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Wellington Pham, Ph.D.

Assistant Professor of Radiology and Radiological Sciences
VICC Member
Researcher

Contact Information:

Vanderbilt University Institute of Imaging Science
1161 21st Avenue South MCN AA-1105
Nashville, TN 37232-2310
615-936-7621

Research Specialty

Develop molecular probes for detection of cancer using Optical, MRI and PET imaging modalities

Publications

  • Richard A McClure, Chad W Chumbley, Michelle Reyzer, Kevin Wilson, Richard M Caprioli, John C Gore and Wellington Pham "Identification of promethazine as an amyloid-binding molecule using a fluorescence high-throughput assay and MALDI imaging mass spectrometry." NeuroImage: Clinical, 2013 (in press).
  • Nolting D, Nickels M, Tantawy MN, Yu JYH, Xie JP, Peterson TE, Crews BA, Marnett L, Gore JC and Pham W "Convergent synthesis and evaluation of 18F-labeled azulene COX2 probes for cancer imaging." Frontiers in Cancer Imaging and Diagnosis, 2012 (in press).
  • Kumagai H, Pham W, Kataoka M, Hiwatari KI, McBride J, Wilson K, Tachikawa H, Kimura R, Nakamura K, Liu E, Gore J, Sakuma S "Multifunctional Nanobeacon for Imaging Thomsen-Friedenreich Antigen-Associated Colorectal Cancer." International Journal of Cancer, 2012 (in press).
  • Nolting DD, Nickels ML, Guo N, Pham W "Molecular Imaging Probe Development: A Chemistry Perspective." Am J Nucl Med Mol Imaging, 2273-311, 2012.
  • Wellington Pham "Quantitative Analysis and Safety Issues of Nanotechnology in Healthcare Research." J Mol Biomark Diagn, 3(5), 1000e111, 2012.
  • Sakuma S, Kataoka M, Higashino H, Yano T, Masaoka Y, Yamashita S, Hiwatari K, Kimura R, Nakamura K, Kumagai H, Gore J, and Pham W "A Potential of Peanut Agglutinin-Immobilized Fluorescent Nanospheres as a Safe Candidate of Diagnostic Drugs for Colonoscopy." European Journal of Pharmaceutical Sciences, 42(4), 340-347, 2011 .
  • Sakuma S, Higashino H, Oshitani H, Masaoka Y, Kataoka M, Yamashita S, Hiwatari KI, Tachikawa H, Kimura R, Nakamura K, Kumagai H, Gore JC, Pham w "Essence of affinity and specificity of peanut agglutinin-immobilized fluorescent nanospheres with surface poly(N-vinylacetamide) chains for colorectal cancer." European Journal of Pharmaceutics and Biopharmaceutics, 79537-43, 2011 .
  • Sakuma S, Yamashita S, Hiwatari KI, Hoffman RM, Pham W "Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective." Curr Drug Discov Technol, 8367-78, 2011 .
  • Mackay, PS, Kremers GJ, Kobukai S, Cobb JG, Kuley A, Rosenthal SJ, Koktysh DS, Gore JC, Pham W "MULTIMODAL IMAGING OF DENDRITIC CELLS USING A NOVEL HYBRID MAGNETO-OPTICAL NANOPROBE." Nanomedicine:Nanotechnology, Biology, and Medicine, 7489-496, 2011 .
  • Nolting DD, Gore JC and Pham W "Near-Infrared Dyes: Probe Development and Applications in Optical Molecular Imaging." Curr Org Synth, 8521-534, 2011 .
  • Sampson UK, Perati RR, Prins PA, Pham W, Liu Z, Harell F, Linton MF, Gore JC, Kon V, Fazio S "Quantitative estimates of variability of in vivo ultrasound imaging measurements of mouse aorta important for studies of abdominal aortic aneurysms and related arterial diseases." J Ultras Med, 30773-784, 2011 .
  • Dmitry Koktysh, Vanessa Bright, Wellington Pham "Fluorescent Magnetic Hybrid Nanoprobe for Multimodal Bioimaging." Nanotechnology, 22275606, 2011.
