News: July, 2012

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Lung Cancer Mutations Suggest New Therapies

Tuesday, July 31st, 2012

Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors. The investigators found that the protein encoded by this gene, called EPHA3, normally inhibits tumor formation, and that loss or mutation of the gene – as often happens in lung cancer – diminishes this […]

On the Hunt for Bladder Cancer Factors

Thursday, July 26th, 2012

Nearly 15,000 people in the United States die each year from metastatic bladder cancer. Signaling pathways that cause bladder tumor recurrence and spread are not clear. David DeGraff, Ph.D., a post-doctoral fellow in Urologic Surgery, and a multi-disciplinary team of colleagues including basic scientists, clinical pathologists and urologic surgeons, examined the role of the transcription […]

Proteins Guard Against Cancer Spread

Thursday, July 26th, 2012

Prostate cancer cells metastasize mainly to bone, yet bone metastases are resistant to common therapies and are often fatal. A key receptor for the growth factor TGF-β (TβRII) is lost in the connective tissue (stroma) of most prostate cancers, but the effects of this loss on metastasis and bone lesion development are undefined. Recently in […]

Colon Cancer Added to Gene Mutation Testing

Thursday, July 19th, 2012

Vanderbilt-Ingram Cancer Center has initiated tumor mutation testing for a limited number of patients with metastatic colorectal cancer. This pilot project for colorectal cancer is part of VICC’s Personalized Cancer Medicine Initiative (PCMI), a program to identify genetic mutations in a patient’s tumor that may be useful in matching the appropriate therapy with each patient. […]

Study Finds Stress Fuels Breast Cancer Metastasis to Bone

Wednesday, July 18th, 2012

Stress can promote breast cancer cell colonization of bone, Vanderbilt Center for Bone Biology investigators have discovered. The studies, reported July 17 in PLoS Biology, demonstrate in mice that activation of the sympathetic nervous system – the “fight-or-flight” response to stress – primes the bone environment for breast cancer cell metastasis. The researchers were able […]

High Consumption of Vitamin E May Lower Liver Cancer Risk

Wednesday, July 18th, 2012

High consumption of vitamin E either from diet or vitamin supplements may lower the risk of liver cancer, according to a study published July 17 in the Journal of the National Cancer Institute. The study was conducted by investigators from the Shanghai Cancer Institute, Vanderbilt-Ingram Cancer Center and the National Cancer Institute. Vitamin E is […]

Uncommon BRAF Melanoma Mutation

Wednesday, July 18th, 2012

An uncommon mutation of the BRAF gene in melanoma patients has been found to respond to MEK inhibitor drugs, providing a rationale for routine screening and therapy in melanoma patients who harbor the BRAF L597 mutation. The new study by co-first-authors Kimberly Brown Dahlman, Ph.D., Junfeng Xia, Ph.D., and Katherine Hutchinson, B.S., Vanderbilt-Ingram Cancer Center […]

New Cancer Drug Shows Promise

Thursday, July 12th, 2012

An experimental drug that activates T-cells and promotes an immune response to fight tumors has shown promising early results in patients with kidney cancer, melanoma and non-small cell lung cancer. Vanderbilt-Ingram Cancer Center investigators Leora Horn, M.D., Jeffrey Sosman, M.D., and researchers from several other cancer centers tested the new compound. The results of the […]

Childhood Cancer Investigator Lands ‘Lemonade Stand’ Grant

Thursday, July 12th, 2012

Chin Chiang, Ph.D., professor of Cell and Developmental Biology and member of the Vanderbilt-Ingram Cancer Center faculty, has been awarded a $200,000 grant to study an aggressive form of childhood cancer. The two-year Innovation Award from Alex’s Lemonade Stand Foundation (ALSF) will help fund Chiang’s research on rhabdomyosarcoma (RMS), the most common soft tissue malignancy […]

Photo: Living Well Through Cancer

Thursday, July 12th, 2012

Olympic gold medal skating champion and cancer survivor Scott Hamilton was the keynote speaker at Vanderbilt-Ingram Cancer Center’s annual cancer survivors day event held at the Vanderbilt Student Life Center. Nearly 600 people attended “Going for the Gold: Living Well through Cancer,” which featured activities for cancer patients, survivors, friends and families. (photo by Debra […]