Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer. Abnormal regulation of this pathway leads to several human malignancies, including small cell lung cancer and pancreatic cancer, and therefore it is a potential drug target for cancer. Small molecules have […]
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The death rates for most forms of cancer continue to decline at a modest pace among men, women and children in the United States, according to the Annual Report to the Nation on the Status of Cancer 1975 – 2011. The report from the National Cancer Institute, a division of the National Institutes of Health, […]
Vanderbilt-Ingram Cancer Center investigators have identified the mechanisms used by a gene and its binding protein to drive tumor growth in several forms of cancer, including non-small cell lung cancer. In a report published online recently in the Proceedings of the National Academy of Sciences (PNAS), first author Jun Qian, Ph.D., lead investigator Pierre Massion, M.D., […]
Improvements in cancer diagnosis and treatment have led to longer survival for most cancer patients in the United States. However, the improvement in survival was substantially greater among younger patients and those who are white in most of the cancers studied, according to new research by Vanderbilt University investigators. The study was published online recently […]
November is well-known as Lung Cancer Awareness Month. It is also the month that highlights awareness of less publicized forms of cancer including pancreatic cancer and stomach cancer. All three of these diseases share a common risk factor — cigarette smoking. “Smoking is the leading cause of preventable disease and death and it is claiming […]
Somatic mutations, which can occur in any cell except sperm or egg, are not inheritable. Several recent studies have demonstrated that disease-causing mutations commonly alter protein folding, protein stability and protein-protein interactions. It has been difficult, however, to determine which somatic mutations identified in tumor samples “drive” the cancer development and which are just “along […]
FDG-PET technology is less accurate in diagnosing lung cancer versus benign disease in regions where infections like histoplasmosis or tuberculosis are common, a recent study has found.
Joe B. (Bill) Putnam Jr., M.D., Ingram Professor of Cancer Research and chair of the Department of Thoracic Surgery, and colleague Felix Fernandez, M.D., assistant professor of Surgery, Emory University School of Medicine, Atlanta, have received a grant to investigate the most effective forms of surgery to treat lung cancer patients.
Lung cancer patients with specific gene alterations may benefit from combination therapy that targets two different cancer pathways, a recent study suggests.
A new study estimates that tobacco smoking has been linked to approximately 2 million deaths among adult men and women in Asia in recent years and predicts a rising death toll. The study, published in PLOS Medicine, was led by Wei Zheng, M.D., Ph.D., MPH, professor of Medicine and director of the Vanderbilt Epidemiology Center, […]