Vanderbilt-Ingram Cancer Center

See also:

• Vanderbilt University Institute of Imaging Science
• Breast Cancer Research Program
• Physics and Astronomy
• Radiology and Radiological Sciences
• BRET: Biomedical Research Education & Training Faculty Listing

The requirement to study cancer in its native environment has lead to the development of imaging technologies that can non-invasively and quantitatively interrogate both primary and metastatic disease. This involves mathematical modeling, application of these models in small animal tumors systems, and ultimately applying the most promising techniques in human breast cancer.
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Publications

• Dula, AN, Arlinghaus, LR, Dortch, RD, Dewey, BE, Whisenant, JG, Ayers, GD, Yankeelov, TE, Smith, SA Amide proton transfer imaging of the breast at 3 T: Establishing reproducibility and possible feasibility assessing chemotherapy response. Magn Reson Med, 2012.
• Li, X, Abramson, RG, Arlinghaus, LR, Chakravarthy, AB, Abramson, V, Mayer, I, Farley, J, Delbeke, D, Yankeelov, TE An algorithm for longitudinal registration of PET/CT images acquired during neoadjuvant chemotherapy in breast cancer: preliminary results. EJNMMI Res, 2(1), 62, 2012.
• Barnes, SL, Whisenant, JG, Loveless, ME, Ayers, GD, Yankeelov, TE Assessing the reproducibility of dynamic contrast enhanced magnetic resonance imaging in a murine model of breast cancer. Magn Reson Med, 2012.
• Quarles, CC, Gore, JC, Xu, L, Yankeelov, TE Comparison of dual-echo DSC-MRI- and DCE-MRI-derived contrast agent kinetic parameters. Magn Reson Imaging, 2012.
• Skinner, JT, Yankeelov, TE, Peterson, TE, Does, MD Comparison of dynamic contrast-enhanced MRI and quantitative SPECT in a rat glioma model. Contrast Media Mol Imaging, 7(6), 494-500, 2012.
• Loveless, ME, Lawson, D, Collins, M, Nadella, MV, Reimer, C, Huszar, D, Halliday, J, Waterton, JC, Gore, JC, Yankeelov, TE Comparisons of the efficacy of a Jak1/2 inhibitor (AZD1480) with a VEGF signaling inhibitor (cediranib) and sham treatments in mouse tumors using DCE-MRI, DW-MRI, and histology. Neoplasia, 14(1), 54-64, 2012.
• Abramson, RG, Arlinghaus, LR, Weis, JA, Li, X, Dula, AN, Chekmenev, EY, Smith, SA, Miga, MI, Abramson, VG, Yankeelov, TE Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy. Breast Cancer (London), 2012(4), 139-154, 2012.
• Barnes, SL, Whisenant, JG, Loveless, ME, Yankeelov, TE Practical Dynamic Contrast Enhanced MRI in Small Animal Models of Cancer: Data Acquisition, Data Analysis, and Interpretation. Pharmaceutics, 4(3), 442-478, 2012.
• Yankeelov, TE, Gore, JC Preface to the special issue on quantitative imaging in cancer. Magn Reson Imaging, 30(9), 1201-2, 2012.
• Smith, DS, Gore, JC, Yankeelov, TE, Welch, EB Real-Time Compressive Sensing MRI Reconstruction Using GPU Computing and Split Bregman Methods. Int J Biomed Imaging, 2012864827, 2012.
• Whisenant, JG, Peterson, TE, Fluckiger, JU, Tantawy, MN, Ayers, GD, Yankeelov, TE Reproducibility of Static and Dynamic (18)F-FDG, (18)F-FLT, and (18)F-FMISO MicroPET Studies in a Murine Model of HER2+ Breast Cancer. Mol Imaging Biol, 2012.
• Smith, DS, Li, X, Gambrell, JV, Arlinghaus, LR, Quarles, CC, Yankeelov, TE, Welch, EB Robustness of quantitative compressive sensing MRI: the effect of random undersampling patterns on derived parameters for DCE- and DSC-MRI. IEEE Trans Med Imaging, 31(2), 504-11, 2012.
• Yankeelov, TE, Peterson, TE, Abramson, RG, Garcia-Izquierdo, D, Arlinghaus, LR, Li, X, Atuegwu, NC, Catana, C, Manning, HC, Fayad, ZA, Gore, JC Simultaneous PET-MRI in oncology: a solution looking for a problem. Magn Reson Imaging, 2012.
