The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
Thomas M. Harris, Ph.D.
Orrin Henry Ingram Distinguished Prof of Engineering
Chair, Biomedical Engineering & Computing
Professor of Biomedical Engineering
Researcher
Contact Information:
Vanderbilt University Medical Center
Box 1724 Sta B
Nashville, TN 37232
615-322-0842
Research Specialty
Transport of fluid and solutes in the lung microcirculation
Research Description
This research is concentrated on the quantitative physiology of the exchange of fluids and solutes in the capillaries of the lung. We seek to understand the basic biophysical mechanisms by which the exchange functions of the lung are regulated, how injury affects these functions and how diseases which lead to lung vascular injury should be treated. Our scientific goals are the establishment of a precise mathematical description of lung vascular fluid mechanics, diffusion and exchange in normal and abnormal situations. Our medical goals are to improve the diagnosis and treatment of lung vascular diseases especially Adult Respiratory Distress Syndrome. Our engineering goals are the development of minimally invasive instruments and methods to evaluate lung vascular function and fluid balance in patients. We perform experiments on isolated endothelial cell systems, isolated perfused lungs and intact animals. In addition, there is collaboration with clinical investigators in studies on patients. Lung vascular transport is measured with radioisotopes, the surgical cannulation and collection of lung lymph, infrared spectroscopy, gamma scanning and magnetic resonance imaging. The computer is prominent in our work, and we are engaged in several studies involving mathematical simulation of lung function and the use of scientific visualization methods to guide advanced computer analysis of the lung.
Current Projects Include:
(1) The control of functioning capillary surface area in the lung.
(2) The analysis of heterogeneous perfusion in the lung.
(3) Optical densitometry as an instrument for on-line evaluation of indicator dilution curves in animals and patients.
(4) Development of a computerized system for the simulation of lung fluid balance and solute exchange.
(5) Development of minimally invasive instrumentation for measuring lung vascular function.
Publications
- Seale, Kevin T, Pou, N A, Krivitski, N, Harris, Thomas R Quantification of lung microvascular injury with ultrasound. Ann Biomed Eng, 30(5), 671-82, 2002.
- Harris, Thomas R, Bransford, John D, Brophy, Sean P Roles for learning sciences and learning technologies in biomedical engineering education: a review of recent advances. Annu Rev Biomed Eng, 429-48, 2002.
- Seale, Kevin T. and Harris, T. R "A three-compartment model of osmotic water exchange in the lung microvasculature." 28, Ann Biomedical Engr.g1019-1027, 2000.
- Seale, K T, Harris, T R A three-compartment model of osmotic water exchange in the lung microvasculature. Ann Biomed Eng, 28(8), 1019-27, 2000.
- DeMarino, S., Olson, L.E., Galloway, R.L., Pou, A., Harris, T.R "Optical and radioisotope measures of capillary transport in isolated dog lungs during increased vascular pressure and increased vascular permeability." Ann. Biomed. Engrg., 26417-430, 1998.
- Caruthers, S.D., Paschal, C.B., Pou, N.A., Roselli, R. J., Harris, T. R "Regional measurement of pulmonary edema using magnetic resonance imaging." J. Applied Physiol, 842143-2153, 1998.
- Caruthers, S D, Paschal, C B, Pou, N A, Roselli, R J, Harris, T R Regional measurements of pulmonary edema by using magnetic resonance imaging. J Appl Physiol, 84(6), 2143-53, 1998.
- Roselli, R.J., Tack, G., Harris, T.R "A model of fluid, erythrocyte, and solute transport in the lung." Ann. Biomed. Engr, 2546-61, 1997.
- Roselli, R J, Tack, G, Harris, T R A model of fluid, erythrocyte, and solute transport in the lung. Ann Biomed Eng, 25(1), 46-61, 1997.
- Caruthers, S.D., Paschal, C.P., Pou, N.A., Harris, T.R "Relative quantification of pulmonary edema with non- contrast enhanced MRI." Jo. Magnetic Res. Imag, 7544-550, 1997.
- Caruthers, S D, Paschal, C B, Pou, N A, Harris, T R Relative quantification of pulmonary edema with noncontrast-enhanced MRI. J Magn Reson Imaging, 7(3), 544-50, 1997.
