News: Cancer Research

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Study Tracks How Gene May Promote Lung Cancer Tumors

Friday, August 10th, 2012

Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors. The investigators found that the protein encoded by this gene, called EPHA3, normally inhibits tumor formation, and that loss or mutation of the gene — as often happens in lung cancer — diminishes this […]

Ancestry Impacts Smoking Risk for Lungs

Wednesday, August 8th, 2012

Smoking tobacco reduces lung function. African Americans have lower lung function compared to European Americans, but it is unclear if African ancestry modifies smoking’s impact on lung function. Melinda Aldrich, Ph.D., MPH, assistant professor of Thoracic Surgery, and colleagues evaluated lung function, tobacco smoking exposure and genetic ancestry in a large population of African Americans who […]

Proteins May Point to Prostate Cancer Drug Targets

Tuesday, August 7th, 2012

Two proteins that act in opposing directions – one that promotes cancer and one that suppresses cancer — regulate the same set of genes in prostate cancer, Vanderbilt-Ingram Cancer Center researchers have found. The findings, reported recently in the Journal of Clinical Investigation, point toward potential drug targets and prognostic markers for prostate cancer. “We […]

Arteaga Named to Komen Scientific Advisory Board

Thursday, August 2nd, 2012

Carlos Arteaga, M.D., associate director for Clinical Research and director of the Breast Cancer Program at Vanderbilt-Ingram Cancer Center (VICC), has been named to the Scientific Advisory Board of the Susan G. Komen for the Cure Breast Cancer Research Foundation. Komen is the one of the largest nonprofit organizations dedicated to funding breast cancer research […]

Hassanein Lands Lung Cancer Research Grant

Thursday, August 2nd, 2012

Mohamed Hassanein, Ph.D., research instructor in Pulmonary Medicine, has received a Career Development Award from the LUNGevity Foundation to work on the development of noninvasive tests to help diagnose lung cancer. He will receive $300,000 over three years in support of his research efforts. Hassanein, who specializes in molecular biology and genetics, works in the […]

Lung Cancer Mutations Suggest New Therapies

Tuesday, July 31st, 2012

Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors. The investigators found that the protein encoded by this gene, called EPHA3, normally inhibits tumor formation, and that loss or mutation of the gene – as often happens in lung cancer – diminishes this […]

On the Hunt for Bladder Cancer Factors

Thursday, July 26th, 2012

Nearly 15,000 people in the United States die each year from metastatic bladder cancer. Signaling pathways that cause bladder tumor recurrence and spread are not clear. David DeGraff, Ph.D., a post-doctoral fellow in Urologic Surgery, and a multi-disciplinary team of colleagues including basic scientists, clinical pathologists and urologic surgeons, examined the role of the transcription […]

Proteins Guard Against Cancer Spread

Thursday, July 26th, 2012

Prostate cancer cells metastasize mainly to bone, yet bone metastases are resistant to common therapies and are often fatal. A key receptor for the growth factor TGF-β (TβRII) is lost in the connective tissue (stroma) of most prostate cancers, but the effects of this loss on metastasis and bone lesion development are undefined. Recently in […]

Colon Cancer Added to Gene Mutation Testing

Thursday, July 19th, 2012

Vanderbilt-Ingram Cancer Center has initiated tumor mutation testing for a limited number of patients with metastatic colorectal cancer. This pilot project for colorectal cancer is part of VICC’s Personalized Cancer Medicine Initiative (PCMI), a program to identify genetic mutations in a patient’s tumor that may be useful in matching the appropriate therapy with each patient. […]

Study Finds Stress Fuels Breast Cancer Metastasis to Bone

Wednesday, July 18th, 2012

Stress can promote breast cancer cell colonization of bone, Vanderbilt Center for Bone Biology investigators have discovered. The studies, reported July 17 in PLoS Biology, demonstrate in mice that activation of the sympathetic nervous system – the “fight-or-flight” response to stress – primes the bone environment for breast cancer cell metastasis. The researchers were able […]