forman, M B Reperfusion enhances the local release of endothelin after regional myocardial ischemia. Am Heart J, 128(3), 441-51, 1994.
• Chaki, S, Guo, D F, Yamano, Y, Ohyama, K, Tani, M, Mizukoshi, M, Shirai, H, Inagami, T Role of carboxyl tail of the rat angiotensin II type 1A receptor in agonist-induced internalization of the receptor. Kidney Int, 46(6), 1492-5, 1994.
• Guo, D F, Furuta, H, Mizukoshi, M, Inagami, T The genomic organization of human angiotensin II type 1 receptor. Biochem Biophys Res Commun, 200(1), 313-9, 1994.
• Guo, D F, Inagami, T The genomic organization of the rat angiotensin II receptor AT1B. Biochim Biophys Acta, 1218(1), 91-4, 1994.
• Inagami, T The renin-angiotensin system. Essays Biochem, 28147-64, 1994.
• Tamura, M, Konishi, F, Inagami, T A novel endogenous sodium-pump inhibitor in pig urine: purification and comparison with the inhibitor purified from bovine adrenal glands. J Cardiovasc Pharmacol, 22 Suppl 2S47-50, 1993.
• Inagami, T, Iwai, N, Sasaki, K, Guo, D F, Furuta, H, Yamano, Y, Bardhan, S, Chaki, S, Makito, N, Badr, K Angiotensin II receptors: cloning and regulation. Arzneimittelforschung, 43(2A), 226-8, 1993.
• Inagami, T, Yamano, Y, Bardhan, S, Iwai, N, Sasaki, K, Chaki, S, Ohyama, K, Makita, N, Badr, K F Angiotensin II receptors: cloning, structure, function and regulation. Nippon Jinzo Gakkai Shi, 35(5), 421-3, 1993.
• Nakajo, S, Inagami, T Atrial natriuretic factor stimulates phosphorylation of a 52-kDa calmodulin-binding protein in vascular smooth muscle cells. Arch Biochem Biophys, 301(2), 320-4, 1993.
• T Hamakubo, M Yoshida, K Nakajima, TX Watanabe, R Mosqueda-Garcia & T Inagami "Central cardiovascular effects of joining peptide in the genetically hypertensive rat." AJ Physiol, 265R1184-1190, 1993.
• Hamakubo, T, Yoshida, M, Nakajima, K, Watanabe, T X, Mosqueda-Garcia, R, Inagami, T Central cardiovascular effects of joining peptide in genetically hypertensive rats. Am J Physiol, 265(5 Pt 2), R1184-90, 1993.
• Burns, K D, Inagami, T, Harris, R C Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium. Am J Physiol, 264(4 Pt 2), F645-54, 1993.
• Kondo, T, Konishi, F, Inui, H, Inagami, T Differing signal transductions elicited by three isoforms of platelet-derived growth factor in vascular smooth muscle cells. J Biol Chem, 268(6), 4458-64, 1993.
• Mosqueda-Garcia, R, Inagami, T, Appalsamy, M, Sugiura, M, Robertson, R M Endothelin as a neuropeptide. Cardiovascular effects in the brainstem of normotensive rats. Circ Res, 72(1), 20-35, 1993.
• Biaggioni, I, Garcia, F, Inagami, T, Haile, V Hyporeninemic normoaldosteronism in severe autonomic failure. J Clin Endocrinol Metab, 76(3), 580-6, 1993.
• Kakinuma, Y, Fogo, A, Inagami, T, Ichikawa, I Intrarenal localization of angiotensin II type 1 receptor mRNA in the rat. Kidney Int, 43(6), 1229-35, 1993.
• Velasco, C E, Jackson, E K, Morrow, J A, Vitola, J V, Inagami, T, Forman, M B Intravenous adenosine suppresses cardiac release of endothelin after myocardial ischaemia and reperfusion. Cardiovasc Res, 27(1), 121-8, 1993.
