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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

Thomas M. Aune, Ph.D.

Professor of Medicine (Rheumatology)
Associate Professor of Pathology, Microbiology and Immunology
Researcher

Contact Information:

Vanderbilt University Medical Center
T-3219 Medical Center North
Nashville, TN 37232
615-343-7353

Research Description

Our research focuses on the use of functional genomic and epigenetic approaches to understand gene regulation. Our interests range from detailed mechanistic studies of the interferon-gamma gene, a key cytokine produced by cells of the innate and adaptive immune system, a critical cytokine required to induce cell-mediated inflammation to the use of these approaches to gain new insights into human disease, including diseases of the endocrine system. These include recent studies evaluating relationships among gene expression signatures in atherosclerosis, type 2 diabetes and metabolic syndrome and study of copy number polymorphisms in type 1 diabetes, type 2 diabetes, and multiple sclerosis.

Publications
  • Spurlock CF, Tossberg JT, Olsen NJ, Aune TM. Cutting Edge: Chronic NF-¿B Activation in CD4+ T Cells in Rheumatoid Arthritis Is Genetically Determined by HLA Risk Alleles. J. Immunol [print-electronic]. 2015 Aug 8/1/2015; 195(3): 791-5. PMID: 26091715, PMCID: PMC4506868, PII: jimmunol.1500267, DOI: 10.4049/jimmunol.1500267, ISSN: 1550-6606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26091715.
  • Aune TM, Spurlock CF. Long non-coding RNAs in innate and adaptive immunity. Virus Res [print-electronic]. 2015 Jul 7/9/2015; PMID: 26166759, PII: S0168-1702(15)30007-1, DOI: 10.1016/j.virusres.2015.07.003, ISSN: 1872-7492.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26166759.
  • Ohnuma K, Hatano R, Aune TM, Otsuka H, Iwata S, Dang NH, Yamada T, Morimoto C. Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes. J. Immunol [print-electronic]. 2015 Apr 4/15/2015; 194(8): 3697-712. PMID: 25786689, PMCID: PMC4568737, PII: jimmunol.1402785, DOI: 10.4049/jimmunol.1402785, ISSN: 1550-6606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25786689.
  • Spurlock CF, Gass HM, Bryant CJ, Wells BC, Olsen NJ, Aune TM. Methotrexate-mediated inhibition of nuclear factor ¿B activation by distinct pathways in T cells and fibroblast-like synoviocytes. Rheumatology (Oxford) [print-electronic]. 2015 Jan; 54(1): 178-87. PMID: 25118313, PMCID: PMC4269792, PII: keu279, DOI: 10.1093/rheumatology/keu279, ISSN: 1462-0332.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25118313.
  • Spurlock CF, Tossberg JT, Guo Y, Collier SP, Crooke PS, Aune TM. Expression and functions of long noncoding RNAs during human T helper cell differentiation. Nat Commun. 2015; 6: 6932. PMID: 25903499, PMCID: PMC4410435, PII: ncomms7932, DOI: 10.1038/ncomms7932, ISSN: 2041-1723.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25903499.
  • Spurlock CF, Tossberg JT, Guo Y, Sriram S, Crooke PS, Aune TM. Defective structural RNA processing in relapsing-remitting multiple sclerosis. Genome Biol. 2015; 16: 58. PMID: 25885816, PMCID: PMC4403723, PII: 10.1186/s13059-015-0629-x, DOI: 10.1186/s13059-015-0629-x, ISSN: 1474-760X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25885816.
  • Spurlock CF, Tossberg JT, Matlock BK, Olsen NJ, Aune TM. Methotrexate inhibits NF-¿B activity via long intergenic (noncoding) RNA-p21 induction. Arthritis & rheumatology (Hoboken, N.J.). 2014 Nov; 66(11): 2947-57. PMID: 25077978, PMCID: PMC4211976, DOI: 10.1002/art.38805, ISSN: 2326-5205.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25077978.
  • Collier SP, Henderson MA, Tossberg JT, Aune TM. Regulation of the Th1 genomic locus from Ifng through Tmevpg1 by T-bet. J. Immunol [print-electronic]. 2014 Oct 10/15/2014; 193(8): 3959-65. PMID: 25225667, PMCID: PMC4185266, PII: jimmunol.1401099, DOI: 10.4049/jimmunol.1401099, ISSN: 1550-6606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25225667.
