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‘Stretched’ cells promote cancer

Thursday, February 26th, 2015

Interactions between tumor cells and other cell types in the surrounding microenvironment (stroma) are crucial for tumor cell growth, survival and metastatic spread. Although tumor cells are known to induce mechanical changes in their microenvironment, few studies have examined the effect of mechanical stimuli on stromal cells such as fibroblasts. Donna Webb, Ph.D., Deyu Li, […]

Arteaga named a fellow of the AACR Academy

Thursday, February 26th, 2015

Carlos L. Arteaga, M.D., director of the Center for Cancer Targeted Therapies and director of the Breast Cancer Program at Vanderbilt-Ingram Cancer Center (VICC), has been named a fellow of the AACR Academy. He is among 11 new fellows announced by the American Association for Cancer Research, the largest international cancer organization dedicated to cancer […]

Antibiotics with anticancer potential

Thursday, February 26th, 2015

The type II topoisomerases – enzymes that manage tangles and supercoils in DNA – exist in all organisms and are important drug targets. Widely prescribed anticancer agents including etoposide and doxorubicin target human type II topoisomerases, and quinolone antibiotics such as ciprofloxacin target bacterial topoisomerases. Clinically relevant quinolones have no activity against human type II […]

Cancer survival improvements vary by age, race

Thursday, February 26th, 2015

Improvements in cancer diagnosis and treatment have led to longer survival for most cancer patients in the United States. However, the improvement in survival was substantially greater among younger patients and those who are white in most of the cancers studied, according to new research by Vanderbilt University investigators. The study was published online recently […]

Gene profile predicts metastasis

Thursday, February 12th, 2015

Gene expression profiling has been applied to predict metastatic recurrence, the leading cause of deaths in patients with colorectal carcinoma. However, the biological mechanism is not completely understood, driving poor clinical outcomes. To address this issue, Dan Beauchamp, M.D., Bing Zhang, Ph.D., and colleagues analyzed the 11 human microarray datasets from 1,295 tumor specimens as […]

BlackHawk’s support reaches milestone

Thursday, February 12th, 2015

Country music group BlackHawk recently presented a check for $20,000 to Harold (Hal) Moses, M.D., Ingram Professor of Cancer Research and director emeritus of Vanderbilt-Ingram Cancer Center (VICC), in support of cancer research. Since 2006, the group has raised and donated $100,000 to VICC in remembrance of one of the original members of the multi-platinum […]

Pink Out! game set for Sunday, Feb. 8

Thursday, February 5th, 2015

The stands inside Memorial Gymnasium are expected to resemble a sea of pink as fans don pink attire for the Vanderbilt Commodores Women’s Basketball game Sunday, Feb. 8, at noon. The Commodores will play the University of Kentucky Wildcats during the annual Pink Out! Game, which is designed to raise awareness of breast cancer and […]

Grant bolsters Kirschner’s prostate cancer research

Thursday, February 5th, 2015

Austin Kirschner, M.D., Ph.D., assistant professor of Radiation Oncology and Cancer Biology, has received the Urology Care Foundation Research Scholars Award for the study of advanced prostate cancer. “I am very honored to receive this important award in support of research to help men with difficult-to-treat forms of prostate cancer,” said Kirschner, who joined the […]

New certification focuses on genetics nursing

Thursday, February 5th, 2015

A nurse practitioner at the Vanderbilt Hereditary Cancer clinic is expected to be one of the first nurses in the country to receive a newly created certification in Advanced Genetics Nursing from the American Nurses Credentialing Center (ANCC). Kate McReynolds, APRN, M.Sc., MSN, helped the ANCC develop the guidelines and scope for the Advanced Genetics […]

Exploring myeloma treatment’s impact on heart

Thursday, February 5th, 2015

  Vanderbilt is embarking on an observational study to define and understand how a promising treatment for multiple myeloma affects the heart. The Prospective Observation of Cardiac Safety with Proteasome Inhibition (PROTECT) trial capitalizes on the collaborative relationship between Vanderbilt Heart and Vascular Institute and Vanderbilt-Ingram Cancer Center, with the goal of managing cardiac toxicity […]