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Data mining reveals cancer-driving genes

Thursday, January 22nd, 2015

Prospecting for genes that might be implicated in cancer, a Vanderbilt University Medical Center research team has struck pay dirt. Zhongming Zhao, Ph.D., Peilin Jia, Ph.D., and colleagues use novel computational methods to sift through online repositories of molecular data gathered by cancer researchers worldwide. These results, and further analyses planned by the team, can […]

Cancer groups call for regulation of e-cigarettes

Thursday, January 15th, 2015

Two leading cancer organizations are calling for regulation of e-cigarettes and other electronic nicotine delivery systems (ENDS). The American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO) issued the joint statement calling for greater oversight of the products and more research about their effects on the long-term health of users. […]

Enzyme affects tumor metastasis

Thursday, January 8th, 2015

Breast cancer remains the most common type of cancer in females, with survival rates decreasing sharply for those with distant metastases. MMP2, a type of enzyme that degrades the extracellular matrix, has previously been implicated in the development of distant tumor metastases, but without a clearly defined role. In the Journal of Pathology, Barbara Fingleton, […]

Combo therapy may help fight melanoma

Thursday, January 8th, 2015

Two therapies already in clinical development as single agents may work in combination to treat many subtypes of melanoma, a recent study suggests.

Potential Prostate Cancer Blood Test

Tuesday, January 6th, 2015

Vanderbilt University researcher William Mitchell, M.D., Ph.D., and colleagues in Germany and Canada have demonstrated a method for detecting “cell-free” tumor DNA in the bloodstream.

Visit unites stem cell transplant patient, donor

Monday, December 15th, 2014

When Darlena Clark of Hendersonville, Tennessee, saw Jon Strong for the first time at Nashville International Airport she, “just grabbed him and hugged him and just held on.” Strong, a U.S. Navy hospital corpsman based at Camp Pendleton, California, was the stranger from across the country who had volunteered to be a bone marrow donor, […]

Tindle to lead Tobacco Research and Treatment

Friday, November 21st, 2014

November is well-known as Lung Cancer Awareness Month. It is also the month that highlights awareness of less publicized forms of cancer including pancreatic cancer and stomach cancer. All three of these diseases share a common risk factor — cigarette smoking. “Smoking is the leading cause of preventable disease and death and it is claiming […]

Gene linked to breast cancer therapy response

Friday, November 21st, 2014

A group of Vanderbilt-led investigators has identified a new gene mutation that may explain why some breast cancer patients do not respond to anti-hormone therapy. The study was published online in the Journal of Clinical Investigation. Luis Schwarz, M.D., and Emily Fox, Ph.D., served as co-first authors of the study, led by senior author Carlos […]

More breast cancer patients choose mastectomy

Friday, November 21st, 2014

Far more breast cancer patients are choosing to undergo mastectomy, including removal of both breasts, instead of choosing breast conservation surgery even when they have early stage disease that is confined to one breast, a Vanderbilt study shows.

New insight on oral cancer culprits

Wednesday, November 12th, 2014

Oral squamous cell carcinoma (OSCC) treatments have been slow to advance despite the aggressive nature of these tumors that commonly metastasize. Models for the development of improved OSCC therapeutics have also been scarce. Thomas Andl, Ph.D., Claudia Andl, Ph.D., and colleagues previously observed coordinated loss of connective molecules (E-cadherin) and growth factor (TGFbeta) signaling in […]