Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer. Abnormal regulation of this pathway leads to several human malignancies, including small cell lung cancer and pancreatic cancer, and therefore it is a potential drug target for cancer. Small molecules have […]
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Small interfering RNA (siRNA) molecules can suppress tumor growth and target cells otherwise untreatable by conventional therapeutics, but targeted, intracellular delivery is a significant limitation to siRNA translation. To deliver the siRNA molecules into tumor cells, researchers have packaged them in micelles that express folic acid, which is internalized by cancer cells that overexpress folate […]
The death rates for most forms of cancer continue to decline at a modest pace among men, women and children in the United States, according to the Annual Report to the Nation on the Status of Cancer 1975 – 2011. The report from the National Cancer Institute, a division of the National Institutes of Health, […]
Carlos L. Arteaga, M.D., director of the Center for Cancer Targeted Therapies and director of the Breast Cancer Program at Vanderbilt-Ingram Cancer Center (VICC), has been named a fellow of the AACR Academy. He is among 11 new fellows announced by the American Association for Cancer Research, the largest international cancer organization dedicated to cancer […]
The stands inside Memorial Gymnasium are expected to resemble a sea of pink as fans don pink attire for the Vanderbilt Commodores Women’s Basketball game Sunday, Feb. 8, at noon. The Commodores will play the University of Kentucky Wildcats during the annual Pink Out! Game, which is designed to raise awareness of breast cancer and […]
Breast cancer remains the most common type of cancer in females, with survival rates decreasing sharply for those with distant metastases. MMP2, a type of enzyme that degrades the extracellular matrix, has previously been implicated in the development of distant tumor metastases, but without a clearly defined role. In the Journal of Pathology, Barbara Fingleton, […]
Two therapies already in clinical development as single agents may work in combination to treat many subtypes of melanoma, a recent study suggests.
A group of Vanderbilt-led investigators has identified a new gene mutation that may explain why some breast cancer patients do not respond to anti-hormone therapy. The study was published online in the Journal of Clinical Investigation. Luis Schwarz, M.D., and Emily Fox, Ph.D., served as co-first authors of the study, led by senior author Carlos […]
Far more breast cancer patients are choosing to undergo mastectomy, including removal of both breasts, instead of choosing breast conservation surgery even when they have early stage disease that is confined to one breast, a Vanderbilt study shows.
A new study explaining the cellular activity that leads to breast tumor metastasis among women who have recently given birth may offer new treatment direction for postpartum breast cancer.