Breast cancer remains the most common type of cancer in females, with survival rates decreasing sharply for those with distant metastases. MMP2, a type of enzyme that degrades the extracellular matrix, has previously been implicated in the development of distant tumor metastases, but without a clearly defined role. In the Journal of Pathology, Barbara Fingleton, […]
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Two therapies already in clinical development as single agents may work in combination to treat many subtypes of melanoma, a recent study suggests.
Vanderbilt University researcher William Mitchell, M.D., Ph.D., and colleagues in Germany and Canada have demonstrated a method for detecting “cell-free” tumor DNA in the bloodstream.
Oral squamous cell carcinoma (OSCC) treatments have been slow to advance despite the aggressive nature of these tumors that commonly metastasize. Models for the development of improved OSCC therapeutics have also been scarce. Thomas Andl, Ph.D., Claudia Andl, Ph.D., and colleagues previously observed coordinated loss of connective molecules (E-cadherin) and growth factor (TGFbeta) signaling in […]
Vanderbilt University investigators have discovered a new molecular mechanism that regulates the dynamics of microtubules, which form the cell’s internal skeleton. The unexpected finding, reported in Developmental Cell, has implications for cancer drug discovery,
For years, scientists have known that regular aspirin use may reduce the risk of cancer. “Studies have shown that aspirin administration for five or more years reduces the incidence of all cancers by 38 percent,” said Pierre Massion, M.D., professor of Medicine and Cancer Biology and director of the Thoracic Program at Vanderbilt-Ingram Cancer Center. […]
FDG-PET technology is less accurate in diagnosing lung cancer versus benign disease in regions where infections like histoplasmosis or tuberculosis are common, a recent study has found.
by Dagny Stuart Colorectal cancer is one of the leading causes of death among populations around the world. While diet, physical activity and other lifestyle factors can influence the risk of developing the disease, hereditary factors also play an important role. Genetic factors identified to date explain only a small fraction of colorectal cancer (CRC), […]
by Dagny Stuart Two Vanderbilt-Ingram Cancer Center investigators have received multi-year breast cancer research grants from the Susan G. Komen for the Cure Breast Cancer Foundation. Justin Balko, Ph.D., Pharm.D., research assistant professor of Medicine, won support for his research project which will use molecular profiling to prioritize adjuvant targeted therapy for triple negative breast […]
by Dagny Stuart A new study in East Asian women has identified three genetic changes linked to an increased risk of breast cancer. The research, led by Vanderbilt University investigators, was published online this week in Nature Genetics. While breast cancer is one of the most common malignancies among women worldwide, most studies of the […]