• Tamura, M, Harris, T M, Konishi, F, Inagami, T Isolation and characterization of an endogenous Na+,K(+)-ATPase-specific inhibitor from pig urine. Eur J Biochem, 211(1-2), 317-27, 1993.
• Tamura, M, Naruse, M, Sakakibara, M, Inagami, T Isolation of an endogenous Na-pump specific inhibitor from normal pig urine: characterization and comparison with the inhibitor purified from bovine adrenal glands. Biochim Biophys Acta, 1157(1), 15-22, 1993.
• Kambayashi, Y., Bardhan, S., Takahashi, K., Inui, H., Hamakubo, T., Inagami, T "Molecular Cloning of a Novel Angiotensin II Receptor Isoform Involved in Phosphotyrosine Phosphatase Inhibition." J. Biol. Chem, 26824543-24546, 1993.
• Kambayashi, Y, Bardhan, S, Takahashi, K, Tsuzuki, S, Inui, H, Hamakubo, T, Inagami, T Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem, 268(33), 24543-6, 1993.
• Chaki, S, Inagami, T New signaling mechanism of angiotensin II in neuroblastoma neuro-2A cells: activation of soluble guanylyl cyclase via nitric oxide synthesis. Mol Pharmacol, 43(4), 603-8, 1993.
• Kambayashi, Y, Bardhan, S, Inagami, T Peptide growth factors markedly decrease the ligand binding of angiotensin II type 2 receptor in rat cultured vascular smooth muscle cells. Biochem Biophys Res Commun, 194(1), 478-82, 1993.
• Kato, H, Iwai, N, Inui, H, Kimoto, K, Uchiyama, Y, Inagami, T Regulation of vascular angiotensin release. Hypertension, 21(4), 446-54, 1993.
• H Inui, Y Kitami, T Kondo and T Inagami "Transduction of mitogenic activity of platelet-derived growth factor (PDGF) AB by PDGF ? receptor without participation of PDGF receptor in vascular smooth muscle cells." J Biol Chem, 26317045-17050, 1993.
• Inui, H, Kitami, Y, Kondo, T, Inagami, T Transduction of mitogenic activity of platelet-derived growth factor (PDGF) AB by PDGF-beta receptor without participation of PDGF-alpha receptor in vascular smooth muscle cells. J Biol Chem, 268(23), 17045-50, 1993.
• Hamakubo, T, Furuta, H, Ichimura, M, Appalsamy, M, Mosqueda-Garcia, R, Robertson, D, Inagami, T A Na pump inhibitor from bovine posterior pituitary: purification, structure determination and its cardiovascular effect in rat. Biochem Biophys Res Commun, 189(2), 691-6, 1992.
• Chaki, S, Inagami, T A newly found angiotensin II receptor subtype mediates cyclic GMP formation in differentiated Neuro-2A cells. Eur J Pharmacol, 225(4), 355-6, 1992.
• Yoshida, H, Kakuchi, J, Guo, D F, Furuta, H, Iwai, N, van der Meer-de Jong, R, Inagami, T, Ichikawa, I Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human). Biochem Biophys Res Commun, 186(2), 1042-9, 1992.
• Inagami, T, Iwai, N, Sasaki, K, Yamamo, Y, Bardhan, S, Chaki, S, Guo, D F, Furuta, H Cloning, expression and regulation of angiotensin II receptors. J Hypertens, 10(8), 713-6, 1992.
• Kondo, T, Konishi, F, Inui, H, Inagami, T Diacylglycerol formation from phosphatidylcholine in angiotensin II-stimulated vascular smooth muscle cells. Biochem Biophys Res Commun, 187(3), 1460-5, 1992.
• Ohyama, K, Yamano, Y, Chaki, S, Kondo, T, Inagami, T Domains for G-protein coupling in angiotensin II receptor type I: studies by site-directed mutagenesis. Biochem Biophys Res Commun, 189(2), 677-83, 1992.
• Fogo, A, Hellings, S E, Inagami, T, Kon, V Endothelin receptor antagonism is protective in in vivo acute cyclosporine toxicity. Kidney Int, 42(3), 770-4, 1992.
