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Valerie M.  Jansen

Valerie M. Jansen, M.D., Ph.D.

Instructor in Medicine

Profile

I am a physician-scientist with clinical and research interest in breast cancer. My research efforts are focused on identifying novel combination therapies for breast cancer and the mechanisms that lead to drug resistance.

Specifically, my research proposal addresses the mechanisms by which the kinase 3-phosphoinoside dependent protein kinase-1 (PDK1) mediates resistance to cell cycle related CDK4/6 inhibition in ER+ breast cancer and explores the in vivo effects of inhibiting PDK1 in combination with CDK4/6 inhibitors toward ER+ breast cancer growth.

In the clinic, I care for the very patients whose cancer I investigate in the laboratory, exemplifying the bench-to-bedside-to-bench model.

Education
  • M.D., University of Chicago Pritzker School of Medicine, Chicago, Illinois (2010)
  • Ph.D., University of Tennessee Center for Health Science, Memphis, Tennessee (2009)
  • B.A., Maryville College, Maryville, Tennessee, (2001)
 
Publications
  • Jansen VM, Mayer IA, Arteaga CL. Is There a Future for AKT Inhibitors in the Treatment of Cancer?. Clin. Cancer Res [print-electronic]. 2016 Jun 6/1/2016; 22(11): 2599-601. PMID: 26979397, PMCID: PMC4891224, PII: 1078-0432.CCR-16-0100, DOI: 10.1158/1078-0432.CCR-16-0100, ISSN: 1078-0432.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26979397.
  • Bhola NE, Jansen VM, Koch JP, Li H, Formisano L, Williams JA, Grandis JR, Arteaga CL. Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population. Cancer Res [print-electronic]. 2016 Jan 1/15/2016; 76(2): 440-52. PMID: 26676751, PMCID: PMC4715956, PII: 0008-5472.CAN-15-1640-T, DOI: 10.1158/0008-5472.CAN-15-1640-T, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26676751.
  • Bhola NE, Jansen VM, Bafna S, Giltnane JM, Balko JM, Estrada MV, Meszoely I, Mayer I, Abramson V, Ye F, Sanders M, Dugger TC, Allen EV, Arteaga CL. Kinome-wide functional screen identifies role of PLK1 in hormone-independent, ER-positive breast cancer. Cancer Res [print-electronic]. 2015 Jan 1/15/2015; 75(2): 405-14. PMID: 25480943, PMCID: PMC4297507, PII: 0008-5472.CAN-14-2475, DOI: 10.1158/0008-5472.CAN-14-2475, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25480943.