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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 
Yu  Shyr

Yu Shyr, Ph.D.

Associate Director for Quantitative Sciences
Harold L. Moses Professor of Cancer Research
Professor of Biostatistics, Biomedical Informatics, Cancer Biology, and Health Policy
Director, Vanderbilt Center for Quantitative Sciences
Scientific Director, Quantitative Sciences Shared Resource
Director, Vanderbilt Technologies for Advanced Genomics Analysis and Research Design (VANGARD)
Researcher

Contact Information:

Vanderbilt University Medical Center
2220 Pierce Ave.
571 Preston Building
Nashville, TN 37232-6848
615-936-2572

Profile

Yu Shyr received his PhD in biostatistics from the University of Michigan (Ann Arbor) in 1994 and subsequently joined the faculty at Vanderbilt University School of Medicine. At Vanderbilt, he has collaborated on numerous research projects; assisted investigators in developing clinical research protocols; collaborated on multiple grants funded through external peer-reviewed mechanisms; and developed biostatistical methodologies for clinical trial design, high-dimensional data preprocessing, and other statistical approaches, published in journals such as Statistics in Medicine, Bioinformatics, and Clinical Trials in the last three years.
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Yu Shyr received his PhD in biostatistics from the University of Michigan (Ann Arbor) in 1994 and subsequently joined the faculty at Vanderbilt University School of Medicine. At Vanderbilt, he has collaborated on numerous research projects; assisted investigators in developing clinical research protocols; collaborated on multiple grants funded through external peer-reviewed mechanisms; and developed biostatistical methodologies for clinical trial design, high-dimensional data preprocessing, and other statistical approaches, published in journals such as Statistics in Medicine, Bioinformatics, and Clinical Trials in the last three years.

Dr. Shyr is a Fellow of the American Statistical Association and an FDA advisory committee voting member. He has delivered more than 190 abstracts at professional meetings and has published more than 300 peer-reviewed papers. Dr. Shyr has served on numerous NIH/NCI SPORE, P01, and CCSG review panels/committees and has been a member of the invited faculty at the AACR/ASCO Methods in Clinical Cancer Research Vail Workshop since 2004. He currently serves on the external advisory board for a dozen national cancer centers, and directs the biostatistics and bioinformatics cores for the NCI-funded Vanderbilt University Breast Cancer SPORE, GI Cancer SPORE, and other program projects. In addition, Dr. Shyr is the Principle Investigator of a UO1 grant for the Barrett's esophagus translational research network coordinating center (BETRNetCC). Dr. Shyr's current research interests focus on developing statistical bioinformatic methods for analyzing next-generation sequencing data including a series of papers on estimating the sample size requirements for studies conducting RNA sequencing analysis.

Education
 
  • Ph.D., Biostatistics, University of Michigan, Ann Arbor, Michigan
  • M.S., Statistics, Michigan State University, East Lansing, Michigan
  • B.B.A., Tamkang University, Tamsui
       