• Takeda, M, Breyer, M D, Noland, T D, Homma, T, Hoover, R L, Inagami, T, Kon, V Endothelin-1 receptor antagonist: effects on endothelin- and cyclosporine-treated mesangial cells. Kidney Int, 41(6), 1713-9, 1992.
• Iwai, N, Kurtz, T W, Inagami, T Further evidence of the SA gene as a candidate gene contributing to the hypertension in spontaneously hypertensive rat. Biochem Biophys Res Commun, 188(1), 64-9, 1992.
• Chaki, S, Inagami, T Identification and characterization of a new binding site for angiotensin II in mouse neuroblastoma neuro-2A cells. Biochem Biophys Res Commun, 182(1), 388-94, 1992.
• Iwai, N, Inagami, T Identification of a candidate gene responsible for the high blood pressure of spontaneously hypertensive rats. J Hypertens, 10(10), 1155-7, 1992.
• Yamano, Y, Ohyama, K, Chaki, S, Guo, D F, Inagami, T Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis. Biochem Biophys Res Commun, 187(3), 1426-31, 1992.
• Iwai, N, Inagami, T Identification of two subtypes in the rat type I angiotensin II receptor. FEBS Lett, 298(2-3), 257-60, 1992.
• Inagami, T, Mizuno, K, Kawamura, M, Okamura, T, Clemens, D L, Higashimori, K Localization of components of the renin-angiotensin system within the kidney and sustained release of angiotensins from isolated and perfused kidney. Tohoku J Exp Med, 166(1), 17-26, 1992.
• Furuta, H, Guo, D F, Inagami, T Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor. Biochem Biophys Res Commun, 183(1), 8-13, 1992.
• T Kondo, H Inui, F Konishi and T Inagami "Phospholipase D mimics platelet-derived growth factor as a competence factor in VSMC." 267, J Biol Chem23609-23616, 1992.
• Kondo, T, Inui, H, Konishi, F, Inagami, T Phospholipase D mimics platelet-derived growth factor as a competence factor in vascular smooth muscle cells. J Biol Chem, 267(33), 23609-16, 1992.
• Inui, H, Kondo, T, Inagami, T Platelet-derived growth factor AA homodimer stimulates protein synthesis rather than DNA synthesis in vascular smooth muscle cells from spontaneously hypertensive rats but not from normotensive rats. Biochem Biophys Res Commun, 188(2), 524-30, 1992.
• Iwai, N, Inagami, T Quantitative analysis of renin gene expression in extrarenal tissues by polymerase chain reaction method. J Hypertens, 10(8), 717-24, 1992.
• Iwai, N, Inagami, T Regulation of the expression of the rat angiotensin II receptor mRNA. Biochem Biophys Res Commun, 182(3), 1094-9, 1992.
• Makita, N, Iwai, N, Inagami, T, Badr, K F Two distinct pathways in the down-regulation of type-1 angiotension II receptor gene in rat glomerular mesangial cells. Biochem Biophys Res Commun, 185(1), 142-6, 1992.
• Sasaki, K., Yamano, Y., Bardhan, S., Iwai, N., Murray, J.J., Hasegawa, N., Inagami, T "Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor gene from bovine adrenocortical cells." Nature, 351230-232, 1991.
• Munger, K A, Sugiura, M, Takahashi, K, Inagami, T, Badr, K F A role for atrial natriuretic peptide in endothelin-induced natriuresis. J Am Soc Nephrol, 1(12), 1278-83, 1991.
• Sasaki, K, Yamano, Y, Bardhan, S, Iwai, N, Murray, J J, Hasegawa, M, Matsuda, Y, Inagami, T Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature, 351(6323), 230-3, 1991.
• Awazu, M, Sugiura, M, Inagami, T, Ichikawa, I, Kon, V Cyclosporine promotes glomerular endothelin binding in vivo. J Am Soc Nephrol, 1(11), 1253-8, 1991.
