News: Cancer Research

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Grant boosts head and neck lymphedema research

Monday, March 9th, 2015

Vanderbilt University School of Nursing (VUSN) has been awarded a four-year, $2.4 million grant from the National Institutes of Health/National Institute of Dental and Craniofacial Research to establish a valid, clinically useful measurement battery for head and neck lymphedema and fibrosis (LEF). Principal investigator Jie Deng, Ph.D., R.N., developed the proposal because she commonly sees […]

‘Stretched’ cells promote cancer

Thursday, February 26th, 2015

Interactions between tumor cells and other cell types in the surrounding microenvironment (stroma) are crucial for tumor cell growth, survival and metastatic spread. Although tumor cells are known to induce mechanical changes in their microenvironment, few studies have examined the effect of mechanical stimuli on stromal cells such as fibroblasts. Donna Webb, Ph.D., Deyu Li, […]

Antibiotics with anticancer potential

Thursday, February 26th, 2015

The type II topoisomerases – enzymes that manage tangles and supercoils in DNA – exist in all organisms and are important drug targets. Widely prescribed anticancer agents including etoposide and doxorubicin target human type II topoisomerases, and quinolone antibiotics such as ciprofloxacin target bacterial topoisomerases. Clinically relevant quinolones have no activity against human type II […]

Cancer survival improvements vary by age, race

Thursday, February 26th, 2015

Improvements in cancer diagnosis and treatment have led to longer survival for most cancer patients in the United States. However, the improvement in survival was substantially greater among younger patients and those who are white in most of the cancers studied, according to new research by Vanderbilt University investigators. The study was published online recently […]

Gene profile predicts metastasis

Thursday, February 12th, 2015

Gene expression profiling has been applied to predict metastatic recurrence, the leading cause of deaths in patients with colorectal carcinoma. However, the biological mechanism is not completely understood, driving poor clinical outcomes. To address this issue, Dan Beauchamp, M.D., Bing Zhang, Ph.D., and colleagues analyzed the 11 human microarray datasets from 1,295 tumor specimens as […]

BlackHawk’s support reaches milestone

Thursday, February 12th, 2015

Country music group BlackHawk recently presented a check for $20,000 to Harold (Hal) Moses, M.D., Ingram Professor of Cancer Research and director emeritus of Vanderbilt-Ingram Cancer Center (VICC), in support of cancer research. Since 2006, the group has raised and donated $100,000 to VICC in remembrance of one of the original members of the multi-platinum […]

Grant bolsters Kirschner’s prostate cancer research

Thursday, February 5th, 2015

Austin Kirschner, M.D., Ph.D., assistant professor of Radiation Oncology and Cancer Biology, has received the Urology Care Foundation Research Scholars Award for the study of advanced prostate cancer. “I am very honored to receive this important award in support of research to help men with difficult-to-treat forms of prostate cancer,” said Kirschner, who joined the […]

Exploring myeloma treatment’s impact on heart

Thursday, February 5th, 2015

  Vanderbilt is embarking on an observational study to define and understand how a promising treatment for multiple myeloma affects the heart. The Prospective Observation of Cardiac Safety with Proteasome Inhibition (PROTECT) trial capitalizes on the collaborative relationship between Vanderbilt Heart and Vascular Institute and Vanderbilt-Ingram Cancer Center, with the goal of managing cardiac toxicity […]

Grant bolsters pancreatic cancer drug discovery

Thursday, January 29th, 2015

The Lustgarten Foundation has awarded a $1.5 million Research Investigator Grant to Stephen Fesik, Ph.D., professor of Biochemistry, Pharmacology and Chemistry, for research designed to discover new drugs for the treatment of pancreatic cancer. This is Fesik’s second three-year award from the Lustgarten Foundation in support of his research targeting K-Ras, a protein mutated in […]

Yoga therapy for cancer patients studied

Thursday, January 29th, 2015

Cancer is bad enough. But cancer patients who receive surgery, radiation and chemotherapy may suffer from side effects that run from irritating to crippling — problems that are postural, musculoskeletal and respiratory, along with lowered self-esteem. Many suffer from lymphedema, swelling caused by retained fluid in a compromised lymphatic system. One answer may be the […]