  • Pabbisetty SK, Rabacal W, Maseda D, Cendron D, Collins PL, Hoek KL, Parekh VV, Aune TM, Sebzda E. KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Jul 7/1/2014; 111(26): 9579-84. PMID: 24979767, PMCID: PMC4084438, PII: 1323493111, DOI: 10.1073/pnas.1323493111, ISSN: 1091-6490.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24979767.
  • Zhang F, Tossberg JT, Spurlock CF, Yao SY, Aune TM, Sriram S. Expression of IL-33 and its epigenetic regulation in Multiple Sclerosis. Ann Clin Transl Neurol. 2014 May 5/1/2014; 1(5): 307-18. PMID: 25215310, PMCID: PMC4157667, DOI: 10.1002/acn3.47, ISSN: 2328-9503.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25215310.
  • Fites JS, Ramsey JP, Holden WM, Collier SP, Sutherland DM, Reinert LK, Gayek AS, Dermody TS, Aune TM, Oswald-Richter K, Rollins-Smith LA. The invasive chytrid fungus of amphibians paralyzes lymphocyte responses. Science. 2013 Oct 10/18/2013; 342(6156): 366-9. PMID: 24136969, PMCID: PMC3956111, PII: 342/6156/366, DOI: 10.1126/science.1243316, ISSN: 1095-9203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24136969.
  • Reed NP, Henderson MA, Oltz EM, Aune TM. Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609. Genes Immun [print-electronic]. 2013 Jan; 14(1): 7-12. PMID: 23076336, PMCID: PMC4028662, PII: gene201247, DOI: 10.1038/gene.2012.47, ISSN: 1476-5470.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23076336.
  • Aune TM, Collins PL, Collier SP, Henderson MA, Chang S. Epigenetic Activation and Silencing of the Gene that Encodes IFN-¿. Front Immunol. 2013; 4: 112. PMID: 23720660, PMCID: PMC3655339, DOI: 10.3389/fimmu.2013.00112, ISSN: 1664-3224.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23720660.
  • Tossberg JT, Crooke PS, Henderson MA, Sriram S, Mrelashvili D, Vosslamber S, Verweij CL, Olsen NJ, Aune TM. Using biomarkers to predict progression from clinically isolated syndrome to multiple sclerosis. J Clin Bioinforma. 2013; 3(1): 18. PMID: 24088512, PMCID: PMC3850501, PII: 2043-9113-3-18, DOI: 10.1186/2043-9113-3-18, ISSN: 2043-9113.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24088512.
  • Collier SP, Collins PL, Williams CL, Boothby MR, Aune TM. Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells. J. Immunol [print-electronic]. 2012 Sep 9/1/2012; 189(5): 2084-8. PMID: 22851706, PMCID: PMC3424368, PII: jimmunol.1200774, DOI: 10.4049/jimmunol.1200774, ISSN: 1550-6606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22851706.
  • Collins PL, Henderson MA, Aune TM. Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element. Genes Immun [print-electronic]. 2012 Sep; 13(6): 481-8. PMID: 22622197, PMCID: PMC4180225, PII: gene201222, DOI: 10.1038/gene.2012.22, ISSN: 1476-5470.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22622197.
  • Spurlock CF, Tossberg JT, Fuchs HA, Olsen NJ, Aune TM. Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum [print-electronic]. 2012 Jun; 64(6): 1780-9. PMID: 22183962, PMCID: PMC3310965, DOI: 10.1002/art.34342, ISSN: 1529-0131.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22183962.
  • Collins PL, Henderson MA, Aune TM. Diverse functions of distal regulatory elements at the IFNG locus. J. Immunol [print-electronic]. 2012 Feb 2/15/2012; 188(4): 1726-33. PMID: 22246629, PMCID: PMC3273639, PII: jimmunol.1102879, DOI: 10.4049/jimmunol.1102879, ISSN: 1550-6606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22246629.
  • Crooke PS, Tossberg JT, Horst SN, Tauscher JL, Henderson MA, Beaulieu DB, Schwartz DA, Olsen NJ, Aune TM. Using gene expression data to identify certain gastro-intestinal diseases. J Clin Bioinforma. 2012; 2(1): 20. PMID: 23171526, PMCID: PMC3599448, PII: 2043-9113-2-20, DOI: 10.1186/2043-9113-2-20, ISSN: 2043-9113.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23171526.
