News: DNA repair

Throwing a Wrench in DNA Machinery

Thursday, December 9th, 2010

Proteins called HDACs are the targets of a new class of anti-cancer compounds (HDAC inhibitors). How these compounds kill tumor cells — and the potential side effects of such drugs — are still open questions. Scott Hiebert, Ph.D., and colleagues at Vanderbilt-Ingram Cancer Center have now discovered that mice missing a particular HDAC (pronounced h-dack) […]

DNA Mechanics

Wednesday, December 8th, 2010

Picture a railroad track, running across the countryside. DNA looks something like that track. Its “rails” are chains of chemicals called nucleotides, each pairing with a partner on the opposite chain to form the “ties.” To ensure timely train traffic – and prevent catastrophic derailments – the railroad track needs regular maintenance. So does DNA. […]

New DNA Repair Mechanism Discovered

Thursday, October 7th, 2010

Tucked within its double-helix structure, DNA contains the chemical blueprint that guides all the processes that take place within the cell and are essential for life. Therefore, repairing damage and maintaining the integrity of its DNA is one of the cell’s highest priorities. Researchers at Vanderbilt University, Pennsylvania State University and the University of Pittsburgh […]

Location Key for Breast Cancer Protein

Friday, September 17th, 2010

Mutations in the BRCA1 gene have been implicated in the development of inherited breast cancers. The BRCA1 protein participates in processes including repair of DNA breaks, DNA replication, and cell death. BRCA1 moves between the cell nucleus and cytoplasm, and Fen Xia, M.D., Ph.D., and colleagues have proposed that active “shuttling” between cellular compartments may […]