• Li, X, Welch, EB, Arlinghaus, LR, Chakravarthy, AB, Xu, L, Farley, J, Loveless, ME, Mayer, IA, Kelley, MC, Meszoely, IM, Means-Powell, JA, Abramson, VG, Grau, AM, Gore, JC, Yankeelov, TE A novel AIF tracking method and comparison of DCE-MRI parameters using individual and population-based AIFs in human breast cancer. Phys Med Biol, 56(17), 5753-69, 2011.
• Loveless, ME, Halliday, J, Liess, C, Xu, L, Dortch, RD, Whisenant, J, Waterton, JC, Gore, JC, Yankeelov, TE A quantitative comparison of the influence of individual versus population-derived vascular input functions on dynamic contrast enhanced-MRI in small animals. Magn Reson Med, 2011.
• Mani, S, Chen, Y, Arlinghaus, LR, Li, X, Chakravarthy, AB, Bhave, SR, Welch, EB, Levy, MA, Yankeelov, TE Early prediction of the response of breast tumors to neoadjuvant chemotherapy using quantitative MRI and machine learning. AMIA Annu Symp Proc, 2011868-77, 2011.
• Atuegwu, NC, Colvin, DC, Loveless, ME, Xu, L, Gore, JC, Yankeelov, TE Incorporation of diffusion-weighted magnetic resonance imaging data into a simple mathematical model of tumor growth. Phys Med Biol, 57(1), 225-240, 2011.
• Atuegwu, NC, Arlinghaus, LR, Li, X, Brianwelch, E, Chakravarthy, BA, Gore, JC, Yankeelov, TE Integration of diffusion-weighted MRI data and a simple mathematical model to predict breast tumor cellularity during neoadjuvant chemotherapy. Magn Reson Med, 2011.
• Gore, JC, Manning, HC, Quarles, CC, Waddell, KW, Yankeelov, TE Magnetic resonance in the era of molecular imaging of cancer. Magn Reson Imaging, 29(5), 587-600, 2011.
• Arlinghaus, LR, Welch, EB, Chakravarthy, AB, Xu, L, Farley, JS, Abramson, VG, Grau, AM, Kelley, MC, Mayer, IA, Means-Powell, JA, Meszoely, IM, Gore, JC, Yankeelov, TE Motion correction in diffusion-weighted MRI of the breast at 3T. J Magn Reson Imaging, 33(5), 1063-70, 2011.
• Arlinghaus, LR, Li, X, Rahman, AR, Welch, EB, Xu, L, Gore, JC, Yankeelov, TE On the relationship between the apparent diffusion coefficient and extravascular extracellular volume fraction in human breast cancer. Magn Reson Imaging, 29(5), 630-8, 2011.
• Smith, DS, Welch, EB, Li, X, Arlinghaus, LR, Loveless, ME, Koyama, T, Gore, JC, Yankeelov, TE Quantitative effects of using compressed sensing in dynamic contrast enhanced MRI. Phys Med Biol, 56(15), 4933-46, 2011.
• Li, X, Welch, EB, Chakravarthy, AB, Xu, L, Arlinghaus, LR, Farley, J, Mayer, IA, Kelley, MC, Meszoely, IM, Means-Powell, J, Abramson, VG, Grau, AM, Gore, JC, Yankeelov, TE Statistical comparison of dynamic contrast-enhanced MRI pharmacokinetic models in human breast cancer. Magn Reson Med, 2011.
• Yankeelov, TE, Arlinghaus, LR, Li, X, Gore, JC The role of magnetic resonance imaging biomarkers in clinical trials of treatment response in cancer. Semin Oncol, 38(1), 16-25, 2011.
• Gore, JC, Xu, J, Colvin, DC, Yankeelov, TE, Parsons, EC, Does, MD Characterization of tissue structure at varying length scales using temporal diffusion spectroscopy. NMR Biomed, 2010.
• Colvin, DC, Loveless, ME, Does, MD, Yue, Z, Yankeelov, TE, Gore, JC Earlier detection of tumor treatment response using magnetic resonance diffusion imaging with oscillating gradients. Magn Reson Imaging, 2010.
• Yankeelov, TE, Atuegwu, NC, Deane, NG, Gore, JC Modeling tumor growth and treatment response based on quantitative imaging data. Integr Biol (Camb), 2010.
• Atuegwu, NC, Gore, JC, Yankeelov, TE The integration of quantitative multi-modality imaging data into mathematical models of tumors. Phys Med Biol, 55(9), 2429-2449, 2010.
• Li, X, Dawant, BM, Welch, EB, Chakravarthy, AB, Xu, L, Mayer, I, Kelley, M, Meszoely, I, Means-Powell, J, Gore, JC, Yankeelov, TE Validation of an algorithm for the nonrigid registration of longitudinal breast MR images using realistic phantoms. Med Phys, 37(6), 2541-52, 2010.