Research Description

statistical bioinformatics

Publications
  • Stover DG, Reddy VK, Shyr Y, Savani BN, Reddy N. Long-term impact of prior rituximab therapy and early lymphocyte recovery on auto-SCT outcome for diffuse large B-cell lymphoma. Bone Marrow Transplant [print-electronic]. 2012 Jan; 47(1): 82-7. PMID: 21358691, PII: bmt201129, DOI: 10.1038/bmt.2011.29, ISSN: 1476-5365.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21358691.
  • Fox EM, Miller TW, Balko JM, Kuba MG, Sánchez V, Smith RA, Liu S, González-Angulo AM, Mills GB, Ye F, Shyr Y, Manning HC, Buck E, Arteaga CL. A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Cancer Res [print-electronic]. 2011 Nov 11/1/2011; 71(21): 6773-84. PMID: 21908557, PMCID: PMC3206206, PII: 0008-5472.CAN-11-1295, DOI: 10.1158/0008-5472.CAN-11-1295, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21908557.
  • Murff HJ, Shrubsole MJ, Chen Z, Smalley WE, Chen H, Shyr Y, Ness RM, Zheng W. Nonsteroidal anti-inflammatory drug use and risk of adenomatous and hyperplastic polyps. Cancer Prev Res (Phila) [print-electronic]. 2011 Nov; 4(11): 1799-807. PMID: 21764857, PMCID: PMC3203989, PII: 1940-6207.CAPR-11-0107, DOI: 10.1158/1940-6207.CAPR-11-0107, ISSN: 1940-6215.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21764857.
  • Fu Z, Shrubsole MJ, Smalley WE, Wu H, Chen Z, Shyr Y, Ness RM, Zheng W. Association of meat intake and meat-derived mutagen exposure with the risk of colorectal polyps by histologic type. Cancer Prev Res (Phila) [print-electronic]. 2011 Oct; 4(10): 1686-97. PMID: 21803984, PMCID: PMC3188364, PII: 1940-6207.CAPR-11-0191, DOI: 10.1158/1940-6207.CAPR-11-0191, ISSN: 1940-6215.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21803984.
  • Dexheimer JW, Talbot TR, Ye F, Shyr Y, Jones I, Gregg WM, Aronsky D. A computerized pneumococcal vaccination reminder system in the adult emergency department. Vaccine [print-electronic]. 2011 Sep 9/16/2011; 29(40): 7035-41. PMID: 21784117, PMCID: PMC3168965, PII: S0264-410X(11)01053-X, DOI: 10.1016/j.vaccine.2011.07.032, ISSN: 1873-2518.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21784117.
  • Villegas R, Xiang YB, Elasy T, Li HL, Yang G, Cai H, Ye F, Gao YT, Shyr Y, Zheng W, Shu XO. Fish, shellfish, and long-chain n-3 fatty acid consumption and risk of incident type 2 diabetes in middle-aged Chinese men and women. Am. J. Clin. Nutr [print-electronic]. 2011 Aug; 94(2): 543-51. PMID: 21677058, PMCID: PMC3142729, PII: ajcn.111.013193, DOI: 10.3945/ajcn.111.013193, ISSN: 1938-3207.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21677058.
  • Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J. Clin. Invest. 2011 Jul; 121(7): 2750-67. PMID: 21633166, PMCID: PMC3127435, PII: 45014, DOI: 10.1172/JCI45014, ISSN: 1558-8238.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21633166.
  • Borkon MJ, Morrow SE, Koehler EA, Shyr Y, Hilmes MA, Miller RS, Neblett WW, Lovvorn HN. Operative intervention for complete pancreatic transection in children sustaining blunt abdominal trauma: revisiting an organ salvage technique. Am Surg. 2011 May; 77(5): 612-20. PMID: 21679597, ISSN: 1555-9823.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21679597.
  • Horn L, Zhao Z, Sandler A, Johnson D, Shyr Y, Wolff S, Devore RF, Laskin J. A phase II study of carboplatin and irinotecan in extensive stage small-cell lung cancer. Clin Lung Cancer [print-electronic]. 2011 May; 12(3): 161-5. PMID: 21663858, PII: S1525-7304(11)00014-3, DOI: 10.1016/j.cllc.2011.03.013, ISSN: 1938-0690.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21663858.
  • Rahman SM, Gonzalez AL, Li M, Seeley EH, Zimmerman LJ, Zhang XJ, Manier ML, Olson SJ, Shah RN, Miller AN, Putnam JB, Miller YE, Franklin WA, Blot WJ, Carbone DP, Shyr Y, Caprioli RM, Massion PP. Lung cancer diagnosis from proteomic analysis of preinvasive lesions. Cancer Res [print-electronic]. 2011 Apr 4/15/2011; 71(8): 3009-17. PMID: 21487035, PMCID: PMC3110721, PII: 0008-5472.CAN-10-2510, DOI: 10.1158/0008-5472.CAN-10-2510, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21487035.