  • Spurlock CF, Aune ZT, Tossberg JT, Collins PL, Aune JP, Huston JW, Crooke PS, Olsen NJ, Aune TM. Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK. Arthritis Rheum. 2011 Sep; 63(9): 2606-16. PMID: 21618198, PMCID: PMC3165146, DOI: 10.1002/art.30457, ISSN: 1529-0131.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21618198.
  • Grayson BL, Wang L, Aune TM. Peripheral blood gene expression profiles in metabolic syndrome, coronary artery disease and type 2 diabetes. Genes Immun [print-electronic]. 2011 Jul; 12(5): 341-51. PMID: 21368773, PMCID: PMC3137736, PII: gene201113, DOI: 10.1038/gene.2011.13, ISSN: 1476-5470.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21368773.
  • Wang L, Jia P, Wolfinger RD, Chen X, Grayson BL, Aune TM, Zhao Z. An efficient hierarchical generalized linear mixed model for pathway analysis of genome-wide association studies. Bioinformatics [print-electronic]. 2011 Mar 3/1/2011; 27(5): 686-92. PMID: 21266443, PMCID: PMC3042187, PII: btq728, DOI: 10.1093/bioinformatics/btq728, ISSN: 1367-4811.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21266443.
  • Grayson BL, Aune TM. A comparison of genomic copy number calls by Partek Genomics Suite, Genotyping Console and Birdsuite algorithms to quantitative PCR. BioData Min. 2011; 4: 8. PMID: 21489293, PMCID: PMC3084167, PII: 1756-0381-4-8, DOI: 10.1186/1756-0381-4-8, ISSN: 1756-0381.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21489293.
  • Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, Joyce S, Thomas JW, Van Kaer L, Sebzda E. Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Immunity [print-electronic]. 2010 Aug 8/27/2010; 33(2): 254-65. PMID: 20691614, PMCID: PMC2929658, PII: S1074-7613(10)00281-5, DOI: 10.1016/j.immuni.2010.07.016, ISSN: 1097-4180.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20691614.
  • Collins PL, Chang S, Henderson M, Soutto M, Davis GM, McLoed AG, Townsend MJ, Glimcher LH, Mortlock DP, Aune TM. Distal regions of the human IFNG locus direct cell type-specific expression. J. Immunol [print-electronic]. 2010 Aug 8/1/2010; 185(3): 1492-501. PMID: 20574006, PMCID: PMC2923829, PII: jimmunol.1000124, DOI: 10.4049/jimmunol.1000124, ISSN: 1550-6606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20574006.
  • Collins PL, Aune TM. Keeping one's option open. Immunity. 2010 May 5/28/2010; 32(5): 581-3. PMID: 20510865, PII: S1074-7613(10)00174-3, DOI: 10.1016/j.immuni.2010.05.008, ISSN: 1097-4180.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20510865.
  • Grayson BL, Smith ME, Thomas JW, Wang L, Dexheimer P, Jeffrey J, Fain PR, Nanduri P, Eisenbarth GS, Aune TM. Genome-wide analysis of copy number variation in type 1 diabetes. PLoS ONE. 2010; 5(11): e15393. PMID: 21085585, PMCID: PMC2981564, DOI: 10.1371/journal.pone.0015393, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21085585.
  • Aune TM, Collins PL, Chang S. Epigenetics and T helper 1 differentiation. Immunology [print-electronic]. 2009 Mar; 126(3): 299-305. PMID: 19178593, PMCID: PMC2669810, PII: IMM3026, DOI: 10.1111/j.1365-2567.2008.03026.x, ISSN: 1365-2567.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19178593.
  • Liu Z, Sokka T, Maas K, Olsen NJ, Aune TM. Prediction of disease severity in patients with early rheumatoid arthritis by gene expression profiling. Hum Genomics Proteomics. 2009; 2009: PMID: 20948566, PMCID: PMC2950309, DOI: 10.4061/2009/484351, ISSN: 1757-4242.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20948566.
  • Chang S, Collins PL, Aune TM. T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation. J. Immunol. 2008 Dec 12/15/2008; 181(12): 8372-81. PMID: 19050254, PMCID: PMC2794428, PII: 181/12/8372, ISSN: 1550-6606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19050254.
