The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
Thomas Andl, Ph.D.
Assistant Professor of Medicine
VICC Member
Researcher
Contact Information:
Vanderbilt University Medical Center
A2310B Medical Center North, 1161 21st Avenue S
Nashville, TN 37232-2600
615-322-1716
Fax: 615-343-4365
Research Specialty
the role of microRNAs in normal and pathological conditions of the skin
Research Description
My major interests are in understanding how epithelial cells of the surface ectoderm can form many different appendages, how this capability is altered in the adult organism, how this relates to malignant transformation of epithelial stem cells in the course of tumorigenesis, and how human primary keratinocytes can be genetically engineered for gene therapy purposes. In particular I am interested in the role of Dicer and microRNAs in squamous epithelial carcinogenesis.
Additionally, Dicer has important functions in the control of the epigenome by regulating the formation and maintenance of heterochromatin. Therefore, another aspect of my research interest is to determine how changes in the epigenome during lifetime affect aging and susceptibility to diseases like cancer.
Publications
- Benetti, R, Gonzalo, S, Jaco, I, Muñoz, P, Gonzalez, S, Schoeftner, S, Murchison, E, Andl, T, Chen, T, Klatt, P, Li, E, Serrano, M, Millar, S, Hannon, G, Blasco, MA A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol, 15(3), 268-79, 2008.
- Liu, F, Chu, EY, Watt, B, Zhang, Y, Gallant, NM, Andl, T, Yang, SH, Lu, MM, Piccolo, S, Schmidt-Ullrich, R, Taketo, MM, Morrisey, EE, Atit, R, Dlugosz, AA, Millar, SE Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol, 313(1), 210-24, 2008.
- Stark, J, Andl, T, Millar, SE Hairy math: insights into hair-follicle spacing and orientation. Cell, 128(1), 17-20, 2007.
- Liu, F, Thirumangalathu, S, Gallant, NM, Yang, SH, Stoick-Cooper, CL, Reddy, ST, Andl, T, Taketo, MM, Dlugosz, AA, Moon, RT, Barlow, LA, Millar, SE Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet, 39(1), 106-12, 2007.
- Ito, M, Yang, Z, Andl, T, Cui, C, Kim, N, Millar, SE, Cotsarelis, G Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature, 447(7142), 316-20, 2007.
- de Guzman Strong, C, Wertz, PW, Wang, C, Yang, F, Meltzer, PS, Andl, T, Millar, SE, Ho, IC, Pai, SY, Segre, JA Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol, 175(4), 661-70, 2006.
- Andl, T, Murchison, EP, Liu, F, Zhang, Y, Yunta-Gonzalez, M, Tobias, JW, Andl, CD, Seykora, JT, Hannon, GJ, Millar, SE The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol, 16(10), 1041-9, 2006.
- Shu, W, Guttentag, S, Wang, Z, Andl, T, Ballard, P, Lu, MM, Piccolo, S, Birchmeier, W, Whitsett, JA, Millar, SE, Morrisey, EE Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol, 283(1), 226-39, 2005.
- Chu, EY, Hens, J, Andl, T, Kairo, A, Yamaguchi, TP, Brisken, C, Glick, A, Wysolmerski, JJ, Millar, SE Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development, 131(19), 4819-29, 2004.
- Andl, T, Ahn, K, Kairo, A, Chu, EY, Wine-Lee, L, Reddy, ST, Croft, NJ, Cebra-Thomas, JA, Metzger, D, Chambon, P, Lyons, KM, Mishina, Y, Seykora, JT, Crenshaw, EB, Millar, SE Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development, 131(10), 2257-68, 2004.
- Reddy, ST, Andl, T, Lu, MM, Morrisey, EE, Millar, SE Expression of Frizzled genes in developing and postnatal hair follicles. J Invest Dermatol, 123(2), 275-82, 2004.
- Millar, SE, Koyama, E, Reddy, ST, Andl, T, Gaddapara, T, Piddington, R, Gibson, CW Over- and ectopic expression of Wnt3 causes progressive loss of ameloblasts in postnatal mouse incisor teeth. Connect Tissue Res, 44 Suppl 1124-9, 2003.
- Andl, T, Reddy, ST, Gaddapara, T, Millar, SE WNT signals are required for the initiation of hair follicle development. Dev Cell, 2(5), 643-53, 2002.
- Reddy, S, Andl, T, Bagasra, A, Lu, MM, Epstein, DJ, Morrisey, EE, Millar, SE Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev, 107(1-2), 69-82, 2001.
- Hsu, M, Andl, T, Li, G, Meinkoth, JL, Herlyn, M Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression. J Cell Sci, 113 ( Pt 9)1535-42, 2000.
- Nesbit, M, Nesbit, HK, Bennett, J, Andl, T, Hsu, MY, Dejesus, E, McBrian, M, Gupta, AR, Eck, SL, Herlyn, M Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes. Oncogene, 18(47), 6469-76, 1999.
- Herold-Mende, C, Steiner, HH, Andl, T, Riede, D, Buttler, A, Reisser, C, Fusenig, NE, Mueller, MM Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells. Lab Invest, 79(12), 1573-82, 1999.
- Herold-Mende, C, Andl, T, Laemmler, F, Reisser, C, Eichhorn, S [Expression and localization profile of tenascin in squamous cell carcinomas of the head and neck. HNO, 47(8), 723-9, 1999.
- Herold-Mende, C, Andl, T, Laemmler, F, Reisser, C, Mueller, MM [Functional expression of vascular endothelial growth factor receptor Flt-1 on squamous cell carcinoma of the head and neck. HNO, 47(8), 706-11, 1999.
- Helbig, M, Andl, T, Kahn, T, Klein-Kühne, W, Conradt, C, Dietz, A, Bosch, FX [The role of oncogenic human papillomaviruses in tonsillar squamous cell carcinomas with functional inactivation of the retinoblastoma protein. HNO, 47(9), 796-803, 1999.
- Spanbroek, R, Stark, HJ, Janssen-Timmen, U, Kraft, S, Hildner, M, Andl, T, Bosch, FX, Fusenig, NE, Bieber, T, RÃ¥dmark, O, Samuelsson, B, Habenicht, AJ 5-Lipoxygenase expression in Langerhans cells of normal human epidermis. Proc Natl Acad Sci U S A, 95(2), 663-8, 1998.
- Andl, T, Kahn, T, Pfuhl, A, Nicola, T, Erber, R, Conradt, C, Klein, W, Helbig, M, Dietz, A, Weidauer, H, Bosch, FX Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res, 58(1), 5-13, 1998.
- Erber, R, Klein, W, Andl, T, Enders, C, Born, AI, Conradt, C, Bartek, J, Bosch, FX Aberrant p21(CIP1/WAF1) protein accumulation in head-and-neck cancer. Int J Cancer, 74(4), 383-9, 1997.
- Nees, M, Homann, N, Discher, H, Andl, T, Enders, C, Herold-Mende, C, Schuhmann, A, Bosch, FX Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors. Cancer Res, 53(18), 4189-96, 1993.
- Homann, N, Andl, T, Nees, M, Schuhmann, A, Herold-Mende, C, Bosch, FX [Significance of aberrant p53 protein in head-neck tumors and its effect on proliferation and differentiation. HNO, 41(5), 254-60, 1993.
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