 Journal Watch
Madan Jagasia, M.D., co-authored a paper in the journal Cancer Research. The paper, "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis," can be seen in the May 1, 2006, issue of the journal. Myelodysplastic syndromes (MDS) are a type of clonal disorder affecting hematopoiesis that leads to fatal cytopenias or acute myeloid leukemia (AML). To see the full article online go to:
http://cancerres.aacrjournals.org.
Raymond DuBois, M.D., Ph.D.,
and Sudhansu K. Dey, Ph.D., co-authored a paper, "Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression," in the July 1, 2006, issue of Cancer Research. The study was featured on the cover of the issue. It found that prostaglandin dehydrogenase, or PGDH, may serve a tumor suppressor function in colorectal cancer and provide a possible COX-2—independent way to target PGE2 to inhibit cancer progression. To see the full article online go to:
http://cancerres.aacrjournals.org.
Carlos Arteaga, M.D., co-authored a paper in the journal Cancer Cell. The paper, "HER2/neu (ErbB2) kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGF receptors and resistance to EGFR tyrosine kinase inhibitors," can be seen in the July 1, 2006, issue. These data suggest that (1) HER2YVMA activates cellular substrates more potently than HER2WT; and (2) cancer cells expressing this mutation remain sensitive to HER2-
targeted therapies but insensitive to EGFR TKIs. To see the full article online go to:
www.cancercell.org.
Mace Rothenberg, M.D. and co-authors have a paper in Clinical Cancer Research, "Phase I and pharmacokinetic study of intravenous irinotecan in refractory solid tumor patients with hepatic dysfunction." The paper discusses findings on safe starting doses of Irinotecan given by IV for patients with liver problems. It can be seen in the June 15, 2006, issue of the journal. To see the full text online go to:
http://clincancerres.aacrjournals.org.
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