  • Chang S, Aune TM. Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells. Nat. Immunol [print-electronic]. 2007 Jul; 8(7): 723-31. PMID: 17546034, PII: ni1473, DOI: 10.1038/ni1473, ISSN: 1529-2908.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17546034.
  • Fossey SC, Vnencak-Jones CL, Olsen NJ, Sriram S, Garrison G, Deng X, Crooke PS, Aune TM. Identification of molecular biomarkers for multiple sclerosis. J Mol Diagn. 2007 Apr; 9(2): 197-204. PMID: 17384211, PMCID: PMC1867435, PII: S1525-1578(10)60380-7, DOI: 10.2353/jmoldx.2007.060147, ISSN: 1525-1578.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17384211.
  • Eivazova ER, Vassetzky YS, Aune TM. Selective matrix attachment regions in T helper cell subsets support loop conformation in the Ifng gene. Genes Immun [print-electronic]. 2007 Jan; 8(1): 35-43. PMID: 17093503, PII: 6364349, DOI: 10.1038/sj.gene.6364349, ISSN: 1466-4879.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17093503.
  • Zhang F, Thomas LR, Oltz EM, Aune TM. Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608. Nat. Immunol [print-electronic]. 2006 Dec; 7(12): 1309-16. PMID: 17057722, PII: ni1397, DOI: 10.1038/ni1397, ISSN: 1529-2908.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17057722.
  • Liu Z, Aune TM. Deregulated stress system in non-obese diabetic lymphocyte. Genes Immun [print-electronic]. 2006 Jul; 7(5): 352-8. PMID: 16691184, PII: 6364306, DOI: 10.1038/sj.gene.6364306, ISSN: 1466-4879.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16691184.
  • Liu Z, Maas K, Aune TM. Identification of gene expression signatures in autoimmune disease without the influence of familial resemblance. Hum. Mol. Genet [print-electronic]. 2006 Feb 2/1/2006; 15(3): 501-9. PMID: 16371420, PII: ddi466, DOI: 10.1093/hmg/ddi466, ISSN: 0964-6906.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16371420.
  • Liu Z, Yelverton RW, Kraft B, Tanner SB, Olsen NJ, Aune TM. Highly conserved gene expression profiles in humans with allergic rhinitis altered by immunotherapy. Clin. Exp. Allergy. 2005 Dec; 35(12): 1581-90. PMID: 16393324, PII: CEA2382, DOI: 10.1111/j.1365-2222.2005.02382.x, ISSN: 0954-7894.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16393324.
  • Chang S, Aune TM. Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Nov 11/22/2005; 102(47): 17095-100. PMID: 16286661, PMCID: PMC1283154, PII: 0502129102, DOI: 10.1073/pnas.0502129102, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16286661.
  • Maas K, Chen H, Shyr Y, Olsen NJ, Aune T. Shared gene expression profiles in individuals with autoimmune disease and unaffected first-degree relatives of individuals with autoimmune disease. Hum. Mol. Genet [print-electronic]. 2005 May 5/15/2005; 14(10): 1305-14. PMID: 15814587, PII: ddi141, DOI: 10.1093/hmg/ddi141, ISSN: 0964-6906.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15814587.
  • Maas K, Westfall M, Pietenpol J, Olsen NJ, Aune T. Reduced p53 in peripheral blood mononuclear cells from patients with rheumatoid arthritis is associated with loss of radiation-induced apoptosis. Arthritis Rheum. 2005 Apr; 52(4): 1047-57. PMID: 15818671, DOI: 10.1002/art.20931, ISSN: 0004-3591.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15818671.
  • Tong Y, Aune T, Boothby M. T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Feb 2/8/2005; 102(6): 2034-9. PMID: 15684083, PMCID: PMC548570, PII: 0409510102, DOI: 10.1073/pnas.0409510102, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15684083.
  • Olsen N, Sokka T, Seehorn CL, Kraft B, Maas K, Moore J, Aune TM. A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. Ann. Rheum. Dis. 2004 Nov; 63(11): 1387-92. PMID: 15479887, PMCID: PMC1754808, PII: 63/11/1387, DOI: 10.1136/ard.2003.017194, ISSN: 0003-4967.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15479887.