• Mizuno, K, Fukuchi, S, Inagami, T Distinct localization of renin and angiotensins in separate subcellular fractions of the rat adrenal cortex. Endocrinol Jpn, 38(6), 655-60, 1991.
• Mizuno, K, Higashimori, K, Fukuchi, S, Inagami, T Exaggerated response to electrical nerve stimulation of angiotensin II release in isolated perfused hind legs of spontaneously hypertensive rats. Clin Exp Hypertens A, 13(5), 839-47, 1991.
• Iwai, N, Inagami, T Isolation of preferentially expressed genes in the kidneys of hypertensive rats. Hypertension, 17(2), 161-9, 1991.
• Inagami, T, Mizuno, K, Higashimori, K Juxtaglomerular cells as a source of intrarenal angiotensin II production. Kidney Int Suppl, 32S20-2, 1991.
• Konishi, F, Kondo, T, Inagami, T Phospholipase D in cultured rat vascular smooth muscle cells and its activation by phorbol ester. Biochem Biophys Res Commun, 179(2), 1070-6, 1991.
• Inagami, T Purification of renin and prorenin. Hypertension, 18(3), 241-51, 1991.
• Iwai, N, Yamano, Y, Chaki, S, Konishi, F, Bardhan, S, Tibbetts, C, Sasaki, K, Hasegawa, M, Matsuda, Y, Inagami, T Rat angiotensin II receptor: cDNA sequence and regulation of the gene expression. Biochem Biophys Res Commun, 177(1), 299-304, 1991.
• Awazu, M, Kon, V, Harris, R C, Imada, T, Inagami, T, Ichikawa, I Renal sympathetic nerves modulate glomerular ANP receptors and filtration. Am J Physiol, 261(1 Pt 2), F29-35, 1991.
• Inagami, T, Murakami, T, Higuchi, K, Nakajo, S Role of vascular wall renin: intracellular and extracellular mechanism. Blood Vessels, 28(1-3), 217-23, 1991.
• Inagami, T, Murakami, T, Higuchi, K, Nakajo, S Roles of renal and vascular renin in spontaneous hypertension and switching of the mechanism upon nephrectomy. Lack of hypotensive effects of inhibition of renin, converting enzyme, and angiotensin II receptor blocker after bilateral nephrectomy. Am J Hypertens, 4(1 Pt 2), 15S-22S, 1991.
• Higashimori, K, Gante, J, Holzemann, G, Inagami, T Significance of vascular renin for local generation of angiotensins. Hypertension, 17(3), 270-7, 1991.
• Jackson, E K, Inagami, T Blockade of the pre- and postjunctional effects of angiotensin in vivo with a non-peptide angiotensin receptor antagonist. Life Sci, 46(13), 945-53, 1990.
• Inagami, T, Mizuno, K, Naruse, K, Okamura, T, Kawamura, M Intracellular formation and release of angiotensins from juxtaglomerular cells. Kidney Int Suppl, 30S33-7, 1990.
• Iwai, N, Inagami, T Molecular cloning of a complementary DNA to rat cyclophilin-like protein mRNA. Kidney Int, 37(6), 1460-5, 1990.
• Nakajo, S, Sugiura, M, Inagami, T Native form of endothelin receptor in human placental membranes. Biochem Biophys Res Commun, 167(1), 280-6, 1990.
• Mizuno, K, Higashimori, K, Stone, W J, Shimamoto, K, Fukuchi, S, Inagami, T Re-evaluation of the plasma renin-angiotensin system in anephric patients. Clin Exp Hypertens A, 12(7), 1135-57, 1990.
• Kon, V, Sugiura, M, Inagami, T, Harvie, B R, Ichikawa, I, Hoover, R L Role of endothelin in cyclosporine-induced glomerular dysfunction. Kidney Int, 37(6), 1487-91, 1990.
• Fogo, A, Hakim, R C, Sugiura, M, Inagami, T, Kon, V Severe endothelial injury in a renal transplant patient receiving cyclosporine. Transplantation, 49(6), 1190-2, 1990.