- Bosan, S. and Harris, T.R "Visualization based analysis of multi-parameter models using EN-DIMAN (Environment for N-Dimensional Model Analysis." Computers and Biomedical Research, 30171-187, 1997.
- Bosan, S, Harris, T R Visualization-based analysis of multiparameter models using environment for N-dimensional model analysis. Comput Biomed Res, 30(3), 171-87, 1997.
- Stead, W. W., Borden, R., Bourne, J., Guise, D., Guise, N., Harris, T. R., Miller, R.A., Olsen, A ". The Vanderbilt University fast track to IAIMS: Transition from planning to operations." J. Am. Med. Inf. Assoc, 3308-317, 1996.
- Bosan, S., and Harris, T.R "A visualization-based analysis method for multiparameter models of capillary- tissue exchange." Ann. Biomed. Engrg, 24124-138., 1996.
- Bosan, S, Harris, T R A visualization-based analysis method for multiparameter models of capillary tissue-exchange. Ann Biomed Eng, 24(1), 124-38, 1996.
- Bosan, S., Harris, T.R "Graphical Lung Analysis and Simulation Environment, Comp." Methods and Programs in Biomedicine, 49211-228, 1996.
- Bosan, S, Harris, T R Graphical lung analysis and simulation environment. Comput Methods Programs Biomed, 49(3), 211-28, 1996.
- Stead, W W, Borden, R, Bourne, J, Giuse, D, Giuse, N, Harris, T R, Miller, R A, Olsen, A J The Vanderbilt University fast track to IAIMS: transition from planning to implementation. J Am Med Inform Assoc, 3(5), 308-17, 1996.
- Olson, L.E., Harris, T.R., Pou, A., Syed-Ahmed, M.N., Galloway, R.L "An optical multiple indicator dilution technique to measure lung permeability surface area: Calibration and baseline measurement. IEEE Trans." BME , 42451-463, 1995.
- Caruthers, S D, Harris, T R, Overholser, K A, Pou, N A, Parker, R E Effects of flow heterogeneity on the measurement of capillary exchange in the lung. J Appl Physiol, 79(5), 1449-60, 1995.
- Caruthers, S.D., Harris, T.R, Overholser, K.A., Pou, N.A., Parker, R.E "The effects of flow heterogenity on the measurement of capillary exchange in the lung." J. Appl. Physiol., 791449-1460, 1995.
- Tack, G, Roselli, R J, Overholser, K A, Harris, T R The use of microsoft excel as a user interface for biological simulations. Comput Biomed Res, 28(1), 24-37, 1995.
- Overholser, K.A., Lomangino, N.A., Parker, R.E., Pou, N.A., Harris, T.R "Pulmonary vascular resistance distribution and the recruitment of microvascular area." J. Appl. Physiol, 77845-855, 1994.
- Overholser, K A, Lomangino, N A, Harris, T R, Bradley, J D, Bosan, S Deduction of pulmonary microvascular hematocrit from indicator dilution curves. Bull Math Biol, 56(2), 225-47, 1994.
- Caruthers, S D, Harris, T R Effects of pulmonary blood flow on the fractal nature of flow heterogeneity in sheep lungs. J Appl Physiol, 77(3), 1474-9, 1994.
- Harris, P A, Bosan, S, Harris, T R, Laughlin, M H, Overholser, K A Parameter identification in coronary pressure flow models: a graphical approach. Ann Biomed Eng, 22(6), 622-37, 1994.
- Overholser, K A, Lomangino, N A, Parker, R E, Pou, N A, Harris, T R Pulmonary vascular resistance distribution and recruitment of microvascular surface area. J Appl Physiol, 77(2), 845-55, 1994.
- Olson, L.E., Staton, D.J., Young, M., Galloway, R.L., Harris, T.R "Sulfhemoglobinated erythrocytes as an optical intravascular tracer in the lung." Ann. Biomed. Engrg, 22323-331, 1994.
- Olson, L E, Staton, D J, Young, M, Galloway, R L, Harris, T R Sulfhemoglobinated erythrocytes as an optical intravascular tracer in the lung. Ann Biomed Eng, 22(3), 319-27, 1994.