  • Aune TM, Parker JS, Maas K, Liu Z, Olsen NJ, Moore JH. Co-localization of differentially expressed genes and shared susceptibility loci in human autoimmunity. Genet. Epidemiol. 2004 Sep; 27(2): 162-72. PMID: 15305332, DOI: 10.1002/gepi.20013, ISSN: 0741-0395.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15305332.
  • Liu Z, Maas K, Aune TM. Comparison of differentially expressed genes in T lymphocytes between human autoimmune disease and murine models of autoimmune disease. Clin. Immunol. 2004 Sep; 112(3): 225-30. PMID: 15308114, PII: S1521661604001081, DOI: 10.1016/j.clim.2004.03.017, ISSN: 1521-6616.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15308114.
  • Zhou W, Chang S, Aune TM. Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation. Proc. Natl. Acad. Sci. U.S.A. 2004 Feb 2/24/2004; 101(8): 2440-5. PMID: 14983028, PMCID: PMC356969, PII: 101/8/2440, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14983028.
  • Eivazova ER, Aune TM. Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Jan 1/6/2004; 101(1): 251-6. PMID: 14691261, PMCID: PMC314171, PII: 0303919101, DOI: 10.1073/pnas.0303919101, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14691261.
  • Aune TM, Maas K, Parker J, Moore JH, Olsen NJ. Profiles of gene expression in human autoimmune disease. Cell Biochem. Biophys. 2004; 40(2): 81-96. PMID: 15054216, PII: CBB:40:2:081, DOI: 10.1385/CBB:40:2:081, ISSN: 1085-9195.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15054216.
  • Olsen NJ, Moore JH, Aune TM. Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells. Arthritis Res. Ther [print-electronic]. 2004; 6(3): 120-8. PMID: 15142262, PMCID: PMC416456, PII: ar1190, DOI: 10.1186/ar1190, ISSN: 1478-6362.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15142262.
  • Zhang F, Liang Z, Matsuki N, Van Kaer L, Joyce S, Wakeland EK, Aune TM. A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation. J. Immunol. 2003 Nov 11/1/2003; 171(9): 4613-20. PMID: 14568935, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14568935.
  • Zhou W, Zhang F, Aune TM. Either IL-2 or IL-12 is sufficient to direct Th1 differentiation by nonobese diabetic T cells. J. Immunol. 2003 Jan 1/15/2003; 170(2): 735-40. PMID: 12517935, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12517935.
  • Aune TM, Maas K, Moore JH, Olsen NJ. Gene expression profiles in human autoimmune disease. Curr. Pharm. Des. 2003; 9(23): 1905-17. PMID: 12871194, ISSN: 1381-6128.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12871194.
  • Zhou, W., and Aune, T.M. IL-2 and IL-12 are equivalent Th1 differentiation factors for NOD T cells. J. Immunol. 2003; 170: 735-40.
  • Soutto M, Zhou W, Aune TM. Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-gamma in Th1/Tc1 effector cells. J. Immunol. 2002 Dec 12/15/2002; 169(12): 6664-7. PMID: 12471094, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12471094.
  • Soutto M, Zhang F, Enerson B, Tong Y, Boothby M, Aune TM. A minimal IFN-gamma promoter confers Th1 selective expression. J. Immunol. 2002 Oct 10/15/2002; 169(8): 4205-12. PMID: 12370350, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12370350.
  • Maas K, Chan S, Parker J, Slater A, Moore J, Olsen N, Aune TM. Cutting edge: molecular portrait of human autoimmune disease. J. Immunol. 2002 Jul 7/1/2002; 169(1): 5-9. PMID: 12077221, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12077221.
  • Moore JH, Parker JS, Olsen NJ, Aune TM. Symbolic discriminant analysis of microarray data in autoimmune disease. Genet. Epidemiol. 2002 Jun; 23(1): 57-69. PMID: 12112248, DOI: 10.1002/gepi.1117, ISSN: 0741-0395.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12112248.
  • Maas, Chan, S., Parker J., Slater, A., Moore, J., Olsen, N and Aune, T. Cutting Edge: Molecular Portrait of Human Autoimmune Disease. J. Immunol. 2002; 169: 5-9.
  • Moore, J.H., Parker, J.S., Olsen, N., and Aune, T.M. Symbolic Discriminant Analysis of Microarray Data in Autoimmune Disease. Genetic Epidemiology. 2002; 23: 57-69.