• Li, X, Dawant, BM, Welch, EB, Chakravarthy, AB, Freehardt, D, Mayer, I, Kelley, M, Meszoely, I, Gore, JC, Yankeelov, TE A nonrigid registration algorithm for longitudinal breast MR images and the analysis of breast tumor response. Magn Reson Imaging, 2009.
• Quarles, CC, Gochberg, DF, Gore, JC, Yankeelov, TE A theoretical framework to model DSC-MRI data acquired in the presence of contrast agent extravasation. Phys Med Biol, 54(19), 5749-5766, 2009.
• Loveless, ME, Whisenant, JG, Wilson, K, Lyshchik, A, Sinha, TK, Gore, JC, Yankeelov, TE Coregistration of ultrasonography and magnetic resonance imaging with a preliminary investigation of the spatial colocalization of vascular endothelial growth factor receptor 2 expression and tumor perfusion in a murine tumor model. Mol Imaging, 8(4), 187-98, 2009.
• Dortch, RD, Yankeelov, TE, Yue, Z, Quarles, CC, Gore, JC, Does, MD Evidence of multiexponential T(2) in rat glioblastoma. NMR Biomed, 2009.
• Yankeelov, TE, Avison, MJ, Damon, BM, Manning, HC, Peterson, TE, Gore, JC Frontiers of Biomedical Imaging Science 2009: Workshop Report and Research Opportunities. Cancer Res, 2009.
• Yankeelov, TE, Gore, JC Has quantitative multimodal imaging of treatment response arrived. Clin Cancer Res, 15(21), 6473-5, 2009.
• Gore, JC, Yankeelov, TE, Peterson, TE, Avison, MJ Molecular Imaging Without Radiopharmaceuticals. J Nucl Med, 50(6), 999-1007, 2009.
• Bevers TB, Anderson BO, Bonaccio E, Buys S, Daly MB, Dempsey PJ, Farrar WB, Fleming I, Garber JE, Harris RE, Heerdt AS, Helvie M, Huff JG, Khakpour N, Khan SA, Krontiras H, Lyman G, Rafferty E, Shaw S, Smith ML, Tsangaris TN, Williams C, Yankeelov T. NCCN Clinical Practice Guidelines in Oncology: Breast Cancer Screening and Diagnosis.. J Natl Compr Canc Netw, 7(10), 1060-96, 2009.
• Planey, CR, Welch, EB, Xu, L, Chakravarthy, AB, Gatenby, JC, Freehardt, D, Mayer, I, Meszeoly, I, Kelley, M, Means-Powell, J, Gore, JC, Yankeelov, TE Temporal sampling requirements for reference region modeling of DCE-MRI data in human breast cancer. J Magn Reson Imaging, 30(1), 121-34, 2009.
• Loveless, ME, Li, X, Huamani, J, Lyshchik, A, Dawant, B, Hallahan, D, Gore, JC, Yankeelov, TE A method for assessing the microvasculature in a murine tumor model using contrast-enhanced ultrasonography. J Ultrasound Med, 27(12), 1699-709, 2008.
• Li, X, Yankeelov, TE, Peterson, TE, Gore, JC, Dawant, BM Automatic nonrigid registration of whole body CT mice images. Med Phys, 35(4), 1507-20, 2008.
• Li, X, Yankeelov, TE, Rosen, GD, Gore, JC, Dawant, BM Enhancement of histological volumes through averaging and their use for the analysis of magnetic resonance images. Magn Reson Imaging, 2008.
• Ou, JJ, Ong, RE, Yankeelov, TE, Miga, MI Evaluation of 3D modality-independent elastography for breast imaging: a simulation study. Phys Med Biol, 53(1), 147-63, 2008.
• Quarles, CC, Lepage, M, Gorden, DL, Fingleton, B, Yankeelov, TE, Price, RR, Matrisian, LM, Gore, JC, McIntyre, JO Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn Reson Med, 60(3), 718-26, 2008.
• Lee, RE, Welch, EB, Cobb, JG, Sinha, T, Gore, JC, Yankeelov, TE Implementation of a Semi-automated Post-processing System for Parametric MRI Mapping of Human Breast Cancer. J Digit Imaging, 2008.
• Faranesh, AZ, Yankeelov, TE Incorporating a vascular term into a reference region model for the analysis of DCE-MRI data: a simulation study. Phys Med Biol, 53(10), 2617-31, 2008.
• Yankeelov, TE, Luci, JJ, Debusk, LM, Lin, PC, Gore, JC Incorporating the effects of transcytolemmal water exchange in a reference region model for DCE-MRI analysis: Theory, simulations, and experimental results. Magn Reson Med, 59(2), 326-35, 2008.