- Caruthers, S.D., Harris, T.R "The effects of pulmonary blood flow on the fractal nature of flow heterogeneity in sheep lungs." J. Appl. Physiol, 771474-1479, 1994.
- Harris, T R, Waters, C M, Haselton, F R Use of scaling theory to relate measurements of lung endothelial barrier permeability. J Appl Physiol, 77(5), 2496-505, 1994.
- Waters, C M, Alexander, J S, Harris, T R, Haselton, F R Perilla ketone increases endothelial cell monolayer permeability in vitro. J Appl Physiol, 74(5), 2493-501, 1993.
- Waters, C.M., Alexander, J.S., Harris, T.R., Haselton, F.R "Perilla ketone increases endothelial cell monolayer permeability in vitro." J. Appl. Physiol, 742493-2501, 1993.
- Stead, W W, Baker, W, Harris, T R, Hodges, T M, Sittig, D F A fast track to IAIMS: the Vanderbilt University strategy. Proc Annu Symp Comput Appl Med Care, 527-31, 1992.
- Olson, L E, Pou, A, Harris, T R Surface area-independent assessment of lung microvascular permeability with an amphipathic tracer. J Appl Physiol, 70(3), 1085-96, 1991.
- Olson, L.E., Pou, A., Harris, T.R "Surface-area independent assessment of lung microvascular permeability using an amphipathic tracer." J. Appl. Physiol., 701085-1096, 1991.
- Bradley, J D, Parker, R E, Harris, T R, Overholser, K A Effects of ligation and embolization on Kf and multiple tracer measurements in dog lungs. J Appl Physiol, 69(4), 1460-6, 1990.
- Harris, T.R., Bernard, G.R., Brigham, K.L., Higgins, S.B., Rinaldo, J.E., Borovetz, H.S., Sibbald, W.J., Kariman, K., Sprung, C.L "Lung microvascular transport properties measured by multiple indicator dilution methods in ARDS patients: A comparison between patients reversing respiratory failure and those failing to reverse." AM. Rev. Resp. Dis., 67280-292, 1990.
- Harris, T R, Bernard, G R, Brigham, K L, Higgins, S B, Rinaldo, J E, Borovetz, H S, Sibbald, W J, Kariman, K, Sprung, C L Lung microvascular transport properties measured by multiple indicator dilution methods in patients with adult respiratory distress syndrome. A comparison between patients reversing respiratory failure and those failing to reverse. Am Rev Respir Dis, 141(2), 272-80, 1990.
- Roselli, R.J., Harris, T.R "Lung fluid and macromolecular transport." Chapter 16 in Respiration Physiology: A Quantitative Approach, Chang and Paiva, editors, Dekker, New York, 633-735, 1989.
- Pou, N A, Roselli, R J, Parker, R E, Clanton, J A, Harris, T R Measurement of lung fluid volumes and albumin exclusion in sheep. J Appl Physiol, 67(4), 1323-30, 1989.
- Harris, T.R., Roselli, R.J "The exchange of small molecules in the normal and abnormal lung circulatory bed." Respiration Physiology: A Quantitative Approach, Chang and Paiva, editors, Dekker, New York, 737-798, 1989.
- Bradley, J.D., Roselli, R.J., Parker, R.E., Harris, T.R "Effects of endotoxemia on the sheep lung microvascular membrane: A two-pore theory." J. Appl. Physiol, 642675-2683, 1988.
- Bradley, J D, Roselli, R J, Parker, R E, Harris, T R Effects of endotoxemia on the sheep lung microvascular membrane: a two-pore theory. J Appl Physiol, 64(6), 2675-83, 1988.
- Haselton, F.R., Roselli, R.J., Parker, R.E., Harris, T.R "An effective-diffusivity model of pulmonary capillary exchange: General theory, limiting cases, and sensitivity analysis." Math. Biosciences, 70237-263, 1984.
- Harris, T.R "The influence of endothelial volume on the kinetics of reacting indicators in the lung." J. Appl. Physiol, 571528-1530, 1984.
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