News: Department of Veterans Affairs

Target Acquired for Aggressive Tumor

Friday, September 28th, 2012

Angiosarcoma, a rare, aggressive tumor that arises from cells that line blood vessels, has a mortality rate of around 80 percent. Because of their constant contact with the blood stream, these tumors can spread quickly and freely throughout the body. The INK4a/ARF locus on chromosome 9 – a region that encodes tumor suppressor proteins – […]

Study Tracks How Gene May Promote Lung Cancer Tumors

Friday, August 10th, 2012

Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors. The investigators found that the protein encoded by this gene, called EPHA3, normally inhibits tumor formation, and that loss or mutation of the gene — as often happens in lung cancer — diminishes this […]

Smoking Stokes Cells’ Cancer Capacity

Friday, March 16th, 2012

Smoking contributes to the vast majority (around 85 percent) of lung cancer cases. The TGF-beta signaling pathway – which regulates cell growth and proliferation – is altered in several cancer types, but little is known about how smoking affects this pathway. To investigate this, Debangshu Samanta, Pran Datta, Ph.D., and colleagues exposed human lung epithelial […]

Drugs Reverse Lung Cancer Cell Changes

Friday, February 3rd, 2012

The protein transforming growth factor β (TGF-β) can act as either a tumor suppressor or a tumor promoter depending on the stage of cancer. Loss of TGF-β’s tumor suppressor activity may play an important role in lung cancer progression. Pran Datta, Ph.D., and colleagues previously showed that this loss of responsiveness to TGF-β occurs mainly […]