Two leading cancer organizations are calling for regulation of e-cigarettes and other electronic nicotine delivery systems (ENDS). The American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO) issued the joint statement calling for greater oversight of the products and more research about their effects on the long-term health of users. […]
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Breast cancer remains the most common type of cancer in females, with survival rates decreasing sharply for those with distant metastases. MMP2, a type of enzyme that degrades the extracellular matrix, has previously been implicated in the development of distant tumor metastases, but without a clearly defined role. In the Journal of Pathology, Barbara Fingleton, […]
Two therapies already in clinical development as single agents may work in combination to treat many subtypes of melanoma, a recent study suggests.
Vanderbilt University researcher William Mitchell, M.D., Ph.D., and colleagues in Germany and Canada have demonstrated a method for detecting “cell-free” tumor DNA in the bloodstream.
Ten-to-one. Cell for cell, they’ve got us outnumbered. And as a group, they have 100 times more genes than we do. Fortunately, these microbes that share our corporeal space are usually on our side. Known collectively as the microbiome, the microbial species that flourish along our mucosal surfaces—the linings of our intestines, mouth and nose, […]
When Darlena Clark of Hendersonville, Tennessee, saw Jon Strong for the first time at Nashville International Airport she, “just grabbed him and hugged him and just held on.” Strong, a U.S. Navy hospital corpsman based at Camp Pendleton, California, was the stranger from across the country who had volunteered to be a bone marrow donor, […]
November is well-known as Lung Cancer Awareness Month. It is also the month that highlights awareness of less publicized forms of cancer including pancreatic cancer and stomach cancer. All three of these diseases share a common risk factor — cigarette smoking. “Smoking is the leading cause of preventable disease and death and it is claiming […]
A group of Vanderbilt-led investigators has identified a new gene mutation that may explain why some breast cancer patients do not respond to anti-hormone therapy. The study was published online in the Journal of Clinical Investigation. Luis Schwarz, M.D., and Emily Fox, Ph.D., served as co-first authors of the study, led by senior author Carlos […]
Far more breast cancer patients are choosing to undergo mastectomy, including removal of both breasts, instead of choosing breast conservation surgery even when they have early stage disease that is confined to one breast, a Vanderbilt study shows.
Oral squamous cell carcinoma (OSCC) treatments have been slow to advance despite the aggressive nature of these tumors that commonly metastasize. Models for the development of improved OSCC therapeutics have also been scarce. Thomas Andl, Ph.D., Claudia Andl, Ph.D., and colleagues previously observed coordinated loss of connective molecules (E-cadherin) and growth factor (TGFbeta) signaling in […]