  • Soutto, M., Zhang, F., Emerson, B., Tong, Y., Boothby, M., and Aune, T.M. A minimal IFN-gamma promoter confers Th1 selective expression. J. Immunol. 2002; 169: 4205-12.
  • Soutto, M., Zhou, W., and Aune, T.M. Cutting Edge: Distal regulatory elements are required to achieve selective expression of IFN-gamma in Th1/Tc1 effector cells. J. Immunol. 2002; 169: 6664-7.
  • Aune TM. Transcriptional reprogramming during T helper cell differentiation. Immunol. Res. 2001; 23(2-3): 193-204. PMID: 11444384, PII: IR:23:2-3:193, DOI: 10.1385/IR:23:2-3:193, ISSN: 0257-277X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11444384.
  • Zhang F, Rincon M, Flavell RA, Aune TM. Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2. J. Immunol. 2000 Aug 8/15/2000; 165(4): 1762-70. PMID: 10925253, PII: ji_v165n4p1762, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10925253.
  • Zhang, F., Rincon, M., Flavell, R.A., and Aune, T.M. Defective Th function induced by a dominant negative cAMP response element binding protein mutation is reversed by Bcl 2. J. Immunol. 2000; 165: 1762 1770.
  • Zhang F, Nakamura T, Aune TM. TCR and IL-12 receptor signals cooperate to activate an individual response element in the IFN-gamma promoter in effector Th cells. J. Immunol. 1999 Jul 7/15/1999; 163(2): 728-35. PMID: 10395664, PII: ji_v163n2p728, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10395664.
  • Aune TM, Mora AL, Kim S, Boothby M, Lichtman AH. Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation. J. Immunol. 1999 May 5/15/1999; 162(10): 5805-12. PMID: 10229814, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10229814.
  • Aune, T.M., A.L. Mora, S. Kim, M. Boothby, and A.H. Lichtman. Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkBa degradation. J. Immunol. 1999; 162: 5805-11.
  • Zhang, F., Nakamura, T., and Aune, T.M.. T cell receptor and IL-12 receptor signals cooperate to activate an individual response element in the IFNγ promoter in effector T helper cells. J. Immunol. 1999; 163: 728-35.
  • Zhang, F., T. Nakamura, and T.M. Aune. TCR and IL-12 receptor signals cooperate to activate an individual response element in the IFN-gamma promoter in effector Th cells. J. Immunol. 1999; 163: 728-35.
  • Zhang F, Wang DZ, Boothby M, Penix L, Flavell RA, Aune TM. Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation. J. Immunol. 1998 Dec 12/1/1998; 161(11): 6105-12. PMID: 9834094, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9834094.
  • Zhang, F., D.Z Wang, M.Boothby, L.Penix, R.A. Flavell, and T.M. Aune. Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation. J. Immuno. 1998; 161: 6105-12.
  • Aune, T.M., L. A. Penix, M.R. Rincon, and R. A. Flavell. Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells. Mol. Cel. Biol. 1997; 17: 199-208.
  • Aune, T.M., and R. A. Flavell. Differential expression of transcription directed by a discrete NF-AT binding element from the IL-4 promoter in naive and effector CD4 T cells. J. Immunol. 1997; 159: 36-43.
  • Aune, T.M., Golden, H.W., and McGrath, K.M. Inhibition of serotonin synthesis or inhibition of serotonin 1A receptors inhibits T cell function in vitro and in vivo. J. Immunol. 1994; 153: 489-98.
  • Aune, T.M., McGrath, K.M., Sarr, T., Bombara, M.P., and Kelley, K.A. Expression of 5HT1a receptors on activated human T lymphocytes: Regulation of cAMP levels and T cell proliferation by 5HT. J. Immunol. 1993; 151: 1175-83.
  • Bombara, M.P., Webb, D.L., Conrad, P., Marlor, C.W., Sarr, T., Ranges, G.E., Aune, T.M., and Blue, M-L. Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines. J. Leuk. Biol. 1993; 54: 399-406.
  • Rothman, B.L., Kennure, N., Kelley, K.A., Katz, M., and Aune, T.M. Elevation of intracellular cAMP in human T lymphocytes by an anti-CD44 mAb. J. Immunol. 1993; 151: 6036-42.
