News: COX-2

Urine Biomarker for Colon Cancer?

Friday, March 2nd, 2012

About half of colorectal tumors express elevated levels of COX-2, the key enzyme responsible for generating prostaglandins that promote cancer development. Prostaglandin E2 (PGE2) is likely the primary mediator of most of COX-2’s tumor-promoting effects, and the PGE2 metabolite, PGE-M, can be measured noninvasively in urine. To assess the utility of PGE-M as a biomarker […]

Marnett’s Research Lauded

Friday, November 4th, 2011

Lawrence Marnett, Ph.D., University Professor and director of the Vanderbilt Institute of Chemical Biology, is the first recipient of the George and Christine Sosnovsky Award for Cancer Research from the American Chemical Society. The award recognizes “outstanding achievements in the elucidation of the chemical and biochemical pathways underlying human cancers, leading to the discovery and […]