Gene expression profiling has been applied to predict metastatic recurrence, the leading cause of deaths in patients with colorectal carcinoma. However, the biological mechanism is not completely understood, driving poor clinical outcomes. To address this issue, Dan Beauchamp, M.D., Bing Zhang, Ph.D., and colleagues analyzed the 11 human microarray datasets from 1,295 tumor specimens as […]
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Country music group BlackHawk recently presented a check for $20,000 to Harold (Hal) Moses, M.D., Ingram Professor of Cancer Research and director emeritus of Vanderbilt-Ingram Cancer Center (VICC), in support of cancer research. Since 2006, the group has raised and donated $100,000 to VICC in remembrance of one of the original members of the multi-platinum […]
Austin Kirschner, M.D., Ph.D., assistant professor of Radiation Oncology and Cancer Biology, has received the Urology Care Foundation Research Scholars Award for the study of advanced prostate cancer. “I am very honored to receive this important award in support of research to help men with difficult-to-treat forms of prostate cancer,” said Kirschner, who joined the […]
Vanderbilt is embarking on an observational study to define and understand how a promising treatment for multiple myeloma affects the heart. The Prospective Observation of Cardiac Safety with Proteasome Inhibition (PROTECT) trial capitalizes on the collaborative relationship between Vanderbilt Heart and Vascular Institute and Vanderbilt-Ingram Cancer Center, with the goal of managing cardiac toxicity […]
The Lustgarten Foundation has awarded a $1.5 million Research Investigator Grant to Stephen Fesik, Ph.D., professor of Biochemistry, Pharmacology and Chemistry, for research designed to discover new drugs for the treatment of pancreatic cancer. This is Fesik’s second three-year award from the Lustgarten Foundation in support of his research targeting K-Ras, a protein mutated in […]
Cancer is bad enough. But cancer patients who receive surgery, radiation and chemotherapy may suffer from side effects that run from irritating to crippling — problems that are postural, musculoskeletal and respiratory, along with lowered self-esteem. Many suffer from lymphedema, swelling caused by retained fluid in a compromised lymphatic system. One answer may be the […]
Prospecting for genes that might be implicated in cancer, a Vanderbilt University Medical Center research team has struck pay dirt. Zhongming Zhao, Ph.D., Peilin Jia, Ph.D., and colleagues use novel computational methods to sift through online repositories of molecular data gathered by cancer researchers worldwide. These results, and further analyses planned by the team, can […]
Breast cancer remains the most common type of cancer in females, with survival rates decreasing sharply for those with distant metastases. MMP2, a type of enzyme that degrades the extracellular matrix, has previously been implicated in the development of distant tumor metastases, but without a clearly defined role. In the Journal of Pathology, Barbara Fingleton, […]
Two therapies already in clinical development as single agents may work in combination to treat many subtypes of melanoma, a recent study suggests.
Vanderbilt University researcher William Mitchell, M.D., Ph.D., and colleagues in Germany and Canada have demonstrated a method for detecting “cell-free” tumor DNA in the bloodstream.