  • Piela-Smith, T.H., Aune, T.M., Aneiro, L., Nuveen, E., and Korn, J.H. Impairment of lymphocyte adhesion to cultured fibroblasts and endothelial cells by gamma-irradiation. J. Immunol. 1992; 148: 41-6.
  • Rothman, B.L., Blue, M-L, Kelley, K.A., Wunderlich, D., Mierz, D.V., and Aune, T.M. Human T cell activation by OKT3 is inhibited by a monoclonal antibody to CD44. J. Immunol. 1991; 147: 2493-9.
  • Aune, T.M., Kelley, K.A., Ranges, G.E., and Bombara, M.P. Serotonin activated signal transduction in human T cells. J. Immunol. 1990; 145: 1826-31.
  • Webb, D.R., Mensi, N., Freire-Moar, J., Schnaper, H.W., Lewis R.V., Semenuk, G., Devens, B.H., Koontz, A., Danho, W., Pan, Y-C, Wesselschmidt, R., Aune, T.M. and Pierce, C.W. Putative amino terminal sequence of murine soluble immune response suppressor (SIRS): Significant homology with short neurotoxin 1. Inter. Immunol. 1990; 2: 765-74.
  • Aune, T.M., and Pogue, S.L. Generation and initial characterization of a human CD8+ suppressor T cell line. J. Immunol. 1989; 142: 3731-9.
  • Aune, T.M., and Pogue, S.L. Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: Induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide. J. Clin. Invest. 1989; 84: 863-75.
  • Schnaper, H.W., and Aune, T.M. Steroid sensitive mechanism of soluble immune response suppressor production in steroid responsive nephrotic syndrome. J.Clin.Invest. 1987; 79: 254-64.
  • Schnaper, H.W., and Aune, T.M. Suppression of immune responses to sheep erythrocytes by the lymphokine soluble immune response suppressor (SIRS) in vivo. J.Immunol. 1986; 137: 863-7.
  • Aune, T.M. ELISA for the detection of the lymphokine soluble immune response suppressor. J. Immunol. Methods. 1985; 84: 33-44.
  • Aune, T.M. Inhibition of soluble immune response suppressor activity by growth factors. Proc. Nat'l Acad. Sci. U.S.A. 1985; 82: 6260-4.
  • Aune, T.M., Freeman, G.L., and Colley,. D.G. Production of the lymphokine, SIRS, during chronic experimental schistosomiasis mansoni. J.Immunol. 1985; 135: 2768-71.
  • Schnaper, H.W., and Aune, T.M. Identification of the lymphokine, soluble immune response suppressor, in urine of patients with nephrotic syndrome. J.Clin. Invest. 1985; 76: 341-9.
  • Webb, D.R., Mason, K., Semenuk, G., Aune, T.M. and Pierce, C. W. Purification and isolation of isoforms of soluble immune response suppressor (SIRS). J.Immunol. 1985; 135: 3238-42.
  • Webb, D.R., Mason, K., Semenuk, G., Aune, T.M. and Pierce, C. W. Purification and isolation of isoforms of soluble immune response suppressor (SIRS). J.Immunol. 1985; 135: 3238-42.
  • Aune, T.M., Webb, D.R., and Pierce, C.W. Purification and initial characterization of the lymphokine, soluble immune response suppressor. J. Immunol. 1983; 131: 2848-52.
  • Aune, T.M., Webb, D.R., and Pierce, C.W. Purification of radiolabeled soluble immune responses suppressor. Interleukins, Lymphokines and Cytokines, J.J. Oppenheim and Cohen, eds. Academic Press, New York. 1983; 383-9.
  • Aune, T.M., and Pierce, C.W. Inhibition of interferon or soluble immune response suppressor mediated suppression by levamisole. Int. J. Immunopharm. 1983; 5: 91-8.
  • Schnaper, H.W., Aune, T.M., and Pierce, C.W. Suppressor T cell Activation by human lymphocyte interferon. J. Immunol. 1983; 131: 2301-6.
  • Aune, T.M. and Pierce, C.W. Activation of A Suppressor T Cell Pathway by Interferon. Proc. Nat'l Acad. Sci. 1982; 79: 3808-12.
  • Aune, T.M., Pierce, C.W. Conversion of Soluble Immune Response Suppressor to Macrophage-derived Suppressor Factor by Peroxide. Proc. Nat'l Acad. Sci. 1981; 78: 5099-103.