  • Miller TW, Balko JM, Ghazoui Z, Dunbier A, Anderson H, Dowsett M, González-Angulo AM, Mills GB, Miller WR, Wu H, Shyr Y, Arteaga CL. A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance. Clin. Cancer Res [print-electronic]. 2011 Apr 4/1/2011; 17(7): 2024-34. PMID: 21346144, PMCID: PMC3221728, PII: 1078-0432.CCR-10-2567, DOI: 10.1158/1078-0432.CCR-10-2567, ISSN: 1078-0432.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21346144.
  • Li M, Chen S, Zhang J, Chen H, Shyr Y. Wave-spec: a preprocessing package for mass spectrometry data. Bioinformatics [print-electronic]. 2011 Mar 3/1/2011; 27(5): 739-40. PMID: 21208983, PMCID: PMC3105479, PII: btq724, DOI: 10.1093/bioinformatics/btq724, ISSN: 1367-4811.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21208983.
  • Brantley-Sieders DM, Dunaway CM, Rao M, Short S, Hwang Y, Gao Y, Li D, Jiang A, Shyr Y, Wu JY, Chen J. Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium. Cancer Res [print-electronic]. 2011 Feb 2/1/2011; 71(3): 976-87. PMID: 21148069, PMCID: PMC3032824, PII: 0008-5472.CAN-10-3396, DOI: 10.1158/0008-5472.CAN-10-3396, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21148069.
  • Rosenbluth JM, Mays DJ, Jiang A, Shyr Y, Pietenpol JA. Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Feb 2/1/2011; 108(5): 2076-81. PMID: 21245298, PMCID: PMC3033306, PII: 1011936108, DOI: 10.1073/pnas.1011936108, ISSN: 1091-6490.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21245298.
  • Fohn LE, Rodriguez A, Kelley MC, Ye F, Shyr Y, Stricklin G, Robbins JB. D2-40 lymphatic marker for detecting lymphatic invasion in thin to intermediate thickness melanomas: association with sentinel lymph node status and prognostic value-a retrospective case study. J. Am. Acad. Dermatol. 2011 Feb; 64(2): 336-45. PMID: 21238827, PII: S0190-9622(10)00304-X, DOI: 10.1016/j.jaad.2010.03.005, ISSN: 1097-6787.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21238827.
  • Boutté AM, McDonald WH, Shyr Y, Yang L, Lin PC. Characterization of the MDSC proteome associated with metastatic murine mammary tumors using label-free mass spectrometry and shotgun proteomics. PLoS ONE [print-electronic]. 2011; 6(8): e22446. PMID: 21853032, PMCID: PMC3154190, PII: PONE-D-11-06025, DOI: 10.1371/journal.pone.0022446, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21853032.
  • Brantley-Sieders DM, Jiang A, Sarma K, Badu-Nkansah A, Walter DL, Shyr Y, Chen J. Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. PLoS ONE [print-electronic]. 2011; 6(9): e24426. PMID: 21935409, PMCID: PMC3174170, PII: PONE-D-11-14906, DOI: 10.1371/journal.pone.0024426, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21935409.
  • Yu DS, Zhao R, Hsu EL, Cayer J, Ye F, Guo Y, Shyr Y, Cortez D. Cyclin-dependent kinase 9-cyclin K functions in the replication stress response. EMBO Rep [print-electronic]. 2010 Nov; 11(11): 876-82. PMID: 20930849, PMCID: PMC2966956, PII: embor2010153, DOI: 10.1038/embor.2010.153, ISSN: 1469-3178.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20930849.
  • Barton CE, Johnson KN, Mays DM, Boehnke K, Shyr Y, Boukamp P, Pietenpol JA. Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation. Cell Death Dis. 2010; 1: e74. PMID: 21151771, PMCID: PMC3000738, DOI: 10.1038/cddis.2010.49, ISSN: 2041-4889.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21151771.
  • Hatakeyama H, Cheng H, Wirth P, Counsell A, Marcrom SR, Wood CB, Pohlmann PR, Gilbert J, Murphy B, Yarbrough WG, Wheeler DL, Harari PM, Guo Y, Shyr Y, Slebos RJ, Chung CH. Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. PLoS ONE. 2010; 5(9): e12702. PMID: 20856931, PMCID: PMC2938338, DOI: 10.1371/journal.pone.0012702, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20856931.