• Sinha, TK, Khatib-Shahidi, S, Yankeelov, TE, Mapara, K, Ehtesham, M, Cornett, DS, Dawant, BM, Caprioli, RM, Gore, JC Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging. Nat Methods, 5(1), 57-9, 2008.
• Colvin, DC, Yankeelov, TE, Does, MD, Yue, Z, Quarles, C, Gore, JC New insights into tumor microstructure using temporal diffusion spectroscopy. Cancer Res, 68(14), 5941-7, 2008.
• Yankeelov TE and Gore JC Dynamic Contrast Enhanced Magnetic Resonance Imaging in Oncology: Theory, Data Acquisition,Analysis, and Examples. Curent Medical Imaging Reviews, 3(2), 91-107, 2007.
• Yankeelov, TE, Cron, GO, Addison, CL, Wallace, JC, Wilkins, RC, Pappas, BA, Santyr, GE, Gore, JC Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data. Magn Reson Med, 57(2), 353-361, 2007.
• Pellerin, M, Yankeelov, TE, Lepage, M Incorporating contrast agent diffusion into the analysis of DCE-MRI data. Magn Reson Med, 58(6), 1124-34, 2007.
• Yankeelov, TE, Lepage, M, Chakravarthy, A, Broome, EE, Niermann, KJ, Kelley, MC, Meszoely, I, Mayer, IA, Herman, CR, McManus, K, Price, RR, Gore, JC Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results. Magn Reson Imaging, 25(1), 1-13, 2007.
• Niermann, KJ, Fleischer, AC, Huamani, J, Yankeelov, TE, Kim, DW, Wilson, WD, Hallahan, DE Measuring tumor perfusion in control and treated murine tumors: correlation of microbubble contrast-enhanced sonography to dynamic contrast-enhanced magnetic resonance imaging and fluorodeoxyglucose positron emission tomography. J Ultrasound Med, 26(6), 749-56, 2007.
• Zhang, Z, Ramirez, NE, Yankeelov, TE, Li, Z, Ford, LE, Qi, Y, Pozzi, A, Zutter, MM {alpha}2{beta}1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor-cell specific manner. Blood, 2007.
• Yankeelov, TE, Niermann, KJ, Huamani, J, Kim, DW, Quarles, CC, Fleischer, AC, Hallahan, DE, Price, RR, Gore, JC Correlation between estimates of tumor perfusion from microbubble contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging. J Ultrasound Med, 25(4), 487-97, 2006.
• Kim, DW, Huamani, J, Niermann, KJ, Lee, H, Geng, L, Leavitt, LL, Baheza, RA, Jones, CC, Tumkur, S, Yankeelov, TE, Fleischer, AC, Hallahan, DE Noninvasive assessment of tumor vasculature response to radiation-mediated, vasculature-targeted therapy using quantified power Doppler sonography: implications for improvement of therapy schedules. J Ultrasound Med, 25(12), 1507-17, 2006.
• Yankeelov, TE, DeBusk, LM, Billheimer, DD, Luci, JJ, Lin, PC, Price, RR, Gore, JC Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T. J Magn Reson Imaging, 24(5), 1140-7, 2006.
• Yankeelov, TE, Rooney, WD, Huang, W, Dyke, JP, Li, X, Tudorica, A, Lee, JH, Koutcher, JA, Springer, CS Evidence for shutter-speed variation in CR bolus-tracking studies of human pathology. NMR Biomed, 18(3), 173-85, 2005.
• Yankeelov, TE, Luci, JJ, Lepage, M, Li, R, Debusk, L, Lin, PC, Price, RR, Gore, JC Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model. Magn Reson Imaging, 23(4), 519-29, 2005.
• Li, X, Huang, W, Yankeelov, TE, Tudorica, A, Rooney, WD, Springer, CS Shutter-speed analysis of contrast reagent bolus-tracking data: Preliminary observations in benign and malignant breast disease. Magn Reson Med, 53(3), 724-9, 2005.
• Zhou, R, Pickup, S, Yankeelov, TE, Springer, CS, Glickson, JD Simultaneous measurement of arterial input function and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchange. Magn Reson Med, 52(2), 248-57, 2004.
• Fleischer, AC, Niermann, KJ, Donnelly, EF, Yankeelov, TE, Canniff, KM, Hallahan, DE, Rothenberg, ME Sonographic depiction of microvessel perfusion: principles and potential. J Ultrasound Med, 23(11), 1499-506, 2004.
• Yankeelov TE, Rooney WD, Li X, Springer CS Jr. Variation of the relaxographic "shutter-speed" for transcytolemmal water exchange affects the CR bolus-tracking curve shape. Magn Reson Med, 50(6), 1151-69, 2003.