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Study Tracks How Gene May Promote Lung Cancer Tumors

Friday, August 10th, 2012

Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors. The investigators found that the protein encoded by this gene, called EPHA3, normally inhibits tumor formation, and that loss or mutation of the gene — as often happens in lung cancer — diminishes this […]

Proteins May Point to Prostate Cancer Drug Targets

Tuesday, August 7th, 2012

Two proteins that act in opposing directions – one that promotes cancer and one that suppresses cancer — regulate the same set of genes in prostate cancer, Vanderbilt-Ingram Cancer Center researchers have found. The findings, reported recently in the Journal of Clinical Investigation, point toward potential drug targets and prognostic markers for prostate cancer. “We […]

Arteaga Named to Komen Scientific Advisory Board

Thursday, August 2nd, 2012

Carlos Arteaga, M.D., associate director for Clinical Research and director of the Breast Cancer Program at Vanderbilt-Ingram Cancer Center (VICC), has been named to the Scientific Advisory Board of the Susan G. Komen for the Cure Breast Cancer Research Foundation. Komen is the one of the largest nonprofit organizations dedicated to funding breast cancer research […]

Hassanein Lands Lung Cancer Research Grant

Thursday, August 2nd, 2012

Mohamed Hassanein, Ph.D., research instructor in Pulmonary Medicine, has received a Career Development Award from the LUNGevity Foundation to work on the development of noninvasive tests to help diagnose lung cancer. He will receive $300,000 over three years in support of his research efforts. Hassanein, who specializes in molecular biology and genetics, works in the […]

Colon Cancer Added to Gene Mutation Testing

Thursday, July 19th, 2012

Vanderbilt-Ingram Cancer Center has initiated tumor mutation testing for a limited number of patients with metastatic colorectal cancer. This pilot project for colorectal cancer is part of VICC’s Personalized Cancer Medicine Initiative (PCMI), a program to identify genetic mutations in a patient’s tumor that may be useful in matching the appropriate therapy with each patient. […]

Study Finds Stress Fuels Breast Cancer Metastasis to Bone

Wednesday, July 18th, 2012

Stress can promote breast cancer cell colonization of bone, Vanderbilt Center for Bone Biology investigators have discovered. The studies, reported July 17 in PLoS Biology, demonstrate in mice that activation of the sympathetic nervous system – the “fight-or-flight” response to stress – primes the bone environment for breast cancer cell metastasis. The researchers were able […]

Uncommon BRAF Melanoma Mutation

Wednesday, July 18th, 2012

An uncommon mutation of the BRAF gene in melanoma patients has been found to respond to MEK inhibitor drugs, providing a rationale for routine screening and therapy in melanoma patients who harbor the BRAF L597 mutation. The new study by co-first-authors Kimberly Brown Dahlman, Ph.D., Junfeng Xia, Ph.D., and Katherine Hutchinson, B.S., Vanderbilt-Ingram Cancer Center […]

New Cancer Drug Shows Promise

Thursday, July 12th, 2012

An experimental drug that activates T-cells and promotes an immune response to fight tumors has shown promising early results in patients with kidney cancer, melanoma and non-small cell lung cancer. Vanderbilt-Ingram Cancer Center investigators Leora Horn, M.D., Jeffrey Sosman, M.D., and researchers from several other cancer centers tested the new compound. The results of the […]

Childhood Cancer Investigator Lands ‘Lemonade Stand’ Grant

Thursday, July 12th, 2012

Chin Chiang, Ph.D., professor of Cell and Developmental Biology and member of the Vanderbilt-Ingram Cancer Center faculty, has been awarded a $200,000 grant to study an aggressive form of childhood cancer. The two-year Innovation Award from Alex’s Lemonade Stand Foundation (ALSF) will help fund Chiang’s research on rhabdomyosarcoma (RMS), the most common soft tissue malignancy […]

Hernanz-Schulman to chair commission of the ACR

Monday, July 2nd, 2012

Vanderbilt’s Marta Hernanz-Schulman, M.D., has been named to the Board of Chancellors of the American College of Radiology (ACR) as chair of the Pediatric Commission. Hernanz-Schulman, professor of Radiology and Radiological Sciences and professor of Pediatrics, currently serves as medical director of Diagnostic Imaging at the Monroe Carell Jr. Children’s Hospital at Vanderbilt. The American […]