News: BRCA1

DNA Mechanics

Wednesday, December 8th, 2010

Picture a railroad track, running across the countryside. DNA looks something like that track. Its “rails” are chains of chemicals called nucleotides, each pairing with a partner on the opposite chain to form the “ties.” To ensure timely train traffic – and prevent catastrophic derailments – the railroad track needs regular maintenance. So does DNA. […]

Location Key for Breast Cancer Protein

Friday, September 17th, 2010

Mutations in the BRCA1 gene have been implicated in the development of inherited breast cancers. The BRCA1 protein participates in processes including repair of DNA breaks, DNA replication, and cell death. BRCA1 moves between the cell nucleus and cytoplasm, and Fen Xia, M.D., Ph.D., and colleagues have proposed that active “shuttling” between cellular compartments may […]