News: colorectal cancer

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Colon Cancer Added to Gene Mutation Testing

Thursday, July 19th, 2012

Vanderbilt-Ingram Cancer Center has initiated tumor mutation testing for a limited number of patients with metastatic colorectal cancer. This pilot project for colorectal cancer is part of VICC’s Personalized Cancer Medicine Initiative (PCMI), a program to identify genetic mutations in a patient’s tumor that may be useful in matching the appropriate therapy with each patient. […]

Newly Identified Stem Cells May Hold Clues to Colon Cancer

Thursday, March 29th, 2012

Vanderbilt-Ingram Cancer Center researchers have identified a new population of intestinal stem cells that may hold clues to the origin of colorectal cancer. This new stem cell population, reported March 30 in the journal Cell, appears to be relatively quiescent (inactive) – in contrast to the recent discovery of intestinal stem cells that multiply rapidly […]

Colon Cancer’s Cellular Crossroads

Friday, March 16th, 2012

Colon cancer development and progression involves alterations in several cell signaling pathways. Activation of the Wnt pathway is involved in the early stages of tumor development, while inactivation of signaling through the TGF-beta pathway (which typically suppresses tumor formation) is involved in later stages. However, the interactions between these pathways remain unclear. R. Daniel Beauchamp, […]

Quitting Smoking Can Be Done

Tuesday, March 13th, 2012

Join us on March 20 for a FREE informative evening on your health and wellness. Event is located at Vanderbilt-Ingram Cancer Center at Green Hills 3810 Bedford Avenue Suite 100 Nashville, TN 37215 6 p.m. Registration & Refreshments 6:30 p.m. Speaker 7:15 p.m. Questions & Answers Quitting tobacco is the best thing that you can […]

Dress in Blue for Colon Cancer Awareness

Friday, February 24th, 2012

Everyone is encouraged to wear something blue to spark conversations about the importance of early screening for colon cancer during Dress in Blue Day on Friday, March 2. Dress in Blue Day was launched in 2009 by the Colon Cancer Alliance to raise awareness about colorectal cancer, which is the second leading cause of cancer-related […]

Colorectal Cancer Risk Related to Gene’s Expression

Friday, January 27th, 2012

Individuals who are outside the “normal” range of expression for the APC gene have an increased risk of colorectal cancer, according to a study published in the January issue of Gastroenterology. Mutations in the APC (adenomatous polyposis coli) gene – and variations in the expression of the gene’s two copies (allele-specific expression) — are associated […]

Lymphedema Therapy

Monday, December 19th, 2011

Jadranko “Yadi” Franjic describes lymphedema symptoms and what is done during therapy to help control the swelling in the lymphatic system. Lymphedema is most common among patients who experience trauma to their lymphatic system. Examples include cancer patients undergoing lymphatic node dissection or radiation therapy and those who suffer a traumatic injury. Swelling of the […]

Pathway to Colon Cancer Progression

Friday, December 2nd, 2011

Identifying the molecular pathways that lead normal colon cells to become cancer cell could provide much needed biomarkers and therapeutic targets. Previously, Punita Dhawan, Ph.D., and colleagues showed that claudin-1 – a protein member of “tight junctions” that help bind cells together into an organized tissue structure – was greatly increased and mislocalized in colorectal […]

Dayani Center Ready to Help Smokers Quit

Friday, November 11th, 2011

Barbara Forbes, MSN, keeps a big jar of tar on her desk. The dark, goopy mess is a visual representation of the amount of tar that a smoker will ingest by smoking one pack of cigarettes per day for a year. Forbes is the director of the Smoking Cessation Institute at the Vanderbilt Dayani Center […]

Heart Protein May be Target for Colon Cancer Therapies

Friday, October 7th, 2011

A protein critical in heart development may also play a part in colon cancer progression. Research led by investigators fromVanderbilt-Ingram Cancer Center and the Vanderbilt Eye Institute suggests that the protein BVES (blood vessel endocardial substance) – which also is key in regulating corneal cells – may be a therapeutic target for halting colon cancer metastasis. The study, […]