News: DNA damage

Throwing a Wrench in DNA Machinery

Thursday, December 9th, 2010

Proteins called HDACs are the targets of a new class of anti-cancer compounds (HDAC inhibitors). How these compounds kill tumor cells — and the potential side effects of such drugs — are still open questions. Scott Hiebert, Ph.D., and colleagues at Vanderbilt-Ingram Cancer Center have now discovered that mice missing a particular HDAC (pronounced h-dack) […]