Vanderbilt-Ingram Cancer Center

The Translational Pathology Shared Resource (TPSR) has opened an expanded laboratory on the first floor of Medical Center North, room S-1310. To celebrate the grand opening of the newly renovated space, TPSR is hosting an open house on Wednesday, May 30, from 1-3 p.m. Vanderbilt faculty and staff are invited to tour the new space, [...]

Therapies targeted to a specific mutation in the BRAF gene can significantly reduce tumor burden in metastatic melanoma. But these therapies are not suitable for melanomas lacking the mutation, and even tumors carrying the BRAF mutation eventually become resistant to those therapies. Using human melanoma tumors implanted into mice, Ann Richmond, Ph.D., and colleagues assessed [...]

The Institute of Medicine of the National Academies (IOM), in conjunction with Vanderbilt University School of Medicine, will hold a regional meeting Monday, April 23, 4–6 p.m. in 208 Light Hall. The presentation, “Potential and Pitfalls of Gene and Omics-Based Treatment for Cancer,” will highlight recent advances in cancer research based on gene sequencing, along [...]

Diseases that are treatable in developed nations are often lethal in developing countries. For Wilms’ tumor, the most common childhood kidney cancer, survival rates in developed countries exceed 90 percent – but in developing nations, survival can be as low as 35 percent. Lack of adequate health care resources is largely responsible for this survival [...]

Pelayo Correa, M.D., professor of Pathology, Microbiology and Immunulogy, has been recognized by the American Association for Cancer Research (AACR) and its Minorities in Cancer Research membership group with the Jane Cooke Wright Lectureship. Correa holds the Anne Potter Wilson chair in cancer research in the Division of Gastroenterology, Hepatology and Nutrition. The AACR-MICR-Jane Cooke [...]

Nearly half the world’s population is colonized by the gut bacterium Helicobacter pylori. Not only can this infection cause stomach ulcers and increase one’s risk of gastric cancer, colonization can also significantly slow growth in children. Antibiotic treatment to clear H. pyloriinfection causes growth to rebound in the short term, but it is unclear whether [...]

Head and neck cancers have repeatedly been linked to infection with human papillomavirus (HPV), with more than half of oropharyngeal squamous cell carcinomas (HNSCCs) positive for HPV. Interestingly, HPV-positive HNSCCs respond better to radiation therapy and have a better prognosis than HPV-negative tumors. But the molecular pathways responsible for their different sensitivities are unclear. In [...]

Vanderbilt-Ingram Cancer Center researchers have identified a new population of intestinal stem cells that may hold clues to the origin of colorectal cancer. This new stem cell population, reported March 30 in the journal Cell, appears to be relatively quiescent (inactive) – in contrast to the recent discovery of intestinal stem cells that multiply rapidly [...]

Vanderbilt-Ingram Cancer Center investigators have won two of the five global innovation grants awarded by the “GE Healthymagination Cancer Challenge.” The grants were awarded to Jennifer Pietenpol, Ph.D., director of VICC, and the My Cancer Genome project, developed by Mia Levy, M.D., Ph.D., assistant professor of Medicine and Biomedical Informatics, and William Pao, M.D., Ph.D., [...]

Melanoma patients who are treated with new oral drugs inhibiting the BRAF gene are at increased risk for developing secondary skin cancers. A new study co-authored by Vanderbilt-Ingram Cancer Center investigators and researchers from 12 other cancer centers discovered clues that may explain what is triggering these secondary cancers. VICC’s Igor Puzanov, M.D., assistant professor [...]