• Inagami, T, Mizuno, K, Naruse, M, Nakamaru, M, Naruse, K, Hoffman, L H, McKenzie, J C Active and inactive renin in the adrenal. Am J Hypertens, 2(4), 311-9, 1989.
• Inagami, T Atrial natriuretic factor. J Biol Chem, 264(6), 3043-6, 1989.
• Hollister, A S, Rodeheffer, R J, White, F J, Potts, J R, Imada, T, Inagami, T Clearance of atrial natriuretic factor by lung, liver, and kidney in human subjects and the dog. J Clin Invest, 83(2), 623-8, 1989.
• Inagami, T, Tanaka, I, McKenzie, J C, Nakamaru, M, Takayanagi, R, Imada, T, Pochet, R, Resibois, A, Naruse, M, Naruse, K Discovery of atrial natriuretic factor in the brain: its characterization and cardiovascular implication. Cell Mol Neurobiol, 9(1), 75-85, 1989.
• Sugiura, M, Inagami, T, Hare, G M, Johns, J A Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols. Biochem Biophys Res Commun, 158(1), 170-6, 1989.
• Sugiura, M, Inagami, T, Kon, V Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay. Biochem Biophys Res Commun, 161(3), 1220-7, 1989.
• Badr, K F, Munger, K A, Sugiura, M, Snajdar, R M, Schwartzberg, M, Inagami, T High and low affinity binding sites for endothelin on cultured rat glomerular mesangial cells. Biochem Biophys Res Commun, 161(2), 776-81, 1989.
• Sugiura, M, Snajdar, R M, Schwartzberg, M, Badr, K F, Inagami, T Identification of two types of specific endothelin receptors in rat mesangial cell. Biochem Biophys Res Commun, 162(3), 1396-401, 1989.
• Badr, K F, Murray, J J, Breyer, M D, Takahashi, K, Inagami, T, Harris, R C Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways. J Clin Invest, 83(1), 336-42, 1989.
• Higashimori, K, Mizuno, K, Nakajo, S, Boehm, F H, Marcotte, P A, Egan, D A, Holleman, W H, Heusser, C, Poisner, A M, Inagami, T Pure human inactive renin. Evidence that native inactive renin is prorenin. J Biol Chem, 264(25), 14662-7, 1989.
• Awazu, M, Imada, T, Kon, V, Inagami, T, Ichikawa, I Role of endogenous atrial natriuretic peptide in congestive heart failure. Am J Physiol, 257(3 Pt 2), R641-6, 1989.
• Nakajo, S, Sugiura, M, Snajdar, R M, Boehm, F H, Inagami, T Solubilization and identification of human placental endothelin receptor. Biochem Biophys Res Commun, 164(1), 205-11, 1989.
• Inagami, T Structure and function of renin. J Hypertens Suppl, 7(2), S3-8, 1989.
• Imada, T, Takayanagi, R, Inagami, T Atrioactivase, a specific peptidase in bovine atria for the processing of pro-atrial natriuretic factor. Purification and characterization. J Biol Chem, 263(19), 9515-9, 1988.
• Inagami, T, Nakamaru, M, Mizuno, K, Higashimori, K Conceptual evolution of renin research. Clin Exp Hypertens A, 10(6), 1129-39, 1988.
• Mizuno, K, Higashimori, K, Inagami, T Direct evidence for the local generation of vascular angiotensin II and its prostaglandin-mediated release from isolated hind legs in the rat. J Hypertens Suppl, 6(4), S435-7, 1988.
• Pandey, K N, Pavlou, S N, Inagami, T Identification and characterization of three distinct atrial natriuretic factor receptors. Evidence for tissue-specific heterogeneity of receptor subtypes in vascular smooth muscle, kidney tubular epithelium, and Leydig tumor cells by ligand binding, photoaffinity labeling, and tryptic proteolysis. J Biol Chem, 263(26), 13406-13, 1988.
