News: Cancer Prevention Research

Smoking Stokes Cells’ Cancer Capacity

Friday, March 16th, 2012

Smoking contributes to the vast majority (around 85 percent) of lung cancer cases. The TGF-beta signaling pathway – which regulates cell growth and proliferation – is altered in several cancer types, but little is known about how smoking affects this pathway. To investigate this, Debangshu Samanta, Pran Datta, Ph.D., and colleagues exposed human lung epithelial […]

Urine Biomarker for Colon Cancer?

Friday, March 2nd, 2012

About half of colorectal tumors express elevated levels of COX-2, the key enzyme responsible for generating prostaglandins that promote cancer development. Prostaglandin E2 (PGE2) is likely the primary mediator of most of COX-2’s tumor-promoting effects, and the PGE2 metabolite, PGE-M, can be measured noninvasively in urine. To assess the utility of PGE-M as a biomarker […]

New Views of Inflammation, Cancer

Friday, October 21st, 2011

The enzyme COX-2 – normally expressed at low levels – increases at sites of inflammation and in pre-malignant and malignant tumors, making it an attractive target for molecular imaging to diagnose and treat cancer. Jashim Uddin, Ph.D., Lawrence Marnett, Ph.D., and colleagues are developing novel imaging agents that selectively bind to COX-2. In work featured […]

Red Meat and Colon Polyps

Friday, September 30th, 2011

Scientists have already established an association between a diet high in red meat and the risk of colorectal cancer. Now cancer investigators from Vanderbilt-Ingram Cancer Center and the Veterans Affairs Medical Center (Tennessee Valley Health System in Nashville) have found that eating a steady diet of red or processed meat, especially meat that has been […]