  • Kobuka S, Kremers GJ, Cobb JG, Baheza R, Xie JP, Kuley A, Zhu M, Pham W "Induction of Antitumor Immunity by Dendritic Cells Loaded with Membrane Translocating MUCIN-1 Peptide Antigen." Translational Oncology, 4(1), 1-8, 2011.
  • Nickels M, Xie JP, Cobb J, Gore JC and Pham W "Functionalization of Iron Oxide Nanoparticles With a Versatile Epoxy Amine Linker." J Mater Chem, 204776-4780, 2010.
  • Kobukai S, Baheza R, Cobb J, Virostko J, Xie JP, Gillman A, Koktysh D, Kerns D, Does M, Gore JC and Pham W "Magnetic Nanoparticles for Imaging Dendritic Cells." Magn Reson Med, 631383-1390, 2010.
  • Pham W, Kobukai S, Hotta C, Gore J "Dendritic Cells: Therapy and Imaging." Expert Opin Biol Ther, 9(5), 539-564, 2009.
  • Nolting DD, Nickels M, Price R, Gore JC, Pham W "Synthesis of Bicyclo[5.3.0]Azulene Derivatives." Nat Protoc, 41113-1117, 2009.
  • Pham W, Cassell L, Gillman A, Koktysh D and Gore JC "A Near-Infrared Dye for Multichannel Imaging." Chem Commun, 161895-1897, 2008.
  • Medarova Z, Pham W, Farrar C, Petkova V, Moore A "In Vivo Imaging of siRNA Delivery and Silencing in Tumors." Nat Med, 13(3), 372-377, 2007.
  • Pham W, Xie JP and Gore JC "Tracking The Migration of Dendritic Cells By In Vivo Optical Imaging." Neoplasia, 9(12), 1130-1137, 2007.
  • Pham W, Pantazopoulos P, Moore A "Imaging Farnesyl Protein Transferase Using a Topologically Activated Probe." J. Am. Chem. Soc., 128(36), 11736-11737, 2006.
  • Medarova Z, Pham W, Kim Y, Dai G, Moore A "In Vivo Imaging of Tumor Response to Therapy Using a Dual-Modality Imaging Strategy." Int. J. Cancer, 1182796-2802, 2006.
  • Pham W, Zhao BQ, Lo EH, Medarova Z, Rosen B, Moore A. "Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging." Neuroimage, 28287-292, 2005.
  • Pham W, Medarova Z, Moore A. "Synthesis and application of a water-soluble near-infrared dye for cancer detection using optical imaging." Bioconjugate Chem., 16735-740, 2005.
  • Pham W, Choi Y, Weissleder R, Tung CH "Developing a peptide-based near-infrared molecular probe for protease sensing." Bioconjugate Chem. (Special feature on imaging chemistry), 151403-1407, 2004.
  • Pham W, Kircher MF, Weissleder R, Tung CH "Enhancing membrane permeability by fatty acylation of oligoarginine peptides." Chembiochem. , 51148-1151, 2004.
  • Chen JW, Pham W, Weissleder R, Bogdanov A, Jr "Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis." Magn. Reson. Med. , 521021-1028, 2004.
  • Pham W, Weissleder R, Tung C-H "A practical approach for the preparation of monofunctional azulenyl squaraine dye." Tetrahedron Lett. , 443975-3978, 2003.
  • Pham W, Lai WF, Weissleder R, Tung CH "High efficiency synthesis of a bioconjugatable near-infrared fluorochrome." Bioconjugate Chem. , 141048-1051, 2003.
  • Pham W, Weissleder R, Tung C-H "An azulene dimer as a near-infrared quencher." Angew. Chem. Int. Ed. , 413659-3662, 2002.
  • Pham W, Weissleder R, Tung C-H "Intermolecular [8+2] cycloaddition reactions of 2H-3-methoxycarbonylcyclohepta[b]furan-2-one with vinyl ethers." Tetrahedron Lett. , 4319-20, 2001.
  • Krishnan V, Pham W, Messer WS, Jr., Peseckis SM "First fatty acylated dipeptides to affect muscarinic receptor ligand binding." Bioorg. Med. Chem. Lett. , 93363-3368, 1999.

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