• Tamura, M, Lam, T T, Inagami, T Isolation and characterization of a specific endogenous Na+,K+-ATPase inhibitor from bovine adrenal. Biochemistry, 27(12), 4244-53, 1988.
• Pandey, K N, Inagami, T Kidney tubular epithelium cells and vascular smooth muscle cells contain different types of atrial natriuretic factor receptors. J Hypertens Suppl, 6(4), S292-4, 1988.
• Mizuno, K, Nakamaru, M, Higashimori, K, Inagami, T Local generation and release of angiotensin II in peripheral vascular tissue. Hypertension, 11(3), 223-9, 1988.
• Kawamura, M, Parmentier, M, Inagami, T Localization and secretion of newly synthesized and stored renin: two compartments and secretory mechanisms. Am J Physiol, 255(1 Pt 2), F100-7, 1988.
• Hagiwara, H, Hollister, A S, Carr, R K, Inagami, T Norepinephrine and epinephrine in human erythrocyte plasma membranes. Biochem Biophys Res Commun, 154(3), 1003-9, 1988.
• Mizuno, K, Hoffman, L H, McKenzie, J C, Inagami, T Presence of renin secretory granules in rat adrenal gland and stimulation of renin secretion by angiotensin II but not by adrenocorticotropin. J Clin Invest, 82(3), 1007-16, 1988.
• Inagami, T, Tamura, M Purification and characterization of specific endogenous ouabainlike substance from bovine adrenal. Am J Med Sci, 295(4), 400-5, 1988.
• Imada, T, Takayanagi, R, Inagami, T Purification of a specific peptidase in bovine atria for the processing of pro-atrial natriuretic factor. Biol Chem Hoppe Seyler, 369 Suppl113-20, 1988.
• Mizuno, K, Higashimori, K, Inagami, T Suppression of angiotensin II release by prostaglandin synthesis inhibitors in hind legs. Hypertension, 12(1), 67-73, 1988.
• Inagami, T, Mizuno, K, Nakamaru, M, Pandey, K N, Naruse, M, Naruse, K, Misono, K, Okamura, T, Kawamura, M, Higashimori, K The renin-angiotensin system: an overview of its intracellular function. Cardiovasc Drugs Ther, 2(4), 453-8, 1988.
• Mizuno, K, Higashimori, K, Imada, T, Inagami, T Direct release of angiotensins I and II from isolated rat kidney perfused with angiotensinogen-free medium. Biochem Biophys Res Commun, 149(2), 475-81, 1987.
• Inagami, T, Tamura, M Identification of Na+,K+-ATPase inhibitors of volume-expanded hog plasma. Hypertension, 10(5 Pt 2), I108-12, 1987.
• Pandey, K N, Inagami, T, Girard, P R, Kuo, J F, Misono, K S New signal transduction mechanisms of atrial natriuretic factor: inhibition of phosphorylation of protein kinase C and A 240 kDa protein in adrenal cortical plasma membrane by cGMP dependent and independent mechanisms. Biochem Biophys Res Commun, 148(2), 589-95, 1987.
• Tamura, M, Lam, T T, Inagami, T Specific endogenous Na, K-ATPase inhibitor purified from bovine adrenal. Biochem Biophys Res Commun, 149(2), 468-74, 1987.
• Inagami, T, Misono, K S, Fukumi, H, Maki, M, Tanaka, I, Takayanagi, R, Imada, T, Grammer, R T, Naruse, M, Naruse, K Structure and physiological actions of rat atrial natriuretic factor. Hypertension, 10(5 Pt 2), I113-7, 1987.
• Pandey, K N, Inagami, T, Misono, K S Three distinct forms of atrial natriuretic factor receptors: kidney tubular epithelium cells and vascular smooth muscle cells contain different types of receptors. Biochem Biophys Res Commun, 147(3), 1146-52, 1987.
• Maki, M., Takayanagi, R. Misono, K.S., Pandey, K.N., Tibbetts C. , Inagami, T "Structure of rat atrial natriuretic factor precursor deduced from cDNA sequence." Nature, 309722-724, 1984.