Somatic mutations, which can occur in any cell except sperm or egg, are not inheritable. Several recent studies have demonstrated that disease-causing mutations commonly alter protein folding, protein stability and protein-protein interactions. It has been difficult, however, to determine which somatic mutations identified in tumor samples “drive” the cancer development and which are just “along […]
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Melanoma, the most lethal form of skin cancer, spreads aggressively and is often resistant to therapy. Melanoma tumor formation is driven in part by nuclear factor-kappa B (NF-kappaB)-mediated gene transcription, and loss of NF-kappaB activity can block melanoma tumor formation. However, NF-kappaB also plays a crucial role in immune cells. In an October online edition […]
A new study explaining the cellular activity that leads to breast tumor metastasis among women who have recently given birth may offer new treatment direction for postpartum breast cancer.
Findings suggest a combination of therapies that may be effective in treating resistant prostate cancers
Vanderbilt University investigators have discovered a new molecular mechanism that regulates the dynamics of microtubules, which form the cell’s internal skeleton. The unexpected finding, reported in Developmental Cell, has implications for cancer drug discovery,
For years, scientists have known that regular aspirin use may reduce the risk of cancer. “Studies have shown that aspirin administration for five or more years reduces the incidence of all cancers by 38 percent,” said Pierre Massion, M.D., professor of Medicine and Cancer Biology and director of the Thoracic Program at Vanderbilt-Ingram Cancer Center. […]
The American Association for Cancer Research (AACR) Cancer Progress Report 2014, released Sept. 16, details advances in cancer research and treatment — and calls for increased research support.
FDG-PET technology is less accurate in diagnosing lung cancer versus benign disease in regions where infections like histoplasmosis or tuberculosis are common, a recent study has found.
Joe B. (Bill) Putnam Jr., M.D., Ingram Professor of Cancer Research and chair of the Department of Thoracic Surgery, and colleague Felix Fernandez, M.D., assistant professor of Surgery, Emory University School of Medicine, Atlanta, have received a grant to investigate the most effective forms of surgery to treat lung cancer patients.
Brian Engelhardt, M.D., MSCI, assistant professor of Medicine, has received a Mentored Career Development Award from the National Heart, Lung, and Blood Institute, a division of the National Institutes of Health, to explore the causes of post-transplant diabetes development.