Vanderbilt-Ingram Cancer Center

Mutations that increase the expression or activity of the epidermal growth factor receptor (EGFR) are associated with several cancer types. Seven different growth factors, also called ligands, bind to EGFR and have three recognized modes of signaling – autocrine, paracrine and juxtacrine. Robert Coffey, M.D., and colleagues have identified a new mode of EGFR ligand [...]