Terence S. Dermody : Vanderbilt-Ingram Cancer Center

The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers

Terence S. Dermody, M.D.

Director, Lamb Center for Pediatric Research
Director, Vanderbilt MSTP
Prof Pediatrics
Prof Microbiology and Immunology
VICC Member
Researcher

Contact Information:

Vanderbilt University Medical Center
D-7235 Medical Center North
Nashville, TN 37232-2581
615-343-9943

Research Specialty

Viral Infections of the Central Nervous System, Entry of Viruses into Host Cells, Development of New Vaccine Vectors

Research Description

Our laboratory uses mammalian reoviruses as models to study mechanisms by which viruses cause disease. Reoviruses infect many mammalian species, including humans, but disease is restricted to the very young. After infection of newborn mice, reoviruses can cause encephalitis, hepatitis, and myocarditis, depending on the viral strain used. We use a multidisciplinary approach to investigate mechanisms of reovirus attachment, cell entry, genome replication, and apoptosis. These studies will provide a comprehensive analysis of the steps in reovirus replication that culminate in disease.

(1) Reovirus cell-attachment. The reovirus attachment protein, sigma 1, plays a key role in target cell selection in the infected host. We are conducting experiments using mutant viruses with defined alterations in receptor-binding functions to determine how independent receptor-binding domains in sigma 1 contribute to cell-attachment and trigger viral entry. We also are investigating the role of reovirus receptors, sialic acid and junctional adhesion molecule A (JAM-A), in reovirus attachment, entry, and pathogenesis. These studies employ polarized cells and mice lacking JAM-A. This work will be interpreted in the context of ongoing structural studies of sigma 1 in complex with its receptors with the goal of determining how sigma 1 structure relates to its function in receptor binding. New research focuses on the identification of receptors in host tissues that do not require JAM-A for productive infection.

(2) Reovirus entry into cells. Reovirus enters cells by clathrin-dependent endocytosis and undergoes proteolytic disassembly in endosomes. We have found that beta 1 integrins are required for reovirus internalization following virus attachment to host cells. Studies are in progress to define mechanisms by which beta 1 integrins mediate viral uptake and transport within the endocytic pathway. Viral disassembly in most cell types is catalyzed by cathepsins B, L, or S. We are using molecular genetics, biochemical analyses, and electron cryomicroscopy to study domains in reovirus outer-capsid proteins that regulate proteolytic cleavage. A final series of experiments seeks to define mechanisms underlying the roles of individual cathepsins in reovirus disease. This research will reveal fundamental mechanisms by which viral and cellular factors cooperate to facilitate viral entry and illuminate new targets for therapy against viruses that use the endocytic pathway to enter cells.

(3) Reovirus-induced apoptosis. Reovirus induces apoptosis in cultured cells and in the murine central nervous system and heart. Our studies indicate that apoptosis is triggered by innate immune response signal transducers initiated by the viral mu 1 protein following reovirus disassembly and penetration of endosomal membranes. Experiments are in progress to identify components of the cell-signaling apparatus required for apoptosis induction by reovirus and to determine the relationship between apoptosis and virulence. These studies will establish new ideas about how RNA-containing viruses interact with innate immune response signaling circuits and lead to a better understanding of how viruses injure their host cells.

(4) Plasmid-based reverse genetics for reovirus. A major roadblock to studies of the Reoviridae family of double-stranded RNA viruses had been the inability to rescue infectious virus from cloned cDNA. We now have developed a fully plasmid-based reverse genetics technology for reovirus that permits selective introduction of desired mutations into each of the 10 viral gene segments. Moreover, gene segment cDNAs can be manipulated to facilitate expression of a transgene. Thus, numerous important hypotheses about virus structure, replication, and pathogenesis are now testable. In addition to advancing studies of reovirus biology, reovirus-mediated gene transduction will foster development of reovirus as a vaccine vector.

Publications

Johnson, EM, Doyle, JD, Wetzel, JD, McClung, RP, Katunuma, N, Chappell, JD, Washington, MK, Dermody, TS Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J Virol, In press2009.
Kobayashi, T, Ooms, LS, Chappell, JD, Dermody, TS Identification of functional domains in reovirus replication proteins muNS and mu2. J Virol, 83(7), 2892-906, 2009.
Cseke, G, Maginnis, MS, Cox, RG, Tollefson, SJ, Podsiad, AB, Wright, DW, Dermody, TS, Williams, JV Integrin alphavbeta1 promotes infection by human metapneumovirus. Proc Natl Acad Sci U S A, 106(5), 1566-71, 2009.
Antar, AA, Konopka, JL, Campbell, JA, Henry, RA, Perdigoto, AL, Carter, BD, Pozzi, A, Abel, TW, Dermody, TS Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe, 5(1), 59-71, 2009.
Zurney, J, Kobayashi, T, Holm, GH, Dermody, TS, Sherry, B Reovirus mu2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor 9. J Virol, 83(5), 2178-87, 2009.
Danthi, P, Coffey, CM, Parker, JS, Abel, TW, Dermody, TS Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain. PLoS Pathog, 4(12), e1000248, 2008.
Maginnis, MS, Mainou, BA, Derdowski, A, Johnson, EM, Zent, R, Dermody, TS NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry. J Virol, 82(7), 3181-91, 2008.
Danthi, P, Kobayashi, T, Holm, GH, Hansberger, MW, Abel, TW, Dermody, TS Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency. J Virol, 82(1), 161-72, 2008.
Excoffon, KJ, Guglielmi, KM, Wetzel, JD, Gansemer, ND, Campbell, JA, Dermody, TS, Zabner, J Reovirus preferentially infects the basolateral surface and is released from the apical surface of polarized human respiratory epithelial cells. J Infect Dis, 197(8), 1189-97, 2008.
Kirchner, E, Guglielmi, KM, Strauss, HM, Dermody, TS, Stehle, T Structure of reovirus sigma1 in complex with its receptor junctional adhesion molecule-A. PLoS Pathog, 4(12), e1000235, 2008.
Kobayashi, T, Antar, AA, Boehme, KW, Danthi, P, Eby, EA, Guglielmi, KM, Holm, GH, Johnson, EM, Maginnis, MS, Naik, S, Skelton, WB, Wetzel, JD, Wilson, GJ, Chappell, JD, Dermody, TS A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe, 1(2), 147-57, 2007.
Hansberger, MW, Campbell, JA, Danthi, P, Arrate, P, Pennington, KN, Marcu, KB, Ballard, DW, Dermody, TS I{kappa}B kinase subunits {alpha} and {gamma} are required for activation of NF-{kappa}B and induction of apoptosis by mammalian reovirus. J Virol, 81(3), 1360-71, 2007.
Laukoetter, MG, Nava, P, Lee, WY, Severson, EA, Capaldo, CT, Babbin, BA, Williams, IR, Koval, M, Peatman, E, Campbell, JA, Dermody, TS, Nusrat, A, Parkos, CA JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med, 204(13), 3067-76, 2007.
Holm, GH, Zurney, J, Tumilasci, V, Leveille, S, Danthi, P, Hiscott, J, Sherry, B, Dermody, TS RIG-I and IPS-1 augment proapoptotic responses following mammalian reovirus infection via IRF-3. J Biol Chem, 282(30), 21953-61, 2007.
Guglielmi, KM, Kirchner, E, Holm, GH, Stehle, T, Dermody, TS Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem, 282(24), 17930-40, 2007.
Schelling, P, Guglielmi, KM, Kirchner, E, Paetzold, B, Dermody, TS, Stehle, T The reovirus sigma 1 aspartic acid sandwich: A trimerization motif poised for conformational change. J Biol Chem, 282(15), 17930-40, 2007.
Johansson, C, Wetzel, JD, He, J, Mikacenic, C, Dermody, TS, Kelsall, BL Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus. J Exp Med, 204(6), 1349-58, 2007.
Guglielmi, KM, Johnson, EM, Stehle, T, Dermody, TS Attachment and cell entry of mammalian orthoreovirus. Curr Top Microbiol Immunol, 3091-38, 2006.
Maginnis, MS, Forrest, JC, Kopecky-Bromberg, SA, Dickeson, SK, Santoro, SA, Zutter, MM, Nemerow, GR, Bergelson, JM, Dermody, TS Beta 1 Integrin Mediates Internalization of Mammalian Reovirus. J Virol, 80(6), 2760-70, 2006.
Kobayashi, T, Chappell, JD, Danthi, P, Dermody, TS Gene-specific inhibition of reovirus replication by RNA interference. J Virol, 80(18), 9053-63, 2006.
ODonnell, SM, Holm, GH, Pierce, JM, Tian, B, Watson, MJ, Chari, RS, Ballard, DW, Brasier, AR, Dermody, TS Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus. J Virol, 80(3), 1077-86, 2006.
Danthi, P, Hansberger, MW, Campbell, JA, Forrest, JC, Dermody, TS JAM-A-independent, antibody-mediated uptake of reovirus into cells leads to apoptosis. J Virol, 80(3), 1261-70, 2006.
Wetzel, JD, Barton, ES, Chappell, JD, Baer, GS, Mochow-Grundy, M, Rodgers, SE, Shyr, Y, Powers, AC, Thomas, JW, Dermody, TS Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice. J Virol, 80(6), 3078-82, 2006.
Clark, KM, Wetzel, JD, Gu, Y, Ebert, DH, McAbee, SA, Stoneman, EK, Baer, GS, Zhu, Y, Wilson, GJ, Prasad, BV, Dermody, TS Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3. J Virol, 80(2), 671-81, 2006.
Huang, IC, Bosch, BJ, Li, F, Li, W, Lee, KH, Ghiran, S, Vasilieva, N, Dermody, TS, Harrison, SC, Dormitzer, PR, Farzan, M, Rottier, PJ, Choe, H SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J Biol Chem, 281(6), 3198-203, 2006.
Dong, X, Li, H, Derdowski, A, Ding, L, Burnett, A, Chen, X, Peters, TR, Dermody, TS, Woodruff, E, Wang, JJ, Spearman, P AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Cell, 120(5), 663-74, 2005.
Campbell, JA, Schelling, P, Wetzel, JD, Johnson, EM, Wilson, GAR, Forrest, JC, Aurrand-Lions, M, Imhof, BA, Stehle, T, Dermody, TS Junctional adhesion molecule A serves as a receptor for prototype and field-isolate strains of mammalian reovirus. J Virol, 79(13), 7967-78, 2005.
O'Donnell, SM, Connolly, JL, Hansberger, MW, Chappell, JD, Watson, MJ, Han, W, Barton, ES, Forrest, Valyi-Nagy, T, JC, Pierce, JM, Yull, FE, Blackwell, TS, Rottman, JN, Sherry, B, Dermody, TS Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest, 115(9), 2341-50, 2005.
Tai, JH, Williams, JV, Edwards, KM, Wright, PF, Crowe, JE, Dermody, TS Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee. J Infect Dis, 191(8), 1221-4, 2005.
Valyi-Nagy, T, Dermody, TS Role of oxidative damage in the pathogenesis of viral infections of the nervous system. Histol Histopathol, 20(3), 957-67, 2005.
Mercier, G T, Campbell, J A, Chappell, J D, Stehle, T, Dermody, T S, Barry, M A A chimeric adenovirus vector encoding reovirus attachment protein sigma 1 targets cells expressing junctional adhesion molecule 1. Proc Natl Acad Sci U S A, 101(16), 6188-93, 2004.
Ebert, D H, Kopecky-Bromberg, S A, Dermody, T S Cathepsin B is inhibited in mutant cells selected during persistent reovirus infection. J Biol Chem, 279(5), 3837-51, 2004.
Tyler, K L, Barton, E S, Ibach, M L, Robinson, C, Campbell, J A, O'Donnell, S M, Valyi-Nagy, T, Clarke, P, Wetzel, J D, Dermody, T S Isolation and molecular characterization of a novel type 3 reovirus from a child with meningitis. J Infect Dis, 189(9), 1664-75, 2004.
Fleeton, M N, Contractor, N, Leon, F, Wetzel, J D, Dermody, T S, Kelsall, B L Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. J Exp Med, 200(2), 235-45, 2004.
Stehle, T, Dermody, T S Structural similarities in the cellular receptors used by adenovirus and reovirus. Viral Immunol, 17(2), 129-43, 2004.
Prota, A E, Campbell, J A, Schelling, P, Forrest, J C, Watson, M J, Peters, T R, Aurrand-Lions, M, Imhof, B A, Dermody, T S, Stehle, T Crystal structure of human junctional adhesion molecule 1: Implications for reovirus binding. Proc Natl Acad Sci U S A, 100(9), 5366-71, 2003.
Forrest, J C, Dermody, T S Reovirus receptors and pathogenesis. J Virol, 77(17), 9109-15, 2003.
Becker, M M, Peters, T R, Dermody, T S Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection. J Virol, 77(10), 5948-63, 2003.
Stewart, Phoebe L, Dermody, Terence S, Nemerow, Glen R Structural basis of nonenveloped virus cell entry. Adv Protein Chem, 64455-91, 2003.
Stehle, T, Dermody, T S Structural evidence for common functions and ancestry of the reovirus and adenovirus attachment proteins. Rev Med Virol, 13(2), 123-32, 2003.
Forrest, J C, Campbell, J A, Schelling, P, Stehle, T, Dermody, T S Structure-function analysis of reovirus binding to junctional adhesion molecule 1: Implications for the mechanism of reovirus attachment. J Biol Chem, 278(48), 48434-44, 2003.
Barton, E S, Youree, B E, Ebert, D H, Forrest, J C, Connolly, J L, Valyi-Nagy, T, Washington, K, Wetzel, J D, Dermody, T S Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease. J Clin Invest, 111(12), 1823-33, 2003.
Wilson, G J, Nason, E L, Hardy, C S, Ebert, D H, Wetzel, J D, Prasad, B V, Dermody, T S A single mutation in the carboxy terminus of reovirus outer-capsid protein sigma 3 confers enhanced kinetics of sigma 3 proteolysis, resistance to inhibitors of viral disassembly, and alterations in sigma 3 structure. J Virol, 76(19), 9832-43, 2002.
Ebert, D H, Deussing, J, Peters, C, Dermody, T S Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem, 277(27), 24609-17, 2002.
Chappell, J D, Prota, A E, Dermody, T S, Stehle, T Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber. EMBO J, 21(1-2), 1-11, 2002.
Leary, T P, Erker, J C, Chalmers, M L, Cruz, A T, Wetzel, J D, Desai, S M, Mushahwar, I K, Dermody, T S Detection of mammalian reovirus RNA by using reverse transcription-PCR: Sequence diversity within the lambda3-encoding L1 gene. J Clin Microbiol, 40(4), 1368-75, 2002.
Milatovic, Dejan, Zhang, Yueli, Olson, Sandra J, Montine, Kathleen S, Roberts, L Jackson, Morrow, Jason D, Montine, Thomas J, Dermody, Terence S, Valyi-Nagy, Tibor Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes. J Neurovirol, 8(4), 295-305, 2002.
Connolly, J L, Dermody, T S Virion disassembly is required for apoptosis induced by reovirus. J Virol, 76(4), 1632-41, 2002.
Nason, E L, Wetzel, J D, Mukherjee, S K, Barton, E S, Prasad, B V, Dermody, T S A monoclonal antibody specific for reovirus outer-capsid protein sigma3 inhibits sigma1-mediated hemagglutination by steric hindrance. J Virol, 756625-34, 2001.
Ebert, D H, Wetzel, J D, Brumbaugh, D E, Chance, S R, Stobie, L E, Baer, G S, Dermody, T S Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3. J Virol, 753197-206, 2001.
Chandran, K, Zhang, X, Olson, N H, Walker, S B, Chappell, J D, Dermody, T S, Baker, T S, Nibert, M L Complete in vitro assembly of the reovirus outer capsid produces highly infectious particles suitable for genetic studies of the receptor-binding protein. J Virol, 755335-42, 2001.
Barton, E S, Forrest, J C, Connolly, J L, Chappell, J D, Liu, Y, Schnell, F J, Nusrat, A, Parkos, C A, Dermody, T S Junction adhesion molecule is a receptor for reovirus. Cell, 104441-51, 2001.
Connolly, J L, Barton, E S, Dermody, T S Reovirus binding to cell surface sialic acid potentiates virus-induced apoptosis. J Virol, 754029-39, 2001.
Becker, M M, Goral, M I, Hazelton, P R, Baer, G S, Rodgers, S E, Brown, E G, Coombs, K M, Dermody, T S Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions. J Virol, 751459-75, 2001.
Poggioli, G J, Dermody, T S, Tyler, K L Reovirus-induced sigma1s-dependent G(2)/M phase cell cycle arrest is associated with inhibition of p34(cdc2). J Virol, 757429-34, 2001.
Mochow-Grundy, M, Dermody, T S The reovirus S4 gene 3' nontranslated region contains a translational operator sequence. J Virol, 75(14), 6517-26, 2001.
Barton, E S, Connolly, J L, Forrest, J C, Chappell, J D, Dermody, T S Utilization of sialic acid as a coreceptor enhances reovirus attachment by multistep adhesion strengthening. J Biol Chem, 2762200-11, 2001.
Valyi-Nagy, T, Olson, S J, Valyi-Nagy, K, Montine, T J, Dermody, T S Herpes simplex virus type 1 latency in the murine nervous system is associated with oxidative damage to neurons. Virology, 278309-21, 2000.
Chappell, J D, Duong, J L, Wright, B W, Dermody, T S Identification of carbohydrate-binding domains in the attachment proteins of type 1 and type 3 reoviruses. J Virol, 748472-9, 2000.
Mbisa, J L, Becker, M M, Zou, S, Dermody, T S, Brown, E G Reovirus mu2 protein determines strain-specific differences in the rate of viral inclusion formation in L929 cells. Virology, 272(1), 16-26, 2000.
Poggioli, G J, Keefer, C, Connolly, J L, Dermody, T S, Tyler, K L Reovirus-induced G(2)/M cell cycle arrest requires sigma1s and occurs in the absence of apoptosis. J Virol, 749562-70, 2000.
Connolly, J L, Rodgers, S E, Clarke, P, Ballard, D W, Kerr, L D, Tyler, K L, Dermody, T S Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. J Virol, 742981-9, 2000.
Valyi-Nagy, T, Sidell, K R, Marnett, L J, Roberts, L J, Dermody, T S, Morrow, J D, Montine, T J Divergence of brain prostaglandin H synthase activity and oxidative damage in mice with encephalitis. J Neuropathol Exp Neurol, 58(12), 1269-75, 1999.
Baer, G S, Ebert, D H, Chung, C J, Erickson, A H, Dermody, T S Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly. J Virol, 739532-43, 1999.
Chappell, J D, Barton, E S, Smith, T H, Baer, G S, Duong, D T, Nibert, M L, Dermody, T S Cleavage susceptibility of reovirus attachment protein sigma1 during proteolytic disassembly of virions is determined by a sequence polymorphism in the sigma1 neck. J Virol, 728205-13, 1998.
Rodgers, S E, Connolly, J L, Chappell, J D, Dermody, T S Reovirus growth in cell culture does not require the full complement of viral proteins: identification of a sigma1s-null mutant. J Virol, 728597-604, 1998.
Wetzel, J D, Chappell, J D, Fogo, A B, Dermody, T S Efficiency of viral entry determines the capacity of murine erythroleukemia cells to support persistent infections by mammalian reoviruses. J Virol, 71299-306, 1997.
Baer, G S, Dermody, T S Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64. J Virol, 714921-8, 1997.
Chappell, J D, Gunn, V L, Wetzel, J D, Baer, G S, Dermody, T S Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1. J Virol, 711834-41, 1997.
Oberhaus, S M, Smith, R L, Clayton, G H, Dermody, T S, Tyler, K L Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J Virol, 712100-6, 1997.
Wetzel, J D, Wilson, G J, Baer, G S, Dunnigan, L R, Wright, J P, Tang, D S, Dermody, T S Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly. J Virol, 711362-9, 1997.
Rodgers, S E, Barton, E S, Oberhaus, S M, Pike, B, Gibson, C A, Tyler, K L, Dermody, T S Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2. J Virol, 712540-6, 1997.
Tyler, K L, Squier, M K, Brown, A L, Pike, B, Willis, D, Oberhaus, S M, Dermody, T S, Cohen, J J Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: Role of the S1 and M2 genes. J Virol, 70(11), 7984-91, 1996.
Wilson, G J, Wetzel, J D, Puryear, W, Bassel-Duby, R, Dermody, T S Persistent reovirus infections of L cells select mutations in viral attachment protein sigma1 that alter oligomer stability. J Virol, 706598-606, 1996.
Goral, M I, Mochow-Grundy, M, Dermody, T S Sequence diversity within the reovirus S3 gene: Reoviruses evolve independently of host species, geographic locale, and date of isolation. Virology, 216(1), 265-71, 1996.
Haller, B L, Barkon, M L, Li, X Y, Hu, W M, Wetzel, J D, Dermody, T S, Virgin, H W Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice. J Virol, 69(6), 3933-7, 1995.
Tyler, K L, Squier, M K, Rodgers, S E, Schneider, B E, Oberhaus, S M, Grdina, T A, Cohen, J J, Dermody, T S Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein sigma 1. J Virol, 696972-9, 1995.
Nibert, M L, Chappell, J D, Dermody, T S Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved sigma 1 protein. J Virol, 69(8), 5057-67, 1995.
Chapell, J D, Goral, M I, Rodgers, S E, dePamphilis, C W, Dermody, T S Sequence diversity within the reovirus S2 gene: Reovirus genes reassort in nature, and their termini are predicted to form a panhandle motif. J Virol, 68(2), 750-6, 1994.
Dermody, T S, Nibert, M L, Wetzel, J D, Tong, X, Fields, B N Cells and viruses with mutations affecting viral entry are selected during persistent infections of L cells with mammalian reoviruses. J Virol, 672055-63, 1993.
Morrison, L A, Fields, B N, Dermody, T S Prolonged replication in the mouse central nervous system of reoviruses isolated from persistently infected cell cultures. J Virol, 67(6), 3019-26, 1993.
Rubin, D H, Wetzel, J D, Williams, W V, Cohen, J A, Dworkin, C, Dermody, T S Binding of type 3 reovirus by a domain of the sigma 1 protein important for hemagglutination leads to infection of murine erythroleukemia cells. J Clin Invest, 90(6), 2536-42, 1992.
Dermody, T S, Schiff, L A, Nibert, M L, Coombs, K M, Fields, B N The S2 gene nucleotide sequences of prototype strains of the three reovirus serotypes: Characterization of reovirus core protein sigma 2. J Virol, 65(11), 5721-31, 1991.
Dermody, T S, Nibert, M L, Bassel-Duby, R, Fields, B N A sigma 1 region important for hemagglutination by serotype 3 reovirus strains. J Virol, 64(10), 5173-6, 1990.
Dermody, T S, Nibert, M L, Bassel-Duby, R, Fields, B N Sequence diversity in S1 genes and S1 translation products of 11 serotype 3 reovirus strains. J Virol, 64(10), 4842-50, 1990.
Nibert, M L, Dermody, T S, Fields, B N Structure of the reovirus cell-attachment protein: A model for the domain organization of sigma 1. J Virol, 64(6), 2976-89, 1990.

Vanderbilt